Department of Hematology
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An abundant erythroid protein that stabilizes free alpha-haemoglobin.
Nature Jun, 2002 | Pubmed ID: 12066189
Biophysical characterization of the alpha-globin binding protein alpha-hemoglobin stabilizing protein.
The Journal of biological chemistry Oct, 2002 | Pubmed ID: 12192002
Cooperative activities of hematopoietic regulators recruit RNA polymerase II to a tissue-specific chromatin domain.
Proceedings of the National Academy of Sciences of the United States of America Sep, 2002 | Pubmed ID: 12193659
Formation of a tissue-specific histone acetylation pattern by the hematopoietic transcription factor GATA-1.
Molecular and cellular biology Feb, 2003 | Pubmed ID: 12556492
GATA-1-mediated proliferation arrest during erythroid maturation.
Molecular and cellular biology Jul, 2003 | Pubmed ID: 12832487
GATA-1-dependent transcriptional repression of GATA-2 via disruption of positive autoregulation and domain-wide chromatin remodeling.
Proceedings of the National Academy of Sciences of the United States of America Jul, 2003 | Pubmed ID: 12857954
Stress-induced apoptosis associated with null mutation of ADAR1 RNA editing deaminase gene.
The Journal of biological chemistry Feb, 2004 | Pubmed ID: 14613934
New insights into erythropoietin and epoetin alfa: mechanisms of action, target tissues, and clinical applications.
The oncologist , 2003 | Pubmed ID: 14671225
Evaluation of alpha hemoglobin stabilizing protein (AHSP) as a genetic modifier in patients with beta thalassemia.
Blood May, 2004 | Pubmed ID: 14715623
Global regulation of erythroid gene expression by transcription factor GATA-1.
Blood Nov, 2004 | Pubmed ID: 15297311
Loss of alpha-hemoglobin-stabilizing protein impairs erythropoiesis and exacerbates beta-thalassemia.
The Journal of clinical investigation Nov, 2004 | Pubmed ID: 15545996
Molecular mechanism of AHSP-mediated stabilization of alpha-hemoglobin.
Cell Nov, 2004 | Pubmed ID: 15550245
Proximity among distant regulatory elements at the beta-globin locus requires GATA-1 and FOG-1.
Molecular cell Feb, 2005 | Pubmed ID: 15694345
Structure of oxidized alpha-haemoglobin bound to AHSP reveals a protective mechanism for haem.
Nature Jun, 2005 | Pubmed ID: 15931225
Repression of c-kit and its downstream substrates by GATA-1 inhibits cell proliferation during erythroid maturation.
Molecular and cellular biology Aug, 2005 | Pubmed ID: 16024808
Early block to erythromegakaryocytic development conferred by loss of transcription factor GATA-1.
Blood Jan, 2006 | Pubmed ID: 16144799
GATA-1 and Oct-1 are required for expression of the human alpha-hemoglobin-stabilizing protein gene.
The Journal of biological chemistry Nov, 2005 | Pubmed ID: 16186125
Designer blood: creating hematopoietic lineages from embryonic stem cells.
Blood Feb, 2006 | Pubmed ID: 16254136
Megakaryocyte biology and related disorders.
The Journal of clinical investigation Dec, 2005 | Pubmed ID: 16322777
Role of alpha-hemoglobin-stabilizing protein in normal erythropoiesis and beta-thalassemia.
Annals of the New York Academy of Sciences , 2005 | Pubmed ID: 16339656
Mitoferrin is essential for erythroid iron assimilation.
Nature Mar, 2006 | Pubmed ID: 16511496
Alpha-haemoglobin stabilising protein is a quantitative trait gene that modifies the phenotype of beta-thalassaemia.
British journal of haematology Jun, 2006 | Pubmed ID: 16704446
Biochemical fates of alpha hemoglobin bound to alpha hemoglobin-stabilizing protein AHSP.
The Journal of biological chemistry Oct, 2006 | Pubmed ID: 16901899
A novel haem-binding interface in the 22 kDa haem-binding protein p22HBP.
Journal of molecular biology Sep, 2006 | Pubmed ID: 16905148
Experimental validation of predicted mammalian erythroid cis-regulatory modules.
Genome research Dec, 2006 | Pubmed ID: 17038566
Assembly of recently translated full-length and C-terminal truncated human gamma-globin chains with a pool of alpha-globin chains to form Hb F in a cell-free system.
Archives of biochemistry and biophysics Jul, 2007 | Pubmed ID: 17418086
An erythroid chaperone that facilitates folding of alpha-globin subunits for hemoglobin synthesis.
The Journal of clinical investigation Jul, 2007 | Pubmed ID: 17607360
Diseased red blood cells topple iron balance.
