Kevin Eggan

Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons.

Using stem cells and reprogramming to understand disease.

Flp recombinase regulated lacZ expression at the ROSA26 locus.

Dnmt1 overexpression causes genomic hypermethylation, loss of imprinting, and embryonic lethality.

Male and female mice derived from the same embryonic stem cell clone by tetraploid embryo complementation.

Abnormal gene expression in cloned mice derived from embryonic stem cell and cumulus cell nuclei.

Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei.

Nuclear cloning, stem cells, and genomic reprogramming.

Derivation of embryonic germ cells and male gametes from embryonic stem cells.

Differentiation of F1 embryonic stem cells into viable male and female mice by tetraploid embryo complementation.

Mice cloned from olfactory sensory neurons.

Micromanipulating dosage compensation: understanding X-chromosome inactivation through nuclear transplantation.

Nuclear cloning, epigenetic reprogramming and cellular differentiation.

Nuclear reprogramming of somatic cells after fusion with human embryonic stem cells.

Ovulated oocytes in adult mice derive from non-circulating germ cells.

A transcriptional logic for nuclear reprogramming.

Dolly's legacy: human nuclear transplantation and better medicines for our children.

Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model.

Developmental reprogramming after chromosome transfer into mitotic mouse zygotes.

The potential of cell fusion for human therapy.

Short-circuiting epiblast development.

Mediators of reprogramming: transcription factors and transitions through mitosis.

Human embryonic stem cell-derived motor neurons are sensitive to the toxic effect of glial cells carrying an ALS-causing mutation.

Optimal timing of inner cell mass isolation increases the efficiency of human embryonic stem cell derivation and allows generation of sibling cell lines.

Targeted bisulfite sequencing reveals changes in DNA methylation associated with nuclear reprogramming.

Digital RNA allelotyping reveals tissue-specific and allele-specific gene expression in human.

Reprogramming after chromosome transfer into mouse blastomeres.

A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog.

Progress toward the clinical application of patient-specific pluripotent stem cells.

Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal.

Recipient cell nuclear factors are required for reprogramming by nuclear transfer.

Shushing down the epigenetic landscape towards stem cell differentiation.

A functionally characterized test set of human induced pluripotent stem cells.

Reference Maps of human ES and iPS cell variation enable high-throughput characterization of pluripotent cell lines.

Somatic coding mutations in human induced pluripotent stem cells.

Constructing and deconstructing stem cell models of neurological disease.

Conversion of mouse and human fibroblasts into functional spinal motor neurons.

Reprogramming within hours following nuclear transfer into mouse but not human zygotes.

Impracticality of egg donor recruitment in the absence of compensation.

Erosion of dosage compensation impacts human iPSC disease modeling.

SnapShot: directed differentiation of pluripotent stem cells.

Developmental bias in cleavage-stage mouse blastomeres.

Analysis of human embryos from zygote to blastocyst reveals distinct gene expression patterns relative to the mouse.

CLP1 links tRNA metabolism to progressive motor-neuron loss.

Directed differentiation and functional maturation of cortical interneurons from human embryonic stem cells.

Modeling human disease with pluripotent stem cells: from genome association to function.

Opportunities and challenges of pluripotent stem cell neurodegenerative disease models.

Derivation of induced pluripotent stem cells from the baboon: a nonhuman primate model for preclinical testing of stem cell therapies.

The mouse C9ORF72 ortholog is enriched in neurons known to degenerate in ALS and FTD.

Picking the lock on pluripotency.

How to make spinal motor neurons.

Axonal transport of TDP-43 mRNA granules is impaired by ALS-causing mutations.

Nanog-independent reprogramming to iPSCs with canonical factors.

Gene profiling of human induced pluripotent stem cell-derived astrocyte progenitors following spinal cord engraftment.

Intrinsic membrane hyperexcitability of amyotrophic lateral sclerosis patient-derived motor neurons.

Pathways disrupted in human ALS motor neurons identified through genetic correction of mutant SOD1.

Ketamine exposure in early development impairs specification of the primary germ cell layers.

Notch inhibition allows oncogene-independent generation of iPS cells.

FUS is sequestered in nuclear aggregates in ALS patient fibroblasts.

DNA methylation dynamics of the human preimplantation embryo.

Genetic validation of a therapeutic target in a mouse model of ALS.

The role of maternal-specific H3K9me3 modification in establishing imprinted X-chromosome inactivation and embryogenesis in mice.

Genetic variation in human DNA replication timing.

Modeling pain in vitro using nociceptor neurons reprogrammed from fibroblasts.

iPSC-derived dopamine neurons reveal differences between monozygotic twins discordant for Parkinson's disease.

Motoneurons derived from induced pluripotent stem cells develop mature phenotypes typical of endogenous spinal motoneurons.

