VIB Center for Inflammation Research
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The use of inhibitors to study endocytic pathways of gene carriers: optimization and pitfalls.
Molecular therapy : the journal of the American Society of Gene Therapy Mar, 2010 | Pubmed ID: 20010917
Matrix metalloproteinase8 has a central role in inflammatory disorders and cancer progression.
Cytokine & growth factor reviews Apr, 2011 | Pubmed ID: 21388856
The first MMP in sepsis.
EMBO molecular medicine Jul, 2011 | Pubmed ID: 21591260
Matrix metalloproteinases as drug targets in ischemia/reperfusion injury.
Drug discovery today Sep, 2011 | Pubmed ID: 21745586
Treatment of TNF mediated diseases by selective inhibition of soluble TNF or TNFR1.
Cytokine & growth factor reviews , 2011 | Pubmed ID: 21962830
Safe TNF-based antitumor therapy following p55TNFR reduction in intestinal epithelium.
The Journal of clinical investigation Jun, 2013 | Pubmed ID: 23676465
Matrix metalloproteinase 13 modulates intestinal epithelial barrier integrity in inflammatory diseases by activating TNF.
EMBO molecular medicine Jul, 2013 | Pubmed ID: 23723167
Mice overexpressing β-1,4-Galactosyltransferase I are resistant to TNF-induced inflammation and DSS-induced colitis.
PloS one , 2013 | Pubmed ID: 24339869
Antisense oligonucleotides against TNFR1 prevent toxicity of TNF/IFNγ treatment in mouse tumor models.
International journal of cancer Aug, 2014 | Pubmed ID: 24382818
An acute phase protein ready to go therapeutic for sepsis.
EMBO molecular medicine Jan, 2014 | Pubmed ID: 24408964
A new angle on blood-CNS interfaces: a role for connexins?
FEBS letters Apr, 2014 | Pubmed ID: 24631535
Choose your models wisely: how different murine bone marrow-derived dendritic cell protocols influence the success of nanoparticulate vaccines in vitro.
Journal of controlled release : official journal of the Controlled Release Society Dec, 2014 | Pubmed ID: 24960224
Tauroursodeoxycholic acid inhibits experimental colitis by preventing early intestinal epithelial cell death.
Laboratory investigation; a journal of technical methods and pathology Dec, 2014 | Pubmed ID: 25310532
Is there new hope for therapeutic matrix metalloproteinase inhibition?
Nature reviews. Drug discovery Dec, 2014 | Pubmed ID: 25376097
An inflammatory triangle in psoriasis: TNF, type I IFNs and IL-17.
Cytokine & growth factor reviews Feb, 2015 | Pubmed ID: 25434285
Generation and characterization of small single domain antibodies inhibiting human tumor necrosis factor receptor 1.
The Journal of biological chemistry Feb, 2015 | Pubmed ID: 25538244
Dual Inhibition of TNFR1 and IFNAR1 in Imiquimod-Induced Psoriasiform Skin Inflammation in Mice.
Journal of immunology (Baltimore, Md. : 1950) Jun, 2015 | Pubmed ID: 25911755
Clinical implications of leukocyte infiltration at the choroid plexus in (neuro)inflammatory disorders.
Drug discovery today Aug, 2015 | Pubmed ID: 25979470
Glucocorticoid-induced microRNA-511 protects against TNF by down-regulating TNFR1.
EMBO molecular medicine Aug, 2015 | Pubmed ID: 25995337
Therapeutic implications of the choroid plexus-cerebrospinal fluid interface in neuropsychiatric disorders.
Brain, behavior, and immunity Nov, 2015 | Pubmed ID: 26116435
Passenger Mutations Confound Interpretation of All Genetically Modified Congenic Mice.
Immunity Jul, 2015 | Pubmed ID: 26163370
Hematopoietic plakophilin-3 regulates acute tissue-specific and systemic inflammation in mice.
European journal of immunology Oct, 2015 | Pubmed ID: 26173741
Amyloid β Oligomers Disrupt Blood-CSF Barrier Integrity by Activating Matrix Metalloproteinases.
