Department of Chemistry
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Revisiting the mechanism of P450 enzymes with the radical clocks norcarane and spiro[2,5]octane.
Journal of the American Chemical Society May, 2002 | Pubmed ID: 12022835
Solution NMR characterization of an unusual distal H-bond network in the active site of the cyanide-inhibited, human heme oxygenase complex of the symmetric substrate, 2,4-dimethyldeuterohemin.
The Journal of biological chemistry Sep, 2002 | Pubmed ID: 12070167
1H NMR detection of immobilized water molecules within a strong distal hydrogen-bonding network of substrate-bound human heme oxygenase-1.
Journal of the American Chemical Society Dec, 2002 | Pubmed ID: 12452690
Cloning and expression of a heme binding protein from the genome of Saccharomyces cerevisiae.
Protein expression and purification Apr, 2003 | Pubmed ID: 12699699
Transformations of cyclic nonaketides by Aspergillus terreus mutants blocked for lovastatin biosynthesis at the lovA and lovC genes.
Organic & biomolecular chemistry Jan, 2003 | Pubmed ID: 12929390
Solution 1H, 15N NMR spectroscopic characterization of substrate-bound, cyanide-inhibited human heme oxygenase: water occupation of the distal cavity.
Journal of the American Chemical Society Nov, 2003 | Pubmed ID: 14583035
1H NMR investigation of the solution structure of substrate-free human heme oxygenase: comparison to the cyanide-inhibited, substrate-bound complex.
The Journal of biological chemistry Mar, 2004 | Pubmed ID: 14660632
Inhibition of human P450 enzymes by nicotinic acid and nicotinamide.
Biochemical and biophysical research communications May, 2004 | Pubmed ID: 15081432
Inhibition of human P450 enzymes by multiple constituents of the Ginkgo biloba extract.
Biochemical and biophysical research communications Jun, 2004 | Pubmed ID: 15147983
Composition and biological activity of traditional and commercial kava extracts.
Biochemical and biophysical research communications Sep, 2004 | Pubmed ID: 15313185
Regio- and chemoselective 6'-N-derivatization of aminoglycosides: bisubstrate inhibitors as probes to study aminoglycoside 6'-N-acetyltransferases.
Angewandte Chemie (International ed. in English) Oct, 2005 | Pubmed ID: 16206301
Replacement of natural cofactors by selected hydrogen peroxide donors or organic peroxides results in improved activity for CYP3A4 and CYP2D6.
Chembiochem : a European journal of chemical biology Jun, 2006 | Pubmed ID: 16671126
Synthesis and structure-activity relationships of truncated bisubstrate inhibitors of aminoglycoside 6'-N-acetyltransferases.
Journal of medicinal chemistry Aug, 2006 | Pubmed ID: 16913716
Progress towards the easier use of P450 enzymes.
Molecular bioSystems Oct, 2006 | Pubmed ID: 17216026
The use of aminoglycoside derivatives to study the mechanism of aminoglycoside 6'-N-acetyltransferase and the role of 6'-NH2 in antibacterial activity.
Bioorganic & medicinal chemistry Apr, 2007 | Pubmed ID: 17317190
Activity of human P450 2D6 in biphasic solvent systems.
Biotechnology and bioengineering Oct, 2007 | Pubmed ID: 17461428
CYP3A4 activity in the presence of organic cosolvents, ionic liquids, or water-immiscible organic solvents.
Chembiochem : a European journal of chemical biology Jul, 2007 | Pubmed ID: 17526062
Sugar-mediated lyoprotection of purified human CYP3A4 and CYP2D6.
Journal of biotechnology Jul, 2007 | Pubmed ID: 17599599
Kinetic and structural analysis of bisubstrate inhibition of the Salmonella enterica aminoglycoside 6'-N-acetyltransferase.
Biochemistry Jan, 2008 | Pubmed ID: 18095712
Ginkgo biloba extract EGb 761 has anti-inflammatory properties and ameliorates colitis in mice by driving effector T cell apoptosis.
Carcinogenesis Sep, 2008 | Pubmed ID: 18567620
Synthesis and use of sulfonamide-, sulfoxide-, or sulfone-containing aminoglycoside-CoA bisubstrates as mechanistic probes for aminoglycoside N-6'-acetyltransferase.
Bioorganic & medicinal chemistry letters Oct, 2008 | Pubmed ID: 18805003
The activity of human CYP2D6 in low water organic solvents.
Biotechnology and bioengineering Mar, 2009 | Pubmed ID: 18988262
Synthesis of a phosphonate-linked aminoglycoside-coenzyme a bisubstrate and use in mechanistic studies of an enzyme involved in aminoglycoside resistance.
Chemistry (Weinheim an der Bergstrasse, Germany) , 2009 | Pubmed ID: 19152351
Elucidating protein binding mechanisms by variable-c ITC.
Chembiochem : a European journal of chemical biology Dec, 2009 | Pubmed ID: 19856370
Synthesis of 4'-aminopantetheine and derivatives to probe aminoglycoside N-6'-acetyltransferase.
Organic & biomolecular chemistry Mar, 2011 | Pubmed ID: 21225062
Competing allosteric mechanisms modulate substrate binding in a dimeric enzyme.
Nature structural & molecular biology Mar, 2011 | Pubmed ID: 21278754
Geminal dialkyl derivatives of N-substituted pantothenamides: synthesis and antibacterial activity.
Bioorganic & medicinal chemistry Apr, 2011 | Pubmed ID: 21440446
Predictable stereoselective and chemoselective hydroxylations and epoxidations with P450 3A4.
Journal of the American Chemical Society May, 2011 | Pubmed ID: 21528858
Inhibition of aminoglycoside-deactivating enzymes APH(3')-IIIa and AAC(6')-Ii by amphiphilic paromomycin O2''-ether analogues.
ChemMedChem Nov, 2011 | Pubmed ID: 21905229
Inhibitors of Aminoglycoside Resistance Activated in Cells.
ACS chemical biology Jan, 2012 | Pubmed ID: 22217014
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