The First Affiliated Hospital
Dr. Libo Zhou is a Postdoctoral Research Associate in the Biomedical Engineering Department, University of Connecticut. Dr. Zhou’s main research project currently is the fabrication and application of novel biomimetic tissue engineering materials, Nano-Matrix, which are self-assembled with Janus DNA based nanotubes and different kinds of biologically active proteins.
She received her ph.D. degree from Jilin University in China with a thesis on the “Mesoporous Carbon Nanospheres as a Multifunctional Carrier for Cancer Theranostics”. She also participated in several projects about the biomedical application of the semiconducting polymer dots at Jilin University. During the last year and a half of her Ph.D. study, she worked at Boston University as a visiting student. Her research is focused on applying semiconducting polymer dots as contrast agents for optical coherence tomography combined with retina volumetric fluorescence angiography and the measurement of flow‐mediated dilation of the mouse femoral artery in vivo by optical coherence tomography.
Anti-Proliferative and Apoptosis-Inducing Effect of Theabrownin against Non-small Cell Lung Adenocarcinoma A549 Cells.
Frontiers in pharmacology , 2016 | Pubmed ID: 27994550
Theabrownin Inhibits Cell Cycle Progression and Tumor Growth of Lung Carcinoma through c-myc-Related Mechanism.
Frontiers in pharmacology , 2017 | Pubmed ID: 28289384
Autologous Stem Cells Combined Core Decompression for Treatment of Avascular Necrosis of the Femoral Head: A Systematic Meta-Analysis.
BioMed research international , 2017 | Pubmed ID: 28840126
Administration of erythropoietin prevents bone loss in osteonecrosis of the femoral head in mice.
Molecular medicine reports Dec, 2017 | Pubmed ID: 29039481
Theabrownin triggers DNA damage to suppress human osteosarcoma U2OS cells by activating p53 signalling pathway.
Journal of cellular and molecular medicine 09, 2018 | Pubmed ID: 29993186
Agkistrodon ameliorates pain response and prevents cartilage degradation in monosodium iodoacetate-induced osteoarthritic rats by inhibiting chondrocyte hypertrophy and apoptosis.
Journal of ethnopharmacology Mar, 2019 | Pubmed ID: 30529425
Intra-Articular Injection of Extract Attenuates Pain Behavior and Cartilage Degeneration in Mono-Iodoacetate Induced Osteoarthritic Rats.
Frontiers in pharmacology , 2018 | Pubmed ID: 30532708
In vivo acute toxicity of detoxified Fuzi (lateral root of Aconitum carmichaeli) after a traditional detoxification process.
EXCLI journal , 2018 | Pubmed ID: 30564068
Chondroprotective effects of platelet lysate towards monoiodoacetate-induced arthritis by suppression of TNF-α-induced activation of NF-ĸB pathway in chondrocytes.
Aging 05, 2019 | Pubmed ID: 31089001
[Mechanisms of tanshinone Ⅱ_A in reducing 4-HNE-induced hepatocyte damage by activating PPARα].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica May, 2019 | Pubmed ID: 31342714
B7-H3 Induces Ovarian Cancer Drugs Resistance Through An PI3K/AKT/BCL-2 Signaling Pathway.
Cancer management and research , 2019 | Pubmed ID: 31819652
Correlation between single nucleotide polymorphisms of DACH1 gene microRNA binding site and susceptibility of patients with endometrial cancer.
Medicine Jun, 2020 | Pubmed ID: 32569224
Evaluation of Long-Time Decoction-Detoxicated (Processed Debeaux Lateral Root With Peel) for Its Acute Toxicity and Therapeutic Effect on Mono-Iodoacetate Induced Osteoarthritis.
Frontiers in pharmacology , 2020 | Pubmed ID: 32848727
Theabrownin Induces Apoptosis and Tumor Inhibition of Hepatocellular Carcinoma Huh7 Cells Through ASK1-JNK-c-Jun Pathway.
