Laboratory of Molecular Microbiology,
National Institute of Allergy and Infectious Diseases,
Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases
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In vitro characterization of primary SIVsmm isolates belonging to different lineages. In vitro growth on rhesus macaque cells is not predictive for in vivo replication in rhesus macaques.
Virology Jun, 2007 | Pubmed ID: 17303205
Acute loss of intestinal CD4+ T cells is not predictive of simian immunodeficiency virus virulence.
Journal of immunology (Baltimore, Md. : 1950) Sep, 2007 | Pubmed ID: 17709518
Cutting edge: Experimentally induced immune activation in natural hosts of simian immunodeficiency virus induces significant increases in viral replication and CD4+ T cell depletion.
Journal of immunology (Baltimore, Md. : 1950) Nov, 2008 | Pubmed ID: 18981083
Pattern of SIVagm infection in patas monkeys suggests that host adaptation to simian immunodeficiency virus infection may result in resistance to infection and virus extinction.
The Journal of infectious diseases Nov, 2010 | Pubmed ID: 20887227
Rapid development of glycan-specific, broad, and potent anti-HIV-1 gp120 neutralizing antibodies in an R5 SIV/HIV chimeric virus infected macaque.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2011 | Pubmed ID: 22123961
Pathogenicity and mucosal transmissibility of the R5-tropic simian/human immunodeficiency virus SHIV(AD8) in rhesus macaques: implications for use in vaccine studies.
Journal of virology Aug, 2012 | Pubmed ID: 22647691
Most rhesus macaques infected with the CCR5-tropic SHIV(AD8) generate cross-reactive antibodies that neutralize multiple HIV-1 strains.
Proceedings of the National Academy of Sciences of the United States of America Nov, 2012 | Pubmed ID: 23129652
Pathogenic features associated with increased virulence upon Simian immunodeficiency virus cross-species transmission from natural hosts.
Journal of virology Jun, 2014 | Pubmed ID: 24696477
Quality and quantity of TFH cells are critical for broad antibody development in SHIVAD8 infection.
Science translational medicine Jul, 2015 | Pubmed ID: 26223303
A single injection of anti-HIV-1 antibodies protects against repeated SHIV challenges.
Nature May, 2016 | Pubmed ID: 27120156
DNA Prime-Boost Vaccine Regimen To Increase Breadth, Magnitude, and Cytotoxicity of the Cellular Immune Responses to Subdominant Gag Epitopes of Simian Immunodeficiency Virus and HIV.
Journal of immunology (Baltimore, Md. : 1950) Nov, 2016 | Pubmed ID: 27733554
Early antibody therapy can induce long-lasting immunity to SHIV.
Nature Mar, 2017 | Pubmed ID: 28289286
Potential of conventional & bispecific broadly neutralizing antibodies for prevention of HIV-1 subtype A, C & D infections.
PLoS pathogens Mar, 2018 | Pubmed ID: 29505593
A single injection of crystallizable fragment domain-modified antibodies elicits durable protection from SHIV infection.
Nature medicine May, 2018 | Pubmed ID: 29662199
Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques.
Nature Jun, 2019 | Pubmed ID: 31142836
Immunotherapy during the acute SHIV infection of macaques confers long-term suppression of viremia.
The Journal of experimental medicine Jan, 2021 | Pubmed ID: 32966579
A broadly neutralizing macaque monoclonal antibody against the HIV-1 V3-Glycan patch.
eLife Oct, 2020 | Pubmed ID: 33084569
Antibody elicited by HIV-1 immunogen vaccination in macaques displaces Env fusion peptide and destroys a neutralizing epitope.
NPJ vaccines Oct, 2021 | Pubmed ID: 34697307
Sequential immunization of macaques elicits heterologous neutralizing antibodies targeting the V3-glycan patch of HIV-1 Env.
Science translational medicine Nov, 2021 | Pubmed ID: 34818054
Neutralizing antibodies induced in immunized macaques recognize the CD4-binding site on an occluded-open HIV-1 envelope trimer.
Nature communications Feb, 2022 | Pubmed ID: 35136084
Harald Hartweger1,
Rajeev Gautam2,
Yoshiaki Nishimura2,
Fabian Schmidt3,5,
Kai-Hui Yao1,
Amelia Escolano1,6,
Mila Jankovic1,
Malcolm A. Martin2,
Michel C. Nussenzweig1,4
1Laboratory of Molecular Immunology, The Rockefeller University,
2Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health,
3Laboratory of Retrovirology, The Rockefeller University,
4Howard Hughes Medical Institute, The Rockefeller University,
5Laboratory of Applied Virology and Precision Medicine, King Abdullah University of Science and Technology (KAUST),
6Vaccine and Immunotherapy Center, Wistar Institute
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