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Department of Cell Biology and Physiology and Center for the Investigation of Membrane Excitability Diseases
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beta-cell hyperexcitability: from hyperinsulinism to diabetes.
Diabetes, obesity & metabolism Nov, 2007 | Pubmed ID: 17919182
Dual-mode phospholipid regulation of human inward rectifying potassium channels.
Biophysical journal Feb, 2011 | Pubmed ID: 21281576
The diabetic β-cell: hyperstimulated vs. hyperexcited.
Diabetes, obesity & metabolism Oct, 2012 | Pubmed ID: 22928573
KATP channels and cardiovascular disease: suddenly a syndrome.
Circulation research Mar, 2013 | Pubmed ID: 23538276
Energetics and location of phosphoinositide binding in human Kir2.1 channels.
The Journal of biological chemistry Jun, 2013 | Pubmed ID: 23564459
Modeling K,ATP--dependent excitability in pancreatic islets.
Biophysical journal Nov, 2014 | Pubmed ID: 25418087
Electrophysiologic consequences of KATP gain of function in the heart: Conduction abnormalities in Cantu syndrome.
Heart rhythm Nov, 2015 | Pubmed ID: 26142302
ABCC8 R1420H Loss-of-Function Variant in a Southwest American Indian Community: Association With Increased Birth Weight and Doubled Risk of Type 2 Diabetes.
Diabetes Dec, 2015 | Pubmed ID: 26246406
Differential mechanisms of Cantú syndrome-associated gain of function mutations in the ABCC9 (SUR2) subunit of the KATP channel.
The Journal of general physiology Dec, 2015 | Pubmed ID: 26621776
K(ATP) channel gain-of-function leads to increased myocardial L-type Ca(2+) current and contractility in Cantu syndrome.
Proceedings of the National Academy of Sciences of the United States of America 06, 2016 | Pubmed ID: 27247394
Adenosine Triphosphate-Sensitive Potassium Currents in Heart Disease and Cardioprotection.
Cardiac electrophysiology clinics 06, 2016 | Pubmed ID: 27261824
Structural basis of control of inward rectifier Kir2 channel gating by bulk anionic phospholipids.
The Journal of general physiology 09, 2016 | Pubmed ID: 27527100
Expression and function of ATP-dependent potassium channels in zebrafish islet β-cells.
Royal Society open science Feb, 2017 | Pubmed ID: 28386438
Control of Kir channel gating by cytoplasmic domain interface interactions.
The Journal of general physiology May, 2017 | Pubmed ID: 28389584
Conformational changes at cytoplasmic intersubunit interactions control Kir channel gating.
The Journal of biological chemistry 06, 2017 | Pubmed ID: 28446610
Transient Notch Activation Induces Long-Term Gene Expression Changes Leading to Sick Sinus Syndrome in Mice.
Circulation research Aug, 2017 | Pubmed ID: 28674041
Conserved functional consequences of disease-associated mutations in the slide helix of Kir6.1 and Kir6.2 subunits of the ATP-sensitive potassium channel.
The Journal of biological chemistry 10, 2017 | Pubmed ID: 28842488
Studying Structural Dynamics of Potassium Channels by Single-Molecule FRET.
Methods in molecular biology (Clifton, N.J.) , 2018 | Pubmed ID: 29058191
Cantu syndrome-associated SUR2 (ABCC9) mutations in distinct structural domains result in K channel gain-of-function by differential mechanisms.
The Journal of biological chemistry 02, 2018 | Pubmed ID: 29275331
Contribution of systemic inflammation to permanence of K-induced neonatal diabetes in mice.
American journal of physiology. Endocrinology and metabolism 12, 2018 | Pubmed ID: 30226997
Polyamines and potassium channels: A 25-year romance.
The Journal of biological chemistry 11, 2018 | Pubmed ID: 30333230
Loss-of-Function ABCC8 Mutations in Pulmonary Arterial Hypertension.
Circulation. Genomic and precision medicine 10, 2018 | Pubmed ID: 30354297
Potassium channel selectivity filter dynamics revealed by single-molecule FRET.
Nature chemical biology 04, 2019 | Pubmed ID: 30833778
Beta-cell excitability and excitability-driven diabetes in adult Zebrafish islets.
Physiological reports 06, 2019 | Pubmed ID: 31161721
ATP-sensitive potassium channels in zebrafish cardiac and vascular smooth muscle.
The Journal of physiology 01, 2022 | Pubmed ID: 34820842
Washington University in St. Louis
Soma S. Singareddy1,
Conor McClenaghan1,
Helen I. Roessler2,
Robert Tryon1,
Colin G. Nichols1
1Department of Cell Biology and Physiology and Center for the Investigation of Membrane Excitability Diseases, Washington University in St. Louis,
2Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University
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