Kyle Caution

Caspase-11 promotes the fusion of phagosomes harboring pathogenic bacteria with lysosomes by modulating actin polymerization.

Exaggerated inflammatory responses mediated by Burkholderia cenocepacia in human macrophages derived from Cystic fibrosis patients.

Depletion of the ubiquitin binding adaptor molecule SQSTM1/p62 from macrophages harboring cftr {Delta}F508 mutation improves the delivery of Burkholderia cenocepacia to the autophagic machinery.

A bacterial protein promotes the recognition of the Legionella pneumophila vacuole by autophagy.

Biofilm-derived Legionella pneumophila evades the innate immune response in macrophages.

Caspase-11 and caspase-1 differentially modulate actin polymerization via RhoA and Slingshot proteins to promote bacterial clearance.

Aging is associated with hypermethylation of autophagy genes in macrophages.

Elevated Mirc1/Mir17-92 cluster expression negatively regulates autophagy and CFTR (cystic fibrosis transmembrane conductance regulator) function in CF macrophages.

The expression of Mirc1/Mir17-92 cluster in sputum samples correlates with pulmonary exacerbations in cystic fibrosis patients.

CASP4/caspase-11 promotes autophagosome formation in response to bacterial infection.

Methylomic correlates of autophagy activity in cystic fibrosis.