Department of Molecular Biology and Genetics
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Dynamics of human DNA topoisomerases IIalpha and IIbeta in living cells.
The Journal of cell biology Apr, 2002 | Pubmed ID: 11927602
Tryptophane-205 of human topoisomerase I is essential for camptothecin inhibition of negative but not positive supercoil removal.
Nucleic acids research , 2007 | Pubmed ID: 17827209
Single-molecule detection of human topoisomerase I cleavage-ligation activity.
ACS nano Jan, 2009 | Pubmed ID: 19206270
Multiplexed detection of site specific recombinase and DNA topoisomerase activities at the single molecule level.
ACS nano Dec, 2009 | Pubmed ID: 19950974
The geometry of DNA supercoils modulates the DNA cleavage activity of human topoisomerase I.
Nucleic acids research Feb, 2011 | Pubmed ID: 20855291
Topoisomerase I deficiency results in chromosomal alterations in cervical cancer cells.
Anticancer research Sep, 2010 | Pubmed ID: 20944095
Strategies for highly sensitive biomarker detection by Rolling Circle Amplification of signals from nucleic acid composed sensors.
Integrative biology : quantitative biosciences from nano to macro Oct, 2011 | Pubmed ID: 21927767
Detection of single enzymatic events in rare or single cells using microfluidics.
ACS nano Oct, 2011 | Pubmed ID: 21936557
Peptide Inhibition of Topoisomerase IB from Plasmodium falciparum.
Molecular biology international , 2011 | Pubmed ID: 22091414
Microfluidics-mediated isothermal detection of enzyme activity at the single molecule level.
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference Aug, 2011 | Pubmed ID: 22255034
Droplet microfluidics platform for highly sensitive and quantitative detection of malaria-causing Plasmodium parasites based on enzyme activity measurement.
ACS nano Dec, 2012 | Pubmed ID: 23121492
DNA-based sensor for real-time measurement of the enzymatic activity of human topoisomerase I.
Sensors (Basel, Switzerland) Mar, 2013 | Pubmed ID: 23529147
Quantum dot-based nanosensors for diagnosis via enzyme activity measurement.
Expert review of molecular diagnostics May, 2013 | Pubmed ID: 23638819
Real-time detection of TDP1 activity using a fluorophore-quencher coupled DNA-biosensor.
Biosensors & bioelectronics Oct, 2013 | Pubmed ID: 23693093
Topoisomerase I as a biomarker: detection of activity at the single molecule level.
Sensors (Basel, Switzerland) Jan, 2014 | Pubmed ID: 24434877
Rolling circle amplification-based detection of human topoisomerase I activity on magnetic beads.
Analytical biochemistry Apr, 2014 | Pubmed ID: 24525043
Synthesis of fluorosurfactants for emulsion-based biological applications.
ACS nano Apr, 2014 | Pubmed ID: 24646088
Decreased camptothecin sensitivity of the stem-cell-like fraction of Caco2 cells correlates with an altered phosphorylation pattern of topoisomerase I.
PloS one , 2014 | Pubmed ID: 24960044
NanoCluster Beacons as reporter probes in rolling circle enhanced enzyme activity detection.
Nanoscale May, 2015 | Pubmed ID: 25901841
Real-time investigation of human topoisomerase I reaction kinetics using an optical sensor: a fast method for drug screening and determination of active enzyme concentrations.
Nanoscale Jun, 2015 | Pubmed ID: 25963854
Correlation between topoisomerase I and tyrosyl-DNA phosphodiesterase 1 activities in non-small cell lung cancer tissue.
Experimental and molecular pathology Aug, 2015 | Pubmed ID: 25987486
Real-Time Label-Free Direct Electronic Monitoring of Topoisomerase Enzyme Binding Kinetics on Graphene.
ACS nano Nov, 2015 | Pubmed ID: 26445172
Microfluidics-Enabled Enzyme Activity Measurement in Single Cells.
Methods in molecular biology (Clifton, N.J.) , 2015 | Pubmed ID: 26542724
Specific detection of the cleavage activity of mycobacterial enzymes using a quantum dot based DNA nanosensor.
Nanoscale Jan, 2016 | Pubmed ID: 26616006
Molecular characterization of irinotecan (SN-38) resistant human breast cancer cell lines.
BMC cancer Jan, 2016 | Pubmed ID: 26801902
Synthesis and biological evaluation of indeno[1,5]naphthyridines as topoisomerase I (TopI) inhibitors with antiproliferative activity.
European journal of medicinal chemistry Jun, 2016 | Pubmed ID: 27017547
Characterization of DNA topoisomerase I in three SN-38 resistant human colon cancer cell lines reveals a new pair of resistance-associated mutations.
