Department of Pharmacology
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Maturation alters the contribution of potassium channels to resting and 5HT-induced tone in small cerebral arteries of the sheep.
Brain research. Developmental brain research Feb, 2002 | Pubmed ID: 11882339
Cardiovascular responses and neurotransmission in the ventrolateral medulla during skeletal muscle contraction following transient middle cerebral artery occlusion and reperfusion.
Brain research Oct, 2002 | Pubmed ID: 12376178
Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells.
Nature genetics Feb, 2003 | Pubmed ID: 12514735
Maturation alters cyclic nucleotide and relaxation responses to nitric oxide donors in ovine cerebral arteries.
Biology of the neonate , 2003 | Pubmed ID: 12576757
Immortalized epithelial cells from human autosomal dominant polycystic kidney cysts.
American journal of physiology. Renal physiology Sep, 2003 | Pubmed ID: 12734101
Cardiovascular responses and neurotransmitter changes following blockade of nNOS within the ventrolateral medulla during static muscle contraction.
Brain research Jul, 2003 | Pubmed ID: 12788516
Gating of the polycystin ion channel signaling complex in neurons and kidney cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Apr, 2004 | Pubmed ID: 14766803
Polycystins and mechanosensation in renal and nodal cilia.
BioEssays : news and reviews in molecular, cellular and developmental biology Aug, 2004 | Pubmed ID: 15273987
Global cytoskeletal control of mechanotransduction in kidney epithelial cells.
Experimental cell research Nov, 2004 | Pubmed ID: 15501441
Involvement of extracellular Ca2+ influx through voltage-independent Ca2+ channels in endothelin-1 function.
Cellular signalling Aug, 2005 | Pubmed ID: 15894164
Chronic hypoxia modulates relations among calcium, myosin light chain phosphorylation, and force differently in fetal and adult ovine basilar arteries.
Journal of applied physiology (Bethesda, Md. : 1985) Jul, 2005 | Pubmed ID: 16036903
Molecular changes in nNOS protein expression within the ventrolateral medulla following transient focal ischemia affect cardiovascular functions.
Brain research Sep, 2005 | Pubmed ID: 16084499
Loss of polycystin-1 in human cyst-lining epithelia leads to ciliary dysfunction.
Journal of the American Society of Nephrology : JASN Apr, 2006 | Pubmed ID: 16565258
Fibrocystin/polyductin, found in the same protein complex with polycystin-2, regulates calcium responses in kidney epithelia.
Molecular and cellular biology Apr, 2007 | Pubmed ID: 17283055
Endothelial cilia are fluid shear sensors that regulate calcium signaling and nitric oxide production through polycystin-1.
Circulation Mar, 2008 | Pubmed ID: 18285569
Ciliary dysfunction in polycystic kidney disease: an emerging model with polarizing potential.
Frontiers in bioscience : a journal and virtual library , 2008 | Pubmed ID: 18508522
Ciliary polycystin-2 is a mechanosensitive calcium channel involved in nitric oxide signaling cascades.
Circulation research Apr, 2009 | Pubmed ID: 19265036
Endothelin.
Cellular and molecular life sciences : CMLS Jan, 2011 | Pubmed ID: 20848158
Failure to ubiquitinate c-Met leads to hyperactivation of mTOR signaling in a mouse model of autosomal dominant polycystic kidney disease.
The Journal of clinical investigation Oct, 2010 | Pubmed ID: 20852388
Calcium-mediated mechanisms of cystic expansion.
Biochimica et biophysica acta Oct, 2011 | Pubmed ID: 20932898
Endothelial cells from humans and mice with polycystic kidney disease are characterized by polyploidy and chromosome segregation defects through survivin down-regulation.
Human molecular genetics Jan, 2011 | Pubmed ID: 21041232
Multiple protein kinases determine the phosphorylated state of the small heat shock protein, HSP27, in SH-SY5Y neuroblastoma cells.
Neuropharmacology Jul-Aug, 2011 | Pubmed ID: 21338617
Lack of primary cilia primes shear-induced endothelial-to-mesenchymal transition.
Circulation research Apr, 2011 | Pubmed ID: 21393577
Multimodal spectral imaging of cells using a transmission diffraction grating on a light microscope.
Applied spectroscopy Jun, 2011 | Pubmed ID: 21639978
Mechanisms regulating cilia growth and cilia function in endothelial cells.
Cellular and molecular life sciences : CMLS Jan, 2012 | Pubmed ID: 21671118
Dopamine receptor type 5 in the primary cilia has dual chemo- and mechano-sensory roles.
Hypertension Aug, 2011 | Pubmed ID: 21709211
The mechanosensory role of primary cilia in vascular hypertension.
International journal of vascular medicine , 2011 | Pubmed ID: 21748021
A Comparative Study of Embedded and Anesthetized Zebrafish in vivo on Myocardiac Calcium Oscillation and Heart Muscle Contraction.
