Division of Immunology,
Department of Biology,
Biotechnology Institute Thurgau,
Division of Immunology, Department of Biology
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The UBA domains of NUB1L are required for binding but not for accelerated degradation of the ubiquitin-like modifier FAT10.
The Journal of biological chemistry Jul, 2006 | Pubmed ID: 16707496
Opposite fate of endocytosed CCR7 and its ligands: recycling versus degradation.
Journal of immunology (Baltimore, Md. : 1950) Aug, 2006 | Pubmed ID: 16887992
Prostaglandin E2 is a key factor for monocyte-derived dendritic cell maturation: enhanced T cell stimulatory capacity despite IDO.
Journal of leukocyte biology Nov, 2007 | Pubmed ID: 17698915
A novel cytosolic class I antigen-processing pathway for endoplasmic-reticulum-targeted proteins.
EMBO reports Oct, 2007 | Pubmed ID: 17853904
Distinct motifs in the chemokine receptor CCR7 regulate signal transduction, receptor trafficking and chemotaxis.
Journal of cell science Aug, 2008 | Pubmed ID: 18664492
Identification of homozygous transgenic mice by genomic real-time PCR.
Methods in molecular biology (Clifton, N.J.) , 2008 | Pubmed ID: 18695958
Quantitative analysis of gene expression relative to 18S rRNA in carcinoma samples using the LightCycler instrument and a SYBR GreenI-based assay: determining FAT10 mRNA levels in hepatocellular carcinoma.
Methods in molecular biology (Clifton, N.J.) , 2008 | Pubmed ID: 18695959
Prostaglandin E(2) enhances T-cell proliferation by inducing the costimulatory molecules OX40L, CD70, and 4-1BBL on dendritic cells.
Blood Mar, 2009 | Pubmed ID: 19029446
Identification of the molecular composition of the 20S proteasome of mouse intestine by high-resolution mass spectrometric proteome analysis.
Methods in molecular biology (Clifton, N.J.) , 2009 | Pubmed ID: 19544023
Substantial reduction of naïve and regulatory T cells following traumatic stress.
Brain, behavior, and immunity Nov, 2009 | Pubmed ID: 19619638
USE1 is a bispecific conjugating enzyme for ubiquitin and FAT10, which FAT10ylates itself in cis.
Nature communications , 2010 | Pubmed ID: 20975683
Cross-talk between TCR and CCR7 signaling sets a temporal threshold for enhanced T lymphocyte migration.
Journal of immunology (Baltimore, Md. : 1950) Dec, 2011 | Pubmed ID: 22043010
Immunoproteasome-specific inhibitors and their application.
Methods in molecular biology (Clifton, N.J.) , 2012 | Pubmed ID: 22350900
Coencapsulation of tumor lysate and CpG-ODN in PLGA-microspheres enables successful immunotherapy of prostate carcinoma in TRAMP mice.
Journal of controlled release : official journal of the Controlled Release Society Aug, 2012 | Pubmed ID: 22709589
Ubiquitylation of the chemokine receptor CCR7 enables efficient receptor recycling and cell migration.
Journal of cell science Oct, 2012 | Pubmed ID: 22797918
Prostaglandin E2 inhibits IL-23 and IL-12 production by human monocytes through down-regulation of their common p40 subunit.
Molecular immunology Mar, 2013 | Pubmed ID: 22982753
Immunoproteasome subunit LMP7 deficiency and inhibition suppresses Th1 and Th17 but enhances regulatory T cell differentiation.
Journal of immunology (Baltimore, Md. : 1950) Oct, 2012 | Pubmed ID: 22984077
The immunoproteasome in antigen processing and other immunological functions.
Current opinion in immunology Feb, 2013 | Pubmed ID: 23219269
Using protease inhibitors in antigen presentation assays.
Methods in molecular biology (Clifton, N.J.) , 2013 | Pubmed ID: 23329476
FAT10ylation as a signal for proteasomal degradation.
Biochimica et biophysica acta Jan, 2014 | Pubmed ID: 23333871
Posttraumatic stress disorder is associated with an enhanced spontaneous production of pro-inflammatory cytokines by peripheral blood mononuclear cells.
BMC psychiatry Jan, 2013 | Pubmed ID: 23360282
Immuno- and constitutive proteasomes do not differ in their abilities to degrade ubiquitinated proteins.
Cell Feb, 2013 | Pubmed ID: 23452861
The unique functions of tissue-specific proteasomes.
Trends in biochemical sciences Jan, 2014 | Pubmed ID: 24286712
Inhibition of the immunoproteasome ameliorates experimental autoimmune encephalomyelitis.
EMBO molecular medicine 02, 2014 | Pubmed ID: 24399752
Investigations into the auto-FAT10ylation of the bispecific E2 conjugating enzyme UBA6-specific E2 enzyme 1.
The FEBS journal Apr, 2014 | Pubmed ID: 24528925
The effect of trauma-focused therapy on the altered T cell distribution in individuals with PTSD: evidence from a randomized controlled trial.
