Kevin Eggan

Department of Molecular and Cell Biology, Harvard

Affiliated withHarvard Broad Institute of MIT and Harvard Harvard University

Research Area

BiologyNeuroscience

Biography

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JoVE Journal Publications

ArticleTotal : 5	Year
Publication title	2006
Publication title	2006
Publication title	2006
Publication title	2006
Publication title	2017

Other Publications

Article	Year
Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons. Science (New York, N.Y.)\| PubMed ID: 18669821	2008
Using stem cells and reprogramming to understand disease. Regenerative medicine\| PubMed ID: 18947303	2008
Flp recombinase regulated lacZ expression at the ROSA26 locus. Genesis (New York, N.Y. : 2000)\| PubMed ID: 11857816	2002
Dnmt1 overexpression causes genomic hypermethylation, loss of imprinting, and embryonic lethality. Molecular and cellular biology\| PubMed ID: 11884600	2002
Male and female mice derived from the same embryonic stem cell clone by tetraploid embryo complementation. Nature biotechnology\| PubMed ID: 11981557	2002
Abnormal gene expression in cloned mice derived from embryonic stem cell and cumulus cell nuclei. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12235366	2002
Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei. Development (Cambridge, England)\| PubMed ID: 12620990	2003
Nuclear cloning, stem cells, and genomic reprogramming. Cloning and stem cells\| PubMed ID: 12630413	2002
Derivation of embryonic germ cells and male gametes from embryonic stem cells. Nature\| PubMed ID: 14668819	2004
Differentiation of F1 embryonic stem cells into viable male and female mice by tetraploid embryo complementation. Methods in enzymology\| PubMed ID: 14696335	2003
Mice cloned from olfactory sensory neurons. Nature\| PubMed ID: 14990966	2004
Micromanipulating dosage compensation: understanding X-chromosome inactivation through nuclear transplantation. Seminars in cell & developmental biology\| PubMed ID: 15015742	2003
Nuclear cloning, epigenetic reprogramming and cellular differentiation. Novartis Foundation symposium\| PubMed ID: 16050253	2005
Nuclear reprogramming of somatic cells after fusion with human embryonic stem cells. Science (New York, N.Y.)\| PubMed ID: 16123299	2005
Ovulated oocytes in adult mice derive from non-circulating germ cells. Nature\| PubMed ID: 16799565	2006
A transcriptional logic for nuclear reprogramming. Cell\| PubMed ID: 16923385	2006
Dolly's legacy: human nuclear transplantation and better medicines for our children. Cloning and stem cells\| PubMed ID: 17386009	2007
Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model. Nature neuroscience\| PubMed ID: 17435754	2007
Developmental reprogramming after chromosome transfer into mitotic mouse zygotes. Nature\| PubMed ID: 17554301	2007
The potential of cell fusion for human therapy. Stem cell reviews\| PubMed ID: 17848721	2006
Short-circuiting epiblast development. Cell stem cell\| PubMed ID: 18371343	2007
Mediators of reprogramming: transcription factors and transitions through mitosis. Nature reviews. Molecular cell biology\| PubMed ID: 18568039	2008
Human embryonic stem cell-derived motor neurons are sensitive to the toxic effect of glial cells carrying an ALS-causing mutation. Cell stem cell\| PubMed ID: 19041780	2008
Optimal timing of inner cell mass isolation increases the efficiency of human embryonic stem cell derivation and allows generation of sibling cell lines. Cell stem cell\| PubMed ID: 19200798	2009
Targeted bisulfite sequencing reveals changes in DNA methylation associated with nuclear reprogramming. Nature biotechnology\| PubMed ID: 19330000	2009
Digital RNA allelotyping reveals tissue-specific and allele-specific gene expression in human. Nature methods\| PubMed ID: 19620972	2009
Reprogramming after chromosome transfer into mouse blastomeres. Current biology : CB\| PubMed ID: 19682906	2009
