Department of Human Anatomy and Cell Science,
Rady Faculty of Health Sciences,
Max Rady College of Medicine,
Biology of Breathing Theme,
Children Hospital Research Institute of Manitoba,
Department of Human Anatomy and Cell Science, Rady Faculty of Health Sciences, Max Rady College of Medicine,
Biology of Breathing Theme, Children Hospital Research Institute of Manitoba
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Cancer-specific toxicity of apoptin is independent of death receptors but involves the loss of mitochondrial membrane potential and the release of mitochondrial cell-death mediators by a Nur77-dependent pathway.
Journal of cell science Oct, 2005 | Pubmed ID: 16179607
Autoimmunity and apoptosis--therapeutic implications.
Current medicinal chemistry , 2007 | Pubmed ID: 18220747
S100A8/A9 at low concentration promotes tumor cell growth via RAGE ligation and MAP kinase-dependent pathway.
Journal of leukocyte biology Jun, 2008 | Pubmed ID: 18339893
Brevinin-2R(1) semi-selectively kills cancer cells by a distinct mechanism, which involves the lysosomal-mitochondrial death pathway.
Journal of cellular and molecular medicine Jun, 2008 | Pubmed ID: 18494941
S100A8/A9: a Janus-faced molecule in cancer therapy and tumorgenesis.
European journal of pharmacology Dec, 2009 | Pubmed ID: 19835859
S100A8/A9: a mediator of severe asthma pathogenesis and morbidity?
Canadian journal of physiology and pharmacology Oct, 2009 | Pubmed ID: 19898558
S100A8/A9 induces autophagy and apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes that involves BNIP3.
Cell research Mar, 2010 | Pubmed ID: 19935772
Statin-triggered cell death in primary human lung mesenchymal cells involves p53-PUMA and release of Smac and Omi but not cytochrome c.
Biochimica et biophysica acta Apr, 2010 | Pubmed ID: 20045437
The mevalonate cascade as a target to suppress extracellular matrix synthesis by human airway smooth muscle.
American journal of respiratory cell and molecular biology Mar, 2011 | Pubmed ID: 20463291
beta-Dystroglycan binds caveolin-1 in smooth muscle: a functional role in caveolae distribution and Ca2+ release.
Journal of cell science Sep, 2010 | Pubmed ID: 20736308
Antifibrotic properties of c-Ski and its regulation of cardiac myofibroblast phenotype and contractility.
American journal of physiology. Cell physiology Jan, 2011 | Pubmed ID: 20943957
Mevalonate cascade regulation of airway mesenchymal cell autophagy and apoptosis: a dual role for p53.
PloS one Jan, 2011 | Pubmed ID: 21304979
The Role of Fas-FasL Signaling Pathway in Induction of Apoptosis in Patients with Sulfur Mustard-Induced Chronic Bronchiolitis.
Journal of toxicology , 2010 | Pubmed ID: 21317984
Simvastatin inhibits TGFβ1-induced fibronectin in human airway fibroblasts.
Respiratory research Aug, 2011 | Pubmed ID: 21864337
Hepatocellular recurrence after orthotopic liver transplantation: Is combination of α-fetoprotein and glypican-3 a reliable marker?: Hepatocellular recurrence after orthotopic liver trasplantation.
Hepatitis monthly Mar, 2011 | Pubmed ID: 22087135
Geranylgeranyl transferase 1 modulates autophagy and apoptosis in human airway smooth muscle.
American journal of physiology. Lung cellular and molecular physiology Feb, 2012 | Pubmed ID: 22160308
Epidermal growth factor cytoplasmic domain affects ErbB protein degradation by the lysosomal and ubiquitin-proteasome pathway in human cancer cells.
Neoplasia (New York, N.Y.) May, 2012 | Pubmed ID: 22745586
Novel non-canonical TGF-β signaling networks: emerging roles in airway smooth muscle phenotype and function.
Pulmonary pharmacology & therapeutics Feb, 2013 | Pubmed ID: 22874922
Guidelines for the use and interpretation of assays for monitoring autophagy.
Autophagy Apr, 2012 | Pubmed ID: 22966490
Autophagy regulates trans fatty acid-mediated apoptosis in primary cardiac myofibroblasts.
Biochimica et biophysica acta Dec, 2012 | Pubmed ID: 23026405
Functional polymorphisms of FAS and FASL gene and risk of breast cancer - pilot study of 134 cases.
PloS one , 2013 | Pubmed ID: 23326385
Asthma and influenza virus infection:focusing on cell death and stress pathways in influenza virus replication.
Iranian journal of allergy, asthma, and immunology Mar, 2013 | Pubmed ID: 23454774
Different faces of hepatocellular carcinoma as a health threat in 21st century.
