Xuekun Li
The Children's Hospital,
School of Medicine,
The Institute of Translational Medicine,
The Children's Hospital, School of Medicine,
The Institute of Translational Medicine, School of Medicine
Zhejiang University
Our lab mainly focuses on epigenetic mechanisms especially DNA and RNA modifications in adult neurogenesis and neurological disorders. We have found that 5-hydroxymethylcytosine in genome and N6-methyladenosine in mRNA play essential roles in regulating adult neurogenesis. Our long term aim is to uncover the function of these epigenetic modifications in neuronal developmental and degenerative diseases.
5-hydroxymethylcytosine-mediated DNA demethylation in stem cells and development.
Stem cells and development May, 2014 | Pubmed ID: 24400731
From development to diseases: the role of 5hmC in brain.
Genomics Nov, 2014 | Pubmed ID: 25205306
Cell cycle-linked MeCP2 phosphorylation modulates adult neurogenesis involving the Notch signalling pathway.
Nature communications Nov, 2014 | Pubmed ID: 25420914
The change tendency of PI3K/Akt pathway after spinal cord injury.
American journal of translational research , 2015 | Pubmed ID: 26807170
Genome-wide alteration of 5-hydroxymenthylcytosine in a mouse model of Alzheimer's disease.
BMC genomics 05, 2016 | Pubmed ID: 27207465
iPSCs: From Bench to Clinical Bed.
Stem cells international , 2016 | Pubmed ID: 27738437
Fat mass and obesity-associated (FTO) protein regulates adult neurogenesis.
Human molecular genetics 07, 2017 | Pubmed ID: 28398475
Ten-eleven translocation 2 interacts with forkhead box O3 and regulates adult neurogenesis.
Nature communications 06, 2017 | Pubmed ID: 28660881
The Dynamic DNA Demethylation during Postnatal Neuronal Development and Neural Stem Cell Differentiation.
Stem cells international , 2018 | Pubmed ID: 29713349
5-Hydroxymethylcytosine alterations in the human postmortem brains of autism spectrum disorder.
Human molecular genetics 09, 2018 | Pubmed ID: 29790956
RYBP modulates stability and function of Ring1B through targeting UBE3A.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 01, 2019 | Pubmed ID: 30040487
Noncoding RNAs and Base Modifications: Epigenomic Players Implicated in Neurological Disorders and Tumorigenesis.
International journal of genomics , 2018 | Pubmed ID: 30402455
Autism spectrum disorders: autistic phenotypes and complicated mechanisms.
World journal of pediatrics : WJP Feb, 2019 | Pubmed ID: 30607884
Base Modifications: Regulation of Stem Cell Functions and Diseases.
Stem cells international , 2018 | Pubmed ID: 30627173
Long Non-coding RNA in Neuronal Development and Neurological Disorders.
Frontiers in genetics , 2018 | Pubmed ID: 30728830
mA Regulates Neurogenesis and Neuronal Development by Modulating Histone Methyltransferase Ezh2.
Genomics, proteomics & bioinformatics 04, 2019 | Pubmed ID: 31154015
Long noncoding RNA CCDC144NL-AS1 knockdown induces naïve-like state conversion of human pluripotent stem cells.
Stem cell research & therapy Jul, 2019 | Pubmed ID: 31358062
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