Institute of Biochemistry
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Reduced flavin: NMR investigation of N5-H exchange mechanism, estimation of ionisation constants and assessment of properties as biological catalyst.
BMC biochemistry Nov, 2005 | Pubmed ID: 16309555
Biochemical evidence that berberine bridge enzyme belongs to a novel family of flavoproteins containing a bi-covalently attached FAD cofactor.
The Journal of biological chemistry Jul, 2006 | Pubmed ID: 16728404
Characterization of a thermostable NADPH:FMN oxidoreductase from the mesophilic bacterium Bacillus subtilis.
Biochemistry Jun, 2006 | Pubmed ID: 16752898
Crystal structure of 12-oxophytodienoate reductase 3 from tomato: self-inhibition by dimerization.
Proceedings of the National Academy of Sciences of the United States of America Sep, 2006 | Pubmed ID: 16983071
Lot6p from Saccharomyces cerevisiae is a FMN-dependent reductase with a potential role in quinone detoxification.
The FEBS journal Mar, 2007 | Pubmed ID: 17298444
Mutagenic analysis of an invariant aspartate residue in chorismate synthase supports its role as an active site base.
Biochemistry Mar, 2007 | Pubmed ID: 17326665
6-S-cysteinylation of bi-covalently attached FAD in berberine bridge enzyme tunes the redox potential for optimal activity.
The Journal of biological chemistry Aug, 2007 | Pubmed ID: 17573342
Conservation of NADPH utilization by chorismate synthase and its implications for the evolution of the shikimate pathway.
Molecular microbiology Sep, 2007 | Pubmed ID: 17662045
Replacement of two invariant serine residues in chorismate synthase provides evidence that a proton relay system is essential for intermediate formation and catalytic activity.
The FEBS journal Apr, 2008 | Pubmed ID: 18279385
A concerted mechanism for berberine bridge enzyme.
Nature chemical biology Dec, 2008 | Pubmed ID: 18953357
Quinone reductase acts as a redox switch of the 20S yeast proteasome.
EMBO reports Jan, 2009 | Pubmed ID: 19029946
Structural and mechanistic studies reveal the functional role of bicovalent flavinylation in berberine bridge enzyme.
The Journal of biological chemistry Jul, 2009 | Pubmed ID: 19457868
Berberine bridge enzyme catalyzes the six electron oxidation of (S)-reticuline to dehydroscoulerine.
Phytochemistry Jun, 2009 | Pubmed ID: 19570558
Mechanism of flavin reduction and oxidation in the redox-sensing quinone reductase Lot6p from Saccharomyces cerevisiae.
Biochemistry Sep, 2009 | Pubmed ID: 19618916
A single intersubunit salt bridge affects oligomerization and catalytic activity in a bacterial quinone reductase.
The FEBS journal Sep, 2009 | Pubmed ID: 19682074
The redox-sensing quinone reductase Lot6p acts as an inducer of yeast apoptosis.
FEMS yeast research Sep, 2009 | Pubmed ID: 19709309
Flavogenomics--a genomic and structural view of flavin-dependent proteins.
The FEBS journal Aug, 2011 | Pubmed ID: 21635694
Biocatalytic organic synthesis of optically pure (S)-scoulerine and berbine and benzylisoquinoline alkaloids.
The Journal of organic chemistry Aug, 2011 | Pubmed ID: 21739961
A stereoselective inverting sec-alkylsulfatase for the deracemization of sec-alcohols.
Organic letters Aug, 2011 | Pubmed ID: 21770430
Characterization of the PLP-dependent aminotransferase NikK from Streptomyces tendae and its putative role in nikkomycin biosynthesis.
The FEBS journal Nov, 2011 | Pubmed ID: 21884568
A novel N,N-8-amino-8-demethyl-D-riboflavin Dimethyltransferase (RosA) catalyzing the two terminal steps of roseoflavin biosynthesis in Streptomyces davawensis.
The Journal of biological chemistry Nov, 2011 | Pubmed ID: 21911488
Entropy-driven binding of opioid peptides induces a large domain motion in human dipeptidyl peptidase III.
Proceedings of the National Academy of Sciences of the United States of America Apr, 2012 | Pubmed ID: 22493238
Activity-based probes for studying the activity of flavin-dependent oxidases and for the protein target profiling of monoamine oxidase inhibitors.
Angewandte Chemie (International ed. in English) Jul, 2012 | Pubmed ID: 22689512
Reverse structural genomics: an unusual flavin-binding site in a putative protease from Bacteroides thetaiotaomicron.
The Journal of biological chemistry Aug, 2012 | Pubmed ID: 22718753
Catalytic and structural role of a conserved active site histidine in berberine bridge enzyme.
Biochemistry Aug, 2012 | Pubmed ID: 22757961
Structural and functional characterization of NikO, an enolpyruvyl transferase essential in nikkomycin biosynthesis.
The Journal of biological chemistry Sep, 2012 | Pubmed ID: 22810238
Structure and mechanism of an inverting alkylsulfatase from Pseudomonas sp. DSM6611 specific for secondary alkyl sulfates.
The FEBS journal Dec, 2012 | Pubmed ID: 23061549
One-pot deracemization of sec-alcohols: enantioconvergent enzymatic hydrolysis of alkyl sulfates using stereocomplementary sulfatases.
Angewandte Chemie (International ed. in English) Mar, 2013 | Pubmed ID: 23401148
The human flavoproteome.