Frontiers in pharmacology , 2010 | Pubmed ID: 21833178
Primary cilia regulates the directional migration and barrier integrity of endothelial cells through the modulation of hsp27 dependent actin cytoskeletal organization.
Journal of cellular physiology Jan, 2012 | Pubmed ID: 21837772
An ACE inhibitor improves vascular outcomes in a PKD model.
American journal of physiology. Renal physiology Nov, 2011 | Pubmed ID: 21880832
Polycystic diseases in visceral organs.
Obstetrics and gynecology international , 2011 | Pubmed ID: 22242024
Primary cilia: highly sophisticated biological sensors.
Sensors (Basel, Switzerland) , 2009 | Pubmed ID: 22423203
Mechanosensory calcium signaling.
Advances in experimental medicine and biology , 2012 | Pubmed ID: 22453981
Cilostazol prevents endothelin-induced smooth muscle constriction and proliferation.
PloS one , 2012 | Pubmed ID: 22957074
Pkd2 mesenteric vessels exhibit a primary defect in endothelium-dependent vasodilatation restored by rosiglitazone.
American journal of physiology. Heart and circulatory physiology Jan, 2013 | Pubmed ID: 23103499
Targeted disruption of Adamts16 gene in a rat genetic model of hypertension.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2012 | Pubmed ID: 23185005
Intestinal transport as a potential determinant of drug bioavailability.
Current clinical pharmacology Aug, 2013 | Pubmed ID: 23343017
Non-motile primary cilia as fluid shear stress mechanosensors.
Methods in enzymology , 2013 | Pubmed ID: 23522462
Development and characterization of nanostructured mists with potential for actively targeting poorly water-soluble compounds into the lungs.
Pharmaceutical research Oct, 2013 | Pubmed ID: 23722411
Cilioplasm is a cellular compartment for calcium signaling in response to mechanical and chemical stimuli.
Cellular and molecular life sciences : CMLS Jun, 2014 | Pubmed ID: 24104765
Survivin-induced abnormal ploidy contributes to cystic kidney and aneurysm formation.
Circulation Feb, 2014 | Pubmed ID: 24235270
Roles of dopamine receptor on chemosensory and mechanosensory primary cilia in renal epithelial cells.
Frontiers in physiology , 2014 | Pubmed ID: 24616705
Real-time vascular mechanosensation through ex vivo artery perfusion.
Biological procedures online , 2014 | Pubmed ID: 24685068
Physico-chemical characterisation, cytotoxic activity, and biocompatibility studies of tamoxifen-loaded solid lipid nanoparticles prepared via a temperature-modulated solidification method.
Journal of microencapsulation , 2014 | Pubmed ID: 24697190
Primary cilium regulates CaV1.2 expression through Wnt signaling.
Journal of cellular physiology Dec, 2014 | Pubmed ID: 24700505
Ciliotherapy: a novel intervention in polycystic kidney disease.
Journal of geriatric cardiology : JGC Mar, 2014 | Pubmed ID: 24748884
Three types of ependymal cells with intracellular calcium oscillation are characterized by distinct cilia beating properties.
Journal of neuroscience research Sep, 2014 | Pubmed ID: 24811319
Sensing a sensor: identifying the mechanosensory function of primary cilia.
Biosensors , 2014 | Pubmed ID: 24839551
Chylomicrons produced by Caco-2 cells contained ApoB-48 with diameter of 80-200 nm.
Physiological reports Jun, 2014 | Pubmed ID: 24907293
L-type calcium channel modulates cystic kidney phenotype.
Biochimica et biophysica acta Sep, 2014 | Pubmed ID: 24925129
Cryptorchidism and infertility in rats with targeted disruption of the Adamts16 locus.
PloS one , 2014 | Pubmed ID: 24983376
Hypertension in Autosomal Dominant Polycystic Kidney Disease: A Clinical and Basic Science Perspective.
International journal of nephrology & urology , 2010 | Pubmed ID: 25364490
The Roles of Primary cilia in Polycystic Kidney Disease.
AIMS molecular science , 2014 | Pubmed ID: 25599087
Effects of (R)-(-)-5-methyl-1-nicotinoyl-2-pyrazoline on glutamate transporter 1 and cysteine/glutamate exchanger as well as ethanol drinking behavior in male, alcohol-preferring rats.
Journal of neuroscience research Jun, 2015 | Pubmed ID: 25601490
Protein composition and movements of membrane swellings associated with primary cilia.
Cellular and molecular life sciences : CMLS Jun, 2015 | Pubmed ID: 25650235
Dopaminergic signaling within the primary cilia in the renovascular system.
Frontiers in physiology , 2015 | Pubmed ID: 25932013
1Department of Pharmacology and Experimental Therapeutics, University of Toledo, College of Pharmacy and Pharmaceutical Sciences,
2Life Sciences Institute, University of Michigan,
3Department of Biomedical & Pharmaceutical Sciences, Chapman University, School of Pharmacy, Rinker Health Science campus
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