BHF Centre of Research Excellence,
Division of Cardiovascular Medicine,
Radcliffe Department of Medicine,
John Radcliffe Hospital,
Wellcome Centre for Human Genetics,
BHF Centre of Research Excellence, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital
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Coronary artery aneurysm rupture mimicking dissection of the thoracic aorta.
International journal of cardiology Jun, 1998 | Pubmed ID: 9699940
Giant coronary artery aneurysm presenting as a mediastinal mass.
The American journal of cardiology Nov, 1998 | Pubmed ID: 9832118
Nitric oxide synthase in atherosclerosis and vascular injury: insights from experimental gene therapy.
Arteriosclerosis, thrombosis, and vascular biology Aug, 2000 | Pubmed ID: 10938006
Mechanisms of superoxide production in human blood vessels: relationship to endothelial dysfunction, clinical and genetic risk factors.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society Dec, 2002 | Pubmed ID: 12512689
Tetrahydrobiopterin-dependent preservation of nitric oxide-mediated endothelial function in diabetes by targeted transgenic GTP-cyclohydrolase I overexpression.
The Journal of clinical investigation Sep, 2003 | Pubmed ID: 12952921
Tetrahydrobiopterin: regulator of endothelial nitric oxide synthase in vascular disease.
Trends in cardiovascular medicine Nov, 2004 | Pubmed ID: 15596110
Radiochemical HPLC detection of arginine metabolism: measurement of nitric oxide synthesis and arginase activity in vascular tissue.
Nitric oxide : biology and chemistry Feb, 2007 | Pubmed ID: 16647284
Functional and structural vascular remodeling in elite rowers assessed by cardiovascular magnetic resonance.
Journal of the American College of Cardiology Aug, 2006 | Pubmed ID: 16904551
5-methyltetrahydrofolate rapidly improves endothelial function and decreases superoxide production in human vessels: effects on vascular tetrahydrobiopterin availability and endothelial nitric oxide synthase coupling.
Circulation Sep, 2006 | Pubmed ID: 16940192
Membrane-bound CC chemokine inhibitor 35K provides localized inhibition of CC chemokine activity in vitro and in vivo.
Journal of immunology (Baltimore, Md. : 1950) Oct, 2006 | Pubmed ID: 17015744
Increased in-stent stenosis in ApoE knockout mice: insights from a novel mouse model of balloon angioplasty and stenting.
Arteriosclerosis, thrombosis, and vascular biology Apr, 2007 | Pubmed ID: 17204666
Gene transfer of neuronal nitric oxide synthase into intracardiac Ganglia reverses vagal impairment in hypertensive rats.
Hypertension (Dallas, Tex. : 1979) Feb, 2007 | Pubmed ID: 17210833
Endothelial Nox2 overexpression potentiates vascular oxidative stress and hemodynamic response to angiotensin II: studies in endothelial-targeted Nox2 transgenic mice.
Circulation research Apr, 2007 | Pubmed ID: 17363703
Global improvement of vascular function and redox state with low-dose folic acid: implications for folate therapy in patients with coronary artery disease.
Circulation May, 2007 | Pubmed ID: 17420345
Multi-modal magnetic resonance imaging quantifies atherosclerosis and vascular dysfunction in patients with type 2 diabetes mellitus.
Diabetes & vascular disease research Mar, 2007 | Pubmed ID: 17469043
Delivery and long-term expression of a 135 kb LDLR genomic DNA locus in vivo by hydrodynamic tail vein injection.
The journal of gene medicine Jun, 2007 | Pubmed ID: 17471590
Effect of distal embolization on myocardial perfusion reserve after percutaneous coronary intervention: a quantitative magnetic resonance perfusion study.
Circulation Sep, 2007 | Pubmed ID: 17785626
In vivo magnetic resonance imaging of acute brain inflammation using microparticles of iron oxide.
Nature medicine Oct, 2007 | Pubmed ID: 17891147
Images in cardiovascular medicine. Optical coherence tomography in the setting of an acute anterior myocardial infarction.
Circulation Oct, 2007 | Pubmed ID: 17909111
Magnetic resonance imaging of endothelial adhesion molecules in mouse atherosclerosis using dual-targeted microparticles of iron oxide.
Arteriosclerosis, thrombosis, and vascular biology Jan, 2008 | Pubmed ID: 17962629
Early changes in arterial structure and function following statin initiation: quantification by magnetic resonance imaging.
Atherosclerosis Apr, 2008 | Pubmed ID: 17977546
Altered plasma versus vascular biopterins in human atherosclerosis reveal relationships between endothelial nitric oxide synthase coupling, endothelial function, and inflammation.
Circulation Dec, 2007 | Pubmed ID: 18040031
Galectin-3 is an amplifier of inflammation in atherosclerotic plaque progression through macrophage activation and monocyte chemoattraction.
Arteriosclerosis, thrombosis, and vascular biology Mar, 2008 | Pubmed ID: 18096829
Uncomplicated obesity is associated with abnormal aortic function assessed by cardiovascular magnetic resonance.
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance Feb, 2008 | Pubmed ID: 18275595
Impaired synaptic plasticity and motor learning in mice with a point mutation implicated in human speech deficits.
Current biology : CB Mar, 2008 | Pubmed ID: 18328704
Abnormal sympathoadrenal development and systemic hypotension in PHD3-/- mice.
Molecular and cellular biology May, 2008 | Pubmed ID: 18332118
A commonly occurring polymorphism upstream of the estrogen receptor alpha alters transcription and is associated with increased HDL.
Atherosclerosis Aug, 2008 | Pubmed ID: 18367190
Reversal of cardiac hypertrophy and fibrosis from pressure overload by tetrahydrobiopterin: efficacy of recoupling nitric oxide synthase as a therapeutic strategy.
