Igor R. Efimov

Mechanisms of make and break excitation revisited: paradoxical break excitation during diastolic stimulation.

The pinwheel experiment re-revisited.

Imaging of the atrioventricular node using optical coherence tomography.

Enhanced transmural fiber rotation and connexin 43 heterogeneity are associated with an increased upper limit of vulnerability in a transgenic rabbit model of human hypertrophic cardiomyopathy.

Phase I and phase II of short-term mechanical restitution in perfused rat left ventricles.

Mechanical alternans and restitution in failing SHHF rat left ventricles.

Mechanisms of shock-induced arrhythmogenesis during acute global ischemia.

Virtual electrodes in virtual reality of defibrillation.

Anode-break excitation during end-diastolic stimulation is explained by half-cell double layer discharge.

Cx43 and dual-pathway electrophysiology of the atrioventricular node and atrioventricular nodal reentry.

Optical mapping technique applied to biventricular pacing: potential mechanisms of ventricular arrhythmias occurrence.

Nonlinear effects in subthreshold virtual electrode polarization.

Fibrillation or neurillation: back to the future in our concepts of sudden cardiac death?

Shock-induced arrhythmogenesis is enhanced by 2,3-butanedione monoxime compared with cytochalasin D.

Site of origin and molecular substrate of atrioventricular junctional rhythm in the rabbit heart.

Diastolic shocking experience: do virtual electrodes exist only during systole?

Virtual electrode theory explains pacing threshold increase caused by cardiac tissue damage.

Effects of lidocaine on shock-induced vulnerability.

Optical imaging of the heart.

Structure-function relationship in the AV junction.

Dynamics of virtual electrode-induced scroll-wave reentry in a 3D bidomain model.

Functional imaging of the embryonic pacemaking and cardiac conduction system over the past 150 years: technologies to overcome the challenges.

The Gurvich waveform has lower defibrillation threshold than the rectilinear waveform and the truncated exponential waveform in the rabbit heart.

Mechanisms of superiority of ascending ramp waveforms: new insights into mechanisms of shock-induced vulnerability and defibrillation.

Optical coherence tomography imaging of the purkinje network.

Mechanisms of enhanced shock-induced arrhythmogenesis in the rabbit heart with healed myocardial infarction.

Differences between left and right ventricular chamber geometry affect cardiac vulnerability to electric shocks.

Chessboard of atrial fibrillation: reentry or focus? Single or multiple source(s)? Neurogenic or myogenic?

Electroporation of the heart.

Hibernator Citellus undulatus maintains safe cardiac conduction and is protected against tachyarrhythmias during extreme hypothermia: possible role of Cx43 and Cx45 up-regulation.

Optical mapping of the atrioventricular junction.

Fluorescence imaging for real-time monitoring of high-intensity focused ultrasound cardiac ablation.

Three-dimensional anatomy of the conduction system of the early embryonic rabbit heart.

Tornado in a dish: revealing the mechanisms of ventricular arrhythmias in engineered cardiac tissues.

Precordial thump and commotio cordis: the yin and yang of mechanoelectric feedback in the heart.

Mechanisms of unpinning and termination of ventricular tachycardia.

Postganglionic nerve stimulation induces temporal inhibition of excitability in rabbit sinoatrial node.

Gene printer: laser-scanning targeted transfection of cultured cardiac neonatal rat cells.

Present understanding of shock polarity for internal defibrillation: the obvious and non-obvious clinical implications.

Localization of Na+ channel isoforms at the atrioventricular junction and atrioventricular node in the rat.

Connections, connections, connexins: towards systems biology paradigm of cardiac arrhythmia.

Direct measurements of membrane time constant during defibrillation strength shocks.

Effects of sterile pericarditis on connexins 40 and 43 in the atria: correlation with abnormal conduction and atrial arrhythmias.

Application of blebbistatin as an excitation-contraction uncoupler for electrophysiologic study of rat and rabbit hearts.

Atrioventricular conduction with and without AV nodal delay: two pathways to the bundle of His in the rabbit heart.

Innovation in optical imaging: looking inside the heart.

Cloning, sequence analysis and phylogeny of connexin43 isolated from American black bear heart.

Optical coherence tomography as a tool for measuring morphogenetic deformation of the looping heart.

Three-dimensional panoramic imaging of cardiac arrhythmias in rabbit heart.

Autonomic control and innervation of the atrioventricular junctional pacemaker.

Finite element modeling of electric field effects of TASER devices on nerve and muscle.

The role of photon scattering in optical signal distortion during arrhythmia and defibrillation.

Connexin 43 expression delineates two discrete pathways in the human atrioventricular junction.

Computer three-dimensional reconstruction of the atrioventricular node.

Images in cardiovascular medicine. Optical mapping of the human atrioventricular junction.

Atria are more susceptible to electroporation than ventricles: implications for atrial stunning, shock-induced arrhythmia and defibrillation failure.

Effect of electroporation on cardiac electrophysiology.

Spatial distribution and extent of electroporation by strong internal shock in intact structurally normal and chronically infarcted rabbit hearts.

Quantification of cardiac fiber orientation using optical coherence tomography.

Nature versus nurture in cardiac conduction: toward integrative paradigm of cardiac tissue engineering.

Quantitative panoramic imaging of epicardial electrical activity.

Membrane time constant during internal defibrillation strength shocks in intact heart: effects of Na+ and Ca2+ channel blockers.

Electrophysiological mechanisms of antiarrhythmic protection during hypothermia in winter hibernating versus nonhibernating mammals.

Panoramic imaging reveals basic mechanisms of induction and termination of ventricular tachycardia in rabbit heart with chronic infarction: implications for low-voltage cardioversion.

