Department of Pathology,
Immunology,
and Laboratory Medicine,
Department of Pathology, Immunology, and Laboratory Medicine
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In vivo and in vitro characterization of insulin-producing cells obtained from murine bone marrow.
Diabetes Jul, 2004 | Pubmed ID: 15220196
Heterophile antibodies segregate in families and are associated with protection from type 1 diabetes.
Proceedings of the National Academy of Sciences of the United States of America Jul, 1999 | Pubmed ID: 10393957
Adeno-associated virus vector-mediated IL-10 gene delivery prevents type 1 diabetes in NOD mice.
Proceedings of the National Academy of Sciences of the United States of America Nov, 2001 | Pubmed ID: 11717448
Microbiology (Reading, England) Apr, 2002 | Pubmed ID: 11932443
Adeno-associated virus transduction of islets with interleukin-4 results in impaired metabolic function in syngeneic marginal islet mass transplantation.
Transplantation Oct, 2002 | Pubmed ID: 12438968
Fatal attraction: chemokines and type 1 diabetes.
The Journal of clinical investigation Dec, 2002 | Pubmed ID: 12464665
Matrix biology : journal of the International Society for Matrix Biology Dec, 2002 | Pubmed ID: 12524049
Adeno-associated virus-mediated IL-10 gene therapy inhibits diabetes recurrence in syngeneic islet cell transplantation of NOD mice.
Diabetes Mar, 2003 | Pubmed ID: 12606512
Gene delivery in renal tubular epithelial cells using recombinant adeno-associated viral vectors.
Journal of the American Society of Nephrology : JASN Apr, 2003 | Pubmed ID: 12660329
Journal of autoimmunity May, 2003 | Pubmed ID: 12753809
Microbiology (Reading, England) Jun, 2003 | Pubmed ID: 12777499
Systemic overexpression of IL-10 induces CD4+CD25+ cell populations in vivo and ameliorates type 1 diabetes in nonobese diabetic mice in a dose-dependent fashion.
Journal of immunology (Baltimore, Md. : 1950) Sep, 2003 | Pubmed ID: 12928371
American journal of industrial medicine Sep, 2003 | Pubmed ID: 12929149
Why can't we prevent type 1 diabetes?: maybe it's time to try a different combination.
Diabetes care Dec, 2003 | Pubmed ID: 14633822
Molecular therapy : the journal of the American Society of Gene Therapy Mar, 2004 | Pubmed ID: 15006610
Timing of initial cereal exposure in infancy and risk of islet autoimmunity.
The Journal of pediatrics May, 2004 | Pubmed ID: 15152374
Heme oxygenase-1 modulates early inflammatory responses: evidence from the heme oxygenase-1-deficient mouse.
The American journal of pathology Sep, 2004 | Pubmed ID: 15331427
American journal of industrial medicine Dec, 2004 | Pubmed ID: 15551364
Diabetes acceleration or prevention by a coxsackievirus B4 infection: critical requirements for both interleukin-4 and gamma interferon.
Journal of virology Jan, 2005 | Pubmed ID: 15613333
Efficient transduction of vascular endothelial cells with recombinant adeno-associated virus serotype 1 and 5 vectors.
Human gene therapy Feb, 2005 | Pubmed ID: 15761263
Changes in hippocampal IL-15, related cytokines, and neurogenesis in IL-2 deficient mice.
Brain research Apr, 2005 | Pubmed ID: 15829231
An integral role for heme oxygenase-1 and carbon monoxide in maintaining peripheral tolerance by CD4+CD25+ regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950) May, 2005 | Pubmed ID: 15843512
ADA Outstanding Scientific Achievement Lecture 2004. Thirty years of investigating the autoimmune basis for type 1 diabetes: why can't we prevent or reverse this disease?
Diabetes May, 2005 | Pubmed ID: 15855308
Functional defects and the influence of age on the frequency of CD4+ CD25+ T-cells in type 1 diabetes.
Diabetes May, 2005 | Pubmed ID: 15855327
Interleukin 10 attenuates neointimal proliferation and inflammation in aortic allografts by a heme oxygenase-dependent pathway.
Proceedings of the National Academy of Sciences of the United States of America May, 2005 | Pubmed ID: 15878989
Biochemical and biophysical research communications Jun, 2005 | Pubmed ID: 15882999
Localized gene expression following administration of adeno-associated viral vectors via pancreatic ducts.
Molecular therapy : the journal of the American Society of Gene Therapy Sep, 2005 | Pubmed ID: 15979413
A comprehensive review of interventions in the NOD mouse and implications for translation.
