Center for Congenital Heart Diseases,
Department of Pediatric Cardiology,
Beatrix Children's Hospital,
Center for Congenital Heart Diseases, Department of Pediatric Cardiology, Beatrix Children's Hospital
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Prostacyclin therapy increases right ventricular capillarisation in a model for flow-associated pulmonary hypertension.
European journal of pharmacology Nov, 2006 | Pubmed ID: 16978602
Treprostinil in advanced experimental pulmonary hypertension: beneficial outcome without reversed pulmonary vascular remodeling.
Journal of cardiovascular pharmacology Nov, 2006 | Pubmed ID: 17110807
Severe pregnancy-induced deterioration of truncal valve regurgitation in an adolescent patient with repaired truncus arteriosus.
Cardiology , 2008 | Pubmed ID: 17726319
Long-term effect of bosentan in adults versus children with pulmonary arterial hypertension associated with systemic-to-pulmonary shunt: does the beneficial effect persist?
American heart journal Oct, 2007 | Pubmed ID: 17893008
Down syndrome and aberrant right subclavian artery.
European journal of pediatrics Sep, 2008 | Pubmed ID: 18172685
Pulmonary arterial hypertension in congenital cardiac disease--the need for refinement of the Evian-Venice classification.
Cardiology in the young Feb, 2008 | Pubmed ID: 18205971
Drug management of fetal tachyarrhythmias: are we ready for a systematic and evidence-based approach?
Pacing and clinical electrophysiology : PACE Feb, 2008 | Pubmed ID: 18226038
Biological serum markers in the management of pediatric pulmonary arterial hypertension.
Pediatric research Mar, 2008 | Pubmed ID: 18287971
Low complication rates with totally implantable access port use in epoprostenol treatment of pulmonary hypertension.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation Mar, 2009 | Pubmed ID: 19285620
Atrial septal defects versus ventricular septal defects in BREATHE-5, a placebo-controlled study of pulmonary arterial hypertension related to Eisenmenger's syndrome: a subgroup analysis.
International journal of cardiology Oct, 2010 | Pubmed ID: 19464064
Clinical characterization of pediatric pulmonary hypertension: complex presentation and diagnosis.
The Journal of pediatrics Aug, 2009 | Pubmed ID: 19524254
Pulse densitometer indocyanine green dilution curves: a simple applicable and accurate method for determination of cardiac shunts.
Congenital heart disease Sep-Oct, 2009 | Pubmed ID: 19740191
Pulmonary vascular remodeling in congenital heart disease: enhanced expression of heat shock proteins.
Indian journal of biochemistry & biophysics Dec, 2009 | Pubmed ID: 20361711
Acute pulmonary vasodilator response in paediatric and adult pulmonary arterial hypertension: occurrence and prognostic value when comparing three response criteria.
European heart journal Dec, 2011 | Pubmed ID: 21893489
Egr-1 expression during neointimal development in flow-associated pulmonary hypertension.
The American journal of pathology Nov, 2011 | Pubmed ID: 21924231
Pediatric pulmonary hypertension in the Netherlands: epidemiology and characterization during the period 1991 to 2005.
Circulation Oct, 2011 | Pubmed ID: 21947294
Clinical features of paediatric pulmonary hypertension: a registry study.
Lancet (London, England) Feb, 2012 | Pubmed ID: 22240409
The origin of fetal sterols in second-trimester amniotic fluid: endogenous synthesis or maternal-fetal transport?
American journal of obstetrics and gynecology Sep, 2012 | Pubmed ID: 22728028
Sildenafil enhances systolic adaptation, but does not prevent diastolic dysfunction, in the pressure-loaded right ventricle.
European journal of heart failure Sep, 2012 | Pubmed ID: 22730335
Physiological interaction of heart and lung in thoracic irradiation.
International journal of radiation oncology, biology, physics Dec, 2012 | Pubmed ID: 22975617
Effect of balloon atrial septostomy on cerebral oxygenation in neonates with transposition of the great arteries.
Pediatric research Jan, 2013 | Pubmed ID: 23095977
The role of maternal-fetal cholesterol transport in early fetal life: current insights.
Biology of reproduction Jan, 2013 | Pubmed ID: 23153566
Pulsatile haemodynamic parameters are predictors of survival in paediatric pulmonary arterial hypertension.