Circulation May, 2008 | Pubmed ID: 18474817
Visualization of activated platelets by targeted magnetic resonance imaging utilizing conformation-specific antibodies against glycoprotein IIb/IIIa.
Journal of vascular research , 2009 | Pubmed ID: 18515970
GCH1 haplotype determines vascular and plasma biopterin availability in coronary artery disease effects on vascular superoxide production and endothelial function.
Journal of the American College of Cardiology Jul, 2008 | Pubmed ID: 18598896
CCR2-mediated antiinflammatory effects of endothelial tetrahydrobiopterin inhibit vascular injury-induced accelerated atherosclerosis.
Circulation Sep, 2008 | Pubmed ID: 18824773
Quantitative regulation of intracellular endothelial nitric-oxide synthase (eNOS) coupling by both tetrahydrobiopterin-eNOS stoichiometry and biopterin redox status: insights from cells with tet-regulated GTP cyclohydrolase I expression.
The Journal of biological chemistry Jan, 2009 | Pubmed ID: 19011239
The effect of alpha-synuclein knockdown on MPP+ toxicity in models of human neurons.
The European journal of neuroscience Dec, 2008 | Pubmed ID: 19032594
Relation of preoperative radial artery flow-mediated dilatation to nitric oxide bioavailability in radial artery grafts used in off-pump coronary artery bypass grafting.
The American journal of cardiology Jan, 2009 | Pubmed ID: 19121439
Targeting redox signaling in the vascular wall: from basic science to clinical practice.
Current pharmaceutical design , 2009 | Pubmed ID: 19149622
GTP cyclohydrolase I expression, protein, and activity determine intracellular tetrahydrobiopterin levels, independent of GTP cyclohydrolase feedback regulatory protein expression.
The Journal of biological chemistry May, 2009 | Pubmed ID: 19286659
Association of plasma asymmetrical dimethylarginine (ADMA) with elevated vascular superoxide production and endothelial nitric oxide synthase uncoupling: implications for endothelial function in human atherosclerosis.
European heart journal May, 2009 | Pubmed ID: 19297385
L-arginine supplementation reduces cardiac noradrenergic neurotransmission in spontaneously hypertensive rats.
Journal of molecular and cellular cardiology Jul, 2009 | Pubmed ID: 19362092
MTHFR 677 C>T Polymorphism reveals functional importance for 5-methyltetrahydrofolate, not homocysteine, in regulation of vascular redox state and endothelial function in human atherosclerosis.
Circulation May, 2009 | Pubmed ID: 19398669
Critical role for tetrahydrobiopterin recycling by dihydrofolate reductase in regulation of endothelial nitric-oxide synthase coupling: relative importance of the de novo biopterin synthesis versus salvage pathways.
The Journal of biological chemistry Oct, 2009 | Pubmed ID: 19666465
Preoperative sCD40L levels predict risk of atrial fibrillation after off-pump coronary artery bypass graft surgery.
Circulation Sep, 2009 | Pubmed ID: 19752364
Adverse ventricular remodeling and exacerbated NOS uncoupling from pressure-overload in mice lacking the beta3-adrenoreceptor.
Journal of molecular and cellular cardiology Nov, 2009 | Pubmed ID: 19766235
Reproducibility and accuracy of automated measurement for dynamic arterial lumen area by cardiovascular magnetic resonance.
The international journal of cardiovascular imaging Dec, 2009 | Pubmed ID: 19779977
Effects of high-dose modified-release nicotinic acid on atherosclerosis and vascular function: a randomized, placebo-controlled, magnetic resonance imaging study.
Journal of the American College of Cardiology Nov, 2009 | Pubmed ID: 19874992
Intimal dissection causing late thrombosis of a covered stent: optical coherence tomography appearances.
Circulation. Cardiovascular interventions Aug, 2009 | Pubmed ID: 20031740
Tetrahydrobiopterin (BH4), a cofactor for nNOS, restores gastric emptying and nNOS expression in female diabetic rats.
American journal of physiology. Gastrointestinal and liver physiology May, 2010 | Pubmed ID: 20185690
Inflammatory cell recruitment in cardiovascular disease: murine models and potential clinical applications.
Clinical science (London, England : 1979) Mar, 2010 | Pubmed ID: 20210786
Cardiac myocyte-specific overexpression of human GTP cyclohydrolase I protects against acute cardiac allograft rejection.
American journal of physiology. Heart and circulatory physiology Jul, 2010 | Pubmed ID: 20418482
Tetrahydrobiopterin: pleiotropic roles in cardiovascular pathophysiology.
Heart (British Cardiac Society) Dec, 2010 | Pubmed ID: 20837663
Preoperative atorvastatin treatment in CABG patients rapidly improves vein graft redox state by inhibition of Rac1 and NADPH-oxidase activity.
Circulation Sep, 2010 | Pubmed ID: 20837928
GTP cyclohydrolase I/BH4 pathway protects EPCs via suppressing oxidative stress and thrombospondin-1 in salt-sensitive hypertension.
Hypertension (Dallas, Tex. : 1979) Dec, 2010 | Pubmed ID: 21059996
Dihydrofolate reductase protects endothelial nitric oxide synthase from uncoupling in tetrahydrobiopterin deficiency.
Free radical biology & medicine Jun, 2011 | Pubmed ID: 21402147
Dynamic changes of edema and late gadolinium enhancement after acute myocardial infarction and their relationship to functional recovery and salvage index.
Circulation. Cardiovascular imaging May, 2011 | Pubmed ID: 21447711
Optical coherence tomography-guided stenting of a large coronary aneurysm: images at implantation and at 6 months.