OncoTargets and therapy , 2020 | Pubmed ID: 32982289
Theaflavin Induces Apoptosis of A375 Human Melanoma Cells and Inhibits Tumor Growth in Xenograft Zebrafishes Through P53- and JNK-Related Mechanism.
Frontiers in pharmacology , 2020 | Pubmed ID: 32982737
Growth factors-based beneficial effects of platelet lysate on umbilical cord-derived stem cells and their synergistic use in osteoarthritis treatment.
Cell death & disease Oct, 2020 | Pubmed ID: 33057008
Theabrownin inhibits the cytoskeleton‑dependent cell cycle, migration and invasion of human osteosarcoma cells through NF‑κB pathway‑related mechanisms.
Oncology reports Dec, 2020 | Pubmed ID: 33125106
A Novel STAT3-Mediated GATA6 Pathway Contributes to -Butylhydroquinone- (tBHQ-) Protected TNF-Activated Vascular Cell Adhesion Molecule 1 (VCAM-1) in Vascular Endothelium.
Oxidative medicine and cellular longevity , 2020 | Pubmed ID: 33274004
Identification of differentially expressed genes, signaling pathways and immune infiltration in rheumatoid arthritis by integrated bioinformatics analysis.
Hereditas Jan, 2021 | Pubmed ID: 33397492
Ferulic acid alleviates lipotoxicity-induced hepatocellular death through the SIRT1-regulated autophagy pathway and independently of AMPK and Akt in AML-12 hepatocytes.
Nutrition & metabolism Jan, 2021 | Pubmed ID: 33468182
The Anatomical and Clinical Significance of the Superior Laryngeal Nerve.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery Nov, 2021 | Pubmed ID: 33618572
Anti-Proliferative, Pro-Apoptotic, Anti-Migrative and Tumor-Inhibitory Effects and Pleiotropic Mechanism of Theaflavin on B16F10 Melanoma Cells.
OncoTargets and therapy , 2021 | Pubmed ID: 33658796
Axillary lymph node metastasis from papillary thyroid carcinoma with elevated CA 19-9 and CA 242 levels: a case report and literature review.
Gland surgery Mar, 2021 | Pubmed ID: 33842258
Activation of AMP-Activated Protein Kinase-Sirtuin 1 Pathway Contributes to Salvianolic Acid A-Induced Browning of White Adipose Tissue in High-Fat Diet Fed Male Mice.
Frontiers in pharmacology , 2021 | Pubmed ID: 34122060
Urine Metabolomics Profiling of Lumbar Disc Herniation and its Traditional Chinese Medicine Subtypes in Patients Through Gas Chromatography Coupled With Mass Spectrometry.
Frontiers in molecular biosciences , 2021 | Pubmed ID: 34179074
A Systematic Review and Meta-Analysis of the SuperPATH Approach in Hip Arthroplasty.
BioMed research international , 2021 | Pubmed ID: 34337015
China experts' consensus on preventive and interceptive orthodontic treatments of malocclusions of children.
Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology Aug, 2021 | Pubmed ID: 34409791
Pain relief and cartilage repair by Nanofat against osteoarthritis: preclinical and clinical evidence.
Stem cell research & therapy Aug, 2021 | Pubmed ID: 34446107
A Novel Scoring System for Predicting the Metastases of Posterior Right Recurrent Laryngeal Nerve Lymph Node Involvement in Patients With Papillary Thyroid Carcinoma by Preoperative Ultrasound.
Frontiers in endocrinology , 2021 | Pubmed ID: 34531829
Identification and validation of hub genes of synovial tissue for patients with osteoarthritis and rheumatoid arthritis.
Hereditas Sep, 2021 | Pubmed ID: 34583778
A Novel Mutation of the KLK6 Gene in a Family With Knee Osteoarthritis.
Frontiers in genetics , 2021 | Pubmed ID: 34858488
Green tea-derived theabrownin induces cellular senescence and apoptosis of hepatocellular carcinoma through p53 signaling activation and bypassed JNK signaling suppression.
Cancer cell international Jan, 2022 | Pubmed ID: 35078476
Acute Developmental Toxicity of Panax notoginseng in Zebrafish Larvae.