Archives of biochemistry and biophysics Jul, 2013 | Pubmed ID: 23500531
Determination of free and bound riboflavin in cow's milk using a novel flavin-binding protein.
Food chemistry Mar, 2014 | Pubmed ID: 24176318
The flavoproteome of the yeast Saccharomyces cerevisiae.
Biochimica et biophysica acta Mar, 2014 | Pubmed ID: 24373875
Disruption of the methyltransferase-like 23 gene METTL23 causes mild autosomal recessive intellectual disability.
Human molecular genetics Aug, 2014 | Pubmed ID: 24626631
Identification of promiscuous ene-reductase activity by mining structural databases using active site constellations.
Nature communications Jun, 2014 | Pubmed ID: 24954722
Collapse of the native structure caused by a single amino acid exchange in human NAD(P)H:quinone oxidoreductase(1.).
The FEBS journal Oct, 2014 | Pubmed ID: 25143260
Structure and stability of an unusual zinc-binding protein from Bacteroides thetaiotaomicron.
Biochimica et biophysica acta Dec, 2014 | Pubmed ID: 25263158
Rationally engineered flavin-dependent oxidase reveals steric control of dioxygen reduction.
The FEBS journal Aug, 2015 | Pubmed ID: 25619330
One-Pot Deracemization of sec-Alcohols: Enantioconvergent Enzymatic Hydrolysis of Alkyl Sulfates Using Stereocomplementary Sulfatases.
Angewandte Chemie (Weinheim an der Bergstrasse, Germany) Mar, 2013 | Pubmed ID: 25821253
Anthranoyl-CoA monooxygenase/reductase from Azoarcus evansii possesses both FMN and FAD in two distinct and independent active sites.
Biochimica et biophysica acta Aug, 2015 | Pubmed ID: 25843773
Oxidation of Monolignols by Members of the Berberine Bridge Enzyme Family Suggests a Role in Plant Cell Wall Metabolism.
The Journal of biological chemistry Jul, 2015 | Pubmed ID: 26037923
Structure-Based Mechanism of Oleate Hydratase from Elizabethkingia meningoseptica.
Chembiochem : a European journal of chemical biology Aug, 2015 | Pubmed ID: 26077980
Mutations in the histamine N-methyltransferase gene, HNMT, are associated with nonsyndromic autosomal recessive intellectual disability.
Human molecular genetics Oct, 2015 | Pubmed ID: 26206890
Structural and biochemical properties of LuxF from Photobacterium leiognathi.
Biochimica et biophysica acta Oct, 2015 | Pubmed ID: 26209460
Structural and kinetic studies on RosA, the enzyme catalysing the methylation of 8-demethyl-8-amino-d-riboflavin to the antibiotic roseoflavin.
The FEBS journal Apr, 2016 | Pubmed ID: 26913589
Substrate complexes of human dipeptidyl peptidase III reveal the mechanism of enzyme inhibition.
Scientific reports Mar, 2016 | Pubmed ID: 27025154
Structure of a Berberine Bridge Enzyme-Like Enzyme with an Active Site Specific to the Plant Family Brassicaceae.
PloS one , 2016 | Pubmed ID: 27276217
Structure and biochemical properties of recombinant human dimethylglycine dehydrogenase and comparison to the disease-related H109R variant.
The FEBS journal 10, 2016 | Pubmed ID: 27486859
Leucine 208 in human histamine N-methyltransferase emerges as a hotspot for protein stability rationalizing the role of the L208P variant in intellectual disability.
Biochimica et biophysica acta Jan, 2017 | Pubmed ID: 27769936
Synthesis of α,β-unsaturated aldehydes as potential substrates for bacterial luciferases.
Bioorganic & medicinal chemistry 02, 2017 | Pubmed ID: 28126438
Catalytic competence, structure and stability of the cancer-associated R139W variant of the human NAD(P)H:quinone oxidoreductase 1 (NQO1).
The FEBS journal 04, 2017 | Pubmed ID: 28236663
Evidence for the generation of myristylated FMN by bacterial luciferase.
Molecular microbiology Jun, 2017 | Pubmed ID: 28345146
Structure, biochemical and kinetic properties of recombinant Pst2p from Saccharomyces cerevisiae, a FMN-dependent NAD(P)H:quinone oxidoreductase.
Biochimica et biophysica acta 08, 2017 | Pubmed ID: 28499769
The family of berberine bridge enzyme-like enzymes: A treasure-trove of oxidative reactions.
Archives of biochemistry and biophysics 10, 2017 | Pubmed ID: 28676375
Biosensor for the characterisation of hMAO B inhibitors and the quantification of selegiline.
Talanta Nov, 2017 | Pubmed ID: 28738644
Regioselective para-Carboxylation of Catechols with a Prenylated Flavin Dependent Decarboxylase.
Angewandte Chemie (International ed. in English) Oct, 2017 | Pubmed ID: 28857436
Crystal structure of dipeptidyl peptidase III from the human gut symbiont Bacteroides thetaiotaomicron.
PloS one , 2017 | Pubmed ID: 29095893
Oxidation of the FAD cofactor to the 8-formyl-derivative in human electron-transferring flavoprotein.
The Journal of biological chemistry Feb, 2018 | Pubmed ID: 29301933
The single berberine bridge enzyme homolog of Physcomitrella patens is a cellobiose oxidase.
The FEBS journal May, 2018 | Pubmed ID: 29633551
Asymmetric Reductive Carbocyclization Using Engineered Ene Reductases.
Angewandte Chemie (International ed. in English) Jun, 2018 | Pubmed ID: 29689601
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