Steven A. Carr

Mass spectrometry-based methods for phosphorylation site mapping of hyperphosphorylated proteins applied to Net1, a regulator of exit from mitosis in yeast.

Improved sensitivity for phosphopeptide mapping using capillary column HPLC and microionspray mass spectrometry: comparative phosphorylation site mapping from gel-derived proteins.

N-Terminal peptide labeling strategy for incorporation of isotopic tags: a method for the determination of site-specific absolute phosphorylation stoichiometry.

TULA: an SH3- and UBA-containing protein that binds to c-Cbl and ubiquitin.

Selective detection of glycopeptides on ion trap mass spectrometers.

Phosphorylation by cyclin B-Cdk underlies release of mitotic exit activator Cdc14 from the nucleolus.

Place of pattern in proteomic biomarker discovery.

Mapping posttranslational modifications of proteins by MS-based selective detection: application to phosphoproteomics.

Systematic identification of human mitochondrial disease genes through integrative genomics.

PEPPeR, a platform for experimental proteomic pattern recognition.

Protein biomarker discovery and validation: the long and uncertain path to clinical utility.

mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s.

The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease.

PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase.

Proteomic screen defines the Polo-box domain interactome and identifies Rock2 as a Plk1 substrate.

Quantitative, multiplexed assays for low abundance proteins in plasma by targeted mass spectrometry and stable isotope dilution.

Accurate inclusion mass screening: a bridge from unbiased discovery to targeted assay development for biomarker verification.

A mitochondrial protein compendium elucidates complex I disease biology.

Metabolic profiling of the human response to a glucose challenge reveals distinct axes of insulin sensitivity.

Metabolite profiling of blood from individuals undergoing planned myocardial infarction reveals early markers of myocardial injury.

Protein quantitation through targeted mass spectrometry: the way out of biomarker purgatory?

Bead-based profiling of tyrosine kinase phosphorylation identifies SRC as a potential target for glioblastoma therapy.

A human proteome detection and quantitation project.

Prediction of high-responding peptides for targeted protein assays by mass spectrometry.

Identifying the proteins to which small-molecule probes and drugs bind in cells.

Directed sample interrogation utilizing an accurate mass exclusion-based data-dependent acquisition strategy (AMEx).

Developing multiplexed assays for troponin I and interleukin-33 in plasma by peptide immunoaffinity enrichment and targeted mass spectrometry.

Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells.

Multi-site assessment of the precision and reproducibility of multiple reaction monitoring-based measurements of proteins in plasma.

Quantification of cardiovascular biomarkers in patient plasma by targeted mass spectrometry and stable isotope dilution.

Proteomic and genetic approaches identify Syk as an AML target.

Empirical Bayes analysis of quantitative proteomics experiments.

Performance metrics for liquid chromatography-tandem mass spectrometry systems in proteomics analyses.

Interlaboratory study characterizing a yeast performance standard for benchmarking LC-MS platform performance.

Introduction: Advances in protein analysis for the clinical laboratory.

Repeatability and reproducibility in proteomic identifications by liquid chromatography-tandem mass spectrometry.

Protein-based multiplex assays: mock presubmissions to the US Food and Drug Administration.

Analytical validation of protein-based multiplex assays: a workshop report by the NCI-FDA interagency oncology task force on molecular diagnostics.

ZBED6, a novel transcription factor derived from a domesticated DNA transposon regulates IGF2 expression and muscle growth.

Automated detection of inaccurate and imprecise transitions in peptide quantification by multiple reaction monitoring mass spectrometry.

Integration of proteomic-based tools for improved biomarkers of myocardial injury.

A mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpoint.

Optimizing performance of glycopeptide capture for plasma proteomics.

Rictor phosphorylation on the Thr-1135 site does not require mammalian target of rapamycin complex 2.

Metabolic signatures of exercise in human plasma.

Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease.

DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilization.

Effect of collision energy optimization on the measurement of peptides by selected reaction monitoring (SRM) mass spectrometry.

Overview of peptide and protein analysis by mass spectrometry.

Evaluation of large scale quantitative proteomic assay development using peptide affinity-based mass spectrometry.

Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans.

A pipeline that integrates the discovery and verification of plasma protein biomarkers reveals candidate markers for cardiovascular disease.

Exoplasmic cysteine Cys384 of the HDL receptor SR-BI is critical for its sensitivity to a small-molecule inhibitor and normal lipid transport activity.

Selective killing of cancer cells by a small molecule targeting the stress response to ROS.

AAK1 identified as an inhibitor of neuregulin-1/ErbB4-dependent neurotrophic factor signaling using integrative chemical genomics and proteomics.

Status and prospects for discovery and verification of new biomarkers of cardiovascular disease by proteomics.

Mutations in MTFMT underlie a human disorder of formylation causing impaired mitochondrial translation.

Cdk5 is required for memory function and hippocampal plasticity via the cAMP signaling pathway.

Identifying cellular targets of small-molecule probes and drugs with biochemical enrichment and SILAC.

Systematic discovery of TLR signaling components delineates viral-sensing circuits.

The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices.

Inter-laboratory evaluation of automated, multiplexed peptide immunoaffinity enrichment coupled to multiple reaction monitoring mass spectrometry for quantifying proteins in plasma.

iTRAQ labeling is superior to mTRAQ for quantitative global proteomics and phosphoproteomics.

STK33 kinase inhibitor BRD-8899 has no effect on KRAS-dependent cancer cell viability.