Molecular and Cellular Oncogenesis Program
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Direct reprogramming of melanocytes to neural crest stem-like cells by one defined factor.
Stem cells (Dayton, Ohio) Nov, 2011 | Pubmed ID: 21948558
Adenoviral gene transfer of beta3 integrin subunit induces conversion from radial to vertical growth phase in primary human melanoma.
The American journal of pathology Nov, 1998 | Pubmed ID: 9811334
Induction of p21(WAF1/CIP1) and inhibition of Cdk2 mediated by the tumor suppressor p16(INK4a).
Molecular and cellular biology May, 1999 | Pubmed ID: 10207115
Mechanism for elimination of a tumor suppressor: aberrant splicing of a brain-specific exon causes loss of function of Bin1 in melanoma.
Proceedings of the National Academy of Sciences of the United States of America Aug, 1999 | Pubmed ID: 10449755
Photocarcinogenesis in human adult skin grafts.
Carcinogenesis Jan, 2002 | Pubmed ID: 11756239
Osteonectin/SPARC induction by ectopic beta(3) integrin in human radial growth phase primary melanoma cells.
Cancer research Jan, 2002 | Pubmed ID: 11782382
Insulin-like growth factor-I-induced migration of melanoma cells is mediated by interleukin-8 induction.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research Feb, 2002 | Pubmed ID: 11864912
Melanoma-stroma interactions: structural and functional aspects.
The lancet oncology Jan, 2002 | Pubmed ID: 11905603
Adenovirus-mediated ex vivo gene transfer of human vascular endothelial growth factor in a rabbit laryngotracheal reconstruction model.
The Annals of otology, rhinology, and laryngology Apr, 2002 | Pubmed ID: 11991579
Cyclin D1 is a candidate oncogene in cutaneous melanoma.
Cancer research Jun, 2002 | Pubmed ID: 12036934
Fibroblast-dependent differentiation of human microvascular endothelial cells into capillary-like 3-dimensional networks.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Aug, 2002 | Pubmed ID: 12060671
Prospective molecular profiling of melanoma metastases suggests classifiers of immune responsiveness.
Cancer research Jul, 2002 | Pubmed ID: 12097256
p53 alone or in combination with antisense cyclin D1 induces apoptosis and reduces tumor size in human melanoma.
Cancer gene therapy Oct, 2002 | Pubmed ID: 12224020
The Role of E-cadherin in the Motility and Invasion of Implantation Site Intermediate Trophoblast.
Placenta Nov, 2002 | Pubmed ID: 12398810
Cell-surface proteolysis, growth factor activation and intercellular communication in the progression of melanoma.
Critical reviews in oncology/hematology Oct, 2002 | Pubmed ID: 12398996
New approaches to the biology of melanoma: a workshop of the National Institutes of Health Pathology B Study Section.
The American journal of pathology Nov, 2002 | Pubmed ID: 12414540
Epidermal growth factor receptor mediates increased cell proliferation, migration, and aggregation in esophageal keratinocytes in vitro and in vivo.
The Journal of biological chemistry Jan, 2003 | Pubmed ID: 12435727
BRAF and RAS mutations in human lung cancer and melanoma.
Cancer research Dec, 2002 | Pubmed ID: 12460918
Differential response of primary and metastatic melanomas to neutrophils attracted by IL-8.
International journal of cancer. Journal international du cancer Jan, 2003 | Pubmed ID: 12471616
Regulation of Notch1 and Dll4 by vascular endothelial growth factor in arterial endothelial cells: implications for modulating arteriogenesis and angiogenesis.
Molecular and cellular biology Jan, 2003 | Pubmed ID: 12482957
Melanoma development and progression: a conspiracy between tumor and host.
Differentiation; research in biological diversity Dec, 2002 | Pubmed ID: 12492494
Constitutive mitogen-activated protein kinase activation in melanoma is mediated by both BRAF mutations and autocrine growth factor stimulation.
Cancer research Feb, 2003 | Pubmed ID: 12591721
Stroma formation and angiogenesis by overexpression of growth factors, cytokines, and proteolytic enzymes in human skin grafted to SCID mice.