The Journal of invasive cardiology Apr, 2011 | Pubmed ID: 21474852
Synthesis and recycling of tetrahydrobiopterin in endothelial function and vascular disease.
Nitric oxide : biology and chemistry Aug, 2011 | Pubmed ID: 21550412
Site-directed mutagenesis of the CC chemokine binding protein 35K-Fc reveals residues essential for activity and mutations that increase the potency of CC chemokine blockade.
Molecular pharmacology Aug, 2011 | Pubmed ID: 21586597
Radial artery graft string sign due to lumen obliteration by neointima: insight from optical coherence tomography.
JACC. Cardiovascular interventions May, 2011 | Pubmed ID: 21596334
Loss of NRF2 impairs gastric nitrergic stimulation and function.
Free radical biology & medicine Aug, 2011 | Pubmed ID: 21605664
Bi-modal dose-dependent cardiac response to tetrahydrobiopterin in pressure-overload induced hypertrophy and heart failure.
Journal of molecular and cellular cardiology Oct, 2011 | Pubmed ID: 21645517
The insulin-like growth factor-1 receptor is a negative regulator of nitric oxide bioavailability and insulin sensitivity in the endothelium.
Diabetes Aug, 2011 | Pubmed ID: 21677284
Rapid, direct effects of statin treatment on arterial redox state and nitric oxide bioavailability in human atherosclerosis via tetrahydrobiopterin-mediated endothelial nitric oxide synthase coupling.
Circulation Jul, 2011 | Pubmed ID: 21730307
OCT characteristics of saphenous vein graft atherosclerosis.
JACC. Cardiovascular imaging Jul, 2011 | Pubmed ID: 21757173
Atrial sources of reactive oxygen species vary with the duration and substrate of atrial fibrillation: implications for the antiarrhythmic effect of statins.
Circulation Sep, 2011 | Pubmed ID: 21844076
Treatment of recurrent vein graft "stent-in-stent" re-stenosis guided by optical coherence tomography.
International journal of cardiology Apr, 2012 | Pubmed ID: 21880385
Induction of vascular GTP-cyclohydrolase I and endogenous tetrahydrobiopterin synthesis protect against inflammation-induced endothelial dysfunction in human atherosclerosis.
Circulation Oct, 2011 | Pubmed ID: 21969008
Multimodal cardiovascular magnetic resonance quantifies regional variation in vascular structure and function in patients with coronary artery disease: relationships with coronary disease severity.
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance Oct, 2011 | Pubmed ID: 22017860
Therapeutic strategies targeting endothelial function in humans: clinical implications.
Current vascular pharmacology Jan, 2012 | Pubmed ID: 22112349
Myocardial redox state predicts in-hospital clinical outcome after cardiac surgery effects of short-term pre-operative statin treatment.
Journal of the American College of Cardiology Jan, 2012 | Pubmed ID: 22192670
Regulation of β-adrenergic control of heart rate by GTP-cyclohydrolase 1 (GCH1) and tetrahydrobiopterin.
Cardiovascular research Mar, 2012 | Pubmed ID: 22241166
Endothelial-specific Nox2 overexpression increases vascular superoxide and macrophage recruitment in ApoE⁻/⁻ mice.
Cardiovascular research Apr, 2012 | Pubmed ID: 22287576
Systemic and vascular oxidation limits the efficacy of oral tetrahydrobiopterin treatment in patients with coronary artery disease.
Circulation Mar, 2012 | Pubmed ID: 22315282
Statins and vein graft failure in coronary bypass surgery.
Current opinion in pharmacology Apr, 2012 | Pubmed ID: 22326889
Lines of Zahn in coronary artery thrombus.
European heart journal May, 2012 | Pubmed ID: 22345124
A leukocyte-mimetic magnetic resonance imaging contrast agent homes rapidly to activated endothelium and tracks with atherosclerotic lesion macrophage content.
Arteriosclerosis, thrombosis, and vascular biology Jun, 2012 | Pubmed ID: 22499989
Novel role of the IGF-1 receptor in endothelial function and repair: studies in endothelium-targeted IGF-1 receptor transgenic mice.
Diabetes Sep, 2012 | Pubmed ID: 22733797
Cardiomyocyte GTP cyclohydrolase 1 and tetrahydrobiopterin increase NOS1 activity and accelerate myocardial relaxation.
Circulation research Aug, 2012 | Pubmed ID: 22798524
Angiogenesis in the infarcted myocardium.
Antioxidants & redox signaling Mar, 2013 | Pubmed ID: 22870932
Endothelial cell repopulation after stenting determines in-stent neointima formation: effects of bare-metal vs. drug-eluting stents and genetic endothelial cell modification.
European heart journal Sep, 2012 | Pubmed ID: 23008511
The role of tetrahydrobiopterin in inflammation and cardiovascular disease.
Thrombosis and haemostasis Nov, 2012 | Pubmed ID: 23052970
Integrated redox sensor and effector functions for tetrahydrobiopterin- and glutathionylation-dependent endothelial nitric-oxide synthase uncoupling.
The Journal of biological chemistry Jan, 2013 | Pubmed ID: 23139420
Tetrahydrobiopterin: a vascular redox target to improve endothelial function.
Current vascular pharmacology Nov, 2012 | Pubmed ID: 23259560
Living without creatine: unchanged exercise capacity and response to chronic myocardial infarction in creatine-deficient mice.
Circulation research Mar, 2013 | Pubmed ID: 23325497
Nox2 NADPH oxidase has a critical role in insulin resistance-related endothelial cell dysfunction.