A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog. Cell stem cell\| PubMed ID: 19818703	2009
Progress toward the clinical application of patient-specific pluripotent stem cells. The Journal of clinical investigation\| PubMed ID: 20051636	2010
Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal. Genes & development\| PubMed ID: 20123909	2010
Recipient cell nuclear factors are required for reprogramming by nuclear transfer. Development (Cambridge, England)\| PubMed ID: 20463036	2010
Shushing down the epigenetic landscape towards stem cell differentiation. Development (Cambridge, England)\| PubMed ID: 20554719	2010
A functionally characterized test set of human induced pluripotent stem cells. Nature biotechnology\| PubMed ID: 21293464	2011
Reference Maps of human ES and iPS cell variation enable high-throughput characterization of pluripotent cell lines. Cell\| PubMed ID: 21295703	2011
Somatic coding mutations in human induced pluripotent stem cells. Nature\| PubMed ID: 21368825	2011
Constructing and deconstructing stem cell models of neurological disease. Neuron\| PubMed ID: 21609821	2011
Conversion of mouse and human fibroblasts into functional spinal motor neurons. Cell stem cell\| PubMed ID: 21852222	2011
Reprogramming within hours following nuclear transfer into mouse but not human zygotes. Nature communications\| PubMed ID: 21971503	2011
Impracticality of egg donor recruitment in the absence of compensation. Cell stem cell\| PubMed ID: 21982228	2011
Erosion of dosage compensation impacts human iPSC disease modeling. Cell stem cell\| PubMed ID: 22560080	2012
SnapShot: directed differentiation of pluripotent stem cells. Cell\| PubMed ID: 22632979	2012
Developmental bias in cleavage-stage mouse blastomeres. Current biology : CB\| PubMed ID: 23177476	2013
Analysis of human embryos from zygote to blastocyst reveals distinct gene expression patterns relative to the mouse. Developmental biology\| PubMed ID: 23261930	2013
CLP1 links tRNA metabolism to progressive motor-neuron loss. Nature\| PubMed ID: 23474986	2013
Directed differentiation and functional maturation of cortical interneurons from human embryonic stem cells. Cell stem cell\| PubMed ID: 23642365	2013
Modeling human disease with pluripotent stem cells: from genome association to function. Cell stem cell\| PubMed ID: 23746975	2013
Opportunities and challenges of pluripotent stem cell neurodegenerative disease models. Nature neuroscience\| PubMed ID: 23799470	2013
Derivation of induced pluripotent stem cells from the baboon: a nonhuman primate model for preclinical testing of stem cell therapies. Cellular reprogramming\| PubMed ID: 24182315	2013
The mouse C9ORF72 ortholog is enriched in neurons known to degenerate in ALS and FTD. Nature neuroscience\| PubMed ID: 24185425	2013
Picking the lock on pluripotency. The New England journal of medicine\| PubMed ID: 24283230	2013
How to make spinal motor neurons. Development (Cambridge, England)\| PubMed ID: 24449832	2014
Axonal transport of TDP-43 mRNA granules is impaired by ALS-causing mutations. Neuron\| PubMed ID: 24507191	2014
Nanog-independent reprogramming to iPSCs with canonical factors. Stem cell reports\| PubMed ID: 24527385	2014
Gene profiling of human induced pluripotent stem cell-derived astrocyte progenitors following spinal cord engraftment. Stem cells translational medicine\| PubMed ID: 24604284	2014
Intrinsic membrane hyperexcitability of amyotrophic lateral sclerosis patient-derived motor neurons. Cell reports\| PubMed ID: 24703839	2014
Pathways disrupted in human ALS motor neurons identified through genetic correction of mutant SOD1. Cell stem cell\| PubMed ID: 24704492	2014
Ketamine exposure in early development impairs specification of the primary germ cell layers. Neurotoxicology and teratology\| PubMed ID: 24746641	2014
Notch inhibition allows oncogene-independent generation of iPS cells. Nature chemical biology\| PubMed ID: 24952596	2014