Chinese journal of integrative medicine Apr, 2023 | Pubmed ID: 35089525
Green tea-derived theabrownin suppresses human non-small cell lung carcinoma in xenograft model through activation of not only p53 signaling but also MAPK/JNK signaling pathway.
Journal of ethnopharmacology Jun, 2022 | Pubmed ID: 35271947
Growth factors-based platelet lysate rejuvenates skin against ageing through NF-κB signalling pathway: In vitro and in vivo mechanistic and clinical studies.
Cell proliferation Apr, 2022 | Pubmed ID: 35274780
Tanshinol suppresses osteosarcoma by specifically inducing apoptosis of U2-OS cells through p53-mediated mechanism.
Journal of ethnopharmacology Jun, 2022 | Pubmed ID: 35331874
Fuzi decoction ameliorates pain and cartilage degeneration of osteoarthritic rats through PI3K-Akt signaling pathway and its clinical retrospective evidence.
Phytomedicine : international journal of phytotherapy and phytopharmacology Jun, 2022 | Pubmed ID: 35378415
Intra-Articular Injection of Adipose-Derived Stem Cells Ameliorates Pain and Cartilage Anabolism/Catabolism in Osteoarthritis: Preclinical and Clinical Evidences.
Frontiers in pharmacology , 2022 | Pubmed ID: 35387326
Sclareol ameliorates hyperglycemia-induced renal injury through inhibiting the MAPK/NF-κB signaling pathway.
Phytotherapy research : PTR Jun, 2022 | Pubmed ID: 35434887
Human umbilical cord-derived mesenchymal stem cells not only ameliorate blood glucose but also protect vascular endothelium from diabetic damage through a paracrine mechanism mediated by MAPK/ERK signaling.
Stem cell research & therapy Jun, 2022 | Pubmed ID: 35715841
Onset of p53/NF-κB signaling crosstalk in human melanoma cells in response to anti-cancer theabrownin.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Aug, 2022 | Pubmed ID: 35779042
Human Umbilical Cord-Derived Mesenchymal Stem Cells Ameliorate Skin Aging of Nude Mice Through Autophagy-Mediated Anti-Senescent Mechanism.
Stem cell reviews and reports Aug, 2022 | Pubmed ID: 35864432
CysLTR Antagonist HAMI 3379 Ameliorates Post-Stroke Depression through NLRP3 Inflammasome/Pyroptosis Pathway in Gerbils.
Brain sciences Jul, 2022 | Pubmed ID: 35892417
Circulating exo-miR-154-5p regulates vascular dementia through endothelial progenitor cell-mediated angiogenesis.
Frontiers in cellular neuroscience , 2022 | Pubmed ID: 35966195
Auricular acupressure for adverse events following immunization after COVID-19 vaccine injection: A multicentre, blinded, randomized controlled trial.
Complementary therapies in medicine Dec, 2022 | Pubmed ID: 36372315
Intra-articular injection of placental mesenchymal stromal cells ameliorates pain and cartilage anabolism/catabolism in knee osteoarthritis.
Frontiers in pharmacology , 2022 | Pubmed ID: 36523496
Nanofat lysate ameliorates pain and cartilage degradation of osteoarthritis through activation of TGF-β-Smad2/3 signaling of chondrocytes.
Frontiers in pharmacology , 2023 | Pubmed ID: 37050907
Haiyan Zhang*,1,
Ronghua Bao*,2,
Jiaan Xu3,
Yanzhi Ge4,
Zuxiang Chen1,
Mengqiang Fan1,
Guangping Yu5,
Li Zhou1,
Le Guo3,
Letian Shan1,
Hangxing Bao1
1The First Affiliated Hospital, Zhejiang Chinese Medical University,
2Fuyang Orthopaedics and Traumatology Affiliated Hospital, Zhejiang Chinese Medical University,
3College of Pharmaceutical Science, Zhejiang Chinese Medical University,
4Affiliated Zhejiang Hospital, Zhejiang University School of Medicine,
5, Xianju County Hospital of Chinese Medicine
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