Department of Chemistry and Biomolecular Sciences
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Does CIP Nomenclature Adequately Handle Molecules with Multiple Stereoelements? A Case Study of Vancomycin and Cognates We would like to thank Professor Dieter Hellwinkel for pointing out to us the stereochemical discrepancies in our review6 and elsewhere in the literature, and Kurt Mislow for stimulating and useful discussions.
Angewandte Chemie (International ed. in English) Feb, 2001 | Pubmed ID: 11241596
Atropselective macrocyclization of diaryl ether ring systems: application to the synthesis of vancomycin model systems.
Journal of the American Chemical Society Sep, 2002 | Pubmed ID: 12197747
Epothilone C macrolactonization and hydrolysis are catalyzed by the isolated thioesterase domain of epothilone polyketide synthase.
Journal of the American Chemical Society Mar, 2003 | Pubmed ID: 12643694
Understanding substrate specificity of polyketide synthase modules by generating hybrid multimodular synthases.
The Journal of biological chemistry Oct, 2003 | Pubmed ID: 12923197
Precursor-directed biosynthesis of epothilone in Escherichia coli.
Journal of the American Chemical Society Jun, 2004 | Pubmed ID: 15198579
Sweetening cyclic peptide libraries.
Chemistry & biology Dec, 2004 | Pubmed ID: 15610840
Total biosynthesis of antitumor nonribosomal peptides in Escherichia coli.
Nature chemical biology Aug, 2006 | Pubmed ID: 16799553
The thioesterase domain from the pimaricin and erythromycin biosynthetic pathways can catalyze hydrolysis of simple thioester substrates.
Bioorganic & medicinal chemistry letters Jun, 2007 | Pubmed ID: 17428661
Sialic acid and N-acyl sialic acid analog production by fermentation of metabolically and genetically engineered Escherichia coli.
Organic & biomolecular chemistry Jun, 2007 | Pubmed ID: 17551639
A new mechanism for benzopyrone formation in aromatic polyketide biosynthesis.
Journal of the American Chemical Society Aug, 2007 | Pubmed ID: 17625867
Orthogonal ligation: a three piece assembly of a PNA-peptide-PNA conjugate.
Chemical communications (Cambridge, England) Jun, 2008 | Pubmed ID: 18688310
Examining the role of hydrogen bonding interactions in the substrate specificity for the loading step of polyketide synthase thioesterase domains.
Biochemistry Nov, 2008 | Pubmed ID: 18850723
Biomimetic transannular oxa-conjugate addition approach to the 2,6-disubstituted dihydropyran of laulimalide yields an unprecedented transannular oxetane.
The Journal of organic chemistry Feb, 2009 | Pubmed ID: 19159194
Polyketide synthase thioesterases catalyze rapid hydrolysis of peptidyl thioesters.
Bioorganic & medicinal chemistry letters Mar, 2009 | Pubmed ID: 19188064
A thioesterase from an iterative fungal polyketide synthase shows macrocyclization and cross coupling activity and may play a role in controlling iterative cycling through product offloading.
Biochemistry Jul, 2009 | Pubmed ID: 19530704
Heterologous expression of the oxytetracycline biosynthetic pathway in Myxococcus xanthus.
Applied and environmental microbiology Apr, 2010 | Pubmed ID: 20208031
Reinvestigation of coenzyme Q10 isolation from Sporidiobolus johnsonii.
Chemistry & biodiversity Jun, 2011 | Pubmed ID: 21674778
6-Deoxyerythronolide B synthase thioesterase-catalyzed macrocyclization is highly stereoselective.
Organic letters May, 2012 | Pubmed ID: 22519860
Non-canonical regioisomerizations and a 'Diels-Alderase' are likely essential in the biosynthesis of spiculoic acid A.
Bioorganic & medicinal chemistry letters Aug, 2012 | Pubmed ID: 22801647
ClusterMine360: a database of microbial PKS/NRPS biosynthesis.
Nucleic acids research Jan, 2013 | Pubmed ID: 23104377
Gene PA2449 is essential for glycine metabolism and pyocyanin biosynthesis in Pseudomonas aeruginosa PAO1.
