Institute for Virology
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Virus-specific CD8+ T cells upregulate programmed death-1 expression during acute friend retrovirus infection but are highly cytotoxic and control virus replication.
Journal of immunology (Baltimore, Md. : 1950) Oct, 2011 | Pubmed ID: 21873525
Interferon-alpha subtype 11 activates NK cells and enables control of retroviral infection.
PLoS pathogens , 2012 | Pubmed ID: 22912583
Modification of one epitope-flanking amino acid allows for the induction of friend retrovirus-specific CD8+ T cells by Adenovirus-based immunization.
Journal of virology Nov, 2012 | Pubmed ID: 22933287
Interleukin 21 augments the hepatitis B virus-specific CD8+ T-cell response in vitro in patients coinfected with HIV-1.
AIDS (London, England) Nov, 2012 | Pubmed ID: 22948268
CD4+ T cells develop antiretroviral cytotoxic activity in the absence of regulatory T cells and CD8+ T cells.
Journal of virology Jun, 2013 | Pubmed ID: 23536666
Overcoming drug-resistant herpes simplex virus (HSV) infection by a humanized antibody.
Proceedings of the National Academy of Sciences of the United States of America Apr, 2013 | Pubmed ID: 23569258
Combining regulatory T cell depletion and inhibitory receptor blockade improves reactivation of exhausted virus-specific CD8+ T cells and efficiently reduces chronic retroviral loads.
PLoS pathogens , 2013 | Pubmed ID: 24339778
Interleukin-encoding adenoviral vectors as genetic adjuvant for vaccination against retroviral infection.
PloS one , 2013 | Pubmed ID: 24349306
The phenotype and activation status of regulatory T cells during Friend retrovirus infection.
Virologica Sinica Feb, 2014 | Pubmed ID: 24452537
CD8+ T cells are essential for controlling acute friend retrovirus infection in C57BL/6 mice.
Journal of virology May, 2014 | Pubmed ID: 24707025
Clonotypic composition of the CD4+ T cell response to a vectored retroviral antigen is determined by its speed.
Journal of immunology (Baltimore, Md. : 1950) Aug, 2014 | Pubmed ID: 25000983
Prophylactic and therapeutic vaccination with a nanoparticle-based peptide vaccine induces efficient protective immunity during acute and chronic retroviral infection.
Nanomedicine : nanotechnology, biology, and medicine Nov, 2014 | Pubmed ID: 25014891
Activated CD8+ T cells induce expansion of Vβ5+ regulatory T cells via TNFR2 signaling.
Journal of immunology (Baltimore, Md. : 1950) Sep, 2014 | Pubmed ID: 25098294
Advantages of Foxp3(+) regulatory T cell depletion using DEREG mice.
Immunity, inflammation and disease Nov, 2014 | Pubmed ID: 25505550
Friend retrovirus drives cytotoxic effectors through Toll-like receptor 3.
Retrovirology Dec, 2014 | Pubmed ID: 25539593
Prevention of herpes simplex virus induced stromal keratitis by a glycoprotein B-specific monoclonal antibody.
PloS one , 2015 | Pubmed ID: 25587898
CEACAM1 induces B-cell survival and is essential for protective antiviral antibody production.
Nature communications Feb, 2015 | Pubmed ID: 25692415
Cooperativity of HIV-Specific Cytolytic CD4 T Cells and CD8 T Cells in Control of HIV Viremia.
Journal of virology Aug, 2015 | Pubmed ID: 25972560
Activated regulatory T cells suppress effector NK cell responses by an IL-2-mediated mechanism during an acute retroviral infection.
Retrovirology Jul, 2015 | Pubmed ID: 26220086
PD-L1 Expression on Retrovirus-Infected Cells Mediates Immune Escape from CD8+ T Cell Killing.
PLoS pathogens Oct, 2015 | Pubmed ID: 26484769
Immunoactivation induced by chronic viral infection inhibits viral replication and drives immunosuppression through sustained IFN-I responses.
European journal of immunology Feb, 2016 | Pubmed ID: 26507703
Interferon-α Subtypes in an Ex Vivo Model of Acute HIV-1 Infection: Expression, Potency and Effector Mechanisms.
PLoS pathogens , 2015 | Pubmed ID: 26529416
CD137 Agonist Therapy Can Reprogram Regulatory T Cells into Cytotoxic CD4+ T Cells with Antitumor Activity.
Journal of immunology (Baltimore, Md. : 1950) Jan, 2016 | Pubmed ID: 26608920
No SEVI-mediated enhancement of rectal HIV-1 transmission of HIV-1 in two humanized mouse cohorts.
