Department of Microbial Infection & Immunity
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Caspase-11 promotes the fusion of phagosomes harboring pathogenic bacteria with lysosomes by modulating actin polymerization.
Immunity Jul, 2012 | Pubmed ID: 22658523
Exaggerated inflammatory responses mediated by Burkholderia cenocepacia in human macrophages derived from Cystic fibrosis patients.
Biochemical and biophysical research communications Jul, 2012 | Pubmed ID: 22728038
Depletion of the ubiquitin binding adaptor molecule SQSTM1/p62 from macrophages harboring cftr {Delta}F508 mutation improves the delivery of Burkholderia cenocepacia to the autophagic machinery.
The Journal of biological chemistry Nov, 2012 | Pubmed ID: 23148214
A bacterial protein promotes the recognition of the Legionella pneumophila vacuole by autophagy.
European journal of immunology May, 2013 | Pubmed ID: 23420491
Biofilm-derived Legionella pneumophila evades the innate immune response in macrophages.
Frontiers in cellular and infection microbiology , 2013 | Pubmed ID: 23750338
Caspase-11 and caspase-1 differentially modulate actin polymerization via RhoA and Slingshot proteins to promote bacterial clearance.
Scientific reports Dec, 2015 | Pubmed ID: 26686473
Aging is associated with hypermethylation of autophagy genes in macrophages.
Epigenetics 05, 2016 | Pubmed ID: 26909551
Elevated Mirc1/Mir17-92 cluster expression negatively regulates autophagy and CFTR (cystic fibrosis transmembrane conductance regulator) function in CF macrophages.
Autophagy 11, 2016 | Pubmed ID: 27541364
The expression of Mirc1/Mir17-92 cluster in sputum samples correlates with pulmonary exacerbations in cystic fibrosis patients.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society Jul, 2018 | Pubmed ID: 29241629
CASP4/caspase-11 promotes autophagosome formation in response to bacterial infection.
Autophagy , 2018 | Pubmed ID: 30165781
Methylomic correlates of autophagy activity in cystic fibrosis.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society Feb, 2019 | Pubmed ID: 30737168
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