Peter Macheroux

Reduced flavin: NMR investigation of N5-H exchange mechanism, estimation of ionisation constants and assessment of properties as biological catalyst.

Biochemical evidence that berberine bridge enzyme belongs to a novel family of flavoproteins containing a bi-covalently attached FAD cofactor.

Characterization of a thermostable NADPH:FMN oxidoreductase from the mesophilic bacterium Bacillus subtilis.

Crystal structure of 12-oxophytodienoate reductase 3 from tomato: self-inhibition by dimerization.

Lot6p from Saccharomyces cerevisiae is a FMN-dependent reductase with a potential role in quinone detoxification.

Mutagenic analysis of an invariant aspartate residue in chorismate synthase supports its role as an active site base.

6-S-cysteinylation of bi-covalently attached FAD in berberine bridge enzyme tunes the redox potential for optimal activity.

Conservation of NADPH utilization by chorismate synthase and its implications for the evolution of the shikimate pathway.

Replacement of two invariant serine residues in chorismate synthase provides evidence that a proton relay system is essential for intermediate formation and catalytic activity.

A concerted mechanism for berberine bridge enzyme.

Quinone reductase acts as a redox switch of the 20S yeast proteasome.

Structural and mechanistic studies reveal the functional role of bicovalent flavinylation in berberine bridge enzyme.

Berberine bridge enzyme catalyzes the six electron oxidation of (S)-reticuline to dehydroscoulerine.

Mechanism of flavin reduction and oxidation in the redox-sensing quinone reductase Lot6p from Saccharomyces cerevisiae.

A single intersubunit salt bridge affects oligomerization and catalytic activity in a bacterial quinone reductase.

The redox-sensing quinone reductase Lot6p acts as an inducer of yeast apoptosis.

Flavogenomics--a genomic and structural view of flavin-dependent proteins.

Biocatalytic organic synthesis of optically pure (S)-scoulerine and berbine and benzylisoquinoline alkaloids.

A stereoselective inverting sec-alkylsulfatase for the deracemization of sec-alcohols.

Characterization of the PLP-dependent aminotransferase NikK from Streptomyces tendae and its putative role in nikkomycin biosynthesis.

A novel N,N-8-amino-8-demethyl-D-riboflavin Dimethyltransferase (RosA) catalyzing the two terminal steps of roseoflavin biosynthesis in Streptomyces davawensis.

Entropy-driven binding of opioid peptides induces a large domain motion in human dipeptidyl peptidase III.

Activity-based probes for studying the activity of flavin-dependent oxidases and for the protein target profiling of monoamine oxidase inhibitors.

Reverse structural genomics: an unusual flavin-binding site in a putative protease from Bacteroides thetaiotaomicron.

Catalytic and structural role of a conserved active site histidine in berberine bridge enzyme.

Structural and functional characterization of NikO, an enolpyruvyl transferase essential in nikkomycin biosynthesis.

Structure and mechanism of an inverting alkylsulfatase from Pseudomonas sp. DSM6611 specific for secondary alkyl sulfates.

One-pot deracemization of sec-alcohols: enantioconvergent enzymatic hydrolysis of alkyl sulfates using stereocomplementary sulfatases.

The human flavoproteome.

Determination of free and bound riboflavin in cow's milk using a novel flavin-binding protein.

The flavoproteome of the yeast Saccharomyces cerevisiae.

Disruption of the methyltransferase-like 23 gene METTL23 causes mild autosomal recessive intellectual disability.

Identification of promiscuous ene-reductase activity by mining structural databases using active site constellations.

Collapse of the native structure caused by a single amino acid exchange in human NAD(P)H:quinone oxidoreductase(1.).

Structure and stability of an unusual zinc-binding protein from Bacteroides thetaiotaomicron.

Rationally engineered flavin-dependent oxidase reveals steric control of dioxygen reduction.

One-Pot Deracemization of sec-Alcohols: Enantioconvergent Enzymatic Hydrolysis of Alkyl Sulfates Using Stereocomplementary Sulfatases.

Anthranoyl-CoA monooxygenase/reductase from Azoarcus evansii possesses both FMN and FAD in two distinct and independent active sites.

Oxidation of Monolignols by Members of the Berberine Bridge Enzyme Family Suggests a Role in Plant Cell Wall Metabolism.

Structure-Based Mechanism of Oleate Hydratase from Elizabethkingia meningoseptica.

Mutations in the histamine N-methyltransferase gene, HNMT, are associated with nonsyndromic autosomal recessive intellectual disability.

Structural and biochemical properties of LuxF from Photobacterium leiognathi.

Structural and kinetic studies on RosA, the enzyme catalysing the methylation of 8-demethyl-8-amino-d-riboflavin to the antibiotic roseoflavin.

Substrate complexes of human dipeptidyl peptidase III reveal the mechanism of enzyme inhibition.

Structure of a Berberine Bridge Enzyme-Like Enzyme with an Active Site Specific to the Plant Family Brassicaceae.

Structure and biochemical properties of recombinant human dimethylglycine dehydrogenase and comparison to the disease-related H109R variant.

Leucine 208 in human histamine N-methyltransferase emerges as a hotspot for protein stability rationalizing the role of the L208P variant in intellectual disability.

Synthesis of α,β-unsaturated aldehydes as potential substrates for bacterial luciferases.

Catalytic competence, structure and stability of the cancer-associated R139W variant of the human NAD(P)H:quinone oxidoreductase 1 (NQO1).

Evidence for the generation of myristylated FMN by bacterial luciferase.

Structure, biochemical and kinetic properties of recombinant Pst2p from Saccharomyces cerevisiae, a FMN-dependent NAD(P)H:quinone oxidoreductase.

The family of berberine bridge enzyme-like enzymes: A treasure-trove of oxidative reactions.

Biosensor for the characterisation of hMAO B inhibitors and the quantification of selegiline.

Regioselective para-Carboxylation of Catechols with a Prenylated Flavin Dependent Decarboxylase.

Crystal structure of dipeptidyl peptidase III from the human gut symbiont Bacteroides thetaiotaomicron.

Oxidation of the FAD cofactor to the 8-formyl-derivative in human electron-transferring flavoprotein.

The single berberine bridge enzyme homolog of Physcomitrella patens is a cellobiose oxidase.

Asymmetric Reductive Carbocyclization Using Engineered Ene Reductases.