Meenhard Herlyn

Molecular and Cellular Oncogenesis Program, The Wistar Institute

Affiliated withThe Wistar Institute Wistar Institute

Research Area

BioengineeringCancer ResearchImmunology and Infection

Biography

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JoVE Journal Publications

ArticleTotal : 3	Year
Publication title	2011
Publication title	2019
Publication title	2021

Other Publications

Article	Year
Direct reprogramming of melanocytes to neural crest stem-like cells by one defined factor. Stem cells (Dayton, Ohio)\| PubMed ID: 21948558	2011
Adenoviral gene transfer of beta3 integrin subunit induces conversion from radial to vertical growth phase in primary human melanoma. The American journal of pathology\| PubMed ID: 9811334	1998
Induction of p21(WAF1/CIP1) and inhibition of Cdk2 mediated by the tumor suppressor p16(INK4a). Molecular and cellular biology\| PubMed ID: 10207115	1999
Mechanism for elimination of a tumor suppressor: aberrant splicing of a brain-specific exon causes loss of function of Bin1 in melanoma. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 10449755	1999
Photocarcinogenesis in human adult skin grafts. Carcinogenesis\| PubMed ID: 11756239	2002
Osteonectin/SPARC induction by ectopic beta(3) integrin in human radial growth phase primary melanoma cells. Cancer research\| PubMed ID: 11782382	2002
Insulin-like growth factor-I-induced migration of melanoma cells is mediated by interleukin-8 induction. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research\| PubMed ID: 11864912	2002
Melanoma-stroma interactions: structural and functional aspects. The lancet oncology\| PubMed ID: 11905603	2002
Adenovirus-mediated ex vivo gene transfer of human vascular endothelial growth factor in a rabbit laryngotracheal reconstruction model. The Annals of otology, rhinology, and laryngology\| PubMed ID: 11991579	2002
Cyclin D1 is a candidate oncogene in cutaneous melanoma. Cancer research\| PubMed ID: 12036934	2002
Fibroblast-dependent differentiation of human microvascular endothelial cells into capillary-like 3-dimensional networks. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 12060671	2002
Prospective molecular profiling of melanoma metastases suggests classifiers of immune responsiveness. Cancer research\| PubMed ID: 12097256	2002
p53 alone or in combination with antisense cyclin D1 induces apoptosis and reduces tumor size in human melanoma. Cancer gene therapy\| PubMed ID: 12224020	2002
The Role of E-cadherin in the Motility and Invasion of Implantation Site Intermediate Trophoblast. Placenta\| PubMed ID: 12398810	2002
Cell-surface proteolysis, growth factor activation and intercellular communication in the progression of melanoma. Critical reviews in oncology/hematology\| PubMed ID: 12398996	2002
New approaches to the biology of melanoma: a workshop of the National Institutes of Health Pathology B Study Section. The American journal of pathology\| PubMed ID: 12414540	2002
Epidermal growth factor receptor mediates increased cell proliferation, migration, and aggregation in esophageal keratinocytes in vitro and in vivo. The Journal of biological chemistry\| PubMed ID: 12435727	2003
BRAF and RAS mutations in human lung cancer and melanoma. Cancer research\| PubMed ID: 12460918	2002
Differential response of primary and metastatic melanomas to neutrophils attracted by IL-8. International journal of cancer. Journal international du cancer\| PubMed ID: 12471616	2003
Regulation of Notch1 and Dll4 by vascular endothelial growth factor in arterial endothelial cells: implications for modulating arteriogenesis and angiogenesis. Molecular and cellular biology\| PubMed ID: 12482957	2003
Melanoma development and progression: a conspiracy between tumor and host. Differentiation; research in biological diversity\| PubMed ID: 12492494	2002
Constitutive mitogen-activated protein kinase activation in melanoma is mediated by both BRAF mutations and autocrine growth factor stimulation. Cancer research\| PubMed ID: 12591721	2003
Stroma formation and angiogenesis by overexpression of growth factors, cytokines, and proteolytic enzymes in human skin grafted to SCID mice. The Journal of investigative dermatology\| PubMed ID: 12648235	2003