International journal of cardiology Sep, 2013 | Pubmed ID: 23340486
TBX4 mutations (small patella syndrome) are associated with childhood-onset pulmonary arterial hypertension.
Journal of medical genetics Aug, 2013 | Pubmed ID: 23592887
The role of disturbed blood flow in the development of pulmonary arterial hypertension: lessons from preclinical animal models.
American journal of physiology. Lung cellular and molecular physiology Jul, 2013 | Pubmed ID: 23624788
Combined pulmonary hypertension and renal thrombotic microangiopathy in cobalamin C deficiency.
Pediatrics Aug, 2013 | Pubmed ID: 23837176
Frequency and prognostic significance of hemoptysis in pediatric pulmonary arterial hypertension.
The American journal of cardiology Nov, 2013 | Pubmed ID: 23972345
A cornerstone of heart failure treatment is not effective in experimental right ventricular failure.
International journal of cardiology Nov, 2013 | Pubmed ID: 24067600
Effect of right ventricular outflow tract obstruction on right ventricular volumes and exercise capacity in patients with repaired tetralogy of fallot.
The American journal of cardiology Feb, 2014 | Pubmed ID: 24355311
Pediatric pulmonary hypertension.
Journal of the American College of Cardiology Dec, 2013 | Pubmed ID: 24355636
Survival differences in pediatric pulmonary arterial hypertension: clues to a better understanding of outcome and optimal treatment strategies.
Journal of the American College of Cardiology May, 2014 | Pubmed ID: 24681143
Ventricular remodelling after pulmonary valve replacement: comparison between pressure-loaded and volume-loaded right ventricles.
Interactive cardiovascular and thoracic surgery Jul, 2014 | Pubmed ID: 24722515
Pulmonary hypertension: smaller kids, smaller steps.
The Lancet. Respiratory medicine May, 2014 | Pubmed ID: 24815801
Sildenafil treatment in established right ventricular dysfunction improves diastolic function and attenuates interstitial fibrosis independent from afterload.
American journal of physiology. Heart and circulatory physiology Aug, 2014 | Pubmed ID: 24878769
A critical role for Egr-1 during vascular remodelling in pulmonary arterial hypertension.
Cardiovascular research Sep, 2014 | Pubmed ID: 25028387
Identification of treatment goals in paediatric pulmonary arterial hypertension.
The European respiratory journal Dec, 2014 | Pubmed ID: 25034572
Current and advancing treatments for pulmonary arterial hypertension in childhood.
Expert review of respiratory medicine Oct, 2014 | Pubmed ID: 25047735
The challenges in paediatric pulmonary arterial hypertension.
European respiratory review : an official journal of the European Respiratory Society Dec, 2014 | Pubmed ID: 25445948
Clinical symptoms of right ventricular failure in experimental chronic pressure load are associated with progressive diastolic dysfunction.
Journal of molecular and cellular cardiology Feb, 2015 | Pubmed ID: 25486580
Echocardiography in pediatric pulmonary arterial hypertension: early study on assessing disease severity and predicting outcome.
Circulation. Cardiovascular imaging Jan, 2015 | Pubmed ID: 25552488
Prognostic factors in pediatric pulmonary arterial hypertension: A systematic review and meta-analysis.
International journal of cardiology Apr, 2015 | Pubmed ID: 25706327
What's the (end) point?
The European respiratory journal Mar, 2015 | Pubmed ID: 25726540
Clinical Worsening as Composite Study End Point in Pediatric Pulmonary Arterial Hypertension.
Chest Sep, 2015 | Pubmed ID: 25741884
Right ventricular failure due to chronic pressure load: What have we learned in animal models since the NIH working group statement?
Heart failure reviews Jul, 2015 | Pubmed ID: 25771982
Adverse pulmonary vascular remodeling in the Fontan circulation.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation Mar, 2015 | Pubmed ID: 25813767
Pulmonary regurgitant volume is superior to fraction using background-corrected phase contrast MRI in determining the severity of regurgitation in repaired tetralogy of Fallot.
The international journal of cardiovascular imaging Aug, 2015 | Pubmed ID: 25944487
Ductus arteriosus aneurysm and vocal cord paralysis.
Circulation May, 2015 | Pubmed ID: 25964282
Effects of sildenafil on invasive haemodynamics and exercise capacity in heart failure patients with preserved ejection fraction and pulmonary hypertension: a randomized controlled trial.
