Mitchell J. Weiss

An abundant erythroid protein that stabilizes free alpha-haemoglobin.

Biophysical characterization of the alpha-globin binding protein alpha-hemoglobin stabilizing protein.

Cooperative activities of hematopoietic regulators recruit RNA polymerase II to a tissue-specific chromatin domain.

Formation of a tissue-specific histone acetylation pattern by the hematopoietic transcription factor GATA-1.

GATA-1-mediated proliferation arrest during erythroid maturation.

GATA-1-dependent transcriptional repression of GATA-2 via disruption of positive autoregulation and domain-wide chromatin remodeling.

Stress-induced apoptosis associated with null mutation of ADAR1 RNA editing deaminase gene.

New insights into erythropoietin and epoetin alfa: mechanisms of action, target tissues, and clinical applications.

Evaluation of alpha hemoglobin stabilizing protein (AHSP) as a genetic modifier in patients with beta thalassemia.

Global regulation of erythroid gene expression by transcription factor GATA-1.

Loss of alpha-hemoglobin-stabilizing protein impairs erythropoiesis and exacerbates beta-thalassemia.

Molecular mechanism of AHSP-mediated stabilization of alpha-hemoglobin.

Proximity among distant regulatory elements at the beta-globin locus requires GATA-1 and FOG-1.

Structure of oxidized alpha-haemoglobin bound to AHSP reveals a protective mechanism for haem.

Repression of c-kit and its downstream substrates by GATA-1 inhibits cell proliferation during erythroid maturation.

Early block to erythromegakaryocytic development conferred by loss of transcription factor GATA-1.

GATA-1 and Oct-1 are required for expression of the human alpha-hemoglobin-stabilizing protein gene.

Designer blood: creating hematopoietic lineages from embryonic stem cells.

Megakaryocyte biology and related disorders.

Role of alpha-hemoglobin-stabilizing protein in normal erythropoiesis and beta-thalassemia.

Mitoferrin is essential for erythroid iron assimilation.

Alpha-haemoglobin stabilising protein is a quantitative trait gene that modifies the phenotype of beta-thalassaemia.

Biochemical fates of alpha hemoglobin bound to alpha hemoglobin-stabilizing protein AHSP.

A novel haem-binding interface in the 22 kDa haem-binding protein p22HBP.

Experimental validation of predicted mammalian erythroid cis-regulatory modules.

Assembly of recently translated full-length and C-terminal truncated human gamma-globin chains with a pool of alpha-globin chains to form Hb F in a cell-free system.

An erythroid chaperone that facilitates folding of alpha-globin subunits for hemoglobin synthesis.

Diseased red blood cells topple iron balance.

Population analysis of the alpha hemoglobin stabilizing protein (AHSP) gene identifies sequence variants that alter expression and function.

STAT1 promotes megakaryopoiesis downstream of GATA-1 in mice.

A GATA-1-regulated microRNA locus essential for erythropoiesis.

An iron responsive element-like stem-loop regulates alpha-hemoglobin-stabilizing protein mRNA.

Trisomy 21 enhances human fetal erythro-megakaryocytic development.

Transcriptional enhancement by GATA1-occupied DNA segments is strongly associated with evolutionary constraint on the binding site motif.

Chaperoning erythropoiesis.

Analysis of human alpha globin gene mutations that impair binding to the alpha hemoglobin stabilizing protein.

Graded repression of PU.1/Sfpi1 gene transcription by GATA factors regulates hematopoietic cell fate.

The role of alpha-hemoglobin stabilizing protein in redox chemistry, denaturation, and hemoglobin assembly.

Stem cells unscramble yolk sac hematopoiesis.

A cis-proline in alpha-hemoglobin stabilizing protein directs the structural reorganization of alpha-hemoglobin.

Mammalian casein kinase 1alpha and its leishmanial ortholog regulate stability of IFNAR1 and type I interferon signaling.

LRF is an essential downstream target of GATA1 in erythroid development and regulates BIM-dependent apoptosis.

Erythroid GATA1 function revealed by genome-wide analysis of transcription factor occupancy, histone modifications, and mRNA expression.

Insights into GATA-1-mediated gene activation versus repression via genome-wide chromatin occupancy analysis.

Getting by with a little help from our friends.

MicroRNAs in erythropoiesis.

miR-451 protects against erythroid oxidant stress by repressing 14-3-3zeta.

MicroRNA expression in maturing murine megakaryocytes.

Analysis of alpha hemoglobin stabilizing protein overexpression in murine β-thalassemia.

AHSP (α-haemoglobin-stabilizing protein) stabilizes apo-α-haemoglobin in a partially folded state.

Protein quality control during erythropoiesis and hemoglobin synthesis.

Identification of distal cis-regulatory elements at mouse mitoferrin loci using zebrafish transgenesis.

A hemoglobin variant associated with neonatal cyanosis and anemia.

Dynamics of the epigenetic landscape during erythroid differentiation after GATA1 restoration.

Functional regulation of pre-B-cell leukemia homeobox interacting protein 1 (PBXIP1/HPIP) in erythroid differentiation.

A new 'Linc' between noncoding RNAs and blood development.

Insights into hemoglobin assembly through in vivo mutagenesis of α-hemoglobin stabilizing protein.