The Journal of neuroscience : the official journal of the Society for Neuroscience Sep, 2015 | Pubmed ID: 26377465
Decreased TNF Levels and Improved Retinal Ganglion Cell Survival in MMP-2 Null Mice Suggest a Role for MMP-2 as TNF Sheddase.
Mediators of inflammation , 2015 | Pubmed ID: 26451076
Friends or Foes: Matrix Metalloproteinases and Their Multifaceted Roles in Neurodegenerative Diseases.
Mediators of inflammation , 2015 | Pubmed ID: 26538832
Endothelial LRP1 transports amyloid-β(1-42) across the blood-brain barrier.
The Journal of clinical investigation Jan, 2016 | Pubmed ID: 26619118
Development and Validation of a Small Single-domain Antibody That Effectively Inhibits Matrix Metalloproteinase 8.
Molecular therapy : the journal of the American Society of Gene Therapy May, 2016 | Pubmed ID: 26775809
Topical imiquimod yields systemic effects due to unintended oral uptake.
Scientific reports Jan, 2016 | Pubmed ID: 26818707
Into rather unexplored terrain-transcellular transport across the blood-brain barrier.
Glia Jul, 2016 | Pubmed ID: 26852907
Comparing exosome-like vesicles with liposomes for the functional cellular delivery of small RNAs.
Journal of controlled release : official journal of the Controlled Release Society Jun, 2016 | Pubmed ID: 27072025
Nanobodies as therapeutics: big opportunities for small antibodies.
Drug discovery today Jul, 2016 | Pubmed ID: 27080147
The effect of aging on brain barriers and the consequences for Alzheimer's disease development.
Mammalian genome : official journal of the International Mammalian Genome Society Aug, 2016 | Pubmed ID: 27143113
Efficient analysis of mouse genome sequences reveal many nonsense variants.
Proceedings of the National Academy of Sciences of the United States of America May, 2016 | Pubmed ID: 27147605
The choroid plexus-cerebrospinal fluid interface in Alzheimer's disease: more than just a barrier.
Neural regeneration research Apr, 2016 | Pubmed ID: 27212900
Caloric restriction: beneficial effects on brain aging and Alzheimer's disease.
Mammalian genome : official journal of the International Mammalian Genome Society Aug, 2016 | Pubmed ID: 27240590
With mouse age comes wisdom: A review and suggestions of relevant mouse models for age-related conditions.
Mechanisms of ageing and development Dec, 2016 | Pubmed ID: 27450180
Identification of a novel mechanism of blood-brain communication during peripheral inflammation via choroid plexus-derived extracellular vesicles.
EMBO molecular medicine Oct, 2016 | Pubmed ID: 27596437
Sizing nanomaterials in bio-fluids by cFRAP enables protein aggregation measurements and diagnosis of bio-barrier permeability.
Nature communications Sep, 2016 | Pubmed ID: 27653841
Mouse models of ageing and their relevance to disease.
Mechanisms of ageing and development Dec, 2016 | Pubmed ID: 27717883
MMP-3 Deficiency Alleviates Endotoxin-Induced Acute Inflammation in the Posterior Eye Segment.
International journal of molecular sciences Nov, 2016 | Pubmed ID: 27809288
A Hidden Epithelial Barrier in the Brain with a Central Role in Regulating Brain Homeostasis. Implications for Aging.
Annals of the American Thoracic Society Dec, 2016 | Pubmed ID: 28005425
Treatment of Intestinal Fibrosis in Experimental Inflammatory Bowel Disease by the Pleiotropic Actions of a Local Rho Kinase Inhibitor.
Gastroenterology Oct, 2017 | Pubmed ID: 28642198
TNFR1 inhibition with a Nanobody protects against EAE development in mice.
Scientific reports Oct, 2017 | Pubmed ID: 29057962
Simultaneous Inhibition of Tumor Necrosis Factor Receptor 1 and Matrix Metalloproteinase 8 Completely Protects Against Acute Inflammation and Sepsis.