The Journal of investigative dermatology Apr, 2003 | Pubmed ID: 12648235
Stimulation of human colonic epithelial cells by leukemia inhibitory factor is dependent on collagen-embedded fibroblasts in organotypic culture.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Jun, 2003 | Pubmed ID: 12692084
p16INK4A and familial melanoma.
Methods in molecular biology (Clifton, N.J.) , 2003 | Pubmed ID: 12710687
The vascular phenotype of melanoma metastasis.
Clinical & experimental metastasis , 2003 | Pubmed ID: 12741681
Function and regulation of melanoma-stromal fibroblast interactions: when seeds meet soil.
Oncogene May, 2003 | Pubmed ID: 12789292
Tumors as elusive targets of T-cell-based active immunotherapy.
Trends in immunology Jun, 2003 | Pubmed ID: 12810110
Fibroblast growth factor-2 but not Mel-CAM and/or beta3 integrin promotes progression of melanocytes to melanoma.
Experimental dermatology Jun, 2003 | Pubmed ID: 12823444
High levels of CUG-initiated FGF-2 expression cause chromatin compaction, decreased cardiomyocyte mitosis, and cell death.
Molecular and cellular biochemistry Apr, 2003 | Pubmed ID: 12841351
Slit-Robo: neuronal guides signal in tumor angiogenesis.
Cancer cell Jul, 2003 | Pubmed ID: 12892705
BRAF as a potential therapeutic target in melanoma and other malignancies.
Cancer cell Aug, 2003 | Pubmed ID: 12957284
Suppression of BRAF(V599E) in human melanoma abrogates transformation.
Cancer research Sep, 2003 | Pubmed ID: 14500344
Cisplatin down-regulation of cellular Fas-associated death domain-like interleukin-1beta-converting enzyme-like inhibitory proteins to restore tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human melanoma cells.
Clinical cancer research : an official journal of the American Association for Cancer Research Sep, 2003 | Pubmed ID: 14519653
VEGF-A and alphaVbeta3 integrin synergistically rescue angiogenesis via N-Ras and PI3-K signaling in human microvascular endothelial cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Oct, 2003 | Pubmed ID: 14519669
Axis of evil: molecular mechanisms of cancer metastasis.
Oncogene Sep, 2003 | Pubmed ID: 14528277
Reciprocal regulation of MelCAM and AKT in human melanoma.
Oncogene Oct, 2003 | Pubmed ID: 14534536
The great escape: another way for melanoma to leave physiological control?
The Journal of investigative dermatology Oct, 2003 | Pubmed ID: 14632176
First international melanoma research congress.
Cancer biology & therapy Nov-Dec, 2003 | Pubmed ID: 14688485
Human melanoblasts in culture: expression of BRN2 and synergistic regulation by fibroblast growth factor-2, stem cell factor, and endothelin-3.
The Journal of investigative dermatology Nov, 2003 | Pubmed ID: 14708619
Induction of melanoma phenotypes in human skin by growth factors and ultraviolet B.
Cancer research Feb, 2004 | Pubmed ID: 14871803
Recent advances in melanoma biology.
The oncologist , 2004 | Pubmed ID: 15047922
Truncation of activated leukocyte cell adhesion molecule: a gateway to melanoma metastasis.
The Journal of investigative dermatology May, 2004 | Pubmed ID: 15140234
Reversal of melanocytic malignancy by keratinocytes is an E-cadherin-mediated process overriding beta-catenin signaling.
Experimental cell research Jul, 2004 | Pubmed ID: 15194432
Death induction by recombinant native TRAIL and its prevention by a caspase 9 inhibitor in primary human esophageal epithelial cells.
The Journal of biological chemistry Sep, 2004 | Pubmed ID: 15226295
Cyclin D1 is essential for neoplastic transformation induced by both E6/E7 and E6/E7/ErbB-2 cooperation in normal cells.
Oncogene Jul, 2004 | Pubmed ID: 15229656
Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling with antitumor activity in cancer cells overexpressing Akt.
