Karine Auclair

Revisiting the mechanism of P450 enzymes with the radical clocks norcarane and spiro[2,5]octane.

Solution NMR characterization of an unusual distal H-bond network in the active site of the cyanide-inhibited, human heme oxygenase complex of the symmetric substrate, 2,4-dimethyldeuterohemin.

1H NMR detection of immobilized water molecules within a strong distal hydrogen-bonding network of substrate-bound human heme oxygenase-1.

Cloning and expression of a heme binding protein from the genome of Saccharomyces cerevisiae.

Transformations of cyclic nonaketides by Aspergillus terreus mutants blocked for lovastatin biosynthesis at the lovA and lovC genes.

Solution 1H, 15N NMR spectroscopic characterization of substrate-bound, cyanide-inhibited human heme oxygenase: water occupation of the distal cavity.

1H NMR investigation of the solution structure of substrate-free human heme oxygenase: comparison to the cyanide-inhibited, substrate-bound complex.

Inhibition of human P450 enzymes by nicotinic acid and nicotinamide.

Inhibition of human P450 enzymes by multiple constituents of the Ginkgo biloba extract.

Composition and biological activity of traditional and commercial kava extracts.

Regio- and chemoselective 6'-N-derivatization of aminoglycosides: bisubstrate inhibitors as probes to study aminoglycoside 6'-N-acetyltransferases.

Replacement of natural cofactors by selected hydrogen peroxide donors or organic peroxides results in improved activity for CYP3A4 and CYP2D6.

Synthesis and structure-activity relationships of truncated bisubstrate inhibitors of aminoglycoside 6'-N-acetyltransferases.

Progress towards the easier use of P450 enzymes.

The use of aminoglycoside derivatives to study the mechanism of aminoglycoside 6'-N-acetyltransferase and the role of 6'-NH2 in antibacterial activity.

Activity of human P450 2D6 in biphasic solvent systems.

CYP3A4 activity in the presence of organic cosolvents, ionic liquids, or water-immiscible organic solvents.

Sugar-mediated lyoprotection of purified human CYP3A4 and CYP2D6.

Kinetic and structural analysis of bisubstrate inhibition of the Salmonella enterica aminoglycoside 6'-N-acetyltransferase.

Ginkgo biloba extract EGb 761 has anti-inflammatory properties and ameliorates colitis in mice by driving effector T cell apoptosis.

Synthesis and use of sulfonamide-, sulfoxide-, or sulfone-containing aminoglycoside-CoA bisubstrates as mechanistic probes for aminoglycoside N-6'-acetyltransferase.

The activity of human CYP2D6 in low water organic solvents.

Synthesis of a phosphonate-linked aminoglycoside-coenzyme a bisubstrate and use in mechanistic studies of an enzyme involved in aminoglycoside resistance.

Elucidating protein binding mechanisms by variable-c ITC.

Synthesis of 4'-aminopantetheine and derivatives to probe aminoglycoside N-6'-acetyltransferase.

Competing allosteric mechanisms modulate substrate binding in a dimeric enzyme.

Geminal dialkyl derivatives of N-substituted pantothenamides: synthesis and antibacterial activity.

Predictable stereoselective and chemoselective hydroxylations and epoxidations with P450 3A4.

Inhibition of aminoglycoside-deactivating enzymes APH(3')-IIIa and AAC(6')-Ii by amphiphilic paromomycin O2''-ether analogues.

Inhibitors of Aminoglycoside Resistance Activated in Cells.