Department of General Surgery
Dr. Jun YANG is a principal investigator at Department of Physiology, Zhejiang University School of Medicine. She was recruited from University of Cambridge in 2014 by “The National Recruitment Program of Global Experts”to be Professor of Department of Cell Biology, Institute of Basic Medical Sciences,Chinese Academy of Medical Sciences. Then she moved to Zhejiang University and funded by the 'Hundred Talents Program' in 2019.
She had undergraduate education in Zhejiang University, and received her Ph.D. degree from Chinese Academy of Medical Sciences & Peking Union Medical College. She devoted on the medical research of cardiopulmonary disease for more than 8 years in university of Cambridge with Professor Nick Morrell. Combined with her expertise on the drug discovery she applied stem cell technology to drug screening for small molecular intervention on BMPR2 signaling for the treatment of pulmonary arterial hypertension. The Yang lab sets up the human inducible pluoripotent stem cell reprogramming and differentiation syestem to study the pathogenesis of related diseases. Also her group professionally generates mutaions in human embroynic stem cells for understanding the vascular development as well as performs mutation correction for potential cell therapy.
She has published more than 30 research papers in the national and internationally recognized journals, including European Respiratory Journal, Circulation Research and Am J Respir Crit Care Med, and applied more than 5 national and international patents. She was awarded British Associate of Lung Research young investigator first prize in British Thoracic Society meeting and Pfizer European pulmonary vascular disease research. Her current project is aim to study the cellular and molecular pathogenesis of cardiopulmonary disease.
Protein kinases and their involvement in the cellular responses to genotoxic stress.
Mutation research Jan, 2003 | Pubmed ID: 12510016
Response of human REV3 gene to gastric cancer inducing carcinogen N-methyl-N'-nitro-N-nitrosoguanidine and its role in mutagenesis.
World journal of gastroenterology May, 2003 | Pubmed ID: 12717825
Altered expression of zinc finger proteins, ADAMs, and integrin-related proteins following treatment of cultured human cells with a low concentration of N-methyl-N'-nitro-N-nitrosoguanidine.
Environmental and molecular mutagenesis , 2003 | Pubmed ID: 12802805
[Reactive oxygen species and mitochondrial KATP-sensitive channels mediated cardioprotection induced by TNF-alpha during hypoxia and reoxygenation].
Sheng li xue bao : [Acta physiologica Sinica] Jun, 2003 | Pubmed ID: 12817295
ATM, ATR and DNA-PK: initiators of the cellular genotoxic stress responses.
Carcinogenesis Oct, 2003 | Pubmed ID: 12919958
Proteomic analysis of cellular responses to low concentration N-methyl-N'-nitro-N-nitrosoguanidine in human amnion FL cells.
Environmental and molecular mutagenesis , 2004 | Pubmed ID: 14991749
Cytokines in Mycoplasma pneumoniae infections.
Cytokine & growth factor reviews Apr-Jun, 2004 | Pubmed ID: 15110799
Zinc finger proteins and other transcription regulators as response proteins in benzo[a]pyrene exposed cells.
Mutation research Jun, 2004 | Pubmed ID: 15135637
Response of REV3 promoter to N-methyl-N'-nitro-N-nitrosoguanidine.
Mutation research Jun, 2004 | Pubmed ID: 15135640
N-methyl-N'-nitro-N-nitrosoguanidine sensitivity, mutator phenotype and sequence specificity of spontaneous mutagenesis in FEN-1-deficient cells.
Mutation research Nov, 2004 | Pubmed ID: 15491627
Study of a novel antiosteoporosis screening model targeted on cathepsin K.
Biomedical and environmental sciences : BES Sep, 2004 | Pubmed ID: 15602824
N-methyl-N'-nitro-N-nitrosoguanidine interferes with the epidermal growth factor receptor-mediated signaling pathway.
Mutation research Mar, 2005 | Pubmed ID: 15708576
Sphingolipids are involved in N-methyl-N'-nitro-N-nitrosoguanidine-induced epidermal growth factor receptor clustering.
Biochemical and biophysical research communications May, 2005 | Pubmed ID: 15796901
A lipidomic study of the effects of N-methyl-N'-nitro-N-nitrosoguanidine on sphingomyelin metabolism.
Acta biochimica et biophysica Sinica Aug, 2005 | Pubmed ID: 16077898
DNA damage evaluated by gammaH2AX foci formation by a selective group of chemical/physical stressors.
Mutation research Apr, 2006 | Pubmed ID: 16423555
A comparative study of using comet assay and gammaH2AX foci formation in the detection of N-methyl-N'-nitro-N-nitrosoguanidine-induced DNA damage.