Hepatitis monthly Feb, 2013 | Pubmed ID: 23613688
Motility, survival, and proliferation.
Comprehensive Physiology Jan, 2012 | Pubmed ID: 23728975
Association of Adiponectin rs1501299 and rs266729 Gene Polymorphisms With Nonalcoholic Fatty Liver Disease.
Hepatitis monthly May, 2013 | Pubmed ID: 23922565
The Ski-Zeb2-Meox2 pathway provides a novel mechanism for regulation of the cardiac myofibroblast phenotype.
Journal of cell science Jan, 2014 | Pubmed ID: 24155330
Autophagy and apoptosis dysfunction in neurodegenerative disorders.
Progress in neurobiology Jan, 2014 | Pubmed ID: 24211851
Reprogramming and carcinogenesis--parallels and distinctions.
International review of cell and molecular biology , 2014 | Pubmed ID: 24411172
Targeting the mevalonate cascade as a new therapeutic approach in heart disease, cancer and pulmonary disease.
Pharmacology & therapeutics Jul, 2014 | Pubmed ID: 24582968
Airway mesenchymal cell death by mevalonate cascade inhibition: integration of autophagy, unfolded protein response and apoptosis focusing on Bcl2 family proteins.
Biochimica et biophysica acta Jul, 2014 | Pubmed ID: 24637330
Mechanisms of therapeutic resistance in cancer (stem) cells with emphasis on thyroid cancer cells.
Frontiers in endocrinology , 2014 | Pubmed ID: 24723911
Apoptins: selective anticancer agents.
Trends in molecular medicine Sep, 2014 | Pubmed ID: 25164066
Human-gyrovirus-Apoptin triggers mitochondrial death pathway--Nur77 is required for apoptosis triggering.
Neoplasia (New York, N.Y.) Sep, 2014 | Pubmed ID: 25246270
Suppression of influenza A virus replication in human lung epithelial cells by noncytotoxic concentrations bafilomycin A1.
American journal of physiology. Lung cellular and molecular physiology Feb, 2015 | Pubmed ID: 25361566
Association between hTERT polymorphisms and the risk of breast cancer in a sample of Southeast Iranian population.
BMC research notes Dec, 2014 | Pubmed ID: 25491902
Association between Interleukin-1 Receptor Antagonist (IL1RN) Variable Number of Tandem Repeats (VNTR) Polymorphism and Pulmonary Tuberculosis.
Iranian journal of allergy, asthma, and immunology Feb, 2015 | Pubmed ID: 25530139
Cellular commitment in the developing cerebellum.
Frontiers in cellular neuroscience , 2014 | Pubmed ID: 25628535
Platinum (IV) coiled coil nanotubes selectively kill human glioblastoma cells.
Nanomedicine : nanotechnology, biology, and medicine May, 2015 | Pubmed ID: 25680541
RAGE Mediates the Pro-Migratory Response of Extracellular S100A4 in Human Thyroid Cancer Cells.
Thyroid : official journal of the American Thyroid Association May, 2015 | Pubmed ID: 25744544
Association between Programmed Cell Death 6 Interacting Protein Insertion/Deletion Polymorphism and the Risk of Breast Cancer in a Sample of Iranian Population.
Disease markers , 2015 | Pubmed ID: 26063962
Pre-administration of turmeric prevents methotrexate-induced liver toxicity and oxidative stress.
BMC complementary and alternative medicine Jul, 2015 | Pubmed ID: 26199067
The expression pattern of PFKFB3 enzyme distinguishes between induced-pluripotent stem cells and cancer stem cells.
Oncotarget Oct, 2015 | Pubmed ID: 26337471
The role of the ubiquitin proteasome system in cerebellar development and medulloblastoma.
Molecular brain Oct, 2015 | Pubmed ID: 26475605
Effects of Ethanol on the Expression Level of Various BDNF mRNA Isoforms and Their Encoded Protein in the Hippocampus of Adult and Embryonic Rats.
International journal of molecular sciences Dec, 2015 | Pubmed ID: 26703578
Hepatitis B and C virus-induced hepatitis: Apoptosis, autophagy, and unfolded protein response.
World journal of gastroenterology Dec, 2015 | Pubmed ID: 26715805
Editorial (Thematic Issue: New Insights into a Classical Pathway: Key Roles of the Mevalonate Cascade in Different Diseases (Part I)).
Current molecular pharmacology , 2017 | Pubmed ID: 26768962
Apoptosis, autophagy and unfolded protein response pathways in Arbovirus replication and pathogenesis.