Cancer research Jul, 2004 | Pubmed ID: 15231645
Rapid apoptosis in the pulmonary vasculature distinguishes non-metastatic from metastatic melanoma cells.
Cancer letters Sep, 2004 | Pubmed ID: 15327836
The role of altered cell-cell communication in melanoma progression.
Journal of molecular histology Mar, 2004 | Pubmed ID: 15339050
Loitering with intent: new evidence for the role of BRAF mutations in the proliferation of melanocytic lesions.
The Journal of investigative dermatology Oct, 2004 | Pubmed ID: 15373800
Adenoviral mediated gene transfer of PDGF-B enhances wound healing in type I and type II diabetic wounds.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society Sep-Oct, 2004 | Pubmed ID: 15453831
Cultivation of normal human epidermal melanocytes in the absence of phorbol esters.
Methods in molecular medicine , 2005 | Pubmed ID: 15492362
Clinical protocol. Phase I trial to evaluate the safety of H5.020CMV.PDGF-b and limb compression bandage for the treatment of venous leg ulcer: trial A.
Human gene therapy Oct, 2004 | Pubmed ID: 15585116
Gene expression profiling of melanoma cells - searching the haystack.
Journal of translational medicine Jan, 2005 | Pubmed ID: 15649323
Functional erythropoietin autocrine loop in melanoma.
The American journal of pathology Mar, 2005 | Pubmed ID: 15743794
Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions.
Nature Apr, 2005 | Pubmed ID: 15829965
CXC chemokine ligand 12 (stromal cell-derived factor 1 alpha) and CXCR4-dependent migration of CTLs toward melanoma cells in organotypic culture.
Journal of immunology (Baltimore, Md. : 1950) May, 2005 | Pubmed ID: 15843590
The prevalence of interferon-alpha transcription defects in malignant melanoma.
Melanoma research Apr, 2005 | Pubmed ID: 15846141
Up-regulated expression of zonula occludens protein-1 in human melanoma associates with N-cadherin and contributes to invasion and adhesion.
The American journal of pathology May, 2005 | Pubmed ID: 15855653
Adhesion, migration and communication in melanocytes and melanoma.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society Jun, 2005 | Pubmed ID: 15892711
The RAS/RAF/MEK/ERK and PI3K/AKT signaling pathways present molecular targets for the effective treatment of advanced melanoma.
Frontiers in bioscience : a journal and virtual library , 2005 | Pubmed ID: 15970553
Metastatic melanoma cells. Introduction.
Cancer metastasis reviews Jun, 2005 | Pubmed ID: 15986131
Bone morphogenetic proteins in melanoma: angel or devil?
Cancer metastasis reviews Jun, 2005 | Pubmed ID: 15986135
Information sharing and collateral damage.
Trends in molecular medicine Aug, 2005 | Pubmed ID: 16002338
Selective evolutionary pressure from the tissue microenvironment drives tumor progression.
Seminars in cancer biology Dec, 2005 | Pubmed ID: 16043361
A tumorigenic subpopulation with stem cell properties in melanomas.
Cancer research Oct, 2005 | Pubmed ID: 16230395
Activation of Notch1 signaling is required for beta-catenin-mediated human primary melanoma progression.
The Journal of clinical investigation Nov, 2005 | Pubmed ID: 16239965
Molecular targets in melanoma: strategies and challenges for diagnosis and therapy.
International journal of cancer. Journal international du cancer Feb, 2006 | Pubmed ID: 16258898
[Melanoma-stroma interactions and melanoma progression].
Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG Oct, 2003 | Pubmed ID: 16281812
Targeting the stromal fibroblasts: a novel approach to melanoma therapy.
Expert review of anticancer therapy Dec, 2005 | Pubmed ID: 16336098
Normal human melanocyte homeostasis as a paradigm for understanding melanoma.
The journal of investigative dermatology. Symposium proceedings / the Society for Investigative Dermatology, Inc. [and] European Society for Dermatological Research Nov, 2005 | Pubmed ID: 16358819
Targeting intracellular signaling pathways as a novel strategy in melanoma therapeutics.