Critical care medicine Jan, 2018 | Pubmed ID: 29095202
Current research into brain barriers and the delivery of therapeutics for neurological diseases: a report on CNS barrier congress London, UK, 2017.
Fluids and barriers of the CNS Nov, 2017 | Pubmed ID: 29110676
The choroid plexus epithelium as a novel player in the stomach-brain axis during Helicobacter infection.
Brain, behavior, and immunity Mar, 2018 | Pubmed ID: 29258921
Correction to: Current research into brain barriers and the delivery of therapeutics for neurological diseases: a report on CNS barrier congress London, UK, 2017.
Fluids and barriers of the CNS 01, 2018 | Pubmed ID: 29329565
Counteracting the effects of TNF receptor-1 has therapeutic potential in Alzheimer's disease.
EMBO molecular medicine Apr, 2018 | Pubmed ID: 29472246
Glucocorticoid receptor dimers control intestinal STAT1 and TNF-induced inflammation in mice.
The Journal of clinical investigation Aug, 2018 | Pubmed ID: 29746256
A New Venue of TNF Targeting.
International journal of molecular sciences May, 2018 | Pubmed ID: 29751683
Overexpression of Gilz Protects Mice Against Lethal Septic Peritonitis.
Shock (Augusta, Ga.) Aug, 2019 | Pubmed ID: 30124596
The N-terminal p.(Ser38Cys) TIMP3 mutation underlying Sorsby fundus dystrophy is a founder mutation disrupting an intramolecular disulfide bond.
Human mutation May, 2019 | Pubmed ID: 30668888
Choroid plexus tumor necrosis factor receptor 1: A new neuroinflammatory piece of the complex Alzheimer's disease puzzle.
Neural regeneration research Jul, 2019 | Pubmed ID: 30804238
A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment.
Nature neuroscience Jun, 2019 | Pubmed ID: 31061494
Choroid plexus-derived miR-204 regulates the number of quiescent neural stem cells in the adult brain.
The EMBO journal Sep, 2019 | Pubmed ID: 31304985
Immunogenicity and Protection Efficacy of a Naked Self-Replicating mRNA-Based Zika Virus Vaccine.
Vaccines Aug, 2019 | Pubmed ID: 31450775
Interferons: A molecular switch between damage and repair in ageing and Alzheimer's disease.
Mechanisms of ageing and development Oct, 2019 | Pubmed ID: 31541624
Blocking connexin43 hemichannels protects mice against tumour necrosis factor-induced inflammatory shock.
Scientific reports 11, 2019 | Pubmed ID: 31719598
Biological membranes in EV biogenesis, stability, uptake, and cargo transfer: an ISEV position paper arising from the ISEV membranes and EVs workshop.
Journal of extracellular vesicles , 2019 | Pubmed ID: 31762963
A Study of Cecal Ligation and Puncture-Induced Sepsis in Tissue-Specific Tumor Necrosis Factor Receptor 1-Deficient Mice.
Frontiers in immunology , 2019 | Pubmed ID: 31787972
Microglial activation arises after aggregation of phosphorylated-tau in a neuron-specific P301S tauopathy mouse model.
Neurobiology of aging May, 2020 | Pubmed ID: 32008854
Tightening the retinal glia limitans attenuates neuroinflammation after optic nerve injury.
Glia Dec, 2020 | Pubmed ID: 32645232
High-precision isotopic analysis of Mg and Ca in biological samples using multi-collector ICP-mass spectrometry after their sequential chromatographic isolation - Application to the characterization of the body distribution of Mg and Ca isotopes in mice.
Analytica chimica acta Sep, 2020 | Pubmed ID: 32892933
Extracellular Vesicles in Alzheimer's and Parkinson's Disease: Small Entities with Large Consequences.
Cells Nov, 2020 | Pubmed ID: 33203181
and the Potential Role in Neurological Disorders: There Is More Than .
Frontiers in immunology , 2020 | Pubmed ID: 33633723
Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization.
Nature neuroscience Apr, 2021 | Pubmed ID: 33782623
Profiling of Extracellular Small RNAs Highlights a Strong Bias towards Non-Vesicular Secretion.