Diabetes Jun, 2013 | Pubmed ID: 23349484
Relationship of plasma neuropeptide Y with angiographic, electrocardiographic and coronary physiology indices of reperfusion during ST elevation myocardial infarction.
Heart (British Cardiac Society) Aug, 2013 | Pubmed ID: 23403409
A real time chemotaxis assay unveils unique migratory profiles amongst different primary murine macrophages.
PloS one , 2013 | Pubmed ID: 23516549
Artifactual elevation of plasma sCD40L by residual platelets in patients with coronary artery disease.
International journal of cardiology Sep, 2013 | Pubmed ID: 23578897
Maintenance of endothelial guanosine triphosphate cyclohydrolase I ameliorates diabetic nephropathy.
Journal of the American Society of Nephrology : JASN Jun, 2013 | Pubmed ID: 23620395
Interactions between vascular wall and perivascular adipose tissue reveal novel roles for adiponectin in the regulation of endothelial nitric oxide synthase function in human vessels.
Circulation Jun, 2013 | Pubmed ID: 23625959
The downstream regulation of chemokine receptor signalling: implications for atherosclerosis.
Mediators of inflammation , 2013 | Pubmed ID: 23690662
A pivotal role for tryptophan 447 in enzymatic coupling of human endothelial nitric oxide synthase (eNOS): effects on tetrahydrobiopterin-dependent catalysis and eNOS dimerization.
The Journal of biological chemistry Oct, 2013 | Pubmed ID: 23965989
Tetrahydrobiopterin determines vascular remodeling through enhanced endothelial cell survival and regeneration.
Circulation Sep, 2013 | Pubmed ID: 24030421
Statins as regulators of redox state in the vascular endothelium: beyond lipid lowering.
Antioxidants & redox signaling Mar, 2014 | Pubmed ID: 24111702
Early change in invasive measures of microvascular function can predict myocardial recovery following PCI for ST-elevation myocardial infarction.
European heart journal Aug, 2014 | Pubmed ID: 24135835
A GCH1 haplotype confers sex-specific susceptibility to pain crises and altered endothelial function in adults with sickle cell anemia.
American journal of hematology Feb, 2014 | Pubmed ID: 24136375
α-Synuclein and mitochondrial bioenergetics regulate tetrahydrobiopterin levels in a human dopaminergic model of Parkinson disease.
Free radical biology & medicine Feb, 2014 | Pubmed ID: 24148766
Tetrahydrobiopterin in cardiovascular health and disease.
Antioxidants & redox signaling Jun, 2014 | Pubmed ID: 24294830
Statins: pleiotropic regulators of cardiovascular redox state.
Antioxidants & redox signaling Mar, 2014 | Pubmed ID: 24409984
GTP cyclohydrolase I prevents diabetic-impaired endothelial progenitor cells and wound healing by suppressing oxidative stress/thrombospondin-1.
American journal of physiology. Endocrinology and metabolism May, 2014 | Pubmed ID: 24644242
Cell-autonomous role of endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation.
Hypertension (Dallas, Tex. : 1979) Sep, 2014 | Pubmed ID: 24777984
Endothelial cell-specific reactive oxygen species production increases susceptibility to aortic dissection.
Circulation Jun, 2014 | Pubmed ID: 24807872
Human CD68 promoter GFP transgenic mice allow analysis of monocyte to macrophage differentiation in vivo.
Blood Oct, 2014 | Pubmed ID: 25030063
Overexpression of GTP cyclohydrolase 1 feedback regulatory protein is protective in a murine model of septic shock.
Shock (Augusta, Ga.) Nov, 2014 | Pubmed ID: 25046538
Reciprocal effects of systemic inflammation and brain natriuretic peptide on adiponectin biosynthesis in adipose tissue of patients with ischemic heart disease.
Arteriosclerosis, thrombosis, and vascular biology Sep, 2014 | Pubmed ID: 25060790
Contrasting in vitro vs. in vivo effects of a cell membrane-specific CC-chemokine binding protein on macrophage chemotaxis.
Journal of molecular medicine (Berlin, Germany) Nov, 2014 | Pubmed ID: 25077938
Fractalkine promotes human monocyte survival via a reduction in oxidative stress.
Arteriosclerosis, thrombosis, and vascular biology Dec, 2014 | Pubmed ID: 25359863
Crucial role for neuronal nitric oxide synthase in early microcirculatory derangement and recipient survival following murine pancreas transplantation.
PloS one , 2014 | Pubmed ID: 25389974
Parkinson's disease in GTP cyclohydrolase 1 mutation carriers.
Brain : a journal of neurology May, 2015 | Pubmed ID: 25398233
Impact of microvascular obstruction on the assessment of coronary flow reserve, index of microcirculatory resistance, and fractional flow reserve after ST-segment elevation myocardial infarction.
Journal of the American College of Cardiology Nov, 2014 | Pubmed ID: 25444143
Regulation of iNOS function and cellular redox state by macrophage Gch1 reveals specific requirements for tetrahydrobiopterin in NRF2 activation.
Free radical biology & medicine Feb, 2015 | Pubmed ID: 25451639
Adiponectin as a link between type 2 diabetes and vascular NADPH oxidase activity in the human arterial wall: the regulatory role of perivascular adipose tissue.
Diabetes Jun, 2015 | Pubmed ID: 25552596
A requirement for Gch1 and tetrahydrobiopterin in embryonic development.
Developmental biology Mar, 2015 | Pubmed ID: 25557619
Effects of tetrahydrobiopterin oral treatment in hypoxia-induced pulmonary hypertension in rat.
Pulmonary circulation Sep, 2014 | Pubmed ID: 25621160
Tetrahydrobiopterin and alkylglycerol monooxygenase substantially alter the murine macrophage lipidome.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2015 | Pubmed ID: 25675482
RGS1 regulates myeloid cell accumulation in atherosclerosis and aortic aneurysm rupture through altered chemokine signalling.