Annals of the New York Academy of Sciences Nov, 2005 | Pubmed ID: 16382039
Expression of PKC isoforms in human melanocytic cells in situ.
Journal of dermatological science Feb, 2006 | Pubmed ID: 16406501
Inhibition of endothelial cell proliferation by Notch1 signaling is mediated by repressing MAPK and PI3K/Akt pathways and requires MAML1.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology May, 2006 | Pubmed ID: 16571776
Defining the conditions for the generation of melanocytes from human embryonic stem cells.
Stem cells (Dayton, Ohio) Jul, 2006 | Pubmed ID: 16574754
Notch1 signaling promotes primary melanoma progression by activating mitogen-activated protein kinase/phosphatidylinositol 3-kinase-Akt pathways and up-regulating N-cadherin expression.
Cancer research Apr, 2006 | Pubmed ID: 16618740
Cancer interaction with the bone microenvironment: a workshop of the National Institutes of Health Tumor Microenvironment Study Section.
The American journal of pathology May, 2006 | Pubmed ID: 16651608
Isolation of a novel population of multipotent adult stem cells from human hair follicles.
The American journal of pathology Jun, 2006 | Pubmed ID: 16723703
Multiple signaling pathways must be targeted to overcome drug resistance in cell lines derived from melanoma metastases.
Molecular cancer therapeutics May, 2006 | Pubmed ID: 16731745
A new organotypic model to study cell interactions in the intestinal mucosa.
European journal of gastroenterology & hepatology Aug, 2006 | Pubmed ID: 16825910
Metastatic potential of melanomas defined by specific gene expression profiles with no BRAF signature.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society Aug, 2006 | Pubmed ID: 16827748
Embryogenesis meets tumorigenesis.
Nature medicine Aug, 2006 | Pubmed ID: 16892028
Differentiation of normal skin and melanoma using high resolution hyperspectral imaging.
Cancer biology & therapy Aug, 2006 | Pubmed ID: 16931902
Coordinated functions of E-cadherin and transforming growth factor beta receptor II in vitro and in vivo.
Cancer research Oct, 2006 | Pubmed ID: 17047049
CCN3 controls 3D spatial localization of melanocytes in the human skin through DDR1.
The Journal of cell biology Nov, 2006 | Pubmed ID: 17101694
Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885.
Cancer research Dec, 2006 | Pubmed ID: 17145850
Life isn't flat: taking cancer biology to the next dimension.
In vitro cellular & developmental biology. Animal Sep-Oct, 2006 | Pubmed ID: 17163781
Microenvironmental influences in melanoma progression.
Journal of cellular biochemistry Jul, 2007 | Pubmed ID: 17171636
An organometallic protein kinase inhibitor pharmacologically activates p53 and induces apoptosis in human melanoma cells.
Cancer research Jan, 2007 | Pubmed ID: 17210701
Dysregulation of claudin-7 leads to loss of E-cadherin expression and the increased invasion of esophageal squamous cell carcinoma cells.
The American journal of pathology Feb, 2007 | Pubmed ID: 17255337
High-throughput oncogene mutation profiling in human cancer.
Nature genetics Mar, 2007 | Pubmed ID: 17293865
Profiles of chemokine receptors in melanocytic lesions: de novo expression of CXCR6 in melanoma.
Human pathology May, 2007 | Pubmed ID: 17306330
Farming cells to rebuild skin and melanoma.
Cancer biology & therapy Mar, 2007 | Pubmed ID: 17374983
Mutant V600E BRAF increases hypoxia inducible factor-1alpha expression in melanoma.
Cancer research Apr, 2007 | Pubmed ID: 17409425
Rewired ERK-JNK signaling pathways in melanoma.
Cancer cell May, 2007 | Pubmed ID: 17482134
Application of a BRAF pyrosequencing assay for mutation detection and copy number analysis in malignant melanoma.
The Journal of molecular diagnostics : JMD Sep, 2007 | Pubmed ID: 17690212
Expression of integrin alpha10 is induced in malignant melanoma.
