Colin G. Nichols

beta-cell hyperexcitability: from hyperinsulinism to diabetes.

Dual-mode phospholipid regulation of human inward rectifying potassium channels.

The diabetic β-cell: hyperstimulated vs. hyperexcited.

KATP channels and cardiovascular disease: suddenly a syndrome.

Energetics and location of phosphoinositide binding in human Kir2.1 channels.

Modeling K,ATP--dependent excitability in pancreatic islets.

Electrophysiologic consequences of KATP gain of function in the heart: Conduction abnormalities in Cantu syndrome.

ABCC8 R1420H Loss-of-Function Variant in a Southwest American Indian Community: Association With Increased Birth Weight and Doubled Risk of Type 2 Diabetes.

Differential mechanisms of Cantú syndrome-associated gain of function mutations in the ABCC9 (SUR2) subunit of the KATP channel.

K(ATP) channel gain-of-function leads to increased myocardial L-type Ca(2+) current and contractility in Cantu syndrome.

Adenosine Triphosphate-Sensitive Potassium Currents in Heart Disease and Cardioprotection.

Structural basis of control of inward rectifier Kir2 channel gating by bulk anionic phospholipids.

Expression and function of ATP-dependent potassium channels in zebrafish islet β-cells.

Control of Kir channel gating by cytoplasmic domain interface interactions.

Conformational changes at cytoplasmic intersubunit interactions control Kir channel gating.

Transient Notch Activation Induces Long-Term Gene Expression Changes Leading to Sick Sinus Syndrome in Mice.

Conserved functional consequences of disease-associated mutations in the slide helix of Kir6.1 and Kir6.2 subunits of the ATP-sensitive potassium channel.

Studying Structural Dynamics of Potassium Channels by Single-Molecule FRET.

Cantu syndrome-associated SUR2 (ABCC9) mutations in distinct structural domains result in K channel gain-of-function by differential mechanisms.

Contribution of systemic inflammation to permanence of K-induced neonatal diabetes in mice.

Polyamines and potassium channels: A 25-year romance.

Loss-of-Function ABCC8 Mutations in Pulmonary Arterial Hypertension.

Potassium channel selectivity filter dynamics revealed by single-molecule FRET.

Beta-cell excitability and excitability-driven diabetes in adult Zebrafish islets.

ATP-sensitive potassium channels in zebrafish cardiac and vascular smooth muscle.