Nature communications Mar, 2015 | Pubmed ID: 25782711
A Randomized Trial of External Stenting for Saphenous Vein Grafts in Coronary Artery Bypass Grafting.
The Annals of thoracic surgery Jun, 2015 | Pubmed ID: 25886810
Redox biomarkers in cardiovascular medicine.
European heart journal Jul, 2015 | Pubmed ID: 25888005
Acute myocardial infarction activates distinct inflammation and proliferation pathways in circulating monocytes, prior to recruitment, and identified through conserved transcriptional responses in mice and humans.
European heart journal Aug, 2015 | Pubmed ID: 25982896
Reducing In-Stent Restenosis: Therapeutic Manipulation of miRNA in Vascular Remodeling and Inflammation.
Journal of the American College of Cardiology Jun, 2015 | Pubmed ID: 26022821
Reduction of Neuropathic and Inflammatory Pain through Inhibition of the Tetrahydrobiopterin Pathway.
Neuron Jun, 2015 | Pubmed ID: 26087165
Flow patterns in externally stented saphenous vein grafts and development of intimal hyperplasia.
The Journal of thoracic and cardiovascular surgery Oct, 2015 | Pubmed ID: 26242834
How does coronary stent implantation impact on the status of the microcirculation during primary percutaneous coronary intervention in patients with ST-elevation myocardial infarction?
European heart journal Dec, 2015 | Pubmed ID: 26254178
Endothelial cell tetrahydrobiopterin deficiency attenuates LPS-induced vascular dysfunction and hypotension.
Vascular pharmacology Feb, 2016 | Pubmed ID: 26276526
Zero-Flow Pressure Measured Immediately After Primary Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction Provides the Best Invasive Index for Predicting the Extent of Myocardial Infarction at 6 Months: An OxAMI Study (Oxford Acute Myocardial Infarction).
JACC. Cardiovascular interventions Sep, 2015 | Pubmed ID: 26404192
Activation of endothelial NAD(P)H oxidase accelerates early glomerular injury in diabetic mice.
Laboratory investigation; a journal of technical methods and pathology Jan, 2016 | Pubmed ID: 26552047
Hydrodynamic Gene Delivery of CC Chemokine Binding Fc Fusion Proteins to Target Acute Vascular Inflammation In Vivo.
Scientific reports Dec, 2015 | Pubmed ID: 26620767
OCT imaging of aorto-coronary vein graft pathology modified by external stenting: 1-year post-surgery.
European heart journal. Cardiovascular Imaging Nov, 2016 | Pubmed ID: 26628615
Markers of achievement for assessing and monitoring gender equity in translational research organisations: a rationale and study protocol.
BMJ open Jan, 2016 | Pubmed ID: 26743702
Mutual Regulation of Epicardial Adipose Tissue and Myocardial Redox State by PPAR-γ/Adiponectin Signalling.
Circulation research Mar, 2016 | Pubmed ID: 26838789
Tetrahydrobiopterin Protects Against Hypertrophic Heart Disease Independent of Myocardial Nitric Oxide Synthase Coupling.
Journal of the American Heart Association Mar, 2016 | Pubmed ID: 27001967
A global call for action to include gender in research impact assessment.
Health research policy and systems Jul, 2016 | Pubmed ID: 27432056
Association of Maternal Antiangiogenic Profile at Birth With Early Postnatal Loss of Microvascular Density in Offspring of Hypertensive Pregnancies.
Hypertension (Dallas, Tex. : 1979) 09, 2016 | Pubmed ID: 27456522
Refining the Enrolment Process in Emergency Medicine Research.
The European journal of cardiovascular medicine Apr, 2016 | Pubmed ID: 27499840
Acute exposure to apolipoprotein A1 inhibits macrophage chemotaxis in vitro and monocyte recruitment in vivo.
eLife 08, 2016 | Pubmed ID: 27572261
Episomal Nonviral Gene Therapy Vectors Slow Progression of Atherosclerosis in a Model of Familial Hypercholesterolemia.
Molecular therapy. Nucleic acids Nov, 2016 | Pubmed ID: 27824334
Tracking Monocyte Recruitment and Macrophage Accumulation in Atherosclerotic Plaque Progression Using a Novel hCD68GFP/ApoE-/- Reporter Mouse-Brief Report.
Arteriosclerosis, thrombosis, and vascular biology Feb, 2017 | Pubmed ID: 27908893
The influence of coronary plaque morphology assessed by optical coherence tomography on final microvascular function after stenting in patients with ST-elevation myocardial infarction.
Coronary artery disease May, 2017 | Pubmed ID: 27926579
Splenic T1-mapping: a novel quantitative method for assessing adenosine stress adequacy for cardiovascular magnetic resonance.
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance Jan, 2017 | Pubmed ID: 28081721
A novel role for endothelial tetrahydrobiopterin in mitochondrial redox balance.
Free radical biology & medicine 03, 2017 | Pubmed ID: 28104455
A key role for tetrahydrobiopterin-dependent endothelial NOS regulation in resistance arteries: studies in endothelial cell tetrahydrobiopterin-deficient mice.
British journal of pharmacology 04, 2017 | Pubmed ID: 28128438
The Subcellular Localisation of Neuronal Nitric Oxide Synthase Determines the Downstream Effects of NO on Myocardial Function.
Cardiovascular research 03, 2017 | Pubmed ID: 28158509
A Genomic DNA Reporter Screen Identifies Squalene Synthase Inhibitors That Act Cooperatively with Statins to Upregulate the Low-Density Lipoprotein Receptor.