Cellular oncology : the official journal of the International Society for Cellular Oncology , 2007 | Pubmed ID: 17726260
Association of polymorphisms of FAS-1377, FAS-670, and FASL-844 genes with risk factors for cutaneous malignant melanoma.
Cancer journal (Sudbury, Mass.) Jul-Aug, 2007 | Pubmed ID: 17762755
Old disease, new culprit: tumor stem cells in cancer.
Journal of cellular physiology Dec, 2007 | Pubmed ID: 17786956
Raf inhibitor stabilizes receptor for the type I interferon but inhibits its anti-proliferative effects in human malignant melanoma cells.
Cancer biology & therapy Sep, 2007 | Pubmed ID: 17873516
Unraveling mysteries of the multifunctional protein SPARC.
The Journal of investigative dermatology Nov, 2007 | Pubmed ID: 17934501
The many faces of Notch signaling in skin-derived cells.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society Dec, 2007 | Pubmed ID: 17935489
The functional interplay between EGFR overexpression, hTERT activation, and p53 mutation in esophageal epithelial cells with activation of stromal fibroblasts induces tumor development, invasion, and differentiation.
Genes & development Nov, 2007 | Pubmed ID: 17974918
Roadmap for new opportunities in melanoma research.
Seminars in oncology Dec, 2007 | Pubmed ID: 18083380
Permissive environment in postnatal wounds induced by adenoviral-mediated overexpression of the anti-inflammatory cytokine interleukin-10 prevents scar formation.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society Jan-Feb, 2008 | Pubmed ID: 18086289
The mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitor AZD6244 (ARRY-142886) induces growth arrest in melanoma cells and tumor regression when combined with docetaxel.
Clinical cancer research : an official journal of the American Association for Cancer Research Jan, 2008 | Pubmed ID: 18172275
Microscale solution IEF combined with 2-D DIGE substantially enhances analysis depth of complex proteomes such as mammalian cell and tissue extracts.
Electrophoresis Feb, 2008 | Pubmed ID: 18186533
Cancer testis antigens in human melanoma stem cells: expression, distribution, and methylation status.
Journal of cellular physiology May, 2008 | Pubmed ID: 18205182
Modeling genomic diversity and tumor dependency in malignant melanoma.
Cancer research Feb, 2008 | Pubmed ID: 18245465
The differential role of L1 in ovarian carcinoma and normal ovarian surface epithelium.
Cancer research Feb, 2008 | Pubmed ID: 18281486
Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2008 | Pubmed ID: 18287029
Learning the ABCs of melanoma-initiating cells.
Cancer cell Mar, 2008 | Pubmed ID: 18328422
Salmonella typhimurium as a novel RNA interference vector for cancer gene therapy.
Cancer biology & therapy Jan, 2008 | Pubmed ID: 18347415
Similar biological activities of two isostructural ruthenium and osmium complexes.
Chemistry (Weinheim an der Bergstrasse, Germany) , 2008 | Pubmed ID: 18425743
The essential role of fibroblasts in esophageal squamous cell carcinoma-induced angiogenesis.
Gastroenterology Jun, 2008 | Pubmed ID: 18439605
Unraveling the mysteries of IGF-1 signaling in melanoma.
The Journal of investigative dermatology Jun, 2008 | Pubmed ID: 18478012
Cytotoxicity of the matrix metalloproteinase-activated anthrax lethal toxin is dependent on gelatinase expression and B-RAF status in human melanoma cells.
Molecular cancer therapeutics May, 2008 | Pubmed ID: 18483309
Structure-based design of an organoruthenium phosphatidyl-inositol-3-kinase inhibitor reveals a switch governing lipid kinase potency and selectivity.
ACS chemical biology May, 2008 | Pubmed ID: 18484710
Melanoma stem cells: the dark seed of melanoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology Jun, 2008 | Pubmed ID: 18539969
Identification of a novel subgroup of melanomas with KIT/cyclin-dependent kinase-4 overexpression.
Cancer research Jul, 2008 | Pubmed ID: 18632627
Melanoma and the tumor microenvironment.