Kinetics of α-globin binding to α-hemoglobin stabilizing protein (AHSP) indicate preferential stabilization of hemichrome folding intermediate.

Loss of the miR-144/451 cluster impairs ischaemic preconditioning-mediated cardioprotection by targeting Rac-1.

Integrated protein quality-control pathways regulate free α-globin in murine β-thalassemia.

Self-renewing endodermal progenitor lines generated from human pluripotent stem cells.

CD19 is a major B cell receptor-independent activator of MYC-driven B-lymphomagenesis.

SLC35D3 delivery from megakaryocyte early endosomes is required for platelet dense granule biogenesis and is differentially defective in Hermansky-Pudlak syndrome models.

What's in a name?

An encyclopedia of mouse DNA elements (Mouse ENCODE).

α-Hemoglobin-stabilizing protein is a sensitive and specific marker of erythroid precursors.

Perturbation of fetal liver hematopoietic stem and progenitor cell development by trisomy 21.

Trisomy 21-associated defects in human primitive hematopoiesis revealed through induced pluripotent stem cells.

miR-451 regulates dendritic cell cytokine responses to influenza infection.

α-Hemoglobin stabilizing protein (AHSP) markedly decreases the redox potential and reactivity of α-subunits of human HbA with hydrogen peroxide.

Hemoglobin variants: biochemical properties and clinical correlates.

The secreted lymphangiogenic factor CCBE1 is essential for fetal liver erythropoiesis.

The calcineurin-NFAT pathway negatively regulates megakaryopoiesis.

Patient-derived induced pluripotent stem cells recapitulate hematopoietic abnormalities of juvenile myelomonocytic leukemia.

Long noncoding RNAs in biology and hematopoiesis.

α-Hemoglobin-stabilizing protein (AHSP) perturbs the proximal heme pocket of oxy-α-hemoglobin and weakens the iron-oxygen bond.

Congenital dyserythropoietic anemias: III's a charm.

Ribosomal and hematopoietic defects in induced pluripotent stem cells derived from Diamond Blackfan anemia patients.

Clonal genetic and hematopoietic heterogeneity among human-induced pluripotent stem cell lines.

Development of acute megakaryoblastic leukemia in Down syndrome is associated with sequential epigenetic changes.

Lineage and species-specific long noncoding RNAs during erythro-megakaryocytic development.

Iron-laden macrophage in autoimmune disease.

Erythro-megakaryocytic transcription factors associated with hereditary anemia.

Personalized platelet transfusions: one step closer to the clinic.

Immune hemolytic anemia with drug-induced antibodies to carboplatin and vincristine in a pediatric patient with an optic pathway glioma.

miR-451 deficiency is associated with altered endometrial fibrinogen alpha chain expression and reduced endometriotic implant establishment in an experimental mouse model.

Post-translational transformation of methionine to aspartate is catalyzed by heme iron and driven by peroxide: a novel subunit-specific mechanism in hemoglobin.

Update on the diagnosis and management of thalassemia.

Hematopoietic differentiation of pluripotent stem cells in culture.

Trim58 degrades Dynein and regulates terminal erythropoiesis.

Dynamic shifts in occupancy by TAL1 are guided by GATA factors and drive large-scale reprogramming of gene expression during hematopoiesis.

Divergent functions of hematopoietic transcription factors in lineage priming and differentiation during erythro-megakaryopoiesis.

A comparative encyclopedia of DNA elements in the mouse genome.

Level of RUNX1 activity is critical for leukemic predisposition but not for thrombocytopenia.

MicroRNA-486-5p is an erythroid oncomiR of the myeloid leukemias of Down syndrome.

Pluripotent stem cells reveal erythroid-specific activities of the GATA1 N-terminus.

Dynamics of GATA1 binding and expression response in a GATA1-induced erythroid differentiation system.

Anemia: progress in molecular mechanisms and therapies.

Inducible Gata1 suppression expands megakaryocyte-erythroid progenitors from embryonic stem cells.

Occupancy by key transcription factors is a more accurate predictor of enhancer activity than histone modifications or chromatin accessibility.

Dysregulation of the Transforming Growth Factor β Pathway in Induced Pluripotent Stem Cells Generated from Patients with Diamond Blackfan Anemia.

The Poly(C) Binding Protein Pcbp2 and Its Retrotransposed Derivative Pcbp1 Are Independently Essential to Mouse Development.

Targeted Application of Human Genetic Variation Can Improve Red Blood Cell Production from Stem Cells.

Amelioration of murine sickle cell disease by nonablative conditioning and γ-globin gene-corrected bone marrow cells.

Unlinking an lncRNA from Its Associated cis Element.

Welcoming a new age for gene therapy in hematology.

Pharmacogenetics for Safe Codeine Use in Sickle Cell Disease.

The severity of hereditary porphyria is modulated by the porphyrin exporter and Lan antigen ABCB6.

A genome-editing strategy to treat β-hemoglobinopathies that recapitulates a mutation associated with a benign genetic condition.

miR-144 attenuates the host response to influenza virus by targeting the TRAF6-IRF7 signaling axis.

UBE2O remodels the proteome during terminal erythroid differentiation.