Division of Allergy/Immunology and Rheumatology,
Department of Medicine,
Division of Allergy/Immunology and Rheumatology, Department of Medicine
Javier Rangel-Moreno
Javier Rangel-Moreno is a Research Assistant Professor in the Department of Medicine at the University of Rochester. He received his bachelor degree in Chemistry, Bacteriology and Parasitology and his Ph D in Immunology from the National School of Biological Sciences, National Polytechnic Institute in Mexico City, Mexico. In 2002, He joined as a postdoctoral fellow to Dr. Troy Randall’s lab at Trudeau Institute, where he studied the role of homeostatic chemokines in the orchestration of local immunity against pulmonary pathogens. He moved in 2009 with Troy Randall’s lab to the University of Rochester to continue investigating the mechanisms involved in the formation, organization and functions of tertiary lymphoid organs. In 2012, he joined Dr. Jennifer Anolik’s lab to study the cellular and molecular mechanisms of pathogenesis in auto-immune diseases. Currently, he is interested on understanding the complex interactions of immune cells in target tissues and how they participate in the local induction of protective or pathological immune responses in mouse model and human diseases.
Omental milky spots develop in the absence of lymphoid tissue-inducer cells and support B and T cell responses to peritoneal antigens.
Immunity May, 2009 | Pubmed ID: 19427241
Interleukin-17 is required for T helper 1 cell immunity and host resistance to the intracellular pathogen Francisella tularensis.
Immunity Nov, 2009 | Pubmed ID: 19853481
In a murine tuberculosis model, the absence of homeostatic chemokines delays granuloma formation and protective immunity.
Journal of immunology (Baltimore, Md. : 1950) Dec, 2009 | Pubmed ID: 19933855
Bronchus-associated lymphoid tissue (BALT) and survival in a vaccine mouse model of tularemia.
PloS one Jun, 2010 | Pubmed ID: 20585390
Pathological role of interleukin 17 in mice subjected to repeated BCG vaccination after infection with Mycobacterium tuberculosis.
The Journal of experimental medicine Aug, 2010 | Pubmed ID: 20624887
Antigen-specific clonal expansion and cytolytic effector function of CD8+ T lymphocytes depend on the transcription factor Bcl11b.
The Journal of experimental medicine Aug, 2010 | Pubmed ID: 20660613
Profiling early lung immune responses in the mouse model of tuberculosis.
PloS one Jan, 2011 | Pubmed ID: 21249199
The development of inducible bronchus-associated lymphoid tissue depends on IL-17.
Nature immunology Jun, 2011 | Pubmed ID: 21666689
IL-23 is required for long-term control of Mycobacterium tuberculosis and B cell follicle formation in the infected lung.
Journal of immunology (Baltimore, Md. : 1950) Nov, 2011 | Pubmed ID: 22003199
Lipocalin 2 Regulates Inflammation during Pulmonary Mycobacterial Infections.
PloS one , 2012 | Pubmed ID: 23185529
CXCR5⁺ T helper cells mediate protective immunity against tuberculosis.
The Journal of clinical investigation Feb, 2013 | Pubmed ID: 23281399
Interleukin-17-dependent CXCL13 mediates mucosal vaccine-induced immunity against tuberculosis.
Mucosal immunology Sep, 2013 | Pubmed ID: 23299616
Neonatal irradiation sensitizes mice to delayed pulmonary challenge.
Radiation research Apr, 2013 | Pubmed ID: 23496054
Differential and site specific impact of B cells in the protective immune response to Mycobacterium tuberculosis in the mouse.
PloS one , 2013 | Pubmed ID: 23613902
Pulmonary expression of oncostatin M (OSM) promotes inducible BALT formation independently of IL-6, despite a role for IL-6 in OSM-driven pulmonary inflammation.
Journal of immunology (Baltimore, Md. : 1950) Aug, 2013 | Pubmed ID: 23797667
IL-10 restrains IL-17 to limit lung pathology characteristics following pulmonary infection with Francisella tularensis live vaccine strain.
The American journal of pathology Nov, 2013 | Pubmed ID: 24007881
S100A8/A9 proteins mediate neutrophilic inflammation and lung pathology during tuberculosis.
American journal of respiratory and critical care medicine Nov, 2013 | Pubmed ID: 24047412
Selective ablation of lung epithelial IKK2 impairs pulmonary Th17 responses and delays the clearance of Pneumocystis.
Journal of immunology (Baltimore, Md. : 1950) Nov, 2013 | Pubmed ID: 24078701
Mucosal pre-exposure to Th17-inducing adjuvants exacerbates pathology after influenza infection.
The American journal of pathology Jan, 2014 | Pubmed ID: 24183780
Neutrophil-mediated IFN activation in the bone marrow alters B cell development in human and murine systemic lupus erythematosus.
Journal of immunology (Baltimore, Md. : 1950) Feb, 2014 | Pubmed ID: 24379124
Long-term B cell depletion in murine lupus eliminates autoantibody-secreting cells and is associated with alterations in the kidney plasma cell niche.
Journal of immunology (Baltimore, Md. : 1950) Apr, 2014 | Pubmed ID: 24574498
Unexpected Role for IL-17 in Protective Immunity against Hypervirulent Mycobacterium tuberculosis HN878 Infection.
PLoS pathogens May, 2014 | Pubmed ID: 24831696
Immune requirements for protective Th17 recall responses to Mycobacterium tuberculosis challenge.
