Roosmarijn E. Vandenbroucke

The use of inhibitors to study endocytic pathways of gene carriers: optimization and pitfalls.

Matrix metalloproteinase8 has a central role in inflammatory disorders and cancer progression.

The first MMP in sepsis.

Matrix metalloproteinases as drug targets in ischemia/reperfusion injury.

Treatment of TNF mediated diseases by selective inhibition of soluble TNF or TNFR1.

Safe TNF-based antitumor therapy following p55TNFR reduction in intestinal epithelium.

Matrix metalloproteinase 13 modulates intestinal epithelial barrier integrity in inflammatory diseases by activating TNF.

Mice overexpressing β-1,4-Galactosyltransferase I are resistant to TNF-induced inflammation and DSS-induced colitis.

Antisense oligonucleotides against TNFR1 prevent toxicity of TNF/IFNγ treatment in mouse tumor models.

An acute phase protein ready to go therapeutic for sepsis.

A new angle on blood-CNS interfaces: a role for connexins?

Choose your models wisely: how different murine bone marrow-derived dendritic cell protocols influence the success of nanoparticulate vaccines in vitro.

Tauroursodeoxycholic acid inhibits experimental colitis by preventing early intestinal epithelial cell death.

Is there new hope for therapeutic matrix metalloproteinase inhibition?

An inflammatory triangle in psoriasis: TNF, type I IFNs and IL-17.

Generation and characterization of small single domain antibodies inhibiting human tumor necrosis factor receptor 1.

Dual Inhibition of TNFR1 and IFNAR1 in Imiquimod-Induced Psoriasiform Skin Inflammation in Mice.

Clinical implications of leukocyte infiltration at the choroid plexus in (neuro)inflammatory disorders.

Glucocorticoid-induced microRNA-511 protects against TNF by down-regulating TNFR1.

Therapeutic implications of the choroid plexus-cerebrospinal fluid interface in neuropsychiatric disorders.

Passenger Mutations Confound Interpretation of All Genetically Modified Congenic Mice.

Hematopoietic plakophilin-3 regulates acute tissue-specific and systemic inflammation in mice.

Amyloid β Oligomers Disrupt Blood-CSF Barrier Integrity by Activating Matrix Metalloproteinases.

Decreased TNF Levels and Improved Retinal Ganglion Cell Survival in MMP-2 Null Mice Suggest a Role for MMP-2 as TNF Sheddase.

Friends or Foes: Matrix Metalloproteinases and Their Multifaceted Roles in Neurodegenerative Diseases.

Endothelial LRP1 transports amyloid-β(1-42) across the blood-brain barrier.

Development and Validation of a Small Single-domain Antibody That Effectively Inhibits Matrix Metalloproteinase 8.

Topical imiquimod yields systemic effects due to unintended oral uptake.

Into rather unexplored terrain-transcellular transport across the blood-brain barrier.

Comparing exosome-like vesicles with liposomes for the functional cellular delivery of small RNAs.

Nanobodies as therapeutics: big opportunities for small antibodies.

The effect of aging on brain barriers and the consequences for Alzheimer's disease development.

Efficient analysis of mouse genome sequences reveal many nonsense variants.

The choroid plexus-cerebrospinal fluid interface in Alzheimer's disease: more than just a barrier.

Caloric restriction: beneficial effects on brain aging and Alzheimer's disease.

With mouse age comes wisdom: A review and suggestions of relevant mouse models for age-related conditions.

Identification of a novel mechanism of blood-brain communication during peripheral inflammation via choroid plexus-derived extracellular vesicles.

Sizing nanomaterials in bio-fluids by cFRAP enables protein aggregation measurements and diagnosis of bio-barrier permeability.

Mouse models of ageing and their relevance to disease.

MMP-3 Deficiency Alleviates Endotoxin-Induced Acute Inflammation in the Posterior Eye Segment.

A Hidden Epithelial Barrier in the Brain with a Central Role in Regulating Brain Homeostasis. Implications for Aging.

Treatment of Intestinal Fibrosis in Experimental Inflammatory Bowel Disease by the Pleiotropic Actions of a Local Rho Kinase Inhibitor.

TNFR1 inhibition with a Nanobody protects against EAE development in mice.

Simultaneous Inhibition of Tumor Necrosis Factor Receptor 1 and Matrix Metalloproteinase 8 Completely Protects Against Acute Inflammation and Sepsis.

Current research into brain barriers and the delivery of therapeutics for neurological diseases: a report on CNS barrier congress London, UK, 2017.