Toxicology in vitro : an international journal published in association with BIBRA Sep, 2006 | Pubmed ID: 16473493
Oxidative stress induces H2AX phosphorylation in human spermatozoa.
FEBS letters Nov, 2006 | Pubmed ID: 17064697
Evaluation of sphingolipids changes in brain tissues of rats with pentylenetetrazol-induced kindled seizures using MALDI-TOF-MS.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Nov, 2007 | Pubmed ID: 17931985
Mycoplasma pneumoniae infection induces reactive oxygen species and DNA damage in A549 human lung carcinoma cells.
Infection and immunity Oct, 2008 | Pubmed ID: 18663006
Effects of Mycoplasma pneumoniae infection on sphingolipid metabolism in human lung carcinoma A549 cells.
Microbial pathogenesis Feb, 2009 | Pubmed ID: 19059331
Changes of sphingolipids profiles after ischemia-reperfusion injury in the rat liver.
Chinese medical journal Dec, 2009 | Pubmed ID: 20137496
Interferon and lamivudine combination therapy versus lamivudine monotherapy for hepatitis B e antigen-negative hepatitis B treatment: a meta-analysis of randomized controlled trials.
Hepatobiliary & pancreatic diseases international : HBPD INT Oct, 2010 | Pubmed ID: 20943454
Efficacy and safety of abciximab in diabetic patients who underwent percutaneous coronary intervention with thienopyridines loading: a meta-analysis.
PloS one , 2011 | Pubmed ID: 21677787
Association between occult hepatitis B infection and the risk of hepatocellular carcinoma: a meta-analysis.
Liver international : official journal of the International Association for the Study of the Liver Feb, 2012 | Pubmed ID: 21745272
Role of benzalkonium chloride in DNA strand breaks in human corneal epithelial cells.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie Nov, 2011 | Pubmed ID: 21842132
Nuclear proteome analysis of benzo(a)pyrene-treated HeLa cells.
Mutation research Mar, 2012 | Pubmed ID: 22138005
A panel of five circulating microRNAs as potential biomarkers for prostate cancer.
The Prostate Sep, 2012 | Pubmed ID: 22298030
Intravenous administration of multi-walled carbon nanotubes affects the formation of atherosclerosis in Sprague-Dawley rats.
Journal of occupational health , 2012 | Pubmed ID: 22972483
Quantum dot-related genotoxicity perturbation can be attenuated by PEG encapsulation.
Mutation research Feb, 2013 | Pubmed ID: 23416234
A Meta-Analysis of the Relationship between Cigarette Smoking and Incidence of Myelodysplastic Syndromes.
PloS one , 2013 | Pubmed ID: 23805315
Association between zinc intake and risk of digestive tract cancers: a systematic review and meta-analysis.
Clinical nutrition (Edinburgh, Scotland) Jun, 2014 | Pubmed ID: 24148607
Peripheral T lymphocyte subset imbalances in children with enterovirus 71-induced hand, foot and mouth disease.
Virus research Feb, 2014 | Pubmed ID: 24316007
Proteomic analysis of cellular response induced by multi-walled carbon nanotubes exposure in A549 cells.
PloS one , 2014 | Pubmed ID: 24454774
Global secretome characterization of A549 human alveolar epithelial carcinoma cells during Mycoplasma pneumoniae infection.
BMC microbiology Feb, 2014 | Pubmed ID: 24507763
Module-based functional pathway enrichment analysis of a protein-protein interaction network to study the effects of intestinal microbiota depletion in mice.
Molecular medicine reports Jun, 2014 | Pubmed ID: 24718810
Association between dietary carbohydrate intake and dietary glycemic index and risk of age-related cataract: a meta-analysis.
Investigative ophthalmology & visual science May, 2014 | Pubmed ID: 24833741
Antioxidant effects of lipophilic tea polyphenols on diethylnitrosamine/phenobarbital-induced hepatocarcinogenesis in rats.
In vivo (Athens, Greece) Jul-Aug, 2014 | Pubmed ID: 24982215
Association between vitamin A, retinol intake and blood retinol level and gastric cancer risk: A meta-analysis.
Clinical nutrition (Edinburgh, Scotland) Aug, 2015 | Pubmed ID: 25008141
Diagnostic and prognostic value of microRNA-21 in colorectal cancer: an original study and individual participant data meta-analysis.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology Dec, 2014 | Pubmed ID: 25178983
Aspirin use after diagnosis but not prediagnosis improves established colorectal cancer survival: a meta-analysis.
Gut Sep, 2015 | Pubmed ID: 25239119
Effects of cisplatin on the contractile function of thoracic aorta of Sprague-Dawley rats.