Journal of psychiatric research Jul, 2014 | Pubmed ID: 24726027
Subunit specific inhibitors of proteasomes and their potential for immunomodulation.
Current opinion in chemical biology Dec, 2014 | Pubmed ID: 25217863
The ubiquitin-like modifier FAT10 decorates autophagy-targeted Salmonella and contributes to Salmonella resistance in mice.
Journal of cell science Nov, 2014 | Pubmed ID: 25271057
No evidence for immunoproteasomes in chicken lymphoid organs and activated lymphocytes.
Immunogenetics Jan, 2015 | Pubmed ID: 25403261
Conjugation of the ubiquitin activating enzyme UBE1 with the ubiquitin-like modifier FAT10 targets it for proteasomal degradation.
PloS one , 2015 | Pubmed ID: 25768649
Analgesia in mice with experimental meningitis reduces pain without altering immune parameters.
ALTEX , 2015 | Pubmed ID: 25800953
The ubiquitin-like modifier FAT10 in antigen processing and antimicrobial defense.
Molecular immunology Dec, 2015 | Pubmed ID: 25983082
The ubiquitin-specific protease USP8 is critical for the development and homeostasis of T cells.
Nature immunology Sep, 2015 | Pubmed ID: 26214742
Cytotoxic T cell vaccination with PLGA microspheres interferes with influenza A virus replication in the lung and suppresses the infectious disease.
Journal of controlled release : official journal of the Controlled Release Society Oct, 2015 | Pubmed ID: 26276509
The Ubiquitin-like Modifier FAT10 Is Selectively Expressed in Medullary Thymic Epithelial Cells and Modifies T Cell Selection.
Journal of immunology (Baltimore, Md. : 1950) Nov, 2015 | Pubmed ID: 26401002
The immunoproteasome: a novel drug target for autoimmune diseases.
Clinical and experimental rheumatology Jul-Aug, 2015 | Pubmed ID: 26458097
Inhibition and deficiency of the immunoproteasome subunit LMP7 attenuates LCMV-induced meningitis.
European journal of immunology Jan, 2016 | Pubmed ID: 26464284
Chaperone BAG6 is dispensable for MHC class I antigen processing and presentation.
Molecular immunology Jan, 2016 | Pubmed ID: 26598275
The STEAP1(262-270) peptide encapsulated into PLGA microspheres elicits strong cytotoxic T cell immunity in HLA-A*0201 transgenic mice--A new approach to immunotherapy against prostate carcinoma.
The Prostate Apr, 2016 | Pubmed ID: 26715028
Inhibiting the immunoproteasome exacerbates the pathogenesis of systemic Candida albicans infection in mice.
Scientific reports Jan, 2016 | Pubmed ID: 26776888
A cascading activity-based probe sequentially targets E1-E2-E3 ubiquitin enzymes.
Nature chemical biology 07, 2016 | Pubmed ID: 27182664
The ubiquitin-like modifier FAT10 in cancer development.
The international journal of biochemistry & cell biology 10, 2016 | Pubmed ID: 27393295
Analyzing structure-function relationships of artificial and cancer-associated PARP1 variants by reconstituting TALEN-generated HeLa PARP1 knock-out cells.
Nucleic acids research Dec, 2016 | Pubmed ID: 27694308
Newly translated proteins are substrates for ubiquitin, ISG15, and FAT10.
FEBS letters Jan, 2017 | Pubmed ID: 27926780
Immunoproteasome subunit deficiency has no influence on the canonical pathway of NF-κB activation.
Molecular immunology 03, 2017 | Pubmed ID: 28157553
Chronic stress suppresses anti-tumor T responses and tumor regression following cancer immunotherapy in a mouse model of melanoma.
Brain, behavior, and immunity Oct, 2017 | Pubmed ID: 28457810
No prolongation of skin allograft survival by immunoproteasome inhibition in mice.
Molecular immunology 08, 2017 | Pubmed ID: 28582644
Inhibition and deficiency of the immunoproteasome subunit LMP7 suppress the development and progression of colorectal carcinoma in mice.
Oncotarget Aug, 2017 | Pubmed ID: 28881611
Amelioration of autoimmunity with an inhibitor selectively targeting all active centres of the immunoproteasome.
British journal of pharmacology 01, 2018 | Pubmed ID: 29034459
The immunoproteasome subunit LMP7 is required in the murine thymus for filling up a hole in the T cell repertoire.
European journal of immunology 03, 2018 | Pubmed ID: 29067678
The 20S immunoproteasome and constitutive proteasome bind with the same affinity to PA28αβ and equally degrade FAT10.
Molecular immunology 09, 2019 | Pubmed ID: 29208314
Immunoproteasome inhibition prevents chronic antibody-mediated allograft rejection in renal transplantation.
Kidney international 03, 2018 | Pubmed ID: 29229189
The expression profile of the ubiquitin-like modifier FAT10 in immune cells suggests cell type-specific functions.
Immunogenetics 07, 2018 | Pubmed ID: 29508036
Defective immuno- and thymoproteasome assembly causes severe immunodeficiency.