Stimulation of human colonic epithelial cells by leukemia inhibitory factor is dependent on collagen-embedded fibroblasts in organotypic culture. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 12692084	2003
p16INK4A and familial melanoma. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 12710687	2003
The vascular phenotype of melanoma metastasis. Clinical & experimental metastasis\| PubMed ID: 12741681	2003
Function and regulation of melanoma-stromal fibroblast interactions: when seeds meet soil. Oncogene\| PubMed ID: 12789292	2003
Tumors as elusive targets of T-cell-based active immunotherapy. Trends in immunology\| PubMed ID: 12810110	2003
Fibroblast growth factor-2 but not Mel-CAM and/or beta3 integrin promotes progression of melanocytes to melanoma. Experimental dermatology\| PubMed ID: 12823444	2003
High levels of CUG-initiated FGF-2 expression cause chromatin compaction, decreased cardiomyocyte mitosis, and cell death. Molecular and cellular biochemistry\| PubMed ID: 12841351	2003
Slit-Robo: neuronal guides signal in tumor angiogenesis. Cancer cell\| PubMed ID: 12892705	2003
BRAF as a potential therapeutic target in melanoma and other malignancies. Cancer cell\| PubMed ID: 12957284	2003
Suppression of BRAF(V599E) in human melanoma abrogates transformation. Cancer research\| PubMed ID: 14500344	2003
Cisplatin down-regulation of cellular Fas-associated death domain-like interleukin-1beta-converting enzyme-like inhibitory proteins to restore tumor necrosis factor-related apoptosis-inducin... Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 14519653	2003
VEGF-A and alphaVbeta3 integrin synergistically rescue angiogenesis via N-Ras and PI3-K signaling in human microvascular endothelial cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 14519669	2003
Axis of evil: molecular mechanisms of cancer metastasis. Oncogene\| PubMed ID: 14528277	2003
Reciprocal regulation of MelCAM and AKT in human melanoma. Oncogene\| PubMed ID: 14534536	2003
The great escape: another way for melanoma to leave physiological control? The Journal of investigative dermatology\| PubMed ID: 14632176	2003
First international melanoma research congress. Cancer biology & therapy\| PubMed ID: 14688485	2003
Human melanoblasts in culture: expression of BRN2 and synergistic regulation by fibroblast growth factor-2, stem cell factor, and endothelin-3. The Journal of investigative dermatology\| PubMed ID: 14708619	2003
Induction of melanoma phenotypes in human skin by growth factors and ultraviolet B. Cancer research\| PubMed ID: 14871803	2004
Recent advances in melanoma biology. The oncologist\| PubMed ID: 15047922	2004
Truncation of activated leukocyte cell adhesion molecule: a gateway to melanoma metastasis. The Journal of investigative dermatology\| PubMed ID: 15140234	2004
Reversal of melanocytic malignancy by keratinocytes is an E-cadherin-mediated process overriding beta-catenin signaling. Experimental cell research\| PubMed ID: 15194432	2004
Death induction by recombinant native TRAIL and its prevention by a caspase 9 inhibitor in primary human esophageal epithelial cells. The Journal of biological chemistry\| PubMed ID: 15226295	2004
Cyclin D1 is essential for neoplastic transformation induced by both E6/E7 and E6/E7/ErbB-2 cooperation in normal cells. Oncogene\| PubMed ID: 15229656	2004
Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling with antitumor activity in cancer cells overexpressing Akt. Cancer research\| PubMed ID: 15231645	2004
Rapid apoptosis in the pulmonary vasculature distinguishes non-metastatic from metastatic melanoma cells. Cancer letters\| PubMed ID: 15327836	2004
The role of altered cell-cell communication in melanoma progression. Journal of molecular histology\| PubMed ID: 15339050	2004
Loitering with intent: new evidence for the role of BRAF mutations in the proliferation of melanocytic lesions. The Journal of investigative dermatology\| PubMed ID: 15373800	2004
Adenoviral mediated gene transfer of PDGF-B enhances wound healing in type I and type II diabetic wounds. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society\| PubMed ID: 15453831	2004
