Degrees and relevant experience MD, Université de Sherbrooke (1980) • Msc physiology Université de Sherbrooke (1983) • Postdoctoral training, University of California, San Francisco, USA (1983-1986) • Assistant and associate professor Faculty of medicine, University of Calgary (1986- 1992) • Researcher at research center of the Centre Hospitalier de l’Université de Montréal (1992-2012) • Member of the pulmonary division (1992- 2019) and of the Adult Cystic Fibrosis Clinic (1994 - 2019 ), Centre Hospitalier de l’Université de Montréal. Director clinic and clinical research (2012-2019) Institut de recherches cliniques de Montréal.
Research interest • His research interests focus on the role of lung epithelial cells in the pathophysiology of diseases such as cystic fibrosis or pulmonary oedema. More specifically, he is working to shed light on the interaction between the inflammatory response and epithelial dysfunction in these diseases. More recently, he has also explored the inflammatory response in cystic fibrosis and more specifically its interaction with the development of cystic fibrosis related diabetes. Funding from CIHR and Cystic Fibrosis Canada, has supported his research since 1986. He has published more than 125 papers and supervised numerous students (>25).
Lung edema clearance: 20 years of progress: invited review: alveolar edema fluid clearance in the injured lung.
Journal of applied physiology (Bethesda, Md. : 1985) Dec, 2002 | Pubmed ID: 12433940
The alveolar type I cells: the new knight of the alveolus?
The Journal of physiology May, 2006 | Pubmed ID: 16543260
Alveolar edema fluid clearance and acute lung injury.
Respiratory physiology & neurobiology Dec, 2007 | Pubmed ID: 17604701
Cycloheximide and lipopolysaccharide downregulate αENaC mRNA via different mechanisms in alveolar epithelial cells.
American journal of physiology. Lung cellular and molecular physiology Nov, 2013 | Pubmed ID: 24039256
Oxidative stress modulates the expression of genes involved in cell survival in ΔF508 cystic fibrosis airway epithelial cells.
Physiological genomics Sep, 2014 | Pubmed ID: 24893876
Deleterious impact of hyperglycemia on cystic fibrosis airway ion transport and epithelial repair.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society Jan, 2016 | Pubmed ID: 25920899
Alveolar liquid clearance in lung injury: Evaluation of the impairment of the β-adrenergic agonist response in an ischemia-reperfusion lung injury model.
Respiratory physiology & neurobiology 01, 2019 | Pubmed ID: 30171906
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