The Journal of pharmacology and experimental therapeutics 06, 2017 | Pubmed ID: 28360334
Predictive value of telomere length on outcome following acute myocardial infarction: evidence for contrasting effects of vascular vs. blood oxidative stress.
European heart journal Nov, 2017 | Pubmed ID: 28444175
Linking noise to cardiovascular disease pathogenesis.
European heart journal 10, 2017 | Pubmed ID: 28633421
A novel workflow combining plaque imaging, plaque and plasma proteomics identifies biomarkers of human coronary atherosclerotic plaque disruption.
Clinical proteomics , 2017 | Pubmed ID: 28642677
Metabolic Regulation of Adipose Tissue Macrophage Function in Obesity and Diabetes.
Antioxidants & redox signaling 07, 2018 | Pubmed ID: 28661198
Detecting human coronary inflammation by imaging perivascular fat.
Science translational medicine 07, 2017 | Pubmed ID: 28701474
Maximising value from a United Kingdom Biomedical Research Centre: study protocol.
Health research policy and systems Aug, 2017 | Pubmed ID: 28806989
Endothelium-derived extracellular vesicles promote splenic monocyte mobilization in myocardial infarction.
JCI insight 09, 2017 | Pubmed ID: 28878126
Mammalian γ2 AMPK regulates intrinsic heart rate.
Nature communications 11, 2017 | Pubmed ID: 29097735
Index of Microcirculatory Resistance at the Time of Primary Percutaneous Coronary Intervention Predicts Early Cardiac Complications: Insights From the OxAMI (Oxford Study in Acute Myocardial Infarction) Cohort.
Journal of the American Heart Association Nov, 2017 | Pubmed ID: 29113999
3D reconstruction of coronary arteries from 2D angiographic projections using non-uniform rational basis splines (NURBS) for accurate modelling of coronary stenoses.
PloS one , 2018 | Pubmed ID: 29298341
Gadolinium-Free Cardiac MR Stress T1-Mapping to Distinguish Epicardial From Microvascular Coronary Disease.
Journal of the American College of Cardiology 03, 2018 | Pubmed ID: 29495995
Diagnosis of Microvascular Angina Using Cardiac Magnetic Resonance.
Journal of the American College of Cardiology 03, 2018 | Pubmed ID: 29495996
Effects Of Endothelin-1 On Intracellular Tetrahydrobiopterin Levels In Vascular Tissue.
Scandinavian cardiovascular journal : SCJ 06, 2018 | Pubmed ID: 29566572
Roles for endothelial cell and macrophage Gch1 and tetrahydrobiopterin in atherosclerosis progression.
Cardiovascular research 08, 2018 | Pubmed ID: 29596571
Metabolomic Profiling in Acute ST-Segment-Elevation Myocardial Infarction Identifies Succinate as an Early Marker of Human Ischemia-Reperfusion Injury.
Journal of the American Heart Association 04, 2018 | Pubmed ID: 29626151
Vascular wall regulator of G-protein signalling-1 (RGS-1) is required for angiotensin II-mediated blood pressure control.
Vascular pharmacology 09, 2018 | Pubmed ID: 29654907
Index of Microcirculatory Resistance as a Tool to Characterize Microvascular Obstruction and to Predict Infarct Size Regression in Patients With STEMI Undergoing Primary PCI.
JACC. Cardiovascular imaging 05, 2019 | Pubmed ID: 29680355
JCAD, a Gene at the 10p11 Coronary Artery Disease Locus, Regulates Hippo Signaling in Endothelial Cells.
Arteriosclerosis, thrombosis, and vascular biology 08, 2018 | Pubmed ID: 29794114
Endothelial Cell Tetrahydrobiopterin Modulates Sensitivity to Ang (Angiotensin) II-Induced Vascular Remodeling, Blood Pressure, and Abdominal Aortic Aneurysm.
Hypertension (Dallas, Tex. : 1979) 07, 2018 | Pubmed ID: 29844152
Effect of irradiation and bone marrow transplantation on angiotensin II-induced aortic inflammation in ApoE knockout mice.
Atherosclerosis 09, 2018 | Pubmed ID: 30048944
Non-invasive detection of coronary inflammation using computed tomography and prediction of residual cardiovascular risk (the CRISP CT study): a post-hoc analysis of prospective outcome data.
Lancet (London, England) 09, 2018 | Pubmed ID: 30170852
Tetrahydrobiopterin modulates ubiquitin conjugation to UBC13/UBE2N and proteasome activity by S-nitrosation.
Scientific reports 09, 2018 | Pubmed ID: 30254268
Neonatal Micro-RNA Profile Determines Endothelial Function in Offspring of Hypertensive Pregnancies.
Hypertension (Dallas, Tex. : 1979) 10, 2018 | Pubmed ID: 30287978
The metabolite BH4 controls T cell proliferation in autoimmunity and cancer.
Nature 11, 2018 | Pubmed ID: 30405245
Long-term performance of an external stent for saphenous vein grafts: the VEST IV trial.
Journal of cardiothoracic surgery Nov, 2018 | Pubmed ID: 30453984
Dynamic changes in injured myocardium, very early after acute myocardial infarction, quantified using T1 mapping cardiovascular magnetic resonance.
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 12, 2018 | Pubmed ID: 30567572
Regulation of mycobacterial infection by macrophage Gch1 and tetrahydrobiopterin.
Nature communications 12, 2018 | Pubmed ID: 30573728
Acute Microvascular Impairment Post-Reperfused STEMI Is Reversible and Has Additional Clinical Predictive Value: A CMR OxAMI Study.