Immunity Aug, 2005 | Pubmed ID: 16111631
Diabetes Sep, 2005 | Pubmed ID: 16123339
Systemic overexpression of interleukin-10 fails to protect allogeneic islet transplants in nonobese diabetic mice.
Transplantation Aug, 2005 | Pubmed ID: 16123729
Glucose transporter-2 (GLUT2) promoter mediated transgenic insulin production reduces hyperglycemia in diabetic mice.
FEBS letters Oct, 2005 | Pubmed ID: 16223491
IL-10 suppresses chemokines, inflammation, and fibrosis in a model of chronic renal disease.
Journal of the American Society of Nephrology : JASN Dec, 2005 | Pubmed ID: 16251240
Inhalation toxicology Dec, 2005 | Pubmed ID: 16282156
Type 1 diabetes mellitus: etiology, presentation, and management.
Pediatric clinics of North America Dec, 2005 | Pubmed ID: 16301083
Diabetes Jan, 2006 | Pubmed ID: 16380490
Pediatric diabetes Dec, 2005 | Pubmed ID: 16390385
Efficient delivery of siRNA into cytokine-stimulated insulinoma cells silences Fas expression and inhibits Fas-mediated apoptosis.
FEBS letters Jan, 2006 | Pubmed ID: 16412430
Gene Mar, 2006 | Pubmed ID: 16412588
Enhanced IgE allergic response to Aspergillus fumigatus in CFTR-/- mice.
Laboratory investigation; a journal of technical methods and pathology Feb, 2006 | Pubmed ID: 16424881
Uncoupling of vascular endothelial growth factor with nitric oxide as a mechanism for diabetic vasculopathy.
Journal of the American Society of Nephrology : JASN Mar, 2006 | Pubmed ID: 16436494
Role of Pax4 in Pdx1-VP16-mediated liver-to-endocrine pancreas transdifferentiation.
Laboratory investigation; a journal of technical methods and pathology Aug, 2006 | Pubmed ID: 16732298
Cystic fibrosis transmembrane conductance regulator deficiency exacerbates islet cell dysfunction after beta-cell injury.
Diabetes Jul, 2006 | Pubmed ID: 16804061
Noninvasive imaging of islet grafts using positron-emission tomography.
Proceedings of the National Academy of Sciences of the United States of America Jul, 2006 | Pubmed ID: 16868090
Autoantibody markers for the diagnosis and prediction of type 1 diabetes.
Autoimmunity reviews Jul, 2006 | Pubmed ID: 16890898
IL-10 regulation of lupus in the NZM2410 murine model.
Laboratory investigation; a journal of technical methods and pathology Nov, 2006 | Pubmed ID: 16924244
Molecular therapy : the journal of the American Society of Gene Therapy Dec, 2006 | Pubmed ID: 16982215
Increased natural CD4+CD25+ regulatory T cells and their suppressor activity do not contribute to mortality in murine polymicrobial sepsis.
Journal of immunology (Baltimore, Md. : 1950) Dec, 2006 | Pubmed ID: 17114466
Annals of the New York Academy of Sciences Sep, 2006 | Pubmed ID: 17119209
Diabetic endothelial nitric oxide synthase knockout mice develop advanced diabetic nephropathy.
Journal of the American Society of Nephrology : JASN Feb, 2007 | Pubmed ID: 17202420
Annals of the New York Academy of Sciences Apr, 2007 | Pubmed ID: 17376834
MyD88-dependent expansion of an immature GR-1(+)CD11b(+) population induces T cell suppression and Th2 polarization in sepsis.
The Journal of experimental medicine Jun, 2007 | Pubmed ID: 17548519
Immunology Sep, 2007 | Pubmed ID: 17662044
Treatment with GITR agonistic antibody corrects adaptive immune dysfunction in sepsis.
Blood Nov, 2007 | Pubmed ID: 17690255
Novel synthesis of cerium oxide nanoparticles for free radical scavenging.
Nanomedicine (London, England) Jun, 2007 | Pubmed ID: 17716177
Murine antithymocyte globulin therapy alters disease progression in NOD mice by a time-dependent induction of immunoregulation.
Diabetes Feb, 2008 | Pubmed ID: 18039815
Reversal of streptozotocin-induced diabetes in mice by cellular transduction with recombinant pancreatic transcription factor pancreatic duodenal homeobox-1: a novel protein transduction domain-based therapy.