Journal of experimental & clinical cancer research : CR Mar, 2016 | Pubmed ID: 27029323
DNA hairpins promote temperature controlled cargo encapsulation in a truncated octahedral nanocage structure family.
Nanoscale Jul, 2016 | Pubmed ID: 27341703
Optimized Detection of Plasmodium falciparum Topoisomerase I Enzyme Activity in a Complex Biological Sample by the Use of Molecular Beacons.
Sensors (Basel, Switzerland) Nov, 2016 | Pubmed ID: 27854277
Novel DNA sensor system for highly sensitive and quantitative retrovirus detection using virus encoded integrase as a biomarker.
Nanoscale Jan, 2017 | Pubmed ID: 27934981
Advantages of an optical nanosensor system for the mechanistic analysis of a novel topoisomerase I targeting drug: a case study.
Nanoscale Feb, 2017 | Pubmed ID: 28094391
The Effects of Dithiothreitol on DNA.
Sensors (Basel, Switzerland) May, 2017 | Pubmed ID: 28538659
Interlinked DNA nano-circles for measuring topoisomerase II activity at the level of single decatenation events.
Nucleic acids research Jul, 2017 | Pubmed ID: 28541438
On-slide detection of enzymatic activities in selected single cells.
Nanoscale Sep, 2017 | Pubmed ID: 28872165
Characterization of Camptothecin-induced Genomic Changes in the Camptothecin-resistant T-ALL-derived Cell Line CPT-K5.
Cancer genomics & proteomics , 2018 | Pubmed ID: 29496689
Detection of the Malaria causing Plasmodium Parasite in Saliva from Infected Patients using Topoisomerase I Activity as a Biomarker.
Scientific reports Mar, 2018 | Pubmed ID: 29515150
A new DNA sensor system for specific and quantitative detection of mycobacteria.
Nanoscale Jan, 2019 | Pubmed ID: 30556557
Enzymatic activity in single cells.
Methods in enzymology , 2019 | Pubmed ID: 31668235
Topoisomerase I activity and sensitivity to camptothecin in breast cancer-derived cells: a comparative study.
BMC cancer Nov, 2019 | Pubmed ID: 31783818
Synthesis of novel hybrid quinolino[4,3-b][1,5]naphthyridines and quinolino[4,3-b][1,5]naphthyridin-6(5H)-one derivatives and biological evaluation as topoisomerase I inhibitors and antiproliferatives.
European journal of medicinal chemistry Jun, 2020 | Pubmed ID: 32279049
DNA flowerstructure co-localizes with human pathogens in infected macrophages.
Nucleic acids research Jun, 2020 | Pubmed ID: 32402089
Different Camptothecin Sensitivities in Subpopulations of Colon Cancer Cells Correlate with Expression of Different Phospho-Isoforms of Topoisomerase I with Different Activities.
Cancers May, 2020 | Pubmed ID: 32423158
Fused chromeno and quinolino[1,8]naphthyridines: Synthesis and biological evaluation as topoisomerase I inhibitors and antiproliferative agents.
Bioorganic & medicinal chemistry Jun, 2021 | Pubmed ID: 33962152
A Dual-Sensor-Based Screening System for In Vitro Selection of TDP1 Inhibitors.
Sensors (Basel, Switzerland) Jul, 2021 | Pubmed ID: 34300575
Hybrid Quinolinyl Phosphonates as Heterocyclic Carboxylate Isosteres: Synthesis and Biological Evaluation against Topoisomerase 1B (TOP1B).
Pharmaceuticals (Basel, Switzerland) Aug, 2021 | Pubmed ID: 34451880
Simple and Fast DNA Based Sensor System for Screening of Small-Molecule Compounds Targeting Eukaryotic Topoisomerase 1.
Pharmaceutics Aug, 2021 | Pubmed ID: 34452216
Synthesis of hybrid phosphorated indenoquinolines and biological evaluation as topoisomerase I inhibitors and antiproliferative agents.
Bioorganic & medicinal chemistry letters Feb, 2022 | Pubmed ID: 34952177
TDP1 and TOP1 as targets in anticancer treatment of NSCLC: Activity and protein level in normal and tumor tissue from 150 NSCLC patients correlated to clinical data.
Lung cancer (Amsterdam, Netherlands) Feb, 2022 | Pubmed ID: 34974222
Genetic and Molecular Characterization of the Immortalized Murine Hepatic Stellate Cell Line GRX.
Cells Apr, 2022 | Pubmed ID: 35563813
Topoisomerase 1 inhibits MYC promoter activity by inducing G-quadruplex formation.
Nucleic acids research Jun, 2022 | Pubmed ID: 35687110
Rolling Circle Enhanced Detection of Specific Restriction Endonuclease Activities in Crude Cell Extracts.
Sensors (Basel, Switzerland) Oct, 2022 | Pubmed ID: 36298113
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