European heart journal Oct, 2015 | Pubmed ID: 26188003
Erythropoietin Attenuates Pulmonary Vascular Remodeling in Experimental Pulmonary Arterial Hypertension through Interplay between Endothelial Progenitor Cells and Heme Oxygenase.
Frontiers in pediatrics , 2015 | Pubmed ID: 26380246
Six-minute walking distance and decrease in oxygen saturation during the six-minute walk test in pediatric pulmonary arterial hypertension.
International journal of cardiology Jan, 2016 | Pubmed ID: 26386916
FUTURE-2: Results from an open-label, long-term safety and tolerability extension study using the pediatric FormUlation of bosenTan in pUlmonary arterial hypeRtEnsion.
International journal of cardiology Jan, 2016 | Pubmed ID: 26386921
The Fontan circulation and the liver: A magnetic resonance diffusion-weighted imaging study.
International journal of cardiology Jan, 2016 | Pubmed ID: 26447669
Egr-1 identifies neointimal remodeling and relates to progression in human pulmonary arterial hypertension.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation Apr, 2016 | Pubmed ID: 26774383
Cardiovascular malformations caused by NOTCH1 mutations do not keep left: data on 428 probands with left-sided CHD and their families.
Genetics in medicine : official journal of the American College of Medical Genetics Sep, 2016 | Pubmed ID: 26820064
Common arterial trunk and ventricular non-compaction in Lrp2 knockout mice indicate a crucial role of LRP2 in cardiac development.
Disease models & mechanisms Apr, 2016 | Pubmed ID: 26822476
Acute Vasodilator Response in Pediatric Pulmonary Arterial Hypertension: Current Clinical Practice From the TOPP Registry.
Journal of the American College of Cardiology Mar, 2016 | Pubmed ID: 26988953
Growth in children with pulmonary arterial hypertension: a longitudinal retrospective multiregistry study.
The Lancet. Respiratory medicine Apr, 2016 | Pubmed ID: 26994897
Surgical options after Fontan failure.
Heart (British Cardiac Society) Jul, 2016 | Pubmed ID: 27076374
A Hemodynamically Significant Patent Ductus Arteriosus Does Not Affect Cerebral or Renal Tissue Oxygenation in Preterm Infants.
Neonatology , 2016 | Pubmed ID: 27088709
Renal thrombotic microangiopathy in patients with cblC defect: review of an under-recognized entity.
Pediatric nephrology (Berlin, Germany) Jun, 2016 | Pubmed ID: 27289364
Multisite Tissue Oxygenation Monitoring Indicates Organ-Specific Flow Distribution and Oxygen Delivery Related to Low Cardiac Output in Preterm Infants With Clinical Sepsis.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies Aug, 2016 | Pubmed ID: 27500612
Corrigendum to "FUTURE-2: Results from an open-label, long-term safety and tolerability extension study using the pediatric FormUlation of bosenTan in pUlmonary arterial hypeRtEnsion" [Int. J. Cardiol. 202 (2016) 52-58].
International journal of cardiology Nov, 2016 | Pubmed ID: 27623401
Clinical classification in pediatric pulmonary arterial hypertension associated with congenital heart disease.
Pulmonary circulation Sep, 2016 | Pubmed ID: 27683607
Effects of sildenafil on cardiac structure and function, cardiopulmonary exercise testing and health-related quality of life measures in heart failure patients with preserved ejection fraction and pulmonary hypertension.
European journal of heart failure Jan, 2017 | Pubmed ID: 27873388
Serially Measured Uric Acid Levels Predict Disease Severity and Outcome in Pediatric Pulmonary Arterial Hypertension.
American journal of respiratory and critical care medicine Feb, 2017 | Pubmed ID: 28145758
Physical Activity in Pediatric Pulmonary Arterial Hypertension Measured by Accelerometry. A Candidate Clinical Endpoint.
American journal of respiratory and critical care medicine 07, 2017 | Pubmed ID: 28178426
A bosentan pharmacokinetic study to investigate dosing regimens in paediatric patients with pulmonary arterial hypertension: FUTURE-3.
British journal of clinical pharmacology 08, 2017 | Pubmed ID: 28213957
Diminished liver microperfusion in Fontan patients: A biexponential DWI study.
PloS one , 2017 | Pubmed ID: 28257439
Pulmonary arterial stiffness indices assessed by intravascular ultrasound in children with early pulmonary vascular disease: prediction of advanced disease and mortality during 20-year follow-up.
