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Department of Cell and Molecular Biology
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The extracellular loops of Smoothened play a regulatory role in control of Hedgehog pathway activation.
Development (Cambridge, England) Feb, 2012 | Pubmed ID: 22223683
An Inv(16)(p13.3q24.3)-encoded CBFA2T3-GLIS2 fusion protein defines an aggressive subtype of pediatric acute megakaryoblastic leukemia.
Cancer cell Nov, 2012 | Pubmed ID: 23153540
The unfolded protein response selectively targets active smoothened mutants.
Molecular and cellular biology Jun, 2013 | Pubmed ID: 23572559
Structural insights into the role of the Smoothened cysteine-rich domain in Hedgehog signalling.
Nature communications , 2013 | Pubmed ID: 24351982
Functional Divergence in the Role of N-Linked Glycosylation in Smoothened Signaling.
PLoS genetics Aug, 2015 | Pubmed ID: 26291458
Genetic evidence for a Smoothened-Gα(i) signaling axis in mammals.
Science signaling Sep, 2015 | Pubmed ID: 26373671
Smoothened Regulation: A Tale of Two Signals.
Trends in pharmacological sciences Jan, 2016 | Pubmed ID: 26432668
The small GTPase Rap1 is a modulator of Hedgehog signaling.
Developmental biology Jan, 2016 | Pubmed ID: 26481064
Higher-order oligomerization promotes localization of SPOP to liquid nuclear speckles.
The EMBO journal 06, 2016 | Pubmed ID: 27220849
Sonic Hedgehog Activates Phospholipase A2 to Enhance Smoothened Ciliary Translocation.
Cell reports 06, 2017 | Pubmed ID: 28591579
A fixation method to preserve cultured cell cytonemes facilitates mechanistic interrogation of morphogen transport.
Development (Cambridge, England) 10, 2017 | Pubmed ID: 28827391
Cleavage activates dispatched for Sonic Hedgehog ligand release.
eLife 01, 2018 | Pubmed ID: 29359685
Contributions of Noncanonical Smoothened Signaling During Embryonic Development.
Journal of developmental biology , 2017 | Pubmed ID: 29399514
Dispatching Sonic Hedgehog: Molecular Mechanisms Controlling Deployment.
Trends in cell biology 05, 2019 | Pubmed ID: 30852081
Cytoneme delivery of Sonic Hedgehog from ligand-producing cells requires Myosin 10 and a Dispatched-BOC/CDON co-receptor complex.
eLife 02, 2021 | Pubmed ID: 33570491
SPOP and CUL3 Modulate the Sonic Hedgehog Signal Response Through Controlled Degradation of GLI Family Transcription Factors.
Frontiers in cell and developmental biology , 2021 | Pubmed ID: 34395437
Analysis of Dispatched Protein Processing and Sonic Hedgehog Ligand Release.
Methods in molecular biology (Clifton, N.J.) , 2022 | Pubmed ID: 34562246
Regulatory mechanisms of cytoneme-based morphogen transport.
Cellular and molecular life sciences : CMLS Feb, 2022 | Pubmed ID: 35119540
St. Jude Children’s Research Hospital
Eric T. Hall1,
Christina A. Daly1,2,
Yan Zhang1,
Miriam E. Dillard1,
Stacey K. Ogden1
1Department of Cell and Molecular Biology, St. Jude Children’s Research Hospital,
2, St. Jude Graduate School of Biomedical Sciences
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