Bimodal biophotonic imaging of the structure-function relationship in cardiac tissue.

Chronaxie of defibrillation: a pathway toward further optimization of defibrillation waveform?

Structural and functional evidence for discrete exit pathways that connect the canine sinoatrial node and atria.

Resolution of established cardiac hypertrophy and fibrosis and prevention of systolic dysfunction in a transgenic rabbit model of human cardiomyopathy through thiol-sensitive mechanisms.

Naum Lazarevich Gurvich (1905-1981) and his contribution to the history of defibrillation.

Multiple monophasic shocks improve electrotherapy of ventricular tachycardia in a rabbit model of chronic infarction.

Transient local injury current in right ventricular electrogram after implantable cardioverter-defibrillator shock predicts heart failure progression.

Differential K(ATP) channel pharmacology in intact mouse heart.

Cardioversion: past, present, and future.

Virtual histology of the human heart using optical coherence tomography.

Enhanced susceptibility to alternans in a rabbit model of chronic myocardial infarction.

Molecular remodeling of ion channels, exchangers and pumps in atrial and ventricular myocytes in ischemic cardiomyopathy.

Transmural dispersion of repolarization in failing and nonfailing human ventricle.

Mapping cardiac pacemaker circuits: methodological puzzles of the sinoatrial node optical mapping.

Anatomy and electrophysiology of the human AV node.

小鼠窦房结功能解剖： 锚 B 杂合性小鼠的高分辨率光学映射。

Mechanisms of fibrillation: neurogenic or myogenic? Reentrant or focal? Multiple or single? Still puzzling after 160 years of inquiry.

Complex interactions between the sinoatrial node and atrium during reentrant arrhythmias in the canine heart.

Optical mapping of the isolated coronary-perfused human sinus node.

Termination of sustained atrial flutter and fibrillation using low-voltage multiple-shock therapy.

Structured light imaging of epicardial mechanics.

Multiscale imaging of the human heart: Building the foundation for human systems physiology and translational medicine.

Transmural heterogeneity and remodeling of ventricular excitation-contraction coupling in human heart failure.

Effects of KATP channel openers diazoxide and pinacidil in coronary-perfused atria and ventricles from failing and non-failing human hearts.

Anatomic localization and autonomic modulation of atrioventricular junctional rhythm in failing human hearts.

Role of Pyk2 in cardiac arrhythmogenesis.

Long-term culture of HL-1 cardiomyocytes in modular poly(ethylene glycol) microsphere-based scaffolds crosslinked in the phase-separated state.

Spatiotemporal control of heart rate in a rabbit heart.

Low-energy multistage atrial defibrillation therapy terminates atrial fibrillation with less energy than a single shock.

The role of dynamic instability and wavelength in arrhythmia maintenance as revealed by panoramic imaging with blebbistatin vs. 2,3-butanedione monoxime.

Longitudinal Study of Cardiac Remodelling in Rabbits Following Infarction.

Three Potential Mechanisms for Failure of HIFU Ablation in Cardiac Tissue.

Quantification of the transmural dynamics of atrial fibrillation by simultaneous endocardial and epicardial optical mapping in an acute sheep model.

Dual Vm/Ca imaging of premature ventricular contractions: bridging the gap of anatomical scales.

Transmural APD gradient synchronizes repolarization in the human left ventricular wall.

Diet-induced obesity promotes altered remodeling and exacerbated cardiac hypertrophy following pressure overload.

A technical review of optical mapping of intracellular calcium within myocardial tissue.

Mitochondrial structure and function are not different between nonfailing donor and end-stage failing human hearts.

Technical advances in studying cardiac electrophysiology - Role of rabbit models.

Optical Mapping of Cardiac Electromechanics.

Letter by Ng and Efimov Regarding Article, "Electrophysiological Effects of Selective Atrial Coronary Artery Occlusion in Humans".

Transient Notch Activation Induces Long-Term Gene Expression Changes Leading to Sick Sinus Syndrome in Mice.

Pathways to clinical CLARITY: volumetric analysis of irregular, soft, and heterogeneous tissues in development and disease.

Capacitively Coupled Arrays of Multiplexed Flexible Silicon Transistors for Long-Term Cardiac Electrophysiology.

Computational assessment of the functional role of sinoatrial node exit pathways in the human heart.

β-adrenergic stimulation augments transmural dispersion of repolarization via modulation of delayed rectifier currents I and I in the human ventricle.

Ventricular Fibrillation: Rotors or Foci? Both!

At the Atrioventricular Crossroads: Dual Pathway Electrophysiology in the Atrioventricular Node and its Underlying Heterogeneities.

RHYTHM: An Open Source Imaging Toolkit for Cardiac Panoramic Optical Mapping.

Left Septal Slow Pathway Ablation for Atrioventricular Nodal Reentrant Tachycardia.

Cardiac connexin genotyping for identification of the circuit of atrioventricular nodal re-entrant tachycardia.

Multiparametric slice culture platform for the investigation of human cardiac tissue physiology.

Irreversible electroporation: Proceed with caution.

Open-Source Multiparametric Optocardiography.

Integrative Functional Annotation of 52 Genetic Loci Influencing Myocardial Mass Identifies Candidate Regulatory Variants and Target Genes.

Sudden Heart Rate Reduction Upon Optogenetic Release of Acetylcholine From Cardiac Parasympathetic Neurons in Perfused Hearts.

Heart Rhythm Society-40th anniversary: A history of success.

Optocardiography: A Review of its Past, Present and Future.

Wireless, battery-free, fully implantable multimodal and multisite pacemakers for applications in small animal models.

Genetic algorithm-based personalized models of human cardiac action potential.