Biomedical reports Nov, 2014 | Pubmed ID: 25279165
Cerebrospinal fluid Th1/Th2 cytokine profiles in children with enterovirus 71-associated meningoencephalitis.
Microbiology and immunology Mar, 2015 | Pubmed ID: 25611005
Comparison of thrice-daily premixed insulin (insulin lispro premix) with basal-bolus (insulin glargine once-daily plus thrice-daily prandial insulin lispro) therapy in east Asian patients with type 2 diabetes insufficiently controlled with twice-daily premixed insulin: an open-label, randomised, controlled trial.
The lancet. Diabetes & endocrinology Apr, 2015 | Pubmed ID: 25754414
Novel evidence for an oncogenic role of microRNA-21 in colitis-associated colorectal cancer.
Gut 09, 2016 | Pubmed ID: 25994220
Screening of nutritional risk and nutritional support in general surgery patients: a survey from Shanghai, China.
International surgery May, 2015 | Pubmed ID: 26011204
Measuring costs of data collection at village clinics by village doctors for a syndromic surveillance system-a cross sectional survey from China.
BMC health services research Jul, 2015 | Pubmed ID: 26208506
Evaluation of the diagnostic accuracy of nonstructural protein 1 Ag-based tests for dengue virus in Asian population: a meta-analysis.
BMC infectious diseases Aug, 2015 | Pubmed ID: 26293345
Diagnostic and Prognostic Value of Serum Interleukin-6 in Colorectal Cancer.
Medicine Jan, 2016 | Pubmed ID: 26765465
Depletion of Paraspeckle Protein 1 Enhances Methyl Methanesulfonate-Induced Apoptosis through Mitotic Catastrophe.
PloS one , 2016 | Pubmed ID: 26785254
The effect of perioperative probiotics treatment for colorectal cancer: short-term outcomes of a randomized controlled trial.
Oncotarget Feb, 2016 | Pubmed ID: 26824990
Association between markers of glucose metabolism and risk of colorectal cancer.
BMJ open 06, 2016 | Pubmed ID: 27354075
Follicular helper T cell exhaustion induced by PD-L1 expression in hepatocellular carcinoma results in impaired cytokine expression and B cell help, and is associated with advanced tumor stages.
American journal of translational research , 2016 | Pubmed ID: 27508013
Association between peroxisome proliferator-activated receptor-alpha, delta, and gamma polymorphisms and risk of coronary heart disease: A case-control study and meta-analysis.
Medicine Aug, 2016 | Pubmed ID: 27512842
Dietary restriction protects against diethylnitrosamine-induced hepatocellular tumorigenesis by restoring the disturbed gene expression profile.
Scientific reports 03, 2017 | Pubmed ID: 28262799
Effects of continuous positive airway pressure on neurocognitive architecture and function in patients with obstructive sleep apnoea: study protocol for a multicentre randomised controlled trial.
BMJ open 05, 2017 | Pubmed ID: 28550021
Folate-conjugated and pH-responsive polymeric micelles for target-cell-specific anticancer drug delivery.
Acta biomaterialia 09, 2017 | Pubmed ID: 28713015
ET-26 hydrochloride (ET-26 HCl) has similar hemodynamic stability to that of etomidate in normal and uncontrolled hemorrhagic shock (UHS) rats.
PloS one , 2017 | Pubmed ID: 28813523
Lactobacillus plantarum LP‑Onlly alters the gut flora and attenuates colitis by inducing microbiome alteration in interleukin‑10 knockout mice.
Molecular medicine reports Nov, 2017 | Pubmed ID: 28849048
Effects of a Long-Acting Formulation of Octreotide on Patients with Portal Hypertension.
Gastroenterology research and practice , 2017 | Pubmed ID: 28855918
MicroRNA-542-3p functions as a tumor suppressor via directly targeting survivin in hepatocellular carcinoma.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie Mar, 2018 | Pubmed ID: 29710480
Endoglin is a conserved regulator of vasculogenesis in zebrafish - implications for hereditary haemorrhagic telangiectasia.
Bioscience reports 05, 2019 | Pubmed ID: 31064821
Evaluation of the effects of three sulfa sweeteners on the lifespan and intestinal fat deposition in C. elegans.
Food research international (Ottawa, Ont.) 08, 2019 | Pubmed ID: 31229125
Assessment of Endovascular Treatment for Acute Basilar Artery Occlusion via a Nationwide Prospective Registry.
JAMA neurology May, 2020 | Pubmed ID: 32080711
Is lobe specific lymph node dissection adequate for cN0-1 non-small cell lung cancer?