Cultivation of normal human epidermal melanocytes in the absence of phorbol esters. Methods in molecular medicine\| PubMed ID: 15492362	2005
Clinical protocol. Phase I trial to evaluate the safety of H5.020CMV.PDGF-b and limb compression bandage for the treatment of venous leg ulcer: trial A. Human gene therapy\| PubMed ID: 15585116	2004
Gene expression profiling of melanoma cells - searching the haystack. Journal of translational medicine\| PubMed ID: 15649323	2005
Functional erythropoietin autocrine loop in melanoma. The American journal of pathology\| PubMed ID: 15743794	2005
Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature\| PubMed ID: 15829965	2005
CXC chemokine ligand 12 (stromal cell-derived factor 1 alpha) and CXCR4-dependent migration of CTLs toward melanoma cells in organotypic culture. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15843590	2005
The prevalence of interferon-alpha transcription defects in malignant melanoma. Melanoma research\| PubMed ID: 15846141	2005
Up-regulated expression of zonula occludens protein-1 in human melanoma associates with N-cadherin and contributes to invasion and adhesion. The American journal of pathology\| PubMed ID: 15855653	2005
Adhesion, migration and communication in melanocytes and melanoma. Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society\| PubMed ID: 15892711	2005
The RAS/RAF/MEK/ERK and PI3K/AKT signaling pathways present molecular targets for the effective treatment of advanced melanoma. Frontiers in bioscience : a journal and virtual library\| PubMed ID: 15970553	2005
Metastatic melanoma cells. Introduction. Cancer metastasis reviews\| PubMed ID: 15986131	2005
Bone morphogenetic proteins in melanoma: angel or devil? Cancer metastasis reviews\| PubMed ID: 15986135	2005
Information sharing and collateral damage. Trends in molecular medicine\| PubMed ID: 16002338	2005
Selective evolutionary pressure from the tissue microenvironment drives tumor progression. Seminars in cancer biology\| PubMed ID: 16043361	2005
A tumorigenic subpopulation with stem cell properties in melanomas. Cancer research\| PubMed ID: 16230395	2005
Activation of Notch1 signaling is required for beta-catenin-mediated human primary melanoma progression. The Journal of clinical investigation\| PubMed ID: 16239965	2005
Molecular targets in melanoma: strategies and challenges for diagnosis and therapy. International journal of cancer. Journal international du cancer\| PubMed ID: 16258898	2006
[Melanoma-stroma interactions and melanoma progression]. Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG\| PubMed ID: 16281812	2003
Targeting the stromal fibroblasts: a novel approach to melanoma therapy. Expert review of anticancer therapy\| PubMed ID: 16336098	2005
Normal human melanocyte homeostasis as a paradigm for understanding melanoma. The journal of investigative dermatology. Symposium proceedings / the Society for Investigative Dermatology, Inc. [and] European Society for Dermatological Research\| PubMed ID: 16358819	2005
Targeting intracellular signaling pathways as a novel strategy in melanoma therapeutics. Annals of the New York Academy of Sciences\| PubMed ID: 16382039	2005
Expression of PKC isoforms in human melanocytic cells in situ. Journal of dermatological science\| PubMed ID: 16406501	2006
Inhibition of endothelial cell proliferation by Notch1 signaling is mediated by repressing MAPK and PI3K/Akt pathways and requires MAML1. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 16571776	2006
Defining the conditions for the generation of melanocytes from human embryonic stem cells. Stem cells (Dayton, Ohio)\| PubMed ID: 16574754	2006
Notch1 signaling promotes primary melanoma progression by activating mitogen-activated protein kinase/phosphatidylinositol 3-kinase-Akt pathways and up-regulating N-cadherin expression. Cancer research\| PubMed ID: 16618740	2006
Cancer interaction with the bone microenvironment: a workshop of the National Institutes of Health Tumor Microenvironment Study Section. The American journal of pathology\| PubMed ID: 16651608	2006
Isolation of a novel population of multipotent adult stem cells from human hair follicles. The American journal of pathology\| PubMed ID: 16723703	2006