Current oncology reports Sep, 2008 | Pubmed ID: 18706274
Bortezomib induces apoptosis in esophageal squamous cell carcinoma cells through activation of the p38 mitogen-activated protein kinase pathway.
Molecular cancer therapeutics Sep, 2008 | Pubmed ID: 18790767
Increased cyclin D1 expression can mediate BRAF inhibitor resistance in BRAF V600E-mutated melanomas.
Molecular cancer therapeutics Sep, 2008 | Pubmed ID: 18790768
Endothelin-3 stimulates survival of goblet cells in organotypic cultures of fetal human colonic epithelium.
American journal of physiology. Gastrointestinal and liver physiology Dec, 2008 | Pubmed ID: 18832450
Cleavage of MCM2 licensing protein fosters senescence in human keratinocytes.
Cell cycle (Georgetown, Tex.) Nov, 2008 | Pubmed ID: 19001876
A subpopulation of mouse esophageal basal cells has properties of stem cells with the capacity for self-renewal and lineage specification.
The Journal of clinical investigation Dec, 2008 | Pubmed ID: 19033657
Cracking the system: melanoma complexity demands new therapeutic approaches.
Pigment cell & melanoma research Feb, 2009 | Pubmed ID: 19054340
Integrating tumor-initiating cells into the paradigm for melanoma targeted therapy.
International journal of cancer. Journal international du cancer Mar, 2009 | Pubmed ID: 19089923
Cancer stem cells are everywhere.
Nature medicine Jan, 2009 | Pubmed ID: 19129778
Defining microenvironments within mouse models that enhance tumor aggressiveness.
Cancer biology & therapy Feb, 2009 | Pubmed ID: 19182538
Matricellular proteins produced by melanocytes and melanomas: in search for functions.
Cancer microenvironment : official journal of the International Cancer Microenvironment Society Dec, 2008 | Pubmed ID: 19308688
Driving in the melanoma landscape.
Experimental dermatology Jun, 2009 | Pubmed ID: 19366372
The role of BRAF mutation and p53 inactivation during transformation of a subpopulation of primary human melanocytes.
The American journal of pathology Jun, 2009 | Pubmed ID: 19389934
Active Notch1 confers a transformed phenotype to primary human melanocytes.
Cancer research Jul, 2009 | Pubmed ID: 19549918
Placental gene transfer: transgene screening in mice for trophic effects on the placenta.
American journal of obstetrics and gynecology Nov, 2009 | Pubmed ID: 19716119
Distinct MHC gene expression patterns during progression of melanoma.
Genes, chromosomes & cancer Feb, 2010 | Pubmed ID: 19862823
Embryonic stem cells as a model for studying melanocyte development.
Methods in molecular biology (Clifton, N.J.) , 2010 | Pubmed ID: 19907984
Human dermal stem cells differentiate into functional epidermal melanocytes.
Journal of cell science Mar, 2010 | Pubmed ID: 20159965
What is a good model for melanoma?
The Journal of investigative dermatology Apr, 2010 | Pubmed ID: 20231823
Epidermal growth factor receptor and mutant p53 expand an esophageal cellular subpopulation capable of epithelial-to-mesenchymal transition through ZEB transcription factors.
Cancer research May, 2010 | Pubmed ID: 20424117
A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth.
Cell May, 2010 | Pubmed ID: 20478252
Insulin-like growth factor-binding protein-3 promotes transforming growth factor-{beta}1-mediated epithelial-to-mesenchymal transition and motility in transformed human esophageal cells.
Carcinogenesis Aug, 2010 | Pubmed ID: 20513670
Periostin, a cell adhesion molecule, facilitates invasion in the tumor microenvironment and annotates a novel tumor-invasive signature in esophageal cancer.
Cancer research Jul, 2010 | Pubmed ID: 20516120
Fibroblast-secreted hepatocyte growth factor plays a functional role in esophageal squamous cell carcinoma invasion.
Proceedings of the National Academy of Sciences of the United States of America Jun, 2010 | Pubmed ID: 20534479
The ups and downs of transcription factors in melanoma.