Virology Jan, 2016 | Pubmed ID: 26609939
Circulating HIV-Specific Interleukin-21(+)CD4(+) T Cells Represent Peripheral Tfh Cells with Antigen-Dependent Helper Functions.
Immunity Jan, 2016 | Pubmed ID: 26795249
Inhibition of catecholamine degradation ameliorates while chemical sympathectomy aggravates the severity of acute Friend retrovirus infection in mice.
Brain, behavior, and immunity May, 2016 | Pubmed ID: 26880342
Reduced Frequencies and Activation of Regulatory T Cells After the Treatment of HIV-1-Infected Individuals with the CCR5 Antagonist Maraviroc Are Associated with a Reduction in Viral Loads Rather Than a Direct Effect of the Drug on Regulatory T Cells.
Viral immunology Apr, 2016 | Pubmed ID: 27035639
Combination of nanoparticle-based therapeutic vaccination and transient ablation of regulatory T cells enhances anti-viral immunity during chronic retroviral infection.
Retrovirology Apr, 2016 | Pubmed ID: 27076190
Interferon Alpha Subtype-Specific Suppression of HIV-1 Infection In Vivo.
Journal of virology 07, 2016 | Pubmed ID: 27099312
The V1 region of gp120 is preferentially selected during SIV/HIV transmission and is indispensable for envelope function and virus infection.
Virologica Sinica Jun, 2016 | Pubmed ID: 27117672
Opposing Development of Cytotoxic and Follicular Helper CD4 T Cells Controlled by the TCF-1-Bcl6 Nexus.
Cell reports 11, 2016 | Pubmed ID: 27806296
CD169 macrophages regulate PD-L1 expression via type I interferon and thereby prevent severe immunopathology after LCMV infection.
Cell death & disease 11, 2016 | Pubmed ID: 27809306
Different antiviral effects of IFNα and IFNβ in an HBV mouse model.
Immunobiology 03, 2017 | Pubmed ID: 27839836
Pre-exposure prophylaxis failure with tenofovir disoproxil.
AIDS (London, England) 01, 2017 | Pubmed ID: 27898596
Filariae-Retrovirus Co-infection in Mice is Associated with Suppressed Virus-Specific IgG Immune Response and Higher Viral Loads.
PLoS neglected tropical diseases 12, 2016 | Pubmed ID: 27923052
Natural killer T cells contribute to the control of acute retroviral infection.
Retrovirology 01, 2017 | Pubmed ID: 28122574
Combined toll-like receptor 3/7/9 deficiency on host cells results in T-cell-dependent control of tumour growth.
Nature communications 03, 2017 | Pubmed ID: 28300057
Interference of retroviral envelope with vaccine-induced CD8 T cell responses is relieved by co-administration of cytokine-encoding vectors.
Retrovirology 04, 2017 | Pubmed ID: 28449719
Immunodominance of Adenovirus-Derived CD8 T Cell Epitopes Interferes with the Induction of Transgene-Specific Immunity in Adenovirus-Based Immunization.
Journal of virology 10, 2017 | Pubmed ID: 28768877
Fas Ligand-mediated cytotoxicity of CD4+ T cells during chronic retrovirus infection.
Scientific reports 08, 2017 | Pubmed ID: 28798348
Granulocytic myeloid-derived suppressor cells suppress virus-specific CD8 T cell responses during acute Friend retrovirus infection.
Retrovirology Aug, 2017 | Pubmed ID: 28835242
Dose of Retroviral Infection Determines Induction of Antiviral NK Cell Responses.
Journal of virology 11, 2017 | Pubmed ID: 28904191
Differential Inhibitory Receptor Expression on T Cells Delineates Functional Capacities in Chronic Viral Infection.
Journal of virology 12, 2017 | Pubmed ID: 28904197
Antibody-based immunotherapy of aciclovir resistant ocular herpes simplex virus infections.
Virology 12, 2017 | Pubmed ID: 28985573
Cytomegalovirus reactivation in patients with refractory checkpoint inhibitor-induced colitis.
European journal of cancer (Oxford, England : 1990) 11, 2017 | Pubmed ID: 29055840
Hepatitis B virus sensitivity to interferon-α in hepatocytes is more associated with cellular interferon response than with viral genotype.
Hepatology (Baltimore, Md.) 04, 2018 | Pubmed ID: 29059468
An advanced BLT-humanized mouse model for extended HIV-1 cure studies.
AIDS (London, England) Jan, 2018 | Pubmed ID: 29112072
Impact of low-level BK polyomavirus viremia on intermediate-term renal allograft function.