JACC. Cardiovascular imaging 09, 2019 | Pubmed ID: 30660541
Combined T1-mapping and tissue tracking analysis predicts severity of ischemic injury following acute STEMI-an Oxford Acute Myocardial Infarction (OxAMI) study.
The international journal of cardiovascular imaging Jul, 2019 | Pubmed ID: 30778713
Incremental Value of Coronary Microcirculation Resistive Reserve Ratio in Predicting the Extent of Myocardial Infarction in Patients with STEMI. Insights from the Oxford Acute Myocardial Infarction (OxAMI) Study.
Cardiovascular revascularization medicine : including molecular interventions Dec, 2019 | Pubmed ID: 30797759
Neuropeptide-Y causes coronary microvascular constriction and is associated with reduced ejection fraction following ST-elevation myocardial infarction.
European heart journal 06, 2019 | Pubmed ID: 30859228
A macroeconomic assessment of the impact of medical research expenditure: A case study of NIHR Biomedical Research Centres.
PloS one , 2019 | Pubmed ID: 30970015
Safety of Rotational Atherectomy Using the Radial Access in Patients With Severe Aortic Stenosis.
The American journal of cardiology 08, 2019 | Pubmed ID: 31174836
Nitric Oxide Modulates Metabolic Remodeling in Inflammatory Macrophages through TCA Cycle Regulation and Itaconate Accumulation.
Cell reports 07, 2019 | Pubmed ID: 31269442
Nox2 contributes to age-related oxidative damage to neurons and the cerebral vasculature.
The Journal of clinical investigation 07, 2019 | Pubmed ID: 31329158
Publisher Correction: The metabolite BH4 controls T cell proliferation in autoimmunity and cancer.
Nature Aug, 2019 | Pubmed ID: 31363232
A novel machine learning-derived radiotranscriptomic signature of perivascular fat improves cardiac risk prediction using coronary CT angiography.
European heart journal 11, 2019 | Pubmed ID: 31504423
Adipose tissue-derived WNT5A regulates vascular redox signaling in obesity via USP17/RAC1-mediated activation of NADPH oxidases.
Science translational medicine 09, 2019 | Pubmed ID: 31534019
A key role for the novel coronary artery disease gene JCAD in atherosclerosis via shear stress mechanotransduction.
Cardiovascular research 09, 2020 | Pubmed ID: 31584065
Exercise and cardiovascular health: new routes to reap more rewards.
Cardiovascular research 04, 2020 | Pubmed ID: 31593225
Association of troponin level and age with mortality in 250 000 patients: cohort study across five UK acute care centres.
BMJ (Clinical research ed.) 11, 2019 | Pubmed ID: 31748235
The cardiac sympathetic co-transmitter neuropeptide Y is pro-arrhythmic following ST-elevation myocardial infarction despite beta-blockade.
European heart journal 06, 2020 | Pubmed ID: 31834357
Hyper-acute cardiovascular magnetic resonance T1 mapping predicts infarct characteristics in patients with ST elevation myocardial infarction.
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 01, 2020 | Pubmed ID: 31915031
Prognostic significance of troponin level in 3121 patients presenting with atrial fibrillation (The NIHR Health Informatics Collaborative TROP-AF study).
Journal of the American Heart Association 04, 2020 | Pubmed ID: 32212911
Isolation and culture of murine bone marrow-derived macrophages for nitric oxide and redox biology.
Nitric oxide : biology and chemistry 08, 2020 | Pubmed ID: 32339668
Insulin-induced vascular redox dysregulation in human atherosclerosis is ameliorated by dipeptidyl peptidase 4 inhibition.
Science translational medicine 04, 2020 | Pubmed ID: 32350133
Angiography-derived index of microcirculatory resistance as a novel, pressure-wire-free tool to assess coronary microcirculation in ST elevation myocardial infarction.
The international journal of cardiovascular imaging Aug, 2020 | Pubmed ID: 32409977
Risk of severe COVID-19 disease with ACE inhibitors and angiotensin receptor blockers: cohort study including 8.3 million people.
Heart (British Cardiac Society) 10, 2020 | Pubmed ID: 32737124
Invasive versus non-invasive management of older patients with non-ST elevation myocardial infarction (SENIOR-NSTEMI): a cohort study based on routine clinical data.
Lancet (London, England) 08, 2020 | Pubmed ID: 32861307
Retraction notice to Gadolinium-Free Cardiac MR Stress T1-Mapping to Distinguish Epicardial From Microvascular Coronary Disease: J Am Coll Cardiol 71 (2018) 957-968.
Journal of the American College of Cardiology 10, 2020 | Pubmed ID: 33059839
Retraction notice to Diagnosis of Microvascular Angina Using Cardiac Magnetic Resonance: J Am Coll Cardiol 71 (2018) 969-979.
Journal of the American College of Cardiology 10, 2020 | Pubmed ID: 33059840
Atrial nitroso-redox balance and refractoriness following on-pump cardiac surgery: a randomized trial of atorvastatin.
Cardiovascular research 01, 2022 | Pubmed ID: 33098411
Tetrahydrobiopterin and Nitric Oxide Synthase Recouplers.
Handbook of experimental pharmacology , 2021 | Pubmed ID: 33140223
Paracrine signalling by cardiac calcitonin controls atrial fibrogenesis and arrhythmia.
Nature 11, 2020 | Pubmed ID: 33149301
Oxidation of Protein Kinase A Regulatory Subunit PKARIα Protects Against Myocardial Ischemia-Reperfusion Injury by Inhibiting Lysosomal-Triggered Calcium Release.
Circulation 02, 2021 | Pubmed ID: 33185461
Medium-term effects of SARS-CoV-2 infection on multiple vital organs, exercise capacity, cognition, quality of life and mental health, post-hospital discharge.