Expert reviews in molecular medicine Jan, 2016 | Pubmed ID: 26781343
Cerebellar Expression of the Neurotrophin Receptor p75 in Naked-Ataxia Mutant Mouse.
International journal of molecular sciences Jan, 2016 | Pubmed ID: 26784182
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Autophagy Jan, 2016 | Pubmed ID: 26799652
Inhibition of miR301 enhances Akt-mediated cell proliferation by accumulation of PTEN in nucleus and its effects on cell-cycle regulatory proteins.
Oncotarget Apr, 2016 | Pubmed ID: 26967567
Cancer stem cells, cancer-initiating cells and methods for their detection.
Drug discovery today 05, 2016 | Pubmed ID: 26976692
Chronic expression of Ski induces apoptosis and represses autophagy in cardiac myofibroblasts.
Biochimica et biophysica acta Jun, 2016 | Pubmed ID: 27039037
Perillyl Alcohol (Monoterpene Alcohol), Limonene.
The Enzymes , 2014 | Pubmed ID: 27102697
How Hepatitis C Virus Leads to Hepatocellular Carcinoma: A Network-Based Study.
Hepatitis monthly Feb, 2016 | Pubmed ID: 27148389
Could drugs inhibiting the mevalonate pathway also target cancer stem cells?
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 03, 2016 | Pubmed ID: 27155373
Evaluation of the pri-miR-34b/c rs4938723 polymorphism and its association with breast cancer risk.
Biomedical reports Jul, 2016 | Pubmed ID: 27347415
Perturbation of redox balance after thioredoxin reductase deficiency interrupts autophagy-lysosomal degradation pathway and enhances cell death in nutritionally stressed SH-SY5Y cells.
Free radical biology & medicine 12, 2016 | Pubmed ID: 27693380
Photodynamic N-TiO Nanoparticle Treatment Induces Controlled ROS-mediated Autophagy and Terminal Differentiation of Leukemia Cells.
Scientific reports 10, 2016 | Pubmed ID: 27698385
Inhibition of autophagy inhibits the conversion of cardiac fibroblasts to cardiac myofibroblasts.
Oncotarget Nov, 2016 | Pubmed ID: 27705938
Microfluidic approaches for isolation, detection, and characterization of extracellular vesicles: Current status and future directions.
Biosensors & bioelectronics May, 2017 | Pubmed ID: 28088752
Mevalonate Cascade Inhibition by Simvastatin Induces the Intrinsic Apoptosis Pathway via Depletion of Isoprenoids in Tumor Cells.
Scientific reports 03, 2017 | Pubmed ID: 28344327
New frontiers in the treatment of colorectal cancer: Autophagy and the unfolded protein response as promising targets.
Autophagy May, 2017 | Pubmed ID: 28358273
Corrigendum to "Epidermal Growth Factor Cytoplasmic Domain Affects ErbB Protein Degradation by the Lysosomal and Ubiquitin-Proteasome Pathway in Human Cancer Cells" [Neoplasia 14 (2012) 396-409].
Neoplasia (New York, N.Y.) 04, 2017 | Pubmed ID: 28385276
Human Gyrovirus-Apoptin Interferes with the Cell Cycle and Induces G2/M Arrest Prior to Apoptosis.
Archivum immunologiae et therapiae experimentalis Dec, 2017 | Pubmed ID: 28386695
Editorial: New Insights into a Classical Pathway: Key Roles of the Mevalonate Cascade in Different Diseases (Part II).
Current molecular pharmacology , 2017 | Pubmed ID: 28440195
Association between polymorphisms in TP53 and MDM2 genes and susceptibility to prostate cancer.
Oncology letters Apr, 2017 | Pubmed ID: 28454424
Transdifferentiation and reprogramming: Overview of the processes, their similarities and differences.
Biochimica et biophysica acta. Molecular cell research Jul, 2017 | Pubmed ID: 28460880
Toll like receptor 4 and hepatocellular carcinoma; A systematic review.
Life sciences Jun, 2017 | Pubmed ID: 28472619
Dovitinib enhances temozolomide efficacy in glioblastoma cells.
Molecular oncology 08, 2017 | Pubmed ID: 28500786
Genetic polymorphisms of HOTAIR gene are associated with the risk of breast cancer in a sample of southeast Iranian population.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine Oct, 2017 | Pubmed ID: 29022495
4-bp insertion/deletion (rs3783553) polymorphism within the 3'UTR of IL1A contributes to the risk of prostate cancer in a sample of Iranian population.
Journal of cellular biochemistry 03, 2018 | Pubmed ID: 29023981
Ral signaling pathway in health and cancer.
Cancer medicine Dec, 2017 | Pubmed ID: 29047224
Autophagy and the unfolded protein response promote profibrotic effects of TGF-β in human lung fibroblasts.