Nature medicine Sep, 2007 | Pubmed ID: 17828218
Population analysis of the alpha hemoglobin stabilizing protein (AHSP) gene identifies sequence variants that alter expression and function.
American journal of hematology Feb, 2008 | Pubmed ID: 17874450
STAT1 promotes megakaryopoiesis downstream of GATA-1 in mice.
The Journal of clinical investigation Dec, 2007 | Pubmed ID: 18060035
A GATA-1-regulated microRNA locus essential for erythropoiesis.
Proceedings of the National Academy of Sciences of the United States of America Mar, 2008 | Pubmed ID: 18303114
An iron responsive element-like stem-loop regulates alpha-hemoglobin-stabilizing protein mRNA.
The Journal of biological chemistry Oct, 2008 | Pubmed ID: 18676996
Trisomy 21 enhances human fetal erythro-megakaryocytic development.
Blood Dec, 2008 | Pubmed ID: 18812473
Transcriptional enhancement by GATA1-occupied DNA segments is strongly associated with evolutionary constraint on the binding site motif.
Genome research Dec, 2008 | Pubmed ID: 18818370
Chaperoning erythropoiesis.
Blood Mar, 2009 | Pubmed ID: 19109556
Analysis of human alpha globin gene mutations that impair binding to the alpha hemoglobin stabilizing protein.
Blood Jun, 2009 | Pubmed ID: 19349619
Graded repression of PU.1/Sfpi1 gene transcription by GATA factors regulates hematopoietic cell fate.
Blood Jul, 2009 | Pubmed ID: 19491391
The role of alpha-hemoglobin stabilizing protein in redox chemistry, denaturation, and hemoglobin assembly.
Antioxidants & redox signaling Feb, 2010 | Pubmed ID: 19659437
Stem cells unscramble yolk sac hematopoiesis.
Blood Aug, 2009 | Pubmed ID: 19696206
A cis-proline in alpha-hemoglobin stabilizing protein directs the structural reorganization of alpha-hemoglobin.
The Journal of biological chemistry Oct, 2009 | Pubmed ID: 19706593
Mammalian casein kinase 1alpha and its leishmanial ortholog regulate stability of IFNAR1 and type I interferon signaling.
Molecular and cellular biology Dec, 2009 | Pubmed ID: 19805514
LRF is an essential downstream target of GATA1 in erythroid development and regulates BIM-dependent apoptosis.
Developmental cell Oct, 2009 | Pubmed ID: 19853566
Erythroid GATA1 function revealed by genome-wide analysis of transcription factor occupancy, histone modifications, and mRNA expression.
Genome research Dec, 2009 | Pubmed ID: 19887574
Insights into GATA-1-mediated gene activation versus repression via genome-wide chromatin occupancy analysis.
Molecular cell Nov, 2009 | Pubmed ID: 19941827
Getting by with a little help from our friends.
Current opinion in pediatrics Feb, 2010 | Pubmed ID: 20068412
MicroRNAs in erythropoiesis.
Current opinion in hematology May, 2010 | Pubmed ID: 20216213
miR-451 protects against erythroid oxidant stress by repressing 14-3-3zeta.
Genes & development Aug, 2010 | Pubmed ID: 20679398
MicroRNA expression in maturing murine megakaryocytes.
Blood Dec, 2010 | Pubmed ID: 20720187
Analysis of alpha hemoglobin stabilizing protein overexpression in murine β-thalassemia.
American journal of hematology Oct, 2010 | Pubmed ID: 20815047
AHSP (α-haemoglobin-stabilizing protein) stabilizes apo-α-haemoglobin in a partially folded state.
The Biochemical journal Dec, 2010 | Pubmed ID: 20860551
Protein quality control during erythropoiesis and hemoglobin synthesis.
Hematology/oncology clinics of North America Dec, 2010 | Pubmed ID: 21075281
Identification of distal cis-regulatory elements at mouse mitoferrin loci using zebrafish transgenesis.
Molecular and cellular biology Apr, 2011 | Pubmed ID: 21248200
A hemoglobin variant associated with neonatal cyanosis and anemia.
The New England journal of medicine May, 2011 | Pubmed ID: 21561349
Dynamics of the epigenetic landscape during erythroid differentiation after GATA1 restoration.
Genome research Oct, 2011 | Pubmed ID: 21795386
Functional regulation of pre-B-cell leukemia homeobox interacting protein 1 (PBXIP1/HPIP) in erythroid differentiation.
The Journal of biological chemistry Feb, 2012 | Pubmed ID: 22187427
A new 'Linc' between noncoding RNAs and blood development.
Genes & development Dec, 2011 | Pubmed ID: 22190456
Insights into hemoglobin assembly through in vivo mutagenesis of α-hemoglobin stabilizing protein.