Cells Jun, 2021 | Pubmed ID: 34207405
Effect of Endotoxemia Induced by Intraperitoneal Injection of Lipopolysaccharide on the Mg isotopic Composition of Biofluids and Tissues in Mice.
Frontiers in medicine , 2021 | Pubmed ID: 34368182
Importance of extracellular vesicle secretion at the blood-cerebrospinal fluid interface in the pathogenesis of Alzheimer's disease.
Acta neuropathologica communications Aug, 2021 | Pubmed ID: 34425919
The power of imaging to understand extracellular vesicle biology in vivo.
Nature methods Sep, 2021 | Pubmed ID: 34446922
Extracellular Vesicles: A Double-Edged Sword in Sepsis.
Pharmaceuticals (Basel, Switzerland) Aug, 2021 | Pubmed ID: 34451925
The neurogliovascular unit in hepatic encephalopathy.
JHEP reports : innovation in hepatology Oct, 2021 | Pubmed ID: 34611619
Amelioration of systemic inflammation via the display of two different decoy protein receptors on extracellular vesicles.
Nature biomedical engineering Sep, 2021 | Pubmed ID: 34616047
Low-grade peripheral inflammation affects brain pathology in the Appmouse model of Alzheimer's disease.
Acta neuropathologica communications Oct, 2021 | Pubmed ID: 34620254
Involvement of the Choroid Plexus in the Pathogenesis of Niemann-Pick Disease Type C.
Frontiers in cellular neuroscience , 2021 | Pubmed ID: 34720883
Gastric Infection Partially Protects against Neurotoxicity in A 6-OHDA Parkinson's Disease Mouse Model.
International journal of molecular sciences Oct, 2021 | Pubmed ID: 34768765
Special delEVery: Extracellular Vesicles as Promising Delivery Platform to the Brain.
Biomedicines Nov, 2021 | Pubmed ID: 34829963
Anti-Inflammatory Mesenchymal Stromal Cell-Derived Extracellular Vesicles Improve Pathology in Niemann-Pick Type C Disease.
Biomedicines Dec, 2021 | Pubmed ID: 34944681
Fighting fire with fire: The immune system might be key in our fight against Alzheimer's disease.
Drug discovery today May, 2022 | Pubmed ID: 35032668
The Impact of Systemic Inflammation on Alzheimer's Disease Pathology.
Frontiers in immunology , 2021 | Pubmed ID: 35069578
The tremendous biomedical potential of bacterial extracellular vesicles.
Trends in biotechnology Oct, 2022 | Pubmed ID: 35581020
Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation.
Nature immunology Jun, 2022 | Pubmed ID: 35618831
High-Precision Isotopic Analysis of Cu and Fe Multi-Collector Inductively Coupled Plasma-Mass Spectrometry Reveals Lipopolysaccharide-Induced Inflammatory Effects in Blood Plasma and Brain Tissues.
Frontiers in chemistry , 2022 | Pubmed ID: 35783204
Targeting gliovascular connexins prevents inflammatory blood-brain barrier leakage and astrogliosis.
JCI insight Aug, 2022 | Pubmed ID: 35881483
Biomarker and therapeutic potential of peripheral extracellular vesicles in Alzheimer's disease.
Advanced drug delivery reviews Nov, 2022 | Pubmed ID: 35952829
Recent insights into viral infections as a trigger and accelerator in alzheimer's disease.
Drug discovery today Aug, 2022 | Pubmed ID: 35987492
Differential plasticity and fate of brain-resident and recruited macrophages during the onset and resolution of neuroinflammation.
Immunity Nov, 2022 | Pubmed ID: 36228615
A mouse model of hepatic encephalopathy: bile duct ligation induces brain ammonia overload, glial cell activation and neuroinflammation.
Scientific reports Oct, 2022 | Pubmed ID: 36266427
Choroid plexus-derived extracellular vesicles exhibit brain targeting characteristics.
Biomaterials Nov, 2022 | Pubmed ID: 36302306
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