Martin Hauer-Jensen

Short-term inhibition of ADP-induced platelet aggregation by clopidogrel ameliorates radiation-induced toxicity in rat small intestine.

Deficiency of microvascular thrombomodulin and up-regulation of protease-activated receptor-1 in irradiated rat intestine: possible link between endothelial dysfunction and chronic radiation fibrosis.

The radiotherapeutic injury--a complex 'wound'.

Clinical significance of increased gelatinolytic activity in the rectal mucosa during external beam radiation therapy of prostate cancer.

Hyperhomocysteinemia leads to adverse cardiac remodeling in hypertensive rats.

Alterations in endothelial thrombomodulin expression in zymosan-induced lung injury.

Hyperhomocysteinemia leads to pathological ventricular hypertrophy in normotensive rats.

Normal tissue effects: reporting and analysis.

Bowel injury: current and evolving management strategies.

Statins increase thrombomodulin expression and function in human endothelial cells by a nitric oxide-dependent mechanism and counteract tumor necrosis factor alpha-induced thrombomodulin downregulation.

Up-regulation and activation of proteinase-activated receptor 2 in early and delayed radiation injury in the rat intestine: influence of biological activators of proteinase-activated receptor 2.

Gastrointestinal mucositis.

Perspectives on cancer therapy-induced mucosal injury: pathogenesis, measurement, epidemiology, and consequences for patients.

Radiation injury and the protein C pathway.

Cardiac function in hearts isolated from a rat model deficient in mast cells.

Models for evaluating agents intended for the prophylaxis, mitigation and treatment of radiation injuries. Report of an NCI Workshop, December 3-4, 2003.

Protective role of mast cells in homocysteine-induced cardiac remodeling.

Influence of mast cells on structural and functional manifestations of radiation-induced heart disease.

Modulation of the intestinal response to ionizing radiation by anticoagulant and non-anticoagulant heparins.

Comparative expression profiling in primary and immortalized endothelial cells: changes in gene expression in response to hydroxy methylglutaryl-coenzyme A reductase inhibition.

Regulation of early and delayed radiation responses in rat small intestine by capsaicin-sensitive nerves.

Acute dilatory and negative inotropic effects of homocysteine are inhibited by an adenosine blocker.

Calcitonin gene-related peptide and substance P regulate the intestinal radiation response.

Orazipone, a locally acting immunomodulator, ameliorates intestinal radiation injury: a preclinical study in a novel rat model.

Comparison of mortality rates in statin users versus nonstatin users in a United States veteran population.

Radiation responses in skin and connective tissues: effect on wound healing and surgical outcome.

Influence of mast cells on outcome after heterotopic cardiac transplantation in rats.

Significance of endothelial dysfunction in the pathogenesis of early and delayed radiation enteropathy.

Long-term prognosis in patients with severe late radiation enteropathy: a prospective cohort study.

Simvastatin ameliorates radiation enteropathy development after localized, fractionated irradiation by a protein C-independent mechanism.

Local administration of interleukin-11 ameliorates intestinal radiation injury in rats.

Inactivation of thrombomodulin by ionizing radiation in a cell-free system: possible implications for radiation responses in vascular endothelium.

Protection from adverse myocardial remodeling secondary to chronic volume overload in mast cell deficient rats.

Involvement of heat shock factor 1 in statin-induced transcriptional upregulation of endothelial thrombomodulin.

Prevention and treatment of functional and structural radiation injury in the rat heart by pentoxifylline and alpha-tocopherol.

Radiation damage to the gastrointestinal tract: mechanisms, diagnosis, and management.

Lactate stimulates vasculogenic stem cells via the thioredoxin system and engages an autocrine activation loop involving hypoxia-inducible factor 1.

Influence of endothelin 1 receptor inhibition on functional, structural and molecular changes in the rat heart after irradiation.

Comparative gene expression profiling in three primary human cell lines after treatment with a novel inhibitor of Rho kinase or atorvastatin.

Hyperbaric oxygen stimulates vasculogenic stem cell growth and differentiation in vivo.

Impact of vascular endothelial growth factor on skin graft survival in irradiated rats.

Determination of sample sizes for demonstrating efficacy of radiation countermeasures.

Gamma-tocotrienol, a tocol antioxidant as a potent radioprotector.

The somatostatin analog SOM230 (pasireotide) ameliorates injury of the intestinal mucosa and increases survival after total-body irradiation by inhibiting exocrine pancreatic secretion.

gamma-Tocotrienol ameliorates intestinal radiation injury and reduces vascular oxidative stress after total-body irradiation by an HMG-CoA reductase-dependent mechanism.

