Birgitta R. Knudsen

Dynamics of human DNA topoisomerases IIalpha and IIbeta in living cells.

Tryptophane-205 of human topoisomerase I is essential for camptothecin inhibition of negative but not positive supercoil removal.

Single-molecule detection of human topoisomerase I cleavage-ligation activity.

Multiplexed detection of site specific recombinase and DNA topoisomerase activities at the single molecule level.

The geometry of DNA supercoils modulates the DNA cleavage activity of human topoisomerase I.

Topoisomerase I deficiency results in chromosomal alterations in cervical cancer cells.

Strategies for highly sensitive biomarker detection by Rolling Circle Amplification of signals from nucleic acid composed sensors.

Detection of single enzymatic events in rare or single cells using microfluidics.

Peptide Inhibition of Topoisomerase IB from Plasmodium falciparum.

Microfluidics-mediated isothermal detection of enzyme activity at the single molecule level.

Droplet microfluidics platform for highly sensitive and quantitative detection of malaria-causing Plasmodium parasites based on enzyme activity measurement.

DNA-based sensor for real-time measurement of the enzymatic activity of human topoisomerase I.

Quantum dot-based nanosensors for diagnosis via enzyme activity measurement.

Real-time detection of TDP1 activity using a fluorophore-quencher coupled DNA-biosensor.

Topoisomerase I as a biomarker: detection of activity at the single molecule level.

Rolling circle amplification-based detection of human topoisomerase I activity on magnetic beads.

Synthesis of fluorosurfactants for emulsion-based biological applications.

Decreased camptothecin sensitivity of the stem-cell-like fraction of Caco2 cells correlates with an altered phosphorylation pattern of topoisomerase I.

NanoCluster Beacons as reporter probes in rolling circle enhanced enzyme activity detection.

Real-time investigation of human topoisomerase I reaction kinetics using an optical sensor: a fast method for drug screening and determination of active enzyme concentrations.

Correlation between topoisomerase I and tyrosyl-DNA phosphodiesterase 1 activities in non-small cell lung cancer tissue.

Real-Time Label-Free Direct Electronic Monitoring of Topoisomerase Enzyme Binding Kinetics on Graphene.

Microfluidics-Enabled Enzyme Activity Measurement in Single Cells.

Specific detection of the cleavage activity of mycobacterial enzymes using a quantum dot based DNA nanosensor.

Molecular characterization of irinotecan (SN-38) resistant human breast cancer cell lines.

Synthesis and biological evaluation of indeno[1,5]naphthyridines as topoisomerase I (TopI) inhibitors with antiproliferative activity.

Characterization of DNA topoisomerase I in three SN-38 resistant human colon cancer cell lines reveals a new pair of resistance-associated mutations.

DNA hairpins promote temperature controlled cargo encapsulation in a truncated octahedral nanocage structure family.

Optimized Detection of Plasmodium falciparum Topoisomerase I Enzyme Activity in a Complex Biological Sample by the Use of Molecular Beacons.

Novel DNA sensor system for highly sensitive and quantitative retrovirus detection using virus encoded integrase as a biomarker.

Advantages of an optical nanosensor system for the mechanistic analysis of a novel topoisomerase I targeting drug: a case study.

The Effects of Dithiothreitol on DNA.

Interlinked DNA nano-circles for measuring topoisomerase II activity at the level of single decatenation events.

On-slide detection of enzymatic activities in selected single cells.

Characterization of Camptothecin-induced Genomic Changes in the Camptothecin-resistant T-ALL-derived Cell Line CPT-K5.

Detection of the Malaria causing Plasmodium Parasite in Saliva from Infected Patients using Topoisomerase I Activity as a Biomarker.

A new DNA sensor system for specific and quantitative detection of mycobacteria.

Enzymatic activity in single cells.

Topoisomerase I activity and sensitivity to camptothecin in breast cancer-derived cells: a comparative study.

Synthesis of novel hybrid quinolino[4,3-b][1,5]naphthyridines and quinolino[4,3-b][1,5]naphthyridin-6(5H)-one derivatives and biological evaluation as topoisomerase I inhibitors and antiproliferatives.

DNA flowerstructure co-localizes with human pathogens in infected macrophages.

Different Camptothecin Sensitivities in Subpopulations of Colon Cancer Cells Correlate with Expression of Different Phospho-Isoforms of Topoisomerase I with Different Activities.

Fused chromeno and quinolino[1,8]naphthyridines: Synthesis and biological evaluation as topoisomerase I inhibitors and antiproliferative agents.

A Dual-Sensor-Based Screening System for In Vitro Selection of TDP1 Inhibitors.

Hybrid Quinolinyl Phosphonates as Heterocyclic Carboxylate Isosteres: Synthesis and Biological Evaluation against Topoisomerase 1B (TOP1B).

Simple and Fast DNA Based Sensor System for Screening of Small-Molecule Compounds Targeting Eukaryotic Topoisomerase 1.

Synthesis of hybrid phosphorated indenoquinolines and biological evaluation as topoisomerase I inhibitors and antiproliferative agents.

TDP1 and TOP1 as targets in anticancer treatment of NSCLC: Activity and protein level in normal and tumor tissue from 150 NSCLC patients correlated to clinical data.

Genetic and Molecular Characterization of the Immortalized Murine Hepatic Stellate Cell Line GRX.

Topoisomerase 1 inhibits MYC promoter activity by inducing G-quadruplex formation.

Rolling Circle Enhanced Detection of Specific Restriction Endonuclease Activities in Crude Cell Extracts.