Journal of the National Cancer Institute Aug, 2010 | Pubmed ID: 20660367
NOTCH1 and NOTCH3 coordinate esophageal squamous differentiation through a CSL-dependent transcriptional network.
Gastroenterology Dec, 2010 | Pubmed ID: 20801121
BRAF inhibitor unveils its potential against advanced melanoma.
Cancer cell Oct, 2010 | Pubmed ID: 20951940
Nuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferase.
Cancer cell Oct, 2010 | Pubmed ID: 20951943
PLX4032, a potent inhibitor of the B-Raf V600E oncogene, selectively inhibits V600E-positive melanomas.
Pigment cell & melanoma research Dec, 2010 | Pubmed ID: 20973932
Boris Bastian.
Pigment cell & melanoma research Dec, 2010 | Pubmed ID: 20973934
A systems biology analysis of metastatic melanoma using in-depth three-dimensional protein profiling.
Proteomics Oct, 2010 | Pubmed ID: 21082759
Taking the guesswork out of uveal melanoma.
The New England journal of medicine Dec, 2010 | Pubmed ID: 21083377
A systems biology analysis of metastatic melanoma using in-depth three-dimensional protein profiling.
Proteomics Dec, 2010 | Pubmed ID: 21136598
Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K.
Cancer cell Dec, 2010 | Pubmed ID: 21156289
Dermis-derived stem cells: a source of epidermal melanocytes and melanoma?
Pigment cell & melanoma research Jun, 2011 | Pubmed ID: 21410654
Targeting BRAF in advanced melanoma: a first step toward manageable disease.
Clinical cancer research : an official journal of the American Association for Cancer Research Apr, 2011 | Pubmed ID: 21447722
Will engineered T cells expressing CD20 scFv eradicate Melanoma?
Molecular therapy : the journal of the American Society of Gene Therapy Apr, 2011 | Pubmed ID: 21455210
Detecting and targeting mesenchymal-like subpopulations within squamous cell carcinomas.
Cell cycle (Georgetown, Tex.) Jun, 2011 | Pubmed ID: 21558812
From cancer stem cells to tumor maintenance in melanoma.
The Journal of investigative dermatology Aug, 2011 | Pubmed ID: 21654838
A NOTCH3-mediated squamous cell differentiation program limits expansion of EMT-competent cells that express the ZEB transcription factors.
Cancer research Nov, 2011 | Pubmed ID: 21890822
Sorting through the many opportunities for melanoma therapy.
Pigment cell & melanoma research Oct, 2011 | Pubmed ID: 21899726
Organometallic Pyridylnaphthalimide Complexes as Protein Kinase Inhibitors.
Organometallics Jul, 2011 | Pubmed ID: 21918590
Isolation and cultivation of dermal stem cells that differentiate into functional epidermal melanocytes.
Methods in molecular biology (Clifton, N.J.) , 2012 | Pubmed ID: 22057442
Fibroblasts contribute to melanoma tumor growth and drug resistance.
Molecular pharmaceutics Dec, 2011 | Pubmed ID: 22067046
The molecular pathology of cutaneous melanoma.
Cancer biomarkers : section A of Disease markers , 2011 | Pubmed ID: 22112480
Resistance to BRAF inhibitors: unraveling mechanisms and future treatment options.
Cancer research Dec, 2011 | Pubmed ID: 22131348
Isolation and characterization of mouse and human esophageal epithelial cells in 3D organotypic culture.
Nature protocols , 2012 | Pubmed ID: 22240585
MEK'ing the most of p53 reactivation therapy in melanoma.
The Journal of investigative dermatology Feb, 2012 | Pubmed ID: 22241441
A Unified Approach to Targeting the Lysosome's Degradative and Growth Signaling Roles.
Cancer discovery 11, 2017 | Pubmed ID: 28899863
MSX1-Induced Neural Crest-Like Reprogramming Promotes Melanoma Progression.
The Journal of investigative dermatology 01, 2018 | Pubmed ID: 28927893
Tumor-associated B-cells induce tumor heterogeneity and therapy resistance.