Diabetes Mar, 2008 | Pubmed ID: 18086901
Neonatal formula feeding leads to immunological alterations in an animal model of type 1 diabetes.
Pediatric research Mar, 2008 | Pubmed ID: 18091354
A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in the IL-2 receptor gamma chain gene.
Clinical immunology (Orlando, Fla.) Mar, 2008 | Pubmed ID: 18096436
Assessing the in vitro suppressive capacity of regulatory T cells.
Immunological investigations , 2007 | Pubmed ID: 18161521
Autologous umbilical cord blood infusion for type 1 diabetes.
Experimental hematology Jun, 2008 | Pubmed ID: 18358588
Suppression by CD4+CD25+ regulatory T cells is dependent on expression of heme oxygenase-1 in antigen-presenting cells.
The American journal of pathology Jul, 2008 | Pubmed ID: 18511516
The pivotal role of VEGF on glomerular macrophage infiltration in advanced diabetic nephropathy.
Laboratory investigation; a journal of technical methods and pathology Sep, 2008 | Pubmed ID: 18607348
CFTR mutations impart elevated immune reactivity in a murine model of cystic fibrosis related diabetes.
Cytokine Oct, 2008 | Pubmed ID: 18778952
The "perfect storm" for type 1 diabetes: the complex interplay between intestinal microbiota, gut permeability, and mucosal immunity.
Diabetes Oct, 2008 | Pubmed ID: 18820210
Murine model for cystic fibrosis bone disease demonstrates osteopenia and sex-related differences in bone formation.
Pediatric research Mar, 2009 | Pubmed ID: 19047917
Expansion of human regulatory T-cells from patients with type 1 diabetes.
Diabetes Mar, 2009 | Pubmed ID: 19074986
Connective tissue research , 2008 | Pubmed ID: 19085241
Taking a daily vitamin to prevent type 1 diabetes?
Diabetes Jan, 2009 | Pubmed ID: 19114727
Annals of the New York Academy of Sciences Dec, 2008 | Pubmed ID: 19120260
Annals of the New York Academy of Sciences Dec, 2008 | Pubmed ID: 19120270
Exendin-4 therapy in NOD mice with new-onset diabetes increases regulatory T cell frequency.
Annals of the New York Academy of Sciences Dec, 2008 | Pubmed ID: 19120286
Journal of immunology (Baltimore, Md. : 1950) Jan, 2009 | Pubmed ID: 19124749
Exendin-4 treatment of nonobese diabetic mice increases beta-cell proliferation and fractional insulin reactive area.
Journal of diabetes and its complications May-Jun, 2010 | Pubmed ID: 19217320
Culture-independent identification of gut bacteria correlated with the onset of diabetes in a rat model.
The ISME journal May, 2009 | Pubmed ID: 19225551
Lowering blood pressure blocks mesangiolysis and mesangial nodules, but not tubulointerstitial injury, in diabetic eNOS knockout mice.
The American journal of pathology Apr, 2009 | Pubmed ID: 19246639
Rabbit polyclonal mouse antithymocyte globulin administration alters dendritic cell profile and function in NOD mice to suppress diabetogenic responses.
Journal of immunology (Baltimore, Md. : 1950) Apr, 2009 | Pubmed ID: 19342635
Influence of fecal sample storage on bacterial community diversity.
The open microbiology journal , 2009 | Pubmed ID: 19440250
The pancreas in human type 1 diabetes: providing new answers to age-old questions.
Current opinion in endocrinology, diabetes, and obesity Aug, 2009 | Pubmed ID: 19502978
Immune depletion with cellular mobilization imparts immunoregulation and reverses autoimmune diabetes in nonobese diabetic mice.
Diabetes Oct, 2009 | Pubmed ID: 19628781
The road not taken: a path to curing type 1 diabetes?
European journal of immunology Aug, 2009 | Pubmed ID: 19672902
Hepatocellular carcinoma immunopathogenesis: clinical evidence for global T cell defects and an immunomodulatory role for soluble CD25 (sCD25).
Digestive diseases and sciences Feb, 2010 | Pubmed ID: 19714465
Autologous umbilical cord blood transfusion in very young children with type 1 diabetes.
Diabetes care Nov, 2009 | Pubmed ID: 19875605
Influence of membrane CD25 stability on T lymphocyte activity: implications for immunoregulation.
PloS one , 2009 | Pubmed ID: 19956753
Lactobacillus johnsonii N6.2 mitigates the development of type 1 diabetes in BB-DP rats.
PloS one , 2010 | Pubmed ID: 20463897
The pancreas in human type 1 diabetes.