Multiple signaling pathways must be targeted to overcome drug resistance in cell lines derived from melanoma metastases. Molecular cancer therapeutics\| PubMed ID: 16731745	2006
A new organotypic model to study cell interactions in the intestinal mucosa. European journal of gastroenterology & hepatology\| PubMed ID: 16825910	2006
Metastatic potential of melanomas defined by specific gene expression profiles with no BRAF signature. Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society\| PubMed ID: 16827748	2006
Embryogenesis meets tumorigenesis. Nature medicine\| PubMed ID: 16892028	2006
Differentiation of normal skin and melanoma using high resolution hyperspectral imaging. Cancer biology & therapy\| PubMed ID: 16931902	2006
Coordinated functions of E-cadherin and transforming growth factor beta receptor II in vitro and in vivo. Cancer research\| PubMed ID: 17047049	2006
CCN3 controls 3D spatial localization of melanocytes in the human skin through DDR1. The Journal of cell biology\| PubMed ID: 17101694	2006
Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885. Cancer research\| PubMed ID: 17145850	2006
Life isn't flat: taking cancer biology to the next dimension. In vitro cellular & developmental biology. Animal\| PubMed ID: 17163781	2006
Microenvironmental influences in melanoma progression. Journal of cellular biochemistry\| PubMed ID: 17171636	2007
An organometallic protein kinase inhibitor pharmacologically activates p53 and induces apoptosis in human melanoma cells. Cancer research\| PubMed ID: 17210701	2007
Dysregulation of claudin-7 leads to loss of E-cadherin expression and the increased invasion of esophageal squamous cell carcinoma cells. The American journal of pathology\| PubMed ID: 17255337	2007
High-throughput oncogene mutation profiling in human cancer. Nature genetics\| PubMed ID: 17293865	2007
Profiles of chemokine receptors in melanocytic lesions: de novo expression of CXCR6 in melanoma. Human pathology\| PubMed ID: 17306330	2007
Farming cells to rebuild skin and melanoma. Cancer biology & therapy\| PubMed ID: 17374983	2007
Mutant V600E BRAF increases hypoxia inducible factor-1alpha expression in melanoma. Cancer research\| PubMed ID: 17409425	2007
Rewired ERK-JNK signaling pathways in melanoma. Cancer cell\| PubMed ID: 17482134	2007
Application of a BRAF pyrosequencing assay for mutation detection and copy number analysis in malignant melanoma. The Journal of molecular diagnostics : JMD\| PubMed ID: 17690212	2007
Expression of integrin alpha10 is induced in malignant melanoma. Cellular oncology : the official journal of the International Society for Cellular Oncology\| PubMed ID: 17726260	2007
Association of polymorphisms of FAS-1377, FAS-670, and FASL-844 genes with risk factors for cutaneous malignant melanoma. Cancer journal (Sudbury, Mass.)\| PubMed ID: 17762755	2007
Old disease, new culprit: tumor stem cells in cancer. Journal of cellular physiology\| PubMed ID: 17786956	2007
Raf inhibitor stabilizes receptor for the type I interferon but inhibits its anti-proliferative effects in human malignant melanoma cells. Cancer biology & therapy\| PubMed ID: 17873516	2007
Unraveling mysteries of the multifunctional protein SPARC. The Journal of investigative dermatology\| PubMed ID: 17934501	2007
The many faces of Notch signaling in skin-derived cells. Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society\| PubMed ID: 17935489	2007
The functional interplay between EGFR overexpression, hTERT activation, and p53 mutation in esophageal epithelial cells with activation of stromal fibroblasts induces tumor development, inva... Genes & development\| PubMed ID: 17974918	2007
Roadmap for new opportunities in melanoma research. Seminars in oncology\| PubMed ID: 18083380	2007
Permissive environment in postnatal wounds induced by adenoviral-mediated overexpression of the anti-inflammatory cytokine interleukin-10 prevents scar formation. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society\| PubMed ID: 18086289	2008
The mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitor AZD6244 (ARRY-142886) induces growth arrest in melanoma cells and tumor regression when combined with doc... Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 18172275	2008