FUS is sequestered in nuclear aggregates in ALS patient fibroblasts. Molecular biology of the cell\| PubMed ID: 25009283	2014
DNA methylation dynamics of the human preimplantation embryo. Nature\| PubMed ID: 25079558	2014
Genetic validation of a therapeutic target in a mouse model of ALS. Science translational medicine\| PubMed ID: 25100738	2014
The role of maternal-specific H3K9me3 modification in establishing imprinted X-chromosome inactivation and embryogenesis in mice. Nature communications\| PubMed ID: 25394724	2014
Genetic variation in human DNA replication timing. Cell\| PubMed ID: 25416942	2014
Modeling pain in vitro using nociceptor neurons reprogrammed from fibroblasts. Nature neuroscience\| PubMed ID: 25420066	2015
iPSC-derived dopamine neurons reveal differences between monozygotic twins discordant for Parkinson's disease. Cell reports\| PubMed ID: 25456120	2014
Motoneurons derived from induced pluripotent stem cells develop mature phenotypes typical of endogenous spinal motoneurons. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 25609642	2015
ALS-causative mutations in FUS/TLS confer gain and loss of function by altered association with SMN and U1-snRNP. Nature communications\| PubMed ID: 25625564	2015
Generation of neuropeptidergic hypothalamic neurons from human pluripotent stem cells. Development (Cambridge, England)\| PubMed ID: 25670790	2015
Focus on induced pluripotency and cellular reprogramming. The EMBO journal\| PubMed ID: 25916828	2015
Efficient CRISPR-Cas9-mediated generation of knockin human pluripotent stem cells lacking undesired mutations at the targeted locus. Cell reports\| PubMed ID: 25937281	2015
From Dish to Bedside: Lessons Learned While Translating Findings from a Stem Cell Model of Disease to a Clinical Trial. Cell stem cell\| PubMed ID: 26140603	2015
Automated, high-throughput derivation, characterization and differentiation of induced pluripotent stem cells. Nature methods\| PubMed ID: 26237226	2015
A perspective on stem cell modeling of amyotrophic lateral sclerosis. Cell cycle (Georgetown, Tex.)\| PubMed ID: 26505672	2015
SLC52A3, A Brown-Vialetto-van Laere syndrome candidate gene is essential for mouse development, but dispensable for motor neuron differentiation. Human molecular genetics\| PubMed ID: 26976849	2016
Modeling ALS with motor neurons derived from human induced pluripotent stem cells. Nature neuroscience\| PubMed ID: 27021939	2016
CAT7 and cat7l Long Non-coding RNAs Tune Polycomb Repressive Complex 1 Function during Human and Zebrafish Development. The Journal of biological chemistry\| PubMed ID: 27405765	2016
Loss-of-function mutations in the C9ORF72 mouse ortholog cause fatal autoimmune disease. Science translational medicine\| PubMed ID: 27412785	2016
Comprehensive Protocols for CRISPR/Cas9-based Gene Editing in Human Pluripotent Stem Cells. Current protocols in stem cell biology\| PubMed ID: 27532820	2016
Monitoring peripheral nerve degeneration in ALS by label-free stimulated Raman scattering imaging. Nature communications\| PubMed ID: 27796305	2016
Two familial ALS proteins function in prevention/repair of transcription-associated DNA damage. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 27849576	2016
Generation of a TLE1 homozygous knockout human embryonic stem cell line using CRISPR-Cas9. Stem cell research\| PubMed ID: 27879218	2016
Generation of a TLE3 heterozygous knockout human embryonic stem cell line using CRISPR-Cas9. Stem cell research\| PubMed ID: 27879221	2016
Genetic Ablation of AXL Does Not Protect Human Neural Progenitor Cells and Cerebral Organoids from Zika Virus Infection. Cell stem cell\| PubMed ID: 27912091	2016
Human pluripotent stem cells recurrently acquire and expand dominant negative P53 mutations. Nature\| PubMed ID: 28445466	2017
Assessing the Safety of Human Pluripotent Stem Cells and Their Derivatives for Clinical Applications. Stem cell reports\| PubMed ID: 28700896	2017
