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Department of Biomedical Physiology and Kinesiology
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Proton block of the pore underlies the inhibition of hERG cardiac K+ channels during acidosis.
American journal of physiology. Cell physiology Jun, 2012 | Pubmed ID: 22517356
Voltage-dependent gating of HERG potassium channels.
Frontiers in pharmacology , 2012 | Pubmed ID: 22586397
Functional interactions of voltage sensor charges with an S2 hydrophobic plug in hERG channels.
The Journal of general physiology Sep, 2013 | Pubmed ID: 23980197
External protons destabilize the activated voltage sensor in hERG channels.
European biophysics journal : EBJ Mar, 2014 | Pubmed ID: 24362825
NS1643 interacts around L529 of hERG to alter voltage sensor movement on the path to activation.
Biophysical journal Mar, 2015 | Pubmed ID: 25809253
Extracellular protons accelerate hERG channel deactivation by destabilizing voltage sensor relaxation.
The Journal of general physiology 02, 2019 | Pubmed ID: 30530765
Simon Fraser University
Kyle E. Simpson1,
Shoaib Faizi1,
Ravichandra Venkateshappa1,
Mandy Yip1,
Raj Johal1,
Damon Poburko1,
Yen May Cheng1,
Diana Hunter1,
Eric Lin1,
Glen F. Tibbits1,
Thomas W. Claydon1
1Department of Biomedical Physiology and Kinesiology, Simon Fraser University
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