Oral PEG 15-20 protects the intestine against radiation: role of lipid rafts.

Selective deficiency of HIF-1alpha in myeloid cells influences secondary intention wound healing in mouse skin.

Defining pelvic-radiation disease for the survivorship era.

Influence of sublethal total-body irradiation on immune cell populations in the intestinal mucosa.

Animal models for medical countermeasures to radiation exposure.

Sublethal total body irradiation leads to early cerebellar damage and oxidative stress.

Gamma-tocotrienol protects hematopoietic stem and progenitor cells in mice after total-body irradiation.

Hematological targets of radiation damage.

Novel strategies to ameliorate radiation injury: a possible role for tetrahydrobiopterin.

Targets of potential radioprotective drugs.

Activation of protease activated receptor 2 by exogenous agonist exacerbates early radiation injury in rat intestine.

Skin graft take rates, granulation, and epithelialization: dependence on myeloid cell hypoxia-inducible factor 1alpha.

Reduction of radiation-induced vascular nitrosative stress by the vitamin E analog γ-tocotrienol: evidence of a role for tetrahydrobiopterin.

Decreasing the adverse effects of cancer therapy: National Cancer Institute guidance for the clinical development of radiation injury mitigators.

"Pelvic radiation disease": new understanding and new solutions for a new disease in the era of cancer survivorship.

Development of a combined radiation and burn injury model.

Pentoxifylline enhances the radioprotective properties of γ-tocotrienol: differential effects on the hematopoietic, gastrointestinal and vascular systems.

IKKβ regulates the repair of DNA double-strand breaks induced by ionizing radiation in MCF-7 breast cancer cells.

Mechanisms underlying the radioprotective properties of γ-tocotrienol: comparative gene expression profiling in tocol-treated endothelial cells.

Preclinical evaluation of Som230 as a radiation mitigator in a mouse model: postexposure time window and mechanisms of action.

Epithelial to mesenchymal transition (EMT) induced by bleomycin or TFG(b1)/EGF in murine induced pluripotent stem cell-derived alveolar Type II-like cells.

Literature review and global consensus on management of acute radiation syndrome affecting nonhematopoietic organ systems.

First global consensus for evidence-based management of the hematopoietic syndrome resulting from exposure to ionizing radiation.

γ-Tocotrienol protects against mitochondrial dysfunction and renal cell death.

Novel drugs to ameliorate gastrointestinal normal tissue radiation toxicity in clinical practice: what is emerging from the laboratory?

Statistical analysis of survival data from radiation countermeasure experiments.

Procalcitonin as a predictive biomarker for total body irradiation-induced bacterial load and lethality in mice.

Inhibition of protease-activated receptor 1 ameliorates intestinal radiation mucositis in a preclinical rat model.

Pharmacological targeting of the thrombomodulin-activated protein C pathway mitigates radiation toxicity.

Cardiac inflammation after local irradiation is influenced by the kallikrein-kinin system.

Gamma-tocotrienol, a radiation prophylaxis agent, induces high levels of granulocyte colony-stimulating factor.

BMS-345541 sensitizes MCF-7 breast cancer cells to ionizing radiation by selective inhibition of homologous recombinational repair of DNA double-strand breaks.

Laser capture microdissected mucosa versus whole tissue specimens for assessment of radiation-induced dynamic molecular and pathway changes in the small intestine.

Metabolomic changes in gastrointestinal tissues after whole body radiation in a murine model.

Mobilization of progenitor cells into peripheral blood by gamma-tocotrienol: a promising radiation countermeasure.

Effects of radiation on the epidermal growth factor receptor pathway in the heart.

Characterization of transgenic Gfrp knock-in mice: implications for tetrahydrobiopterin in modulation of normal tissue radiation responses.

PARP1 is required for chromosomal translocations.

Effects of late administration of pentoxifylline and tocotrienols in an image-guided rat model of localized heart irradiation.

Combined radiation and burn injury results in exaggerated early pulmonary inflammation.

Pharmacological induction of transforming growth factor-beta1 in rat models enhances radiation injury in the intestine and the heart.

Gamma tocotrienol, a potent radioprotector, preferentially upregulates expression of anti-apoptotic genes to promote intestinal cell survival.

Luis Felipe Fajardo L-G, MD, 1927-2013.

A novel technique for image-guided local heart irradiation in the rat.

Radiation induced bowel injury: a neglected problem.

Practical advice on calculating confidence intervals for radioprotection effects and reducing animal numbers in radiation countermeasure experiments.

Oral interleukin 11 as a countermeasure to lethal total-body irradiation in a murine model.

