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Xuekun Li

The Children's Hospital,
School of Medicine,
The Institute of Translational Medicine,
The Children's Hospital, School of Medicine,
The Institute of Translational Medicine, School of Medicine

Zhejiang University

BIOGRAPHY

Our lab mainly focuses on epigenetic mechanisms especially DNA and RNA modifications in adult neurogenesis and neurological disorders. We have found that 5-hydroxymethylcytosine in genome and N6-methyladenosine in mRNA play essential roles in regulating adult neurogenesis. Our long term aim is to uncover the function of these epigenetic modifications in neuronal developmental and degenerative diseases.

PUBLICATIONS

5-hydroxymethylcytosine-mediated DNA demethylation in stem cells and development.

Stem cells and development May, 2014 | Pubmed ID: 24400731

From development to diseases: the role of 5hmC in brain.

Genomics Nov, 2014 | Pubmed ID: 25205306

Cell cycle-linked MeCP2 phosphorylation modulates adult neurogenesis involving the Notch signalling pathway.

Nature communications Nov, 2014 | Pubmed ID: 25420914

The change tendency of PI3K/Akt pathway after spinal cord injury.

American journal of translational research , 2015 | Pubmed ID: 26807170

Genome-wide alteration of 5-hydroxymenthylcytosine in a mouse model of Alzheimer's disease.

BMC genomics 05, 2016 | Pubmed ID: 27207465

iPSCs: From Bench to Clinical Bed.

Stem cells international , 2016 | Pubmed ID: 27738437

Fat mass and obesity-associated (FTO) protein regulates adult neurogenesis.

Human molecular genetics 07, 2017 | Pubmed ID: 28398475

Ten-eleven translocation 2 interacts with forkhead box O3 and regulates adult neurogenesis.

Nature communications 06, 2017 | Pubmed ID: 28660881

The Dynamic DNA Demethylation during Postnatal Neuronal Development and Neural Stem Cell Differentiation.

Stem cells international , 2018 | Pubmed ID: 29713349

5-Hydroxymethylcytosine alterations in the human postmortem brains of autism spectrum disorder.

Human molecular genetics 09, 2018 | Pubmed ID: 29790956

RYBP modulates stability and function of Ring1B through targeting UBE3A.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 01, 2019 | Pubmed ID: 30040487

Noncoding RNAs and Base Modifications: Epigenomic Players Implicated in Neurological Disorders and Tumorigenesis.

International journal of genomics , 2018 | Pubmed ID: 30402455

Autism spectrum disorders: autistic phenotypes and complicated mechanisms.

World journal of pediatrics : WJP Feb, 2019 | Pubmed ID: 30607884

Base Modifications: Regulation of Stem Cell Functions and Diseases.

Stem cells international , 2018 | Pubmed ID: 30627173

Long Non-coding RNA in Neuronal Development and Neurological Disorders.

Frontiers in genetics , 2018 | Pubmed ID: 30728830

mA Regulates Neurogenesis and Neuronal Development by Modulating Histone Methyltransferase Ezh2.

Genomics, proteomics & bioinformatics 04, 2019 | Pubmed ID: 31154015

Long noncoding RNA CCDC144NL-AS1 knockdown induces naïve-like state conversion of human pluripotent stem cells.

Stem cell research & therapy Jul, 2019 | Pubmed ID: 31358062

INSTITUTIONS

Zhejiang University

JOVE ARTICLES

The Detection of 5-Hydroxymethylcytosine in Neural Stem Cells and Brains of Mice

Yingliang Zhuang^1,2,

Junchen Chen^1,2,

Weize Xu¹,

Qiang Shu¹,

Xuekun Li^1,2

¹The Children's Hospital, School of Medicine, Zhejiang University,

²The Institute of Translational Medicine, School of Medicine, Zhejiang University

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Xuekun Li

.css-o250i3{font-size:18px;font-family:Open Sans,sans-serif;line-height:21.6px;}The Children's Hospital,School of Medicine,The Institute of Translational Medicine,The Children's Hospital, School of Medicine,The Institute of Translational Medicine, School of Medicine

Zhejiang University

The Detection of 5-Hydroxymethylcytosine in Neural Stem Cells and Brains of Mice

The Children's Hospital,
School of Medicine,
The Institute of Translational Medicine,
The Children's Hospital, School of Medicine,
The Institute of Translational Medicine, School of Medicine