American journal of physiology. Lung cellular and molecular physiology Mar, 2018 | Pubmed ID: 29074489
Inflammasomes and type 2 diabetes: An updated systematic review.
Immunology letters 12, 2017 | Pubmed ID: 29079203
Glioblastoma and chemoresistance to alkylating agents: Involvement of apoptosis, autophagy, and unfolded protein response.
Pharmacology & therapeutics Apr, 2018 | Pubmed ID: 29080702
Simultaneous Detection of Autophagy and Epithelial to Mesenchymal Transition in the Non-small Cell Lung Cancer Cells.
Methods in molecular biology (Clifton, N.J.) , 2019 | Pubmed ID: 29101677
Structure and properties of slow-resorbing nanofibers obtained by (co-axial) electrospinning as tissue scaffolds in regenerative medicine.
PeerJ , 2017 | Pubmed ID: 29302386
Association between single nucleotide polymorphisms in the PI3K/AKT/mTOR pathway and bladder cancer risk in a sample of Iranian population.
EXCLI journal , 2018 | Pubmed ID: 29383014
Autophagy modulates transforming growth factor beta 1 induced epithelial to mesenchymal transition in non-small cell lung cancer cells.
Biochimica et biophysica acta. Molecular cell research May, 2018 | Pubmed ID: 29481833
Evaluation of 4-bp insertion/deletion polymorphism within the 3'UTR of SGSM3 in bladder cancer using mismatch PCR-RFLP method: A preliminary report.
Journal of cellular biochemistry Aug, 2018 | Pubmed ID: 29693742
A Comparison Between Cell, Protein and Peptide-Based Approaches for Selection of Nanobodies Against CD44 from a Synthetic Library.
Protein and peptide letters , 2018 | Pubmed ID: 29848261
Association of PDCD6 polymorphisms with the risk of cancer: Evidence from a meta-analysis.
Oncotarget May, 2018 | Pubmed ID: 29872511
Toll-Like Receptor 4 as an Immune Receptor Against Mycobacterium tuberculosis: A Systematic Review.
Laboratory medicine Aug, 2018 | Pubmed ID: 30124945
Preparation and Characterization of Simvastatin Nanocapsules: Encapsulation of Hydrophobic Drugs in Calcium Alginate.
Methods in molecular biology (Clifton, N.J.) Aug, 2018 | Pubmed ID: 30159829
Association between miR-34b/c rs4938723 polymorphism and risk of cancer: An updated meta-analysis of 27 case-control studies.
Journal of cellular biochemistry Sep, 2018 | Pubmed ID: 30203457
Association of single nucleotide autophagy-related protein 5 gene polymorphism rs2245214 with susceptibility to non-small cell lung cancer.
Journal of cellular biochemistry Sep, 2018 | Pubmed ID: 30242869
LAPTM4B gene polymorphism augments the risk of cancer: Evidence from an updated meta-analysis.
Journal of cellular and molecular medicine Sep, 2018 | Pubmed ID: 30255662
Changes in serum level of trace elements in pulmonary tuberculosis patients during anti-tuberculosis treatment.
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) Dec, 2018 | Pubmed ID: 30262275
Statins: a new approach to combat temozolomide chemoresistance in glioblastoma.
Journal of investigative medicine : the official publication of the American Federation for Clinical Research Oct, 2018 | Pubmed ID: 30368483
Association between CASP3 polymorphisms and overall cancer risk: A meta-analysis of case-control studies.
Journal of cellular biochemistry Oct, 2018 | Pubmed ID: 30368918
Autophagy Activation in Asthma Airways Remodeling.
American journal of respiratory cell and molecular biology Nov, 2018 | Pubmed ID: 30383396
Javad Alizadeh1,2,
Shahla Shojaei1,2,3,
Simone da Silva Rosa1,
Adel Rezaei Moghadam1,2,
Amir A. Zeki4,
Mohammad Hashemi5,
Marek J. Los6,7,8,
Joseph W. Gordon1,9,
Saeid Ghavami1,2,10
1Department of Human Anatomy and Cell Science, Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba,
2Biology of Breathing Theme, Children Hospital Research Institute of Manitoba, University of Manitoba,
3Department of Biochemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences,
4Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, Center for Comparative Respiratory Biology and Medicine,
5Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences,
6Department of Molecular Biology, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia,
7Centre de biophysique moléculaire - UPR 4301, Centre national de la recherche scientifique (CNRS) CS80054,
8, LinkoCare Life Sciences AB,
9College of Nursing and Children's Hospital Research Institute of Manitoba, Rady Faculty of Health Sciences, University of Manitoba,
10Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences
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