Roles of sensory nerves in the regulation of radiation-induced structural and functional changes in the heart.

Ionizing radiation-induced responses: where free radical chemistry meets redox biology and medicine.

Radiation-induced alterations in mitochondria of the rat heart.

Bone marrow transplantation helps restore the intestinal mucosal barrier after total body irradiation in mice.

Toward development of interleukin-11 as a medical countermeasure for use in radiological/nuclear emergencies.

Radiation lethality potentiation in total body irradiated mice by a commonly prescribed proton pump inhibitor, Pantoprazole sodium.

Molecular dynamics guided design of tocoflexol: a new radioprotectant tocotrienol with enhanced bioavailability.

Radiation enteropathy--pathogenesis, treatment and prevention.

C/EBPδ deficiency sensitizes mice to ionizing radiation-induced hematopoietic and intestinal injury.

Liver metabolomics reveals increased oxidative stress and fibrogenic potential in gfrp transgenic mice in response to ionizing radiation.

Palmitoylethanolamide regulates development of intestinal radiation injury in a mast cell-dependent manner.

Synergistic radioprotection by gamma-tocotrienol and pentoxifylline: role of cAMP signaling.

Whole-body proton irradiation causes long-term damage to hematopoietic stem cells in mice.

A tocotrienol-enriched formulation protects against radiation-induced changes in cardiac mitochondria without modifying late cardiac function or structure.

Thrombomodulin contributes to gamma tocotrienol-mediated lethality protection and hematopoietic cell recovery in irradiated mice.

In Vitro Toxicity and Epigenotoxicity of Different Types of Ambient Particulate Matter.

Tocotrienol-Rich Fraction from Rice Bran Demonstrates Potent Radiation Protection Activity.

Novel Use of Proteomic Profiles in a Convex-Hull Ensemble Classifier to Predict Gynecological Cancer Patients' Susceptibility to Gastrointestinal Mucositis as Side Effect of Radiation Therapy.

Total Body Irradiation in the "Hematopoietic" Dose Range Induces Substantial Intestinal Injury in Non-Human Primates.

Combined exposure to protons and (56)Fe leads to overexpression of Il13 and reactivation of repetitive elements in the mouse lung.

Use of biomarkers for assessing radiation injury and efficacy of countermeasures.

Gene expression profiling in non-human primate jejunum, ileum and colon after total-body irradiation: a comparative study of segment-specific molecular and cellular responses.

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice.

EEPD1 Rescues Stressed Replication Forks and Maintains Genome Stability by Promoting End Resection and Homologous Recombination Repair.

Segmental Differences in Radiation-Induced Alterations of Tight Junction-Related Proteins in Non-Human Primate Jejunum, Ileum and Colon.

Space radiation and cardiovascular disease risk.

Timing of the loss of Pten protein determines disease severity in a mouse model of myeloid malignancy.

Particle Beam may have Higher Effectiveness in Treating Chemo-resistant Cancers than Low-LET Photon Beam Therapy.

Modulation of Radiation Response by the Tetrahydrobiopterin Pathway.

James William Osborne, PhD 1928-2015.

Radioprotective Efficacy of Gamma-Tocotrienol in Nonhuman Primates.

A priming dose of protons alters the early cardiac cellular and molecular response to (56)Fe irradiation.

A Quantitative Proteomic Analysis of Urine from Gamma-Irradiated Non-Human Primates.

Radiation-induced changes in DNA methylation of repetitive elements in the mouse heart.

Gamma-Tocotrienol Modulates Radiation-Induced MicroRNA Expression in Mouse Spleen.

γ-Tocotrienol as a Promising Countermeasure for Acute Radiation Syndrome: Current Status.

The Vitamin E Analog Gamma-Tocotrienol (GT3) Suppresses Radiation-Induced Cytogenetic Damage.

Low Doses of Oxygen Ion Irradiation Cause Acute Damage to Hematopoietic Cells in Mice.

Densely ionizing radiation affects DNA methylation of selective LINE-1 elements.

Recombinant Thrombomodulin (Solulin) Ameliorates Early Intestinal Radiation Toxicity in a Preclinical Rat Model.

Minipigs as models in drug discovery.

Loss of C/EBPδ enhances IR-induced cell death by promoting oxidative stress and mitochondrial dysfunction.

Synthesis of (2R,8' S,3' E)-δ-tocodienol, a tocoflexol family member designed to have a superior pharmacokinetic profile compared to δ-tocotrienol.

The Vitamin E Analog Gamma-Tocotrienol (GT3) and Statins Synergistically Up-Regulate Endothelial Thrombomodulin (TM).

Effects of ionizing radiation on the heart.