The choroid plexus epithelium as a novel player in the stomach-brain axis during Helicobacter infection.

Correction to: Current research into brain barriers and the delivery of therapeutics for neurological diseases: a report on CNS barrier congress London, UK, 2017.

Counteracting the effects of TNF receptor-1 has therapeutic potential in Alzheimer's disease.

Glucocorticoid receptor dimers control intestinal STAT1 and TNF-induced inflammation in mice.

A New Venue of TNF Targeting.

Overexpression of Gilz Protects Mice Against Lethal Septic Peritonitis.

The N-terminal p.(Ser38Cys) TIMP3 mutation underlying Sorsby fundus dystrophy is a founder mutation disrupting an intramolecular disulfide bond.

Choroid plexus tumor necrosis factor receptor 1: A new neuroinflammatory piece of the complex Alzheimer's disease puzzle.

A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment.

Choroid plexus-derived miR-204 regulates the number of quiescent neural stem cells in the adult brain.

Immunogenicity and Protection Efficacy of a Naked Self-Replicating mRNA-Based Zika Virus Vaccine.

Interferons: A molecular switch between damage and repair in ageing and Alzheimer's disease.

Blocking connexin43 hemichannels protects mice against tumour necrosis factor-induced inflammatory shock.

Biological membranes in EV biogenesis, stability, uptake, and cargo transfer: an ISEV position paper arising from the ISEV membranes and EVs workshop.

A Study of Cecal Ligation and Puncture-Induced Sepsis in Tissue-Specific Tumor Necrosis Factor Receptor 1-Deficient Mice.

Microglial activation arises after aggregation of phosphorylated-tau in a neuron-specific P301S tauopathy mouse model.

Tightening the retinal glia limitans attenuates neuroinflammation after optic nerve injury.

High-precision isotopic analysis of Mg and Ca in biological samples using multi-collector ICP-mass spectrometry after their sequential chromatographic isolation - Application to the characterization of the body distribution of Mg and Ca isotopes in mice.

Extracellular Vesicles in Alzheimer's and Parkinson's Disease: Small Entities with Large Consequences.

and the Potential Role in Neurological Disorders: There Is More Than .

Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization.

Profiling of Extracellular Small RNAs Highlights a Strong Bias towards Non-Vesicular Secretion.

Effect of Endotoxemia Induced by Intraperitoneal Injection of Lipopolysaccharide on the Mg isotopic Composition of Biofluids and Tissues in Mice.

Importance of extracellular vesicle secretion at the blood-cerebrospinal fluid interface in the pathogenesis of Alzheimer's disease.

The power of imaging to understand extracellular vesicle biology in vivo.

Extracellular Vesicles: A Double-Edged Sword in Sepsis.

The neurogliovascular unit in hepatic encephalopathy.

Amelioration of systemic inflammation via the display of two different decoy protein receptors on extracellular vesicles.

Low-grade peripheral inflammation affects brain pathology in the Appmouse model of Alzheimer's disease.

Involvement of the Choroid Plexus in the Pathogenesis of Niemann-Pick Disease Type C.

Gastric Infection Partially Protects against Neurotoxicity in A 6-OHDA Parkinson's Disease Mouse Model.

Special delEVery: Extracellular Vesicles as Promising Delivery Platform to the Brain.

Anti-Inflammatory Mesenchymal Stromal Cell-Derived Extracellular Vesicles Improve Pathology in Niemann-Pick Type C Disease.

Fighting fire with fire: The immune system might be key in our fight against Alzheimer's disease.

The Impact of Systemic Inflammation on Alzheimer's Disease Pathology.

The tremendous biomedical potential of bacterial extracellular vesicles.

Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation.

High-Precision Isotopic Analysis of Cu and Fe Multi-Collector Inductively Coupled Plasma-Mass Spectrometry Reveals Lipopolysaccharide-Induced Inflammatory Effects in Blood Plasma and Brain Tissues.

Targeting gliovascular connexins prevents inflammatory blood-brain barrier leakage and astrogliosis.

Biomarker and therapeutic potential of peripheral extracellular vesicles in Alzheimer's disease.

Recent insights into viral infections as a trigger and accelerator in alzheimer's disease.

Differential plasticity and fate of brain-resident and recruited macrophages during the onset and resolution of neuroinflammation.

A mouse model of hepatic encephalopathy: bile duct ligation induces brain ammonia overload, glial cell activation and neuroinflammation.

Choroid plexus-derived extracellular vesicles exhibit brain targeting characteristics.