Steven D. Goodman

Biofilms can be dispersed by focusing the immune system on a common family of bacterial nucleoid-associated proteins.

Aberrant community architecture and attenuated persistence of uropathogenic Escherichia coli in the absence of individual IHF subunits.

Targeting bacterial integration host factor to disrupt biofilms associated with cystic fibrosis.

Antibodies directed against integration host factor mediate biofilm clearance from Nasopore.

Structural stability of Burkholderia cenocepacia biofilms is reliant on eDNA structure and presence of a bacterial nucleic acid binding protein.

Evaluation of the kinetics and mechanism of action of anti-integration host factor-mediated disruption of bacterial biofilms.

Antibodies against the majority subunit of type IV Pili disperse nontypeable Haemophilus influenzae biofilms in a LuxS-dependent manner and confer therapeutic resolution of experimental otitis media.

DNABII proteins play a central role in UPEC biofilm structure.

Monoclonal antibodies against DNA-binding tips of DNABII proteins disrupt biofilms in vitro and induce bacterial clearance in vivo.

Identification of biofilms in post-tympanostomy tube otorrhea.

Transcutaneous Immunization with a Band-Aid Prevents Experimental Otitis Media in a Polymicrobial Model.

Nontypeable releases DNA and DNABII proteins via a T4SS-like complex and ComE of the type IV pilus machinery.

Application of single nucleotide extension and MALDI-TOF mass spectrometry in proofreading and DNA repair assay.

The DNABII family of proteins is comprised of the only nucleoid associated proteins required for nontypeable Haemophilus influenzae biofilm structure.

Identification of essential biofilm proteins in middle ear fluids of otitis media with effusion patients.

Antibodies against the DNABII protein integration host factor (IHF) inhibit sinus implant biofilms.

The extracellular DNA lattice of bacterial biofilms is structurally related to Holliday junction recombination intermediates.

Proofreading of single nucleotide insertion/deletion replication errors analyzed by MALDI-TOF mass spectrometry assay.

Immunization with a Biofilm-Disrupting Nontypeable Vaccine Antigen Did Not Alter the Gut Microbiome in Chinchillas, Unlike Oral Delivery of a Broad-Spectrum Antibiotic Commonly Used for Otitis Media.

Targeting a bacterial DNABII protein with a chimeric peptide immunogen or humanised monoclonal antibody to prevent or treat recalcitrant biofilm-mediated infections.

Measurement of uracil-DNA glycosylase activity by matrix assisted laser desorption/ionization time-of-flight mass spectrometry technique.

Nontypeable newly released (NRel) from biofilms by antibody-mediated dispersal antibody-mediated disruption are phenotypically distinct.

Enhanced biofilm and extracellular matrix production by chronic carriage versus acute isolates of Salmonella Typhi.

Escherichia coli Nissle 1917 administered as a dextranomar microsphere biofilm enhances immune responses against human rotavirus in a neonatal malnourished pig model colonized with human infant fecal microbiota.

Humanized Anti-DNABII Fab Fragments Plus Ofloxacin Eradicated Biofilms in Experimental Otitis Media.

The dental plaque biofilm matrix.

in Its Biofilm State Improves Protection from Experimental Necrotizing Enterocolitis.

The extracellular innate-immune effector HMGB1 limits pathogenic bacterial biofilm proliferation.

A Humanized Monoclonal Antibody Potentiates Killing of Diverse Biofilm-Forming Respiratory Tract Pathogens by Antibiotics.

Bacterial Biofilms Utilize an Underlying Extracellular DNA Matrix Structure That Can Be Targeted for Biofilm Resolution.