Journal of cardiothoracic surgery Feb, 2020 | Pubmed ID: 32106870
Impact on mental health and perceptions of psychological care among medical and nursing staff in Wuhan during the 2019 novel coronavirus disease outbreak: A cross-sectional study.
Brain, behavior, and immunity Mar, 2020 | Pubmed ID: 32240764
Diagnostic performance of convolutional neural network-based Tanner-Whitehouse 3 bone age assessment system.
Quantitative imaging in medicine and surgery Mar, 2020 | Pubmed ID: 32269926
Evaluation of the cytotoxic and genotoxic effects by melamine and cyanuric acid co-exposure in human embryonic kidney 293 cells.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas , 2020 | Pubmed ID: 32348426
Association between Hemoglobin Levels and Diabetic Peripheral Neuropathy in Patients with Type 2 Diabetes: A Cross-Sectional Study Using Electronic Health Records.
Journal of diabetes research , 2017 | Pubmed ID: 28713833
Decreased plasma neuregulin 4 concentration is associated with increased high-sensitivity C-reactive protein in newly diagnosed type 2 diabetes mellitus patients: a cross-sectional study.
Acta diabetologica Dec, 2017 | Pubmed ID: 28918492
Plasma Neuregulin 4 Levels Are Associated with Metabolic Syndrome in Patients Newly Diagnosed with Type 2 Diabetes Mellitus.
Disease markers , 2018 | Pubmed ID: 29721105
Changes in glucose-lipid metabolism, insulin resistance, and inflammatory factors in patients with autoimmune thyroid disease.
Journal of clinical laboratory analysis Sep, 2019 | Pubmed ID: 31350776
Reference Values of Carotid Ultrafast Pulse-Wave Velocity: A Prospective, Multicenter, Population-Based Study.
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography Jun, 2021 | Pubmed ID: 33422666
Association of circulating B-type natriuretic peptide with osteoporosis in a Chinese type 2 diabetic population.
BMC musculoskeletal disorders Mar, 2021 | Pubmed ID: 33691659
Research update on the anticancer effects of buparlisib.
Oncology letters Apr, 2021 | Pubmed ID: 33717263
Knockdown of lncRNA TUG1 alleviates diabetic retinal vascular dysfunction through regulating miR-524-5p/FGFR2.
Bioengineered May, 2022 | Pubmed ID: 35599572
Vestibular dysfunction in pediatric patients with cochlear implantation: A systematic review and meta-analysis.
Frontiers in neurology , 2022 | Pubmed ID: 36324374
Characteristics of vestibular migraine, probable vestibular migraine, and recurrent vertigo of childhood in caloric and video head impulse tests.
Frontiers in neurology , 2022 | Pubmed ID: 36530639
Association between triglyceride-glucose index and arterial stiffness reflected by carotid pulse-wave velocity in stage 1 hypertension and individuals with normal/elevated blood pressure.
Journal of clinical hypertension (Greenwich, Conn.) Feb, 2023 | Pubmed ID: 36695004
Accuracy of Gallium-68 Pentixafor Positron Emission Tomography-Computed Tomography for Subtyping Diagnosis of Primary Aldosteronism.
JAMA network open Feb, 2023 | Pubmed ID: 36795418
Predicting postoperative delirium after hip arthroplasty for elderly patients using machine learning.
Aging clinical and experimental research Jun, 2023 | Pubmed ID: 37052817
Building an Immune-Related Genes Model to Predict Treatment, Extracellular Matrix, and Prognosis of Head and Neck Squamous Cell Carcinoma.
Mediators of inflammation , 2023 | Pubmed ID: 37469759
Single-cell RNA sequencing of murine hearts for studying the development of the cardiac conduction system.
Scientific data Sep, 2023 | Pubmed ID: 37666871
The characteristics and molecular targets of antiarrhythmic natural products.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie Dec, 2023 | Pubmed ID: 37897974
1Department of Physiology and Department of Cardiology of the Second Affiliated Hospital, Zhejiang University School of Medicine,
2Department of Cell Biology, State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College,
3Wuxi Lung Transplant Center, Wuxi People's Hospital affiliated to Nanjing Medical University
Yangpeng Li*,1,2,
Jun Yang*,1,
Rui Zhang1,
Tangting Chen1,
Shiyu Zhang1,
Yuqing Zheng1,
Qiang Wen3,
Tao Li1,
Xiaoqiu Tan1,2,
Ming Lei1,4,
Xianhong Ou1
1Key Laboratory of Medical Electrophysiology of Ministry of Education, Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease, Institute of Cardiovascular Research, Southwest Medical University,
2Department of Cardiology, the Affiliated Hospital of Southwest Medical University,
3Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology,
4Department of Pharmacology, University of Oxford
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