Christopher N. Boddy

Does CIP Nomenclature Adequately Handle Molecules with Multiple Stereoelements? A Case Study of Vancomycin and Cognates We would like to thank Professor Dieter Hellwinkel for pointing out to us the stereochemical discrepancies in our review6 and elsewhere in the literature, and Kurt Mislow for stimulating and useful discussions.

Atropselective macrocyclization of diaryl ether ring systems: application to the synthesis of vancomycin model systems.

Epothilone C macrolactonization and hydrolysis are catalyzed by the isolated thioesterase domain of epothilone polyketide synthase.

Understanding substrate specificity of polyketide synthase modules by generating hybrid multimodular synthases.

Precursor-directed biosynthesis of epothilone in Escherichia coli.

Sweetening cyclic peptide libraries.

Total biosynthesis of antitumor nonribosomal peptides in Escherichia coli.

The thioesterase domain from the pimaricin and erythromycin biosynthetic pathways can catalyze hydrolysis of simple thioester substrates.

Sialic acid and N-acyl sialic acid analog production by fermentation of metabolically and genetically engineered Escherichia coli.

A new mechanism for benzopyrone formation in aromatic polyketide biosynthesis.

Orthogonal ligation: a three piece assembly of a PNA-peptide-PNA conjugate.

Examining the role of hydrogen bonding interactions in the substrate specificity for the loading step of polyketide synthase thioesterase domains.

Biomimetic transannular oxa-conjugate addition approach to the 2,6-disubstituted dihydropyran of laulimalide yields an unprecedented transannular oxetane.

Polyketide synthase thioesterases catalyze rapid hydrolysis of peptidyl thioesters.

A thioesterase from an iterative fungal polyketide synthase shows macrocyclization and cross coupling activity and may play a role in controlling iterative cycling through product offloading.

Heterologous expression of the oxytetracycline biosynthetic pathway in Myxococcus xanthus.

Reinvestigation of coenzyme Q10 isolation from Sporidiobolus johnsonii.

6-Deoxyerythronolide B synthase thioesterase-catalyzed macrocyclization is highly stereoselective.

Non-canonical regioisomerizations and a 'Diels-Alderase' are likely essential in the biosynthesis of spiculoic acid A.

ClusterMine360: a database of microbial PKS/NRPS biosynthesis.

Gene PA2449 is essential for glycine metabolism and pyocyanin biosynthesis in Pseudomonas aeruginosa PAO1.

Alternative Sigma Factor Over-Expression Enables Heterologous Expression of a Type II Polyketide Biosynthetic Pathway in Escherichia coli.

Biosynthesis of ebelactone A: isotopic tracer, advanced precursor and genetic studies reveal a thioesterase-independent cyclization to give a polyketide β-lactone.

The role of transcription in heterologous expression of polyketides in bacterial hosts.

Bioinformatics tools for genome mining of polyketide and non-ribosomal peptides.

Habitat-specific type I polyketide synthases in soils and street sediments.

Elucidation of gephyronic acid biosynthetic pathway revealed unexpected SAM-dependent methylations.

Genetic analysis of the assimilation of C5-dicarboxylic acids in Pseudomonas aeruginosa PAO1.

Salvadenosine, a 5'-deoxy-5'-(methylthio) nucleoside from the Bahamian tunicate Didemnum sp.

An evolutionary model encompassing substrate specificity and reactivity of type I polyketide synthase thioesterases.

Resorcylic acid lactone biosynthesis relies on a stereotolerant macrocyclizing thioesterase.

Modulation of antifreeze activity and the effect upon post-thaw HepG2 cell viability after cryopreservation.

Polyketide synthase and non-ribosomal peptide synthetase thioesterase selectivity: logic gate or a victim of fate?

Draft Genome Sequence of Streptomyces sp. Strain PBH53, Isolated from an Urban Environment.

Thermoplasmonic ssDNA Dynamic Release from Gold Nanoparticles Examined with Advanced Fluorescence Microscopy.

Towards a characterization of the structural determinants of specificity in the macrocyclizing thioesterase for deoxyerythronolide B biosynthesis.

Diastereoseletive Transannular Oxa-Conjugate Addition Generates the 2,6-cis-Disubstituted Tetrahydropyran of Neopeltolide.

The Use of ClusterMine360 for the Analysis of Polyketide and Nonribosomal Peptide Biosynthetic Pathways.

First-in-class small molecule potentiators of cancer virotherapy.

Total Biosynthesis of Legionaminic Acid, a Bacterial Sialic Acid Analogue.

Portable, On-Demand Biomolecular Manufacturing.

Natural products: Mapping an amazing thicket.

Sampling Terrestrial Environments for Bacterial Polyketides.