Department of Cell and Molecular Biology
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The extracellular loops of Smoothened play a regulatory role in control of Hedgehog pathway activation.
Development (Cambridge, England) Feb, 2012 | Pubmed ID: 22223683
An Inv(16)(p13.3q24.3)-encoded CBFA2T3-GLIS2 fusion protein defines an aggressive subtype of pediatric acute megakaryoblastic leukemia.
Cancer cell Nov, 2012 | Pubmed ID: 23153540
The unfolded protein response selectively targets active smoothened mutants.
Molecular and cellular biology Jun, 2013 | Pubmed ID: 23572559
Structural insights into the role of the Smoothened cysteine-rich domain in Hedgehog signalling.
Nature communications , 2013 | Pubmed ID: 24351982
Functional Divergence in the Role of N-Linked Glycosylation in Smoothened Signaling.
PLoS genetics Aug, 2015 | Pubmed ID: 26291458
Genetic evidence for a Smoothened-Gα(i) signaling axis in mammals.
Science signaling Sep, 2015 | Pubmed ID: 26373671
Smoothened Regulation: A Tale of Two Signals.
Trends in pharmacological sciences Jan, 2016 | Pubmed ID: 26432668
The small GTPase Rap1 is a modulator of Hedgehog signaling.
Developmental biology Jan, 2016 | Pubmed ID: 26481064
Higher-order oligomerization promotes localization of SPOP to liquid nuclear speckles.
The EMBO journal 06, 2016 | Pubmed ID: 27220849
Sonic Hedgehog Activates Phospholipase A2 to Enhance Smoothened Ciliary Translocation.
Cell reports 06, 2017 | Pubmed ID: 28591579
A fixation method to preserve cultured cell cytonemes facilitates mechanistic interrogation of morphogen transport.
Development (Cambridge, England) 10, 2017 | Pubmed ID: 28827391
Cleavage activates dispatched for Sonic Hedgehog ligand release.
eLife 01, 2018 | Pubmed ID: 29359685
Contributions of Noncanonical Smoothened Signaling During Embryonic Development.
Journal of developmental biology , 2017 | Pubmed ID: 29399514
Dispatching Sonic Hedgehog: Molecular Mechanisms Controlling Deployment.
Trends in cell biology 05, 2019 | Pubmed ID: 30852081
Cytoneme delivery of Sonic Hedgehog from ligand-producing cells requires Myosin 10 and a Dispatched-BOC/CDON co-receptor complex.
eLife 02, 2021 | Pubmed ID: 33570491
SPOP and CUL3 Modulate the Sonic Hedgehog Signal Response Through Controlled Degradation of GLI Family Transcription Factors.
Frontiers in cell and developmental biology , 2021 | Pubmed ID: 34395437
Analysis of Dispatched Protein Processing and Sonic Hedgehog Ligand Release.
Methods in molecular biology (Clifton, N.J.) , 2022 | Pubmed ID: 34562246
Regulatory mechanisms of cytoneme-based morphogen transport.
Cellular and molecular life sciences : CMLS Feb, 2022 | Pubmed ID: 35119540
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