The Journal of biological chemistry Mar, 2012 | Pubmed ID: 22287545
Kinetics of α-globin binding to α-hemoglobin stabilizing protein (AHSP) indicate preferential stabilization of hemichrome folding intermediate.
The Journal of biological chemistry Mar, 2012 | Pubmed ID: 22298770
Loss of the miR-144/451 cluster impairs ischaemic preconditioning-mediated cardioprotection by targeting Rac-1.
Cardiovascular research May, 2012 | Pubmed ID: 22354898
Integrated protein quality-control pathways regulate free α-globin in murine β-thalassemia.
Blood May, 2012 | Pubmed ID: 22427201
Self-renewing endodermal progenitor lines generated from human pluripotent stem cells.
Cell stem cell Apr, 2012 | Pubmed ID: 22482503
CD19 is a major B cell receptor-independent activator of MYC-driven B-lymphomagenesis.
The Journal of clinical investigation Jun, 2012 | Pubmed ID: 22546857
SLC35D3 delivery from megakaryocyte early endosomes is required for platelet dense granule biogenesis and is differentially defective in Hermansky-Pudlak syndrome models.
Blood Jul, 2012 | Pubmed ID: 22611153
What's in a name?
The Journal of clinical investigation Jul, 2012 | Pubmed ID: 22706300
An encyclopedia of mouse DNA elements (Mouse ENCODE).
Genome biology Aug, 2012 | Pubmed ID: 22889292
α-Hemoglobin-stabilizing protein is a sensitive and specific marker of erythroid precursors.
The American journal of surgical pathology Oct, 2012 | Pubmed ID: 22982896
Perturbation of fetal liver hematopoietic stem and progenitor cell development by trisomy 21.
Proceedings of the National Academy of Sciences of the United States of America Oct, 2012 | Pubmed ID: 23045701
Trisomy 21-associated defects in human primitive hematopoiesis revealed through induced pluripotent stem cells.
Proceedings of the National Academy of Sciences of the United States of America Oct, 2012 | Pubmed ID: 23045704
miR-451 regulates dendritic cell cytokine responses to influenza infection.
Journal of immunology (Baltimore, Md. : 1950) Dec, 2012 | Pubmed ID: 23169590
α-Hemoglobin stabilizing protein (AHSP) markedly decreases the redox potential and reactivity of α-subunits of human HbA with hydrogen peroxide.
The Journal of biological chemistry Feb, 2013 | Pubmed ID: 23264625
Hemoglobin variants: biochemical properties and clinical correlates.
Cold Spring Harbor perspectives in medicine Mar, 2013 | Pubmed ID: 23388674
The secreted lymphangiogenic factor CCBE1 is essential for fetal liver erythropoiesis.
Blood Apr, 2013 | Pubmed ID: 23426945
The calcineurin-NFAT pathway negatively regulates megakaryopoiesis.
Blood Apr, 2013 | Pubmed ID: 23446734
Patient-derived induced pluripotent stem cells recapitulate hematopoietic abnormalities of juvenile myelomonocytic leukemia.
Blood Apr, 2013 | Pubmed ID: 23620576
Long noncoding RNAs in biology and hematopoiesis.
Blood Jun, 2013 | Pubmed ID: 23645840
α-Hemoglobin-stabilizing protein (AHSP) perturbs the proximal heme pocket of oxy-α-hemoglobin and weakens the iron-oxygen bond.
The Journal of biological chemistry Jul, 2013 | Pubmed ID: 23696640
Congenital dyserythropoietic anemias: III's a charm.
Blood Jun, 2013 | Pubmed ID: 23744492
Ribosomal and hematopoietic defects in induced pluripotent stem cells derived from Diamond Blackfan anemia patients.
Blood Aug, 2013 | Pubmed ID: 23744582
Clonal genetic and hematopoietic heterogeneity among human-induced pluripotent stem cell lines.
Blood Sep, 2013 | Pubmed ID: 23940280
Development of acute megakaryoblastic leukemia in Down syndrome is associated with sequential epigenetic changes.
Blood Oct, 2013 | Pubmed ID: 23980066
Lineage and species-specific long noncoding RNAs during erythro-megakaryocytic development.
Blood Mar, 2014 | Pubmed ID: 24497530
Iron-laden macrophage in autoimmune disease.
Blood Jan, 2014 | Pubmed ID: 24605366
Erythro-megakaryocytic transcription factors associated with hereditary anemia.
Blood May, 2014 | Pubmed ID: 24652993
Personalized platelet transfusions: one step closer to the clinic.
Cell stem cell Apr, 2014 | Pubmed ID: 24702993
Immune hemolytic anemia with drug-induced antibodies to carboplatin and vincristine in a pediatric patient with an optic pathway glioma.