Reactive Astrocytes Promote ALS-like Degeneration and Intracellular Protein Aggregation in Human Motor Neurons by Disrupting Autophagy through TGF-β1. Stem cell reports\| PubMed ID: 28712846	2017
A Scaled Framework for CRISPR Editing of Human Pluripotent Stem Cells to Study Psychiatric Disease. Stem cell reports\| PubMed ID: 29020615	2017
Generation of a Motor Nerve Organoid with Human Stem Cell-Derived Neurons. Stem cell reports\| PubMed ID: 29107592	2017
Whole genome sequencing in psychiatric disorders: the WGSPD consortium. Nature neuroscience\| PubMed ID: 29184211	2017
Publisher Correction: Whole genome sequencing in psychiatric disorders: the WGSPD consortium. Nature neuroscience\| PubMed ID: 29549319	2018
All-Optical Electrophysiology for High-Throughput Functional Characterization of a Human iPSC-Derived Motor Neuron Model of ALS. Stem cell reports\| PubMed ID: 29779896	2018
Combining NGN2 Programming with Developmental Patterning Generates Human Excitatory Neurons with NMDAR-Mediated Synaptic Transmission. Cell reports\| PubMed ID: 29791859	2018
TDP-43 induces p53-mediated cell death of cortical progenitors and immature neurons. Scientific reports\| PubMed ID: 29802307	2018
The C9orf72-interacting protein Smcr8 is a negative regulator of autoimmunity and lysosomal exocytosis. Genes & development\| PubMed ID: 29950492	2018
Dipeptide repeat proteins activate a heat shock response found in C9ORF72-ALS/FTLD patients. Acta neuropathologica communications\| PubMed ID: 29973287	2018
Hippo signaling in the ovary and polycystic ovarian syndrome. Journal of assisted reproduction and genetics\| PubMed ID: 30120633	2018
All-optical synaptic electrophysiology probes mechanism of ketamine-induced disinhibition. Nature methods\| PubMed ID: 30275587	2018
Comparative genomic analysis of embryonic, lineage-converted and stem cell-derived motor neurons. Development (Cambridge, England)\| PubMed ID: 30337375	2018
Oligodendrocyte differentiation of induced pluripotent stem cells derived from subjects with schizophrenias implicate abnormalities in development. Translational psychiatry\| PubMed ID: 30352993	2018
Convergence of independent DISC1 mutations on impaired neurite growth via decreased UNC5D expression. Translational psychiatry\| PubMed ID: 30410030	2018
A Stem Cell-Based Screening Platform Identifies Compounds that Desensitize Motor Neurons to Endoplasmic Reticulum Stress. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 30446391	2019
ALS-implicated protein TDP-43 sustains levels of STMN2, a mediator of motor neuron growth and repair. Nature neuroscience\| PubMed ID: 30643292	2019
Dysregulated protocadherin-pathway activity as an intrinsic defect in induced pluripotent stem cell-derived cortical interneurons from subjects with schizophrenia. Nature neuroscience\| PubMed ID: 30664768	2019
Comparison of three congruent patient-specific cell types for the modelling of a human genetic Schwann-cell disorder. Nature biomedical engineering\| PubMed ID: 30962586	2019
A High-Content Screen Identifies TPP1 and Aurora B as Regulators of Axonal Mitochondrial Transport. Cell reports\| PubMed ID: 31533043	2019
Cancer-Related Mutations Identified in Primed and Naive Human Pluripotent Stem Cells. Cell stem cell\| PubMed ID: 31543368	2019
RNA-seq as a tool for evaluating human embryo competence. Genome research\| PubMed ID: 31548358	2019
Exome sequencing in amyotrophic lateral sclerosis implicates a novel gene, DNAJC7, encoding a heat-shock protein. Nature neuroscience\| PubMed ID: 31768050	2019
Herpesviral lytic gene functions render the viral genome susceptible to novel editing by CRISPR/Cas9. eLife\| PubMed ID: 31789594	2019
Publisher Correction: Exome sequencing in amyotrophic lateral sclerosis implicates a novel gene, DNAJC7, encoding a heat-shock protein. Nature neuroscience\| PubMed ID: 31857710	2020
A multiplexed gRNA piggyBac transposon system facilitates efficient induction of CRISPRi and CRISPRa in human pluripotent stem cells. Scientific reports\| PubMed ID: 31959800	2020