Nature communications 09, 2017 | Pubmed ID: 28928360
PAK signalling drives acquired drug resistance to MAPK inhibitors in BRAF-mutant melanomas.
Nature 10, 2017 | Pubmed ID: 28953887
Acetylsalicylic Acid Governs the Effect of Sorafenib in -Mutant Cancers.
Clinical cancer research : an official journal of the American Association for Cancer Research 03, 2018 | Pubmed ID: 29196297
Melanoma Therapeutic Strategies that Select against Resistance by Exploiting MYC-Driven Evolutionary Convergence.
Cell reports Dec, 2017 | Pubmed ID: 29212027
Hypoxia-activated prodrug enhances therapeutic effect of sunitinib in melanoma.
Oncotarget Dec, 2017 | Pubmed ID: 29383148
Distinct histone modifications denote early stress-induced drug tolerance in cancer.
Oncotarget Feb, 2018 | Pubmed ID: 29492189
Induction of Telomere Dysfunction Prolongs Disease Control of Therapy-Resistant Melanoma.
Clinical cancer research : an official journal of the American Association for Cancer Research Oct, 2018 | Pubmed ID: 29563139
Co-targeting BET and MEK as salvage therapy for MAPK and checkpoint inhibitor-resistant melanoma.
EMBO molecular medicine 05, 2018 | Pubmed ID: 29650805
Endogenous authentic OCT4A proteins directly regulate FOS/AP-1 transcription in somatic cancer cells.
Cell death & disease May, 2018 | Pubmed ID: 29789579
Age Correlates with Response to Anti-PD1, Reflecting Age-Related Differences in Intratumoral Effector and Regulatory T-Cell Populations.
Clinical cancer research : an official journal of the American Association for Cancer Research Nov, 2018 | Pubmed ID: 29898988
Tumor innate immunity primed by specific interferon-stimulated endogenous retroviruses.
Nature medicine 08, 2018 | Pubmed ID: 30038220
Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response.
Nature 08, 2018 | Pubmed ID: 30089911
Robust prediction of response to immune checkpoint blockade therapy in metastatic melanoma.
Nature medicine 10, 2018 | Pubmed ID: 30127394
Targeting the Warburg effect via LDHA inhibition engages ATF4 signaling for cancer cell survival.
The EMBO journal Oct, 2018 | Pubmed ID: 30209241
Remodeling of the Collagen Matrix in Aging Skin Promotes Melanoma Metastasis and Affects Immune Cell Motility.
Cancer discovery 01, 2019 | Pubmed ID: 30279173
Frontiers in pigment cell and melanoma research.
Pigment cell & melanoma research 11, 2018 | Pubmed ID: 30281213
Publisher Correction: Robust prediction of response to immune checkpoint blockade therapy in metastatic melanoma.
Nature medicine Dec, 2018 | Pubmed ID: 30333558
A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade.
Cell Nov, 2018 | Pubmed ID: 30388455
PPT1 Promotes Tumor Growth and Is the Molecular Target of Chloroquine Derivatives in Cancer.
Cancer discovery 02, 2019 | Pubmed ID: 30442709
Author Correction: PAK signalling drives acquired drug resistance to MAPK inhibitors in BRAF-mutant melanomas.
Nature 01, 2019 | Pubmed ID: 30532003
ER Translocation of the MAPK Pathway Drives Therapy Resistance in BRAF-Mutant Melanoma.
Cancer discovery 03, 2019 | Pubmed ID: 30563872
Loss of Phd2 cooperates with BRAF to drive melanomagenesis.
Nature communications 12, 2018 | Pubmed ID: 30575721
BRAF Targeting Sensitizes Resistant Melanoma to Cytotoxic T Cells.
Clinical cancer research : an official journal of the American Association for Cancer Research May, 2019 | Pubmed ID: 30765391
Genome-wide prediction of synthetic rescue mediators of resistance to targeted and immunotherapy.
Molecular systems biology Mar, 2019 | Pubmed ID: 30858180
Author Correction: Loss of Phd2 cooperates with BRAF to drive melanomagenesis.
Nature communications 03, 2019 | Pubmed ID: 30858377
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