EClinicalMedicine Jan, 2021 | Pubmed ID: 33490928
BH4 Increases nNOS Activity and Preserves Left Ventricular Function in Diabetes.
Circulation research 03, 2021 | Pubmed ID: 33494625
When the genome bluffs: a tandem duplication event during generation of a novel Agmo knockout mouse model fools routine genotyping.
Cell & bioscience Mar, 2021 | Pubmed ID: 33726865
Thymosin β4 protects against aortic aneurysm via endocytic regulation of growth factor signaling.
The Journal of clinical investigation 05, 2021 | Pubmed ID: 33784254
Coronary Microvascular Dysfunction Assessed by Pressure Wire and CMR After STEMI Predicts Long-Term Outcomes.
JACC. Cardiovascular imaging 10, 2021 | Pubmed ID: 33865789
A titan of Cardiovascular Research: Professor Peter Sleight (1929-2020).
Cardiovascular research 04, 2021 | Pubmed ID: 33891679
Angiography-derived index of microcirculatory resistance (IMR) as a novel pressure-wire-free tool to assess coronary microvascular dysfunction in acute coronary syndromes and stable coronary artery disease.
The international journal of cardiovascular imaging Jun, 2021 | Pubmed ID: 33950329
CD200 Limits Monopoiesis and Monocyte Recruitment in Atherosclerosis.
Circulation research 07, 2021 | Pubmed ID: 33975450
Fat-Secreted Ceramides Regulate Vascular Redox State and Influence Outcomes in Patients With Cardiovascular Disease.
Journal of the American College of Cardiology 05, 2021 | Pubmed ID: 34016263
External stenting and disease progression in saphenous vein grafts two years after coronary artery bypass grafting: A multicenter randomized trial.
The Journal of thoracic and cardiovascular surgery Apr, 2021 | Pubmed ID: 34024615
Pressure-controlled intermittent coronary sinus occlusion improves the vasodilatory microvascular capacity and reduces myocardial injury in patients with STEMI.
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 02, 2022 | Pubmed ID: 34051133
Inhibition of myocardial cathepsin-L release during reperfusion following myocardial infarction improves cardiac function and reduces infarct size.
Cardiovascular research Jun, 2021 | Pubmed ID: 34132807
Hyperglycemia Induces Trained Immunity in Macrophages and Their Precursors and Promotes Atherosclerosis.
Circulation 09, 2021 | Pubmed ID: 34255973
Effects of canagliflozin on human myocardial redox signalling: clinical implications.
European heart journal 12, 2021 | Pubmed ID: 34293101
Pre-procedural ATI score (age-thrombus burden-index of microcirculatory resistance) predicts long-term clinical outcomes in patients with ST elevation myocardial infarction treated with primary percutaneous coronary intervention.
International journal of cardiology 09, 2021 | Pubmed ID: 34311009
Hepatic miR-144 Drives Fumarase Activity Preventing NRF2 Activation During Obesity.
Gastroenterology 12, 2021 | Pubmed ID: 34425095
Standardized measurement of coronary inflammation using cardiovascular computed tomography: integration in clinical care as a prognostic medical device.
Cardiovascular research 11, 2021 | Pubmed ID: 34450625
Long-Term Clinical Outcomes in Patients With an Acute ST-Segment-Elevation Myocardial Infarction Stratified by Angiography-Derived Index of Microcirculatory Resistance.
Frontiers in cardiovascular medicine , 2021 | Pubmed ID: 34557531
Endothelial GTPCH (GTP Cyclohydrolase 1) and Tetrahydrobiopterin Regulate Gestational Blood Pressure, Uteroplacental Remodeling, and Fetal Growth.
Hypertension (Dallas, Tex. : 1979) 12, 2021 | Pubmed ID: 34689592
A Randomized, double-blind, dose ranging clinical trial of intravenous FDY-5301 in acute STEMI patients undergoing primary PCI.
International journal of cardiology Jan, 2022 | Pubmed ID: 34774885
A large National Institute for Health Research (NIHR) Biomedical Research Centre facilitates impactful cross-disciplinary and collaborative translational research publications and research collaboration networks: a bibliometric evaluation study.
Journal of translational medicine 11, 2021 | Pubmed ID: 34838033
Bruton's TK regulates myeloid cell recruitment during acute inflammation.
British journal of pharmacology Jun, 2022 | Pubmed ID: 34897650
Risks of myocarditis, pericarditis, and cardiac arrhythmias associated with COVID-19 vaccination or SARS-CoV-2 infection.
Nature medicine 02, 2022 | Pubmed ID: 34907393
Cardiovascular computed tomography imaging for coronary artery disease risk: plaque, flow and fat.
Heart (British Cardiac Society) Jan, 2022 | Pubmed ID: 35022211
Rapid neutrophil mobilisation by VCAM-1+ endothelial extracellular vesicles.
Cardiovascular research Feb, 2022 | Pubmed ID: 35134856
Mortality risk prediction of high-sensitivity C-reactive protein in suspected acute coronary syndrome: A cohort study.
PLoS medicine 02, 2022 | Pubmed ID: 35192610
Prognostic Significance of Ventricular Arrhythmias in 13 444 Patients With Acute Coronary Syndrome: A Retrospective Cohort Study Based on Routine Clinical Data (NIHR Health Informatics Collaborative VA-ACS Study).
Journal of the American Heart Association 03, 2022 | Pubmed ID: 35258317
Implications of elevated troponin on time-to-surgery in non-ST elevation myocardial infarction (NIHR Health Informatics Collaborative: TROP-CABG study).
International journal of cardiology Apr, 2022 | Pubmed ID: 35487318
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