Microscale solution IEF combined with 2-D DIGE substantially enhances analysis depth of complex proteomes such as mammalian cell and tissue extracts. Electrophoresis\| PubMed ID: 18186533	2008
Cancer testis antigens in human melanoma stem cells: expression, distribution, and methylation status. Journal of cellular physiology\| PubMed ID: 18205182	2008
Modeling genomic diversity and tumor dependency in malignant melanoma. Cancer research\| PubMed ID: 18245465	2008
The differential role of L1 in ovarian carcinoma and normal ovarian surface epithelium. Cancer research\| PubMed ID: 18281486	2008
Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18287029	2008
Learning the ABCs of melanoma-initiating cells. Cancer cell\| PubMed ID: 18328422	2008
Salmonella typhimurium as a novel RNA interference vector for cancer gene therapy. Cancer biology & therapy\| PubMed ID: 18347415	2008
Similar biological activities of two isostructural ruthenium and osmium complexes. Chemistry (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 18425743	2008
The essential role of fibroblasts in esophageal squamous cell carcinoma-induced angiogenesis. Gastroenterology\| PubMed ID: 18439605	2008
Unraveling the mysteries of IGF-1 signaling in melanoma. The Journal of investigative dermatology\| PubMed ID: 18478012	2008
Cytotoxicity of the matrix metalloproteinase-activated anthrax lethal toxin is dependent on gelatinase expression and B-RAF status in human melanoma cells. Molecular cancer therapeutics\| PubMed ID: 18483309	2008
Structure-based design of an organoruthenium phosphatidyl-inositol-3-kinase inhibitor reveals a switch governing lipid kinase potency and selectivity. ACS chemical biology\| PubMed ID: 18484710	2008
Melanoma stem cells: the dark seed of melanoma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 18539969	2008
Identification of a novel subgroup of melanomas with KIT/cyclin-dependent kinase-4 overexpression. Cancer research\| PubMed ID: 18632627	2008
Melanoma and the tumor microenvironment. Current oncology reports\| PubMed ID: 18706274	2008
Bortezomib induces apoptosis in esophageal squamous cell carcinoma cells through activation of the p38 mitogen-activated protein kinase pathway. Molecular cancer therapeutics\| PubMed ID: 18790767	2008
Increased cyclin D1 expression can mediate BRAF inhibitor resistance in BRAF V600E-mutated melanomas. Molecular cancer therapeutics\| PubMed ID: 18790768	2008
Endothelin-3 stimulates survival of goblet cells in organotypic cultures of fetal human colonic epithelium. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 18832450	2008
Cleavage of MCM2 licensing protein fosters senescence in human keratinocytes. Cell cycle (Georgetown, Tex.)\| PubMed ID: 19001876	2008
A subpopulation of mouse esophageal basal cells has properties of stem cells with the capacity for self-renewal and lineage specification. The Journal of clinical investigation\| PubMed ID: 19033657	2008
Cracking the system: melanoma complexity demands new therapeutic approaches. Pigment cell & melanoma research\| PubMed ID: 19054340	2009
Integrating tumor-initiating cells into the paradigm for melanoma targeted therapy. International journal of cancer. Journal international du cancer\| PubMed ID: 19089923	2009
Cancer stem cells are everywhere. Nature medicine\| PubMed ID: 19129778	2009
Defining microenvironments within mouse models that enhance tumor aggressiveness. Cancer biology & therapy\| PubMed ID: 19182538	2009
Matricellular proteins produced by melanocytes and melanomas: in search for functions. Cancer microenvironment : official journal of the International Cancer Microenvironment Society\| PubMed ID: 19308688	2008
Driving in the melanoma landscape. Experimental dermatology\| PubMed ID: 19366372	2009
The role of BRAF mutation and p53 inactivation during transformation of a subpopulation of primary human melanocytes. The American journal of pathology\| PubMed ID: 19389934	2009
Active Notch1 confers a transformed phenotype to primary human melanocytes. Cancer research\| PubMed ID: 19549918	2009