ALS-causative mutations in FUS/TLS confer gain and loss of function by altered association with SMN and U1-snRNP.

Generation of neuropeptidergic hypothalamic neurons from human pluripotent stem cells.

Focus on induced pluripotency and cellular reprogramming.

Efficient CRISPR-Cas9-mediated generation of knockin human pluripotent stem cells lacking undesired mutations at the targeted locus.

From Dish to Bedside: Lessons Learned While Translating Findings from a Stem Cell Model of Disease to a Clinical Trial.

Automated, high-throughput derivation, characterization and differentiation of induced pluripotent stem cells.

A perspective on stem cell modeling of amyotrophic lateral sclerosis.

SLC52A3, A Brown-Vialetto-van Laere syndrome candidate gene is essential for mouse development, but dispensable for motor neuron differentiation.

Modeling ALS with motor neurons derived from human induced pluripotent stem cells.

CAT7 and cat7l Long Non-coding RNAs Tune Polycomb Repressive Complex 1 Function during Human and Zebrafish Development.

Loss-of-function mutations in the C9ORF72 mouse ortholog cause fatal autoimmune disease.

Comprehensive Protocols for CRISPR/Cas9-based Gene Editing in Human Pluripotent Stem Cells.

Monitoring peripheral nerve degeneration in ALS by label-free stimulated Raman scattering imaging.

Two familial ALS proteins function in prevention/repair of transcription-associated DNA damage.

Generation of a TLE1 homozygous knockout human embryonic stem cell line using CRISPR-Cas9.

Generation of a TLE3 heterozygous knockout human embryonic stem cell line using CRISPR-Cas9.

Genetic Ablation of AXL Does Not Protect Human Neural Progenitor Cells and Cerebral Organoids from Zika Virus Infection.

Human pluripotent stem cells recurrently acquire and expand dominant negative P53 mutations.

Assessing the Safety of Human Pluripotent Stem Cells and Their Derivatives for Clinical Applications.

Reactive Astrocytes Promote ALS-like Degeneration and Intracellular Protein Aggregation in Human Motor Neurons by Disrupting Autophagy through TGF-β1.

A Scaled Framework for CRISPR Editing of Human Pluripotent Stem Cells to Study Psychiatric Disease.

Generation of a Motor Nerve Organoid with Human Stem Cell-Derived Neurons.

Whole genome sequencing in psychiatric disorders: the WGSPD consortium.

Publisher Correction: Whole genome sequencing in psychiatric disorders: the WGSPD consortium.

All-Optical Electrophysiology for High-Throughput Functional Characterization of a Human iPSC-Derived Motor Neuron Model of ALS.

Combining NGN2 Programming with Developmental Patterning Generates Human Excitatory Neurons with NMDAR-Mediated Synaptic Transmission.

TDP-43 induces p53-mediated cell death of cortical progenitors and immature neurons.

The C9orf72-interacting protein Smcr8 is a negative regulator of autoimmunity and lysosomal exocytosis.

Dipeptide repeat proteins activate a heat shock response found in C9ORF72-ALS/FTLD patients.

Hippo signaling in the ovary and polycystic ovarian syndrome.

All-optical synaptic electrophysiology probes mechanism of ketamine-induced disinhibition.

Comparative genomic analysis of embryonic, lineage-converted and stem cell-derived motor neurons.

Oligodendrocyte differentiation of induced pluripotent stem cells derived from subjects with schizophrenias implicate abnormalities in development.

Convergence of independent DISC1 mutations on impaired neurite growth via decreased UNC5D expression.

A Stem Cell-Based Screening Platform Identifies Compounds that Desensitize Motor Neurons to Endoplasmic Reticulum Stress.

ALS-implicated protein TDP-43 sustains levels of STMN2, a mediator of motor neuron growth and repair.

Dysregulated protocadherin-pathway activity as an intrinsic defect in induced pluripotent stem cell-derived cortical interneurons from subjects with schizophrenia.

Comparison of three congruent patient-specific cell types for the modelling of a human genetic Schwann-cell disorder.

A High-Content Screen Identifies TPP1 and Aurora B as Regulators of Axonal Mitochondrial Transport.

Cancer-Related Mutations Identified in Primed and Naive Human Pluripotent Stem Cells.

RNA-seq as a tool for evaluating human embryo competence.

Exome sequencing in amyotrophic lateral sclerosis implicates a novel gene, DNAJC7, encoding a heat-shock protein.

Herpesviral lytic gene functions render the viral genome susceptible to novel editing by CRISPR/Cas9.

Publisher Correction: Exome sequencing in amyotrophic lateral sclerosis implicates a novel gene, DNAJC7, encoding a heat-shock protein.

A multiplexed gRNA piggyBac transposon system facilitates efficient induction of CRISPRi and CRISPRa in human pluripotent stem cells.