Department of Biomedical Engineering
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Timing and magnitude of systolic stretch affect myofilament activation and mechanical work.
American journal of physiology. Heart and circulatory physiology Aug, 2014 | Pubmed ID: 24878774
Decreased polycystin 2 expression alters calcium-contraction coupling and changes β-adrenergic signaling pathways.
Proceedings of the National Academy of Sciences of the United States of America Nov, 2014 | Pubmed ID: 25368166
Mathematical modeling of aortic valve dynamics during systole.
Journal of theoretical biology Jan, 2015 | Pubmed ID: 25451522
Prospects for In Vitro Myofilament Maturation in Stem Cell-Derived Cardiac Myocytes.
Biomarker insights , 2015 | Pubmed ID: 26085788
Slowing of contractile kinetics by myosin-binding protein C can be explained by its cooperative binding to the thin filament.
Journal of molecular and cellular cardiology 07, 2016 | Pubmed ID: 26454159
Modeling predicts a connection between sinus vortex effects and aortic compliance.
Journal of theoretical biology Jan, 2016 | Pubmed ID: 26585547
Contributions of Ca2+-Independent Thin Filament Activation to Cardiac Muscle Function.
Biophysical journal Nov, 2015 | Pubmed ID: 26588569
Structural determinants of muscle thin filament cooperativity.
Archives of biochemistry and biophysics Mar, 2016 | Pubmed ID: 26891592
Anisotropic engineered heart tissue made from laser-cut decellularized myocardium.
Scientific reports 08, 2016 | Pubmed ID: 27572147
Acute Optogenetic Modulation of Cardiac Twitch Dynamics Explored Through Modeling.
Journal of biomechanical engineering 11, 2016 | Pubmed ID: 27618140
Low-dose dasatinib rescues cardiac function in Noonan syndrome.
JCI insight 12, 2016 | Pubmed ID: 27942593
A Protocol for Collecting Human Cardiac Tissue for Research.
The VAD journal : the journal of mechanical assisted circulation and heart failure , 2016 | Pubmed ID: 28042604
Skeletal myosin binding protein-C isoforms regulate thin filament activity in a Ca-dependent manner.
Scientific reports 02, 2018 | Pubmed ID: 29422607
Force-Dependent Recruitment from the Myosin Off State Contributes to Length-Dependent Activation.
Biophysical journal 08, 2018 | Pubmed ID: 30054031
Precise Binding of Tropomyosin on Actin Involves Sequence-Dependent Variance in Coiled-Coil Twisting.
Biophysical journal 09, 2018 | Pubmed ID: 30195938
Diverse relaxation rates exist among rat cardiomyocytes isolated from a single myocardial region.
The Journal of physiology 02, 2019 | Pubmed ID: 30315728
A short history of the development of mathematical models of cardiac mechanics.
Journal of molecular and cellular cardiology 02, 2019 | Pubmed ID: 30503754
Modelling sarcomeric cardiomyopathies with human cardiomyocytes derived from induced pluripotent stem cells.
The Journal of physiology 07, 2020 | Pubmed ID: 30624779
Sarcomere-Directed Calcium Reporters in Cardiomyocytes.
Circulation research 04, 2019 | Pubmed ID: 30973804
The Effect of Tropomyosin Mutations on Actin-Tropomyosin Binding: In Search of Lost Time.
Biophysical journal 06, 2019 | Pubmed ID: 31130236
Patient mutations linked to arrhythmogenic cardiomyopathy enhance calpain-mediated desmoplakin degradation.
JCI insight 06, 2019 | Pubmed ID: 31194698
Extracellular Matrix From Hypertrophic Myocardium Provokes Impaired Twitch Dynamics in Healthy Cardiomyocytes.
JACC. Basic to translational science Aug, 2019 | Pubmed ID: 31468004
Cardiomyocyte d-dopachrome tautomerase protects against heart failure.
JCI insight 09, 2019 | Pubmed ID: 31484822
A Microwell Cell Capture Device Reveals Variable Response to Dobutamine in Isolated Cardiomyocytes.
Biophysical journal 10, 2019 | Pubmed ID: 31537313
Modular design of a tissue engineered pulsatile conduit using human induced pluripotent stem cell-derived cardiomyocytes.
Acta biomaterialia 01, 2020 | Pubmed ID: 31634626
KBTBD13 and the ever-expanding sarcomeric universe.
The Journal of clinical investigation 02, 2020 | Pubmed ID: 31904591
Polycystin 2 is increased in disease to protect against stress-induced cell death.
Scientific reports 01, 2020 | Pubmed ID: 31941974
Contractile work directly modulates mitochondrial protein levels in human engineered heart tissues.
American journal of physiology. Heart and circulatory physiology 06, 2020 | Pubmed ID: 32383992
Multiscale Modeling of Cardiovascular Function Predicts That the End-Systolic Pressure Volume Relationship Can Be Targeted via Multiple Therapeutic Strategies.
Frontiers in physiology , 2020 | Pubmed ID: 32973561
Fast-relaxing cardiomyocytes exert a dominant role in the relaxation behavior of heterogeneous myocardium.
Archives of biochemistry and biophysics 01, 2021 | Pubmed ID: 33271148
Mavacamten preserves length-dependent contractility and improves diastolic function in human engineered heart tissue.
American journal of physiology. Heart and circulatory physiology 03, 2021 | Pubmed ID: 33449850
Potential impacts of the cardiac troponin I mobile domain on myofilament activation and relaxation.
Journal of molecular and cellular cardiology 06, 2021 | Pubmed ID: 33647310
Evidence for synergy between sarcomeres and fibroblasts in an in vitro model of myocardial reverse remodeling.
Journal of molecular and cellular cardiology 09, 2021 | Pubmed ID: 33992697
Danicamtiv Enhances Systolic Function and Frank-Starling Behavior at Minimal Diastolic Cost in Engineered Human Myocardium.
Journal of the American Heart Association 06, 2021 | Pubmed ID: 34096321
Loss of crossbridge inhibition drives pathological cardiac hypertrophy in patients harboring the TPM1 E192K mutation.
The Journal of general physiology 09, 2021 | Pubmed ID: 34319370
Myofilament glycation in diabetes reduces contractility by inhibiting tropomyosin movement, is rescued by cMyBPC domains.
Journal of molecular and cellular cardiology Jan, 2022 | Pubmed ID: 34487755
MicroRNA function can be reversed by altering target gene expression levels.
iScience Oct, 2021 | Pubmed ID: 34755085
Functional and structural differences between skinned and intact muscle preparations.
The Journal of general physiology Feb, 2022 | Pubmed ID: 35045156
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