Journal of bacteriology May, 2013 | Pubmed ID: 23457254
Alternative Sigma Factor Over-Expression Enables Heterologous Expression of a Type II Polyketide Biosynthetic Pathway in Escherichia coli.
PloS one , 2013 | Pubmed ID: 23724102
Biosynthesis of ebelactone A: isotopic tracer, advanced precursor and genetic studies reveal a thioesterase-independent cyclization to give a polyketide β-lactone.
The Journal of antibiotics Jul, 2013 | Pubmed ID: 23801186
The role of transcription in heterologous expression of polyketides in bacterial hosts.
Natural product reports Oct, 2013 | Pubmed ID: 24061690
Bioinformatics tools for genome mining of polyketide and non-ribosomal peptides.
Journal of industrial microbiology & biotechnology Feb, 2014 | Pubmed ID: 24174214
Habitat-specific type I polyketide synthases in soils and street sediments.
Journal of industrial microbiology & biotechnology Jan, 2014 | Pubmed ID: 24241933
Elucidation of gephyronic acid biosynthetic pathway revealed unexpected SAM-dependent methylations.
Journal of natural products Dec, 2013 | Pubmed ID: 24298873
Genetic analysis of the assimilation of C5-dicarboxylic acids in Pseudomonas aeruginosa PAO1.
Journal of bacteriology Jul, 2014 | Pubmed ID: 24794562
Salvadenosine, a 5'-deoxy-5'-(methylthio) nucleoside from the Bahamian tunicate Didemnum sp.
The Journal of organic chemistry Nov, 2014 | Pubmed ID: 25284474
An evolutionary model encompassing substrate specificity and reactivity of type I polyketide synthase thioesterases.
Chembiochem : a European journal of chemical biology Dec, 2014 | Pubmed ID: 25354333
Resorcylic acid lactone biosynthesis relies on a stereotolerant macrocyclizing thioesterase.
Organic letters Nov, 2014 | Pubmed ID: 25372311
Modulation of antifreeze activity and the effect upon post-thaw HepG2 cell viability after cryopreservation.
Cryobiology Apr, 2015 | Pubmed ID: 25595636
Polyketide synthase and non-ribosomal peptide synthetase thioesterase selectivity: logic gate or a victim of fate?
Natural product reports Feb, 2016 | Pubmed ID: 25642666
Draft Genome Sequence of Streptomyces sp. Strain PBH53, Isolated from an Urban Environment.
Genome announcements Jul, 2015 | Pubmed ID: 26227608
Thermoplasmonic ssDNA Dynamic Release from Gold Nanoparticles Examined with Advanced Fluorescence Microscopy.
The journal of physical chemistry letters Apr, 2015 | Pubmed ID: 26263158
Towards a characterization of the structural determinants of specificity in the macrocyclizing thioesterase for deoxyerythronolide B biosynthesis.
Biochimica et biophysica acta Mar, 2016 | Pubmed ID: 26592346
Diastereoseletive Transannular Oxa-Conjugate Addition Generates the 2,6-cis-Disubstituted Tetrahydropyran of Neopeltolide.
The Journal of organic chemistry Jan, 2016 | Pubmed ID: 26675500
The Use of ClusterMine360 for the Analysis of Polyketide and Nonribosomal Peptide Biosynthetic Pathways.
Methods in molecular biology (Clifton, N.J.) , 2016 | Pubmed ID: 26831712
First-in-class small molecule potentiators of cancer virotherapy.
Scientific reports May, 2016 | Pubmed ID: 27226390
Total Biosynthesis of Legionaminic Acid, a Bacterial Sialic Acid Analogue.
Angewandte Chemie (International ed. in English) Sep, 2016 | Pubmed ID: 27538580
Portable, On-Demand Biomolecular Manufacturing.
Cell Sep, 2016 | Pubmed ID: 27662092
Natural products: Mapping an amazing thicket.
Nature chemical biology Dec, 2016 | Pubmed ID: 27984578
Sampling Terrestrial Environments for Bacterial Polyketides.
Molecules (Basel, Switzerland) Apr, 2017 | Pubmed ID: 28468277
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