European heart journal cardiovascular Imaging 02, 2018 | Pubmed ID: 28329155
Right ventricular recovery after bilateral lung transplantation for pulmonary arterial hypertension†.
Interactive cardiovascular and thoracic surgery 06, 2017 | Pubmed ID: 28329267
Pulmonary arterial hypertension in congenital heart disease: translational opportunities to study the reversibility of pulmonary vascular disease.
European heart journal Jul, 2017 | Pubmed ID: 28369399
Right ventricular-vascular coupling in heart failure with preserved ejection fraction and pre- vs. post-capillary pulmonary hypertension.
European heart journal cardiovascular Imaging 04, 2018 | Pubmed ID: 28531295
Diagnostic value of Doppler echocardiography for identifying hemodynamic significant pulmonary valve regurgitation in tetralogy of Fallot: comparison with cardiac MRI.
The international journal of cardiovascular imaging Nov, 2017 | Pubmed ID: 28567705
Pediatric pulmonary arterial hypertension: on the eve of growing up.
Current opinion in pulmonary medicine 09, 2017 | Pubmed ID: 28590293
Fontan Circulation over Time.
The American journal of cardiology Aug, 2017 | Pubmed ID: 28624095
Prenatal exposure to serotonin reuptake inhibitors and congenital heart anomalies: an exploratory pharmacogenetics study.
Pharmacogenomics Jul, 2017 | Pubmed ID: 28639488
Cerebral and Renal Oxygen Saturation Are Not Compromised in the Presence of Retrograde Blood Flow in either the Ascending or Descending Aorta in Term or Near-Term Infants with Left-Sided Obstructive Lesions.
Neonatology , 2017 | Pubmed ID: 28704832
Volume load-induced right ventricular dysfunction in animal models: insights in a translational gap in congenital heart disease.
European journal of heart failure 04, 2018 | Pubmed ID: 28925007
Amplitude-integrated electroencephalography during the first 72 h after birth in neonates diagnosed prenatally with congenital heart disease.
Pediatric research 04, 2018 | Pubmed ID: 29244798
Identification of gaps in the current knowledge on pulmonary hypertension in extremely preterm infants: A systematic review and meta-analysis.
Paediatric and perinatal epidemiology 05, 2018 | Pubmed ID: 29341209
Quality of life and sexual well-being in patients with a Fontan circulation: An explorative pilot study with a mixed method design.
Congenital heart disease Mar, 2018 | Pubmed ID: 29532606
Risk of cardiac tachyarrhythmia in patients with repaired tetralogy of Fallot: a multicenter cardiac MRI based study.
The international journal of cardiovascular imaging Jan, 2019 | Pubmed ID: 30094564
Pulmonary vasodilator therapy as treatment for patients with a Fontan circulation: the Emperor's new clothes?
Pulmonary circulation Oct-Dec, 2018 | Pubmed ID: 30338725
Assessment of reversibility in pulmonary arterial hypertension and congenital heart disease.
Heart (British Cardiac Society) 02, 2019 | Pubmed ID: 30467194
Paediatric pulmonary arterial hypertension: updates on definition, classification, diagnostics and management.
The European respiratory journal Jan, 2019 | Pubmed ID: 30545978
Early Diagnosis in Pulmonary Arterial Hypertension: The Search for the Holy Grail.
American journal of respiratory and critical care medicine Jun, 2019 | Pubmed ID: 30649901
The Janus-faced Fontan circulation: unravelling its elusive pathophysiology.
European journal of heart failure 06, 2019 | Pubmed ID: 30730092
Converging Paths of Pulmonary Arterial Hypertension and Cellular Senescence.
American journal of respiratory cell and molecular biology 07, 2019 | Pubmed ID: 30758225
Response: Still puzzling about a clear definition of pulmonary arterial hypertension in newborns.
The European respiratory journal Mar, 2019 | Pubmed ID: 30923178
The Natural and Unnatural History of Congenital Aortic Arch Abnormalities Evaluated in an Adult Survival Cohort.
The Canadian journal of cardiology 04, 2019 | Pubmed ID: 30935634
A novel method optimizing the normalization of cardiac parameters in small animal models: the importance of dimensional indexing.
American journal of physiology. Heart and circulatory physiology 06, 2019 | Pubmed ID: 30978120
Multicenter Preclinical Validation of BET Inhibition for the Treatment of Pulmonary Arterial Hypertension.