Transfusion Nov, 2014 | Pubmed ID: 24860959
miR-451 deficiency is associated with altered endometrial fibrinogen alpha chain expression and reduced endometriotic implant establishment in an experimental mouse model.
PloS one , 2014 | Pubmed ID: 24937656
Post-translational transformation of methionine to aspartate is catalyzed by heme iron and driven by peroxide: a novel subunit-specific mechanism in hemoglobin.
The Journal of biological chemistry Aug, 2014 | Pubmed ID: 24939847
Update on the diagnosis and management of thalassemia.
Clinical advances in hematology & oncology : H&O Jan, 2014 | Pubmed ID: 25000317
Hematopoietic differentiation of pluripotent stem cells in culture.
Methods in molecular biology (Clifton, N.J.) , 2014 | Pubmed ID: 25062629
Trim58 degrades Dynein and regulates terminal erythropoiesis.
Developmental cell Sep, 2014 | Pubmed ID: 25241935
Dynamic shifts in occupancy by TAL1 are guided by GATA factors and drive large-scale reprogramming of gene expression during hematopoiesis.
Genome research Dec, 2014 | Pubmed ID: 25319994
Divergent functions of hematopoietic transcription factors in lineage priming and differentiation during erythro-megakaryopoiesis.
Genome research Dec, 2014 | Pubmed ID: 25319996
A comparative encyclopedia of DNA elements in the mouse genome.
Nature Nov, 2014 | Pubmed ID: 25409824
Level of RUNX1 activity is critical for leukemic predisposition but not for thrombocytopenia.
Blood Feb, 2015 | Pubmed ID: 25490895
MicroRNA-486-5p is an erythroid oncomiR of the myeloid leukemias of Down syndrome.
Blood Feb, 2015 | Pubmed ID: 25533034
Pluripotent stem cells reveal erythroid-specific activities of the GATA1 N-terminus.
The Journal of clinical investigation Mar, 2015 | Pubmed ID: 25621499
Dynamics of GATA1 binding and expression response in a GATA1-induced erythroid differentiation system.
Genomics data Jun, 2015 | Pubmed ID: 25729644
Anemia: progress in molecular mechanisms and therapies.
Nature medicine Mar, 2015 | Pubmed ID: 25742458
Inducible Gata1 suppression expands megakaryocyte-erythroid progenitors from embryonic stem cells.
The Journal of clinical investigation Jun, 2015 | Pubmed ID: 25961454
Occupancy by key transcription factors is a more accurate predictor of enhancer activity than histone modifications or chromatin accessibility.
Epigenetics & chromatin , 2015 | Pubmed ID: 25984238
Dysregulation of the Transforming Growth Factor β Pathway in Induced Pluripotent Stem Cells Generated from Patients with Diamond Blackfan Anemia.
PloS one , 2015 | Pubmed ID: 26258650
The Poly(C) Binding Protein Pcbp2 and Its Retrotransposed Derivative Pcbp1 Are Independently Essential to Mouse Development.
Molecular and cellular biology Nov, 2015 | Pubmed ID: 26527618
Targeted Application of Human Genetic Variation Can Improve Red Blood Cell Production from Stem Cells.
Cell stem cell Jan, 2016 | Pubmed ID: 26607381
Amelioration of murine sickle cell disease by nonablative conditioning and γ-globin gene-corrected bone marrow cells.
Molecular therapy. Methods & clinical development , 2015 | Pubmed ID: 26665131
Unlinking an lncRNA from Its Associated cis Element.
Molecular cell Apr, 2016 | Pubmed ID: 27041223
Welcoming a new age for gene therapy in hematology.
Blood May, 2016 | Pubmed ID: 27053534
Pharmacogenetics for Safe Codeine Use in Sickle Cell Disease.
Pediatrics Jul, 2016 | Pubmed ID: 27335380
The severity of hereditary porphyria is modulated by the porphyrin exporter and Lan antigen ABCB6.
Nature communications Aug, 2016 | Pubmed ID: 27507172
A genome-editing strategy to treat β-hemoglobinopathies that recapitulates a mutation associated with a benign genetic condition.
Nature medicine Sep, 2016 | Pubmed ID: 27525524
miR-144 attenuates the host response to influenza virus by targeting the TRAF6-IRF7 signaling axis.
PLoS pathogens Apr, 2017 | Pubmed ID: 28380049
UBE2O remodels the proteome during terminal erythroid differentiation.
Science (New York, N.Y.) Aug, 2017 | Pubmed ID: 28774900
1Department of Molecular Physiology and Biophysics, University of Virginia School of Medicine,
2Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine,
3Department of Hematology, St. Jude Children's Research Hospital,
4Research Histology Core, University of Virginia School of Medicine
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