Leo Q. Wan
Department of Biomedical Engineering,
Center for Biotechnology & Interdisciplinary Studies,
Department of Biological Sciences,
Center for Modeling,
Simulation,
and Imaging in Medicine,
Center for Modeling, Simulation, and Imaging in Medicine
Rensselaer Polytechnic Institute
Dr. Leo Q. Wan is an associate professor in the Department of Biomedical Engineering at the Rensselaer Polytechnic Institute in Troy, NY. His research focuses on understanding physical biology in tissue development and regeneration and includes Tissue Morphogenesis, Stem Cell Mechanobiology, and Functional Tissue Engineering. He is a pioneer in cell chirality research with bioengineering platforms. His lecture titled “Why are human bodies asymmetrical?”, collaborated with TED-Ed, has over 1 million views. Dr. Wan received his Bachelor’s degree in Mechanics and Mechanical Engineering and his Master's degree in Fluid Mechanics from the University of Science and Technology of China. After completing his Ph.D. in Biomedical Engineering at Columbia University in 2007, he became a postdoctoral scientist in the area of Stem Cells and Tissue Engineering. Leo is a Pew scholar (Class 2013), and a recipient of the NIH Director’s New Innovator Award, National Science Foundation Early Career Award, American Heart Association Scientist Development Grant, and the March of Dimes Basil O’Connor Starter Scholar Research Award. He is a fellow of the American Heart Association (FAHA).
Micropatterning of cells reveals chiral morphogenesis.
Stem cell research & therapy Apr, 2013 | Pubmed ID: 23672821
Carbon nanotube-induced loss of multicellular chirality on micropatterned substrate is mediated by oxidative stress.
ACS nano Mar, 2014 | Pubmed ID: 24559311
High-throughput cell aggregate culture for stem cell chondrogenesis.
Methods in molecular biology (Clifton, N.J.) , 2014 | Pubmed ID: 24676785
Large, stratified, and mechanically functional human cartilage grown in vitro by mesenchymal condensation.
Proceedings of the National Academy of Sciences of the United States of America May, 2014 | Pubmed ID: 24778247
Astrocytes increase ATP exocytosis mediated calcium signaling in response to microgroove structures.
Scientific reports , 2015 | Pubmed ID: 25597401
Zinc inhibits Hedgehog autoprocessing: linking zinc deficiency with Hedgehog activation.
The Journal of biological chemistry May, 2015 | Pubmed ID: 25787080
Inhibition of cell-cell adhesion impairs directional epithelial migration on micropatterned surfaces.
Integrative biology : quantitative biosciences from nano to macro May, 2015 | Pubmed ID: 25923643
Effects of Osmolarity on the Spontaneous Calcium Signaling of In Situ Juvenile and Adult Articular Chondrocytes.
Annals of biomedical engineering Apr, 2016 | Pubmed ID: 26219403
Determining Tension-Compression Nonlinear Mechanical Properties of Articular Cartilage from Indentation Testing.
Annals of biomedical engineering Apr, 2016 | Pubmed ID: 26240062
Cellular and Nuclear Alignment Analysis for Determining Epithelial Cell Chirality.
Annals of biomedical engineering May, 2016 | Pubmed ID: 26294010
Sequential gelation of tyramine-substituted hyaluronic acid hydrogels enhances mechanical integrity and cell viability.
Medical & biological engineering & computing Dec, 2016 | Pubmed ID: 27056409
Cell chirality: emergence of asymmetry from cell culture.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 12, 2016 | Pubmed ID: 27821525
Multiaxial Polarity Determines Individual Cellular and Nuclear Chirality.
Cellular and molecular bioengineering Feb, 2017 | Pubmed ID: 28360944
CDC42 is required for epicardial and pro-epicardial development by mediating FGF receptor trafficking to the plasma membrane.
Development (Cambridge, England) 05, 2017 | Pubmed ID: 28465335
Zonal variation of MRI-measurable parameters classifies cartilage degradation.
Journal of biomechanics Dec, 2017 | Pubmed ID: 29126604
Cartilage Metabolism is Modulated by Synovial Fluid Through Metalloproteinase Activity.
Annals of biomedical engineering Jun, 2018 | Pubmed ID: 29589167
Teratogen screening with human pluripotent stem cells.
Integrative biology : quantitative biosciences from nano to macro 09, 2018 | Pubmed ID: 30095839
Cell chirality regulates intercellular junctions and endothelial permeability.
Science advances 10, 2018 | Pubmed ID: 30397640
Temporal effects of cytokine treatment on lubricant synthesis and matrix metalloproteinase activity of fibroblast-like synoviocytes.
Journal of tissue engineering and regenerative medicine 01, 2019 | Pubmed ID: 30403832
Epithelial Cell Chirality Revealed by Three-Dimensional Spontaneous Rotation.
Proceedings of the National Academy of Sciences of the United States of America 11, 2018 | Pubmed ID: 30429314
Intrinsic cellular chirality regulates left-right symmetry breaking during cardiac looping.
Proceedings of the National Academy of Sciences of the United States of America 12, 2018 | Pubmed ID: 30459275
In Vitro Microscale Models for Embryogenesis.
Advanced biosystems Jun, 2018 | Pubmed ID: 30533517
Lineage-Specific Chiral Biases of Human Embryonic Stem Cells during Differentiation.
Stem cells international , 2018 | Pubmed ID: 30627170
Identification of Chondrocyte Genes and Signaling Pathways in Response to Acute Joint Inflammation.
Scientific reports 01, 2019 | Pubmed ID: 30643177
Cell organelle-based analysis of cell chirality.
Communicative & integrative biology , 2019 | Pubmed ID: 31143366
Cardiomyocyte orientation modulated by the Numb family proteins-N-cadherin axis is essential for ventricular wall morphogenesis.
Proceedings of the National Academy of Sciences of the United States of America 07, 2019 | Pubmed ID: 31300538
Cell chirality in cardiovascular development and disease.
APL bioengineering Sep, 2020 | Pubmed ID: 32903894
Hyperosmolar Ionic Solutions Modulate Inflammatory Phenotype and sGAG Loss in a Cartilage Explant Model.
Cartilage 12, 2021 | Pubmed ID: 32975437
Recent Advances in Cellular and Molecular Bioengineering for Building and Translation of Biological Systems.
Cellular and molecular bioengineering Aug, 2021 | Pubmed ID: 34055096
Effects of Alzheimer's Disease-Related Proteins on the Chirality of Brain Endothelial Cells.
Cellular and molecular bioengineering Jun, 2021 | Pubmed ID: 34109002
Cell Chirality as a Novel Measure for Cytotoxicity.
Advanced biology 01, 2022 | Pubmed ID: 34796704
A Micropatterning Assay for Measuring Cell Chirality
1Department of Biomedical Engineering, Rensselaer Polytechnic Institute,
2Center for Biotechnology & Interdisciplinary Studies, Rensselaer Polytechnic Institute,
3Department of Biomedical Engineering, Columbia University,
4Department of Medicine, Columbia University,
5Department of Biological Sciences, Rensselaer Polytechnic Institute,
6Center for Modeling, Simulation, and Imaging in Medicine, Rensselaer Polytechnic Institute