Scientific reports 04, 2018 | Pubmed ID: 29654304
The structure of the ubiquitin-like modifier FAT10 reveals an alternative targeting mechanism for proteasomal degradation.
Nature communications 08, 2018 | Pubmed ID: 30127417
On the role of the immunoproteasome in transplant rejection.
Immunogenetics 03, 2019 | Pubmed ID: 30220008
Co-inhibition of immunoproteasome subunits LMP2 and LMP7 is required to block autoimmunity.
EMBO reports 12, 2018 | Pubmed ID: 30279279
Author Correction: The structure of the ubiquitin-like modifier FAT10 reveals an alternative targeting mechanism for proteasomal degradation.
Nature communications 11, 2018 | Pubmed ID: 30389928
Prevention of neuronal apoptosis by astrocytes through thiol-mediated stress response modulation and accelerated recovery from proteotoxic stress.
Cell death and differentiation 12, 2018 | Pubmed ID: 30390092
Immunoproteasome Inhibition Impairs T and B Cell Activation by Restraining ERK Signaling and Proteostasis.
Frontiers in immunology , 2018 | Pubmed ID: 30416500
Immunoproteasome inhibition induces plasma cell apoptosis and preserves kidney allografts by activating the unfolded protein response and suppressing plasma cell survival factors.
Kidney international 03, 2019 | Pubmed ID: 30685098
The ubiquitin-like modifier FAT10 stimulates the activity of deubiquitylating enzyme OTUB1.
The Journal of biological chemistry 03, 2019 | Pubmed ID: 30718280
The ubiquitin-like modifier FAT10 is required for normal IFN-γ production by activated CD8 T cells.
Molecular immunology 04, 2019 | Pubmed ID: 30818228
Analysis of modification and proteolytic targeting by the ubiquitin-like modifier FAT10.
Methods in enzymology , 2019 | Pubmed ID: 30850054
Harnessing Dendritic Cells for Poly (D,L-lactide--glycolide) Microspheres (PLGA MS)-Mediated Anti-tumor Therapy.
Frontiers in immunology , 2019 | Pubmed ID: 31024545
Testing the Impact of Protease Inhibitors in Antigen Presentation Assays.
Methods in molecular biology (Clifton, N.J.) , 2019 | Pubmed ID: 31147932
Immunoproteasome Inhibition Selectively Kills Human CD14 Monocytes and as a Result Dampens IL-23 Secretion.
Journal of immunology (Baltimore, Md. : 1950) 10, 2019 | Pubmed ID: 31484727
The ubiquitin-like modifier FAT10 interferes with SUMO activation.
Nature communications 10, 2019 | Pubmed ID: 31575873
Competitive Metabolite Profiling of Natural Products Reveals Subunit Specific Inhibitors of the 20S Proteasome.
ACS central science Feb, 2020 | Pubmed ID: 32123742
FAT10 localises in dendritic cell aggresome-like induced structures and contributes to their disassembly.
Journal of cell science 07, 2020 | Pubmed ID: 32546531
Regulation of Interferon Induction by the Ubiquitin-Like Modifier FAT10.
Biomolecules 06, 2020 | Pubmed ID: 32586037
Evidence for an involvement of the ubiquitin-like modifier ISG15 in MHC class I antigen presentation.
European journal of immunology 01, 2021 | Pubmed ID: 32686110
The ubiquitin-like modifier FAT10 - much more than a proteasome-targeting signal.
Journal of cell science 07, 2020 | Pubmed ID: 32719056
The ubiquitin-like modifier FAT10 inhibits retinal PDE6 activity and mediates its proteasomal degradation.
The Journal of biological chemistry 10, 2020 | Pubmed ID: 32817338
Recent insights how combined inhibition of immuno/proteasome subunits enables therapeutic efficacy.
Genes and immunity 11, 2020 | Pubmed ID: 32839530
Parkin is an E3 ligase for the ubiquitin-like modifier FAT10, which inhibits Parkin activation and mitophagy.
Cell reports 03, 2021 | Pubmed ID: 33730565
Immunoproteasome Upregulation Is Not Required to Control Protein Homeostasis during Viral Infection.
Journal of immunology (Baltimore, Md. : 1950) 04, 2021 | Pubmed ID: 33731337
Silencing of the proteasome and oxidative stress impair endoplasmic reticulum targeting and signal cleavage of a prostate carcinoma antigen.
Biochemical and biophysical research communications 05, 2021 | Pubmed ID: 33774280
PLGA-particle vaccine carrying TLR3/RIG-I ligand Riboxxim synergizes with immune checkpoint blockade for effective anti-cancer immunotherapy.
Nature communications 05, 2021 | Pubmed ID: 34006895
On the Role of the Immunoproteasome in Protein Homeostasis.
Cells 11, 2021 | Pubmed ID: 34831438
1School of Medicine, Chongqing University,
2Department of Urological Oncology Surgery, Chongqing University Cancer Hospital,
3Department of Biochemistry and Molecular Biology, College of Basic Medical Science, Army Medical University,
4Division of Immunology, Department of Biology, University of Konstanz,
5Biotechnology Institute Thurgau, University of Konstanz
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