Transplant infectious disease : an official journal of the Transplantation Society Feb, 2018 | Pubmed ID: 29156086
Expression Pattern of Individual IFNA Subtypes in Chronic HIV Infection.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 12, 2017 | Pubmed ID: 29252127
Friend virus limits adaptive cellular immune responses by imprinting a maturation-resistant and T helper type 2-biased immunophenotype in dendritic cells.
PloS one , 2018 | Pubmed ID: 29425215
Regulatory T cells in retroviral infections.
PLoS pathogens 02, 2018 | Pubmed ID: 29447279
Imaging of cytotoxic antiviral immunity while considering the 3R principle of animal research.
Journal of molecular medicine (Berlin, Germany) 04, 2018 | Pubmed ID: 29460050
Interferon α subtypes in HIV infection.
Cytokine & growth factor reviews 04, 2018 | Pubmed ID: 29475588
Induction of Type I Interferons by Therapeutic Nanoparticle-Based Vaccination Is Indispensable to Reinforce Cytotoxic CD8 T Cell Responses During Chronic Retroviral Infection.
Frontiers in immunology , 2018 | Pubmed ID: 29740425
Recent advances in the discovery and development of TLR ligands as novel therapeutics for chronic HBV and HIV infections.
Expert opinion on drug discovery 07, 2018 | Pubmed ID: 29772941
Evaluation of susceptibility of HIV-1 CRF01_AE variants to neutralization by a panel of broadly neutralizing antibodies.
Archives of virology Dec, 2018 | Pubmed ID: 30196320
The Cytotoxic Activity of Natural Killer Cells Is Suppressed by IL-10 Regulatory T Cells During Acute Retroviral Infection.
Frontiers in immunology , 2018 | Pubmed ID: 30210499
Impact of immune suppressive agents on the BK-Polyomavirus non coding control region.
Antiviral research 11, 2018 | Pubmed ID: 30268912
Corrigendum to "Antibody-based immunotherapy of acyclovir resistant ocular herpes simplex virus infection" [Virology 512 (2017) 194-200].
Virology 01, 2019 | Pubmed ID: 30290967
Friend retrovirus infection induces the development of memory-like natural killer cells.
Retrovirology 10, 2018 | Pubmed ID: 30292240
PASylated interferon α efficiently suppresses hepatitis B virus and induces anti-HBs seroconversion in HBV-transgenic mice.
Antiviral research Jan, 2019 | Pubmed ID: 30439382
Induction of herpes simplex virus type 1 cell-to-cell spread inhibiting antibodies by a calcium phosphate nanoparticle-based vaccine.
Nanomedicine : nanotechnology, biology, and medicine 02, 2019 | Pubmed ID: 30594660
Chronic retroviral infection of mice promotes tumor development, but CD137 agonist therapy restores effective tumor immune surveillance.
Cancer immunology, immunotherapy : CII Mar, 2019 | Pubmed ID: 30635687
Effects of Friend Virus Infection and Regulatory T Cells on the Antigen Presentation Function of B Cells.
mBio 01, 2019 | Pubmed ID: 30670616
The detection of BKPyV genotypes II and IV after renal transplantation as a simple tool for risk assessment for PyVAN and transplant outcome already at early stages of BKPyV reactivation.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology Apr, 2019 | Pubmed ID: 30771597
Infection of B Cell Follicle-Resident Cells by Friend Retrovirus Occurs during Acute Infection and Is Maintained during Viral Persistence.
mBio 02, 2019 | Pubmed ID: 30782653
The PD-1/PD-L1 Pathway Affects the Expansion and Function of Cytotoxic CD8 T Cells During an Acute Retroviral Infection.
Frontiers in immunology , 2019 | Pubmed ID: 30804928
Plasmacytoid dendritic cells respond to Epstein-Barr virus infection with a distinct type I interferon subtype profile.
Blood advances Apr, 2019 | Pubmed ID: 30952679
IFI16 Targets the Transcription Factor Sp1 to Suppress HIV-1 Transcription and Latency Reactivation.
Cell host & microbe 06, 2019 | Pubmed ID: 31175045
Johannes Korth1,2,
Helene Sertznig2,
Siegfried Moyrer2,
Adrian Atilla Nicolas Doevelaar2,3,
Timm Henning Westhoff3,
Nina Babel3,
Oliver Witzke4,
Andreas Kribben1,
Ulf Dittmer2,
Marek Widera2
1Department of Nephrology, University of Duisburg-Essen, University Hospital Essen,
2Institute for Virology, University of Duisburg-Essen, University Hospital Essen,
3Center for Translational Medicine, Medical Department I, Marien Hospital Herne, University Hospital of the Ruhr-University of Bochum,
4Department of Infectious Diseases, University of Duisburg-Essen, University Hospital Essen Hufelandstr
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