Mucosal immunology Sep, 2015 | Pubmed ID: 25627812
IL-22 regulates lymphoid chemokine production and assembly of tertiary lymphoid organs.
Proceedings of the National Academy of Sciences of the United States of America Sep, 2015 | Pubmed ID: 26286991
Long-Lasting Impact of Neonatal Exposure to Total Body Gamma Radiation on Secondary Lymphoid Organ Structure and Function.
Radiation research Oct, 2015 | Pubmed ID: 26397175
Mucosal vaccination with attenuated Mycobacterium tuberculosis induces strong central memory responses and protects against tuberculosis.
Nature communications Oct, 2015 | Pubmed ID: 26460802
Production of RANKL by Memory B Cells: A Link Between B Cells and Bone Erosion in Rheumatoid Arthritis.
Arthritis & rheumatology (Hoboken, N.J.) Apr, 2016 | Pubmed ID: 26554541
Helminth-induced arginase-1 exacerbates lung inflammation and disease severity in tuberculosis.
The Journal of clinical investigation Dec, 2015 | Pubmed ID: 26571397
Inhibition of G Protein βγ Subunit Signaling Abrogates Nephritis in Lupus-Prone Mice.
Arthritis & rheumatology (Hoboken, N.J.) 09, 2016 | Pubmed ID: 26990948
Serpine2 deficiency results in lung lymphocyte accumulation and bronchus-associated lymphoid tissue formation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 07, 2016 | Pubmed ID: 27059719
Targeting dendritic cells to accelerate T-cell activation overcomes a bottleneck in tuberculosis vaccine efficacy.
Nature communications 12, 2016 | Pubmed ID: 28004802
HLA Alleles are Genetic Markers for Susceptibility and Resistance towards Leprosy in a Mexican Mestizo Population.
Annals of human genetics Jan, 2017 | Pubmed ID: 28025823
Novel role for IL-22 in protection during chronic Mycobacterium tuberculosis HN878 infection.
Mucosal immunology 07, 2017 | Pubmed ID: 28247861
Rationalized design of a mucosal vaccine protects against challenge in mice.
Journal of leukocyte biology 06, 2017 | Pubmed ID: 28258153
Pneumocystis-Driven Inducible Bronchus-Associated Lymphoid Tissue Formation Requires Th2 and Th17 Immunity.
Cell reports 03, 2017 | Pubmed ID: 28355561
Infiltrating Myeloid Cells Exert Protumorigenic Actions via Neutrophil Elastase.
Molecular cancer research : MCR 09, 2017 | Pubmed ID: 28512253
A Unique Cellular and Molecular Microenvironment Is Present in Tertiary Lymphoid Organs of Patients with Spontaneous Prostate Cancer Regression.
Frontiers in immunology , 2017 | Pubmed ID: 28567040
Neutrophils Slow Disease Progression in Murine Lupus via Modulation of Autoreactive Germinal Centers.
Journal of immunology (Baltimore, Md. : 1950) 07, 2017 | Pubmed ID: 28584005
A novel nanoemulsion vaccine induces mucosal Interleukin-17 responses and confers protection upon Mycobacterium tuberculosis challenge in mice.
Vaccine 09, 2017 | Pubmed ID: 28774560
Interleukin-17 limits hypoxia-inducible factor 1α and development of hypoxic granulomas during tuberculosis.
JCI insight 10, 2017 | Pubmed ID: 28978810
Genetic ablation of histone deacetylase 2 leads to lung cellular senescence and lymphoid follicle formation in COPD/emphysema.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 09, 2018 | Pubmed ID: 29630406
A novel role for C-C motif chemokine receptor 2 during infection with hypervirulent Mycobacterium tuberculosis.
Mucosal immunology 11, 2018 | Pubmed ID: 30115997
Mycobacterium tuberculosis carrying a rifampicin drug resistance mutation reprograms macrophage metabolism through cell wall lipid changes.
Nature microbiology 10, 2018 | Pubmed ID: 30224802
Publisher Correction: Mycobacterium tuberculosis carrying a rifampicin drug resistance mutation reprograms macrophage metabolism through cell wall lipid changes.
Nature microbiology 11, 2018 | Pubmed ID: 30327492
STAT2 Signaling Regulates Macrophage Phenotype During Influenza and Bacterial Super-Infection.
Frontiers in immunology , 2018 | Pubmed ID: 30337919
B cells inhibit bone formation in rheumatoid arthritis by suppressing osteoblast differentiation.
Nature communications 12, 2018 | Pubmed ID: 30510188
Epigenetic Suppression of SERPINB1 Promotes Inflammation-Mediated Prostate Cancer Progression.
Molecular cancer research : MCR 04, 2019 | Pubmed ID: 30610107
A Novel Fluorescent and Bioluminescent Bireporter Influenza A Virus To Evaluate Viral Infections.
Journal of virology May, 2019 | Pubmed ID: 30867298
Selective Sexual Dimorphisms in Musculoskeletal and Cardiopulmonary Pathologic Manifestations and Mortality Incidence in the Tumor Necrosis Factor-Transgenic Mouse Model of Rheumatoid Arthritis.
Arthritis & rheumatology (Hoboken, N.J.) Apr, 2019 | Pubmed ID: 30969024
Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry.
Nature immunology 07, 2019 | Pubmed ID: 31061532
Protective role of B cells in sterile particulate-induced lung injury.
JCI insight May, 2019 | Pubmed ID: 31094704
Group 3 innate lymphoid cells mediate early protective immunity against tuberculosis.
Nature 06, 2019 | Pubmed ID: 31168092
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