Seminars in immunopathology Jan, 2011 | Pubmed ID: 20495921
The Juvenile Diabetes Research Foundation at forty: updates of research in type 1 diabetes.
Diabetes Jul, 2010 | Pubmed ID: 20587801
Toward defining the autoimmune microbiome for type 1 diabetes.
The ISME journal Jan, 2011 | Pubmed ID: 20613793
Human antigen-specific regulatory T cells generated by T cell receptor gene transfer.
PloS one , 2010 | Pubmed ID: 20668510
Butyrate and type 1 diabetes mellitus: can we fix the intestinal leak?
Journal of pediatric gastroenterology and nutrition Oct, 2010 | Pubmed ID: 20706153
Type I diabetes. Preface.
Endocrinology and metabolism clinics of North America Sep, 2010 | Pubmed ID: 20723814
Efforts to prevent and halt autoimmune beta cell destruction.
Endocrinology and metabolism clinics of North America Sep, 2010 | Pubmed ID: 20723818
Influence of serum and soluble CD25 (sCD25) on regulatory and effector T-cell function in hepatocellular carcinoma.
Scandinavian journal of immunology Oct, 2010 | Pubmed ID: 20883314
It's time to consider changing the rules: the rationale for rethinking control groups in clinical trials aimed at reversing type 1 diabetes.
Diabetes Feb, 2011 | Pubmed ID: 21270247
Inhibition of type 1 diabetes correlated to a Lactobacillus johnsonii N6.2-mediated Th17 bias.
Journal of immunology (Baltimore, Md. : 1950) Mar, 2011 | Pubmed ID: 21317395
Alpha-1 antitrypsin protein and gene therapies decrease autoimmunity and delay arthritis development in mouse model.
Journal of translational medicine , 2011 | Pubmed ID: 21345239
Persistence is the twin sister of excellence: an important lesson for attempts to prevent and reverse type 1 diabetes.
Diabetes Mar, 2011 | Pubmed ID: 21357468
Multimodality imaging of β-cells in mouse models of type 1 and 2 diabetes.
Diabetes May, 2011 | Pubmed ID: 21441442
How does type 1 diabetes develop?: the notion of homicide or β-cell suicide revisited.
Diabetes May, 2011 | Pubmed ID: 21525508
Progressive erosion of β-cell function precedes the onset of hyperglycemia in the NOD mouse model of type 1 diabetes.
Diabetes Aug, 2011 | Pubmed ID: 21659497
B cells enhance early innate immune responses during bacterial sepsis.
The Journal of experimental medicine Aug, 2011 | Pubmed ID: 21746813
Evaluating preclinical efficacy.
Science translational medicine Aug, 2011 | Pubmed ID: 21849661
Loss of intra-islet CD20 expression may complicate efficacy of B-cell-directed type 1 diabetes therapies.
Diabetes Nov, 2011 | Pubmed ID: 21926271
Hyperglycemia-induced proliferation of adult human beta cells engrafted into spontaneously diabetic immunodeficient NOD-Rag1null IL2rγnull Ins2Akita mice.
Pancreas Oct, 2011 | Pubmed ID: 21926555
Autologous umbilical cord blood transfusion in young children with type 1 diabetes fails to preserve C-peptide.
Diabetes care Dec, 2011 | Pubmed ID: 22011412
It's time to mow the GRAS in type 1 diabetes.
Diabetes Nov, 2011 | Pubmed ID: 22025772
Structure-based selection of small molecules to alter allele-specific MHC class II antigen presentation.
Journal of immunology (Baltimore, Md. : 1950) Dec, 2011 | Pubmed ID: 22043012
Gut microbiome metagenomics analysis suggests a functional model for the development of autoimmunity for type 1 diabetes.
PloS one , 2011 | Pubmed ID: 22043294
Central role for interleukin-2 in type 1 diabetes.
Diabetes Jan, 2012 | Pubmed ID: 22187370
Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients.
The Journal of experimental medicine Jan, 2012 | Pubmed ID: 22213807
Reversal of autoimmune diabetes by restoration of antigen-specific tolerance using genetically modified Lactococcus lactis in mice.
The Journal of clinical investigation May, 2012 | Pubmed ID: 22484814
Formation of a human β-cell population within pancreatic islets is set early in life.
The Journal of clinical endocrinology and metabolism Sep, 2012 | Pubmed ID: 22745242
In vitro generation of functional insulin-producing cells from human bone marrow-derived stem cells, but long-term culture running risk of malignant