American journal of respiratory and critical care medicine 10, 2019 | Pubmed ID: 31042405
Meaningful and feasible composite clinical worsening definitions in paediatric pulmonary arterial hypertension: An analysis of the TOPP registry.
International journal of cardiology 08, 2019 | Pubmed ID: 31072635
New Strategies for the Conduct of Clinical Trials in Pediatric Pulmonary Arterial Hypertension: Outcome of a Multistakeholder Meeting With Patients, Academia, Industry, and Regulators, Held at the European Medicines Agency on Monday, June 12, 2017.
Journal of the American Heart Association 05, 2019 | Pubmed ID: 31088189
CMR feature tracking left ventricular strain-rate predicts ventricular tachyarrhythmia, but not deterioration of ventricular function in patients with repaired tetralogy of Fallot.
International journal of cardiology 11, 2019 | Pubmed ID: 31402156
Thoracotomy Versus Sternotomy for Patent Ductus Arteriosus Closure in Preterm Neonates.
The Annals of thoracic surgery 01, 2020 | Pubmed ID: 31408645
Reply to Piquereau and Perros and to Pullamsetti and de Jesus Perez.
American journal of respiratory and critical care medicine 11, 2019 | Pubmed ID: 31419387
The ever-expanding phenotypical spectrum of human TBX4 mutations: from toe to lung.
The European respiratory journal Aug, 2019 | Pubmed ID: 31439725
Failing Homeostasis of Quadriceps Muscle Energy- and pH Balance During Bicycling in a Young Patient With a Fontan Circulation.
Frontiers in cardiovascular medicine , 2019 | Pubmed ID: 31497605
Recommendations from the Association for European Paediatric and Congenital Cardiology for training in pulmonary hypertension.
Cardiology in the young Nov, 2019 | Pubmed ID: 31554525
Reply to Ning : More Insights into the Association between RVX-208 and Pulmonary Arterial Hypertension.
American journal of respiratory and critical care medicine 02, 2020 | Pubmed ID: 31560564
Metabolic Remodeling in the Pressure-Loaded Right Ventricle: Shifts in Glucose and Fatty Acid Metabolism-A Systematic Review and Meta-Analysis.
Journal of the American Heart Association 11, 2019 | Pubmed ID: 31657265
Setting the stage for increasing diversity in congenital cardiology: let's celebrate the 75th anniversary of the Blalock-Thomas-Taussig shunt.
Cardiology in the young Mar, 2020 | Pubmed ID: 31910925
Serial cardiovascular magnetic resonance feature tracking indicates early worsening of cardiac function in Fontan patients.
International journal of cardiology 03, 2020 | Pubmed ID: 31918854
Early angiogenic proteins associated with high risk for bronchopulmonary dysplasia and pulmonary hypertension in preterm infants.
American journal of physiology. Lung cellular and molecular physiology Apr, 2020 | Pubmed ID: 31967847
Serial Measurements of N-Terminal Pro-B-Type Natriuretic Peptide Serum Level for Monitoring Pulmonary Arterial Hypertension in Children.
The Journal of pediatrics May, 2020 | Pubmed ID: 32113658
TBX4 variants and pulmonary diseases: getting out of the 'Box'.
Current opinion in pulmonary medicine May, 2020 | Pubmed ID: 32195678
Onset of brain injury in infants with prenatally diagnosed congenital heart disease.
PloS one , 2020 | Pubmed ID: 32210445
GDF-15 (Growth Differentiation Factor 15) Is Associated With Hospitalization and Mortality in Patients With a Fontan Circulation.
Journal of the American Heart Association May, 2020 | Pubmed ID: 32384007
Anne-Marie C. Koop*,1,
Quint A.J. Hagdorn*,1,
Kees (C.) W.A. van de Kolk2,3,
Annemieke van Oosten2,
Michel Weij2,
Herman H.W. Silljé4,
Tineke P. Willems5,
Rolf M.F. Berger1
1Center for Congenital Heart Diseases, Department of Pediatric Cardiology, University Medical Center Groningen, University of Groningen,
2The Central Animal Facility, University Medical Center Groningen, University of Groningen,
3Gronsai (Groningen Small Animal Imaging Facility), University Medical Center Groningen, University of Groningen,
4Department of Cardiology, University Medical Center Groningen, University of Groningen,
5Department of Radiology, University Medical Center Groningen, University of Groningen
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