Placental gene transfer: transgene screening in mice for trophic effects on the placenta. American journal of obstetrics and gynecology\| PubMed ID: 19716119	2009
Distinct MHC gene expression patterns during progression of melanoma. Genes, chromosomes & cancer\| PubMed ID: 19862823	2010
Embryonic stem cells as a model for studying melanocyte development. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 19907984	2010
Human dermal stem cells differentiate into functional epidermal melanocytes. Journal of cell science\| PubMed ID: 20159965	2010
What is a good model for melanoma? The Journal of investigative dermatology\| PubMed ID: 20231823	2010
Epidermal growth factor receptor and mutant p53 expand an esophageal cellular subpopulation capable of epithelial-to-mesenchymal transition through ZEB transcription factors. Cancer research\| PubMed ID: 20424117	2010
A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth. Cell\| PubMed ID: 20478252	2010
Insulin-like growth factor-binding protein-3 promotes transforming growth factor-{beta}1-mediated epithelial-to-mesenchymal transition and motility in transformed human esophageal cells. Carcinogenesis\| PubMed ID: 20513670	2010
Periostin, a cell adhesion molecule, facilitates invasion in the tumor microenvironment and annotates a novel tumor-invasive signature in esophageal cancer. Cancer research\| PubMed ID: 20516120	2010
Fibroblast-secreted hepatocyte growth factor plays a functional role in esophageal squamous cell carcinoma invasion. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20534479	2010
The ups and downs of transcription factors in melanoma. Journal of the National Cancer Institute\| PubMed ID: 20660367	2010
NOTCH1 and NOTCH3 coordinate esophageal squamous differentiation through a CSL-dependent transcriptional network. Gastroenterology\| PubMed ID: 20801121	2010
BRAF inhibitor unveils its potential against advanced melanoma. Cancer cell\| PubMed ID: 20951940	2010
Nuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferase. Cancer cell\| PubMed ID: 20951943	2010
PLX4032, a potent inhibitor of the B-Raf V600E oncogene, selectively inhibits V600E-positive melanomas. Pigment cell & melanoma research\| PubMed ID: 20973932	2010
Boris Bastian. Pigment cell & melanoma research\| PubMed ID: 20973934	2010
A systems biology analysis of metastatic melanoma using in-depth three-dimensional protein profiling. Proteomics\| PubMed ID: 21082759	2010
Taking the guesswork out of uveal melanoma. The New England journal of medicine\| PubMed ID: 21083377	2010
A systems biology analysis of metastatic melanoma using in-depth three-dimensional protein profiling. Proteomics\| PubMed ID: 21136598	2010
Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K. Cancer cell\| PubMed ID: 21156289	2010
Dermis-derived stem cells: a source of epidermal melanocytes and melanoma? Pigment cell & melanoma research\| PubMed ID: 21410654	2011
Targeting BRAF in advanced melanoma: a first step toward manageable disease. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 21447722	2011
Will engineered T cells expressing CD20 scFv eradicate Melanoma? Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 21455210	2011
Detecting and targeting mesenchymal-like subpopulations within squamous cell carcinomas. Cell cycle (Georgetown, Tex.)\| PubMed ID: 21558812	2011
From cancer stem cells to tumor maintenance in melanoma. The Journal of investigative dermatology\| PubMed ID: 21654838	2011
A NOTCH3-mediated squamous cell differentiation program limits expansion of EMT-competent cells that express the ZEB transcription factors. Cancer research\| PubMed ID: 21890822	2011
Sorting through the many opportunities for melanoma therapy. Pigment cell & melanoma research\| PubMed ID: 21899726	2011
Organometallic Pyridylnaphthalimide Complexes as Protein Kinase Inhibitors. Organometallics\| PubMed ID: 21918590	2011
Isolation and cultivation of dermal stem cells that differentiate into functional epidermal melanocytes. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 22057442	2012
Fibroblasts contribute to melanoma tumor growth and drug resistance. Molecular pharmaceutics\| PubMed ID: 22067046	2011
The molecular pathology of cutaneous melanoma. Cancer biomarkers : section A of Disease markers\| PubMed ID: 22112480	2011
Resistance to BRAF inhibitors: unraveling mechanisms and future treatment options. Cancer research\| PubMed ID: 22131348	2011
Isolation and characterization of mouse and human esophageal epithelial cells in 3D organotypic culture. Nature protocols\| PubMed ID: 22240585	2012
MEK'ing the most of p53 reactivation therapy in melanoma. The Journal of investigative dermatology\| PubMed ID: 22241441	2012
A Unified Approach to Targeting the Lysosome's Degradative and Growth Signaling Roles. Cancer discovery\| PubMed ID: 28899863	2017
MSX1-Induced Neural Crest-Like Reprogramming Promotes Melanoma Progression. The Journal of investigative dermatology\| PubMed ID: 28927893	2018
Tumor-associated B-cells induce tumor heterogeneity and therapy resistance. Nature communications\| PubMed ID: 28928360	2017
PAK signalling drives acquired drug resistance to MAPK inhibitors in BRAF-mutant melanomas. Nature\| PubMed ID: 28953887	2017
Acetylsalicylic Acid Governs the Effect of Sorafenib in -Mutant Cancers. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 29196297	2018
Melanoma Therapeutic Strategies that Select against Resistance by Exploiting MYC-Driven Evolutionary Convergence. Cell reports\| PubMed ID: 29212027	2017
Hypoxia-activated prodrug enhances therapeutic effect of sunitinib in melanoma. Oncotarget\| PubMed ID: 29383148	2017
Distinct histone modifications denote early stress-induced drug tolerance in cancer. Oncotarget\| PubMed ID: 29492189	2018
Induction of Telomere Dysfunction Prolongs Disease Control of Therapy-Resistant Melanoma. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 29563139	2018
Co-targeting BET and MEK as salvage therapy for MAPK and checkpoint inhibitor-resistant melanoma. EMBO molecular medicine\| PubMed ID: 29650805	2018
Endogenous authentic OCT4A proteins directly regulate FOS/AP-1 transcription in somatic cancer cells. Cell death & disease\| PubMed ID: 29789579	2018
Age Correlates with Response to Anti-PD1, Reflecting Age-Related Differences in Intratumoral Effector and Regulatory T-Cell Populations. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 29898988	2018
Tumor innate immunity primed by specific interferon-stimulated endogenous retroviruses. Nature medicine\| PubMed ID: 30038220	2018
Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response. Nature\| PubMed ID: 30089911	2018
Robust prediction of response to immune checkpoint blockade therapy in metastatic melanoma. Nature medicine\| PubMed ID: 30127394	2018
Targeting the Warburg effect via LDHA inhibition engages ATF4 signaling for cancer cell survival. The EMBO journal\| PubMed ID: 30209241	2018
Remodeling of the Collagen Matrix in Aging Skin Promotes Melanoma Metastasis and Affects Immune Cell Motility. Cancer discovery\| PubMed ID: 30279173	2019
Frontiers in pigment cell and melanoma research. Pigment cell & melanoma research\| PubMed ID: 30281213	2018
Publisher Correction: Robust prediction of response to immune checkpoint blockade therapy in metastatic melanoma. Nature medicine\| PubMed ID: 30333558	2018
A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade. Cell\| PubMed ID: 30388455	2018
PPT1 Promotes Tumor Growth and Is the Molecular Target of Chloroquine Derivatives in Cancer. Cancer discovery\| PubMed ID: 30442709	2019
Author Correction: PAK signalling drives acquired drug resistance to MAPK inhibitors in BRAF-mutant melanomas. Nature\| PubMed ID: 30532003	2019
ER Translocation of the MAPK Pathway Drives Therapy Resistance in BRAF-Mutant Melanoma. Cancer discovery\| PubMed ID: 30563872	2019
Loss of Phd2 cooperates with BRAF to drive melanomagenesis. Nature communications\| PubMed ID: 30575721	2018
BRAF Targeting Sensitizes Resistant Melanoma to Cytotoxic T Cells. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 30765391	2019
Genome-wide prediction of synthetic rescue mediators of resistance to targeted and immunotherapy. Molecular systems biology\| PubMed ID: 30858180	2019
Author Correction: Loss of Phd2 cooperates with BRAF to drive melanomagenesis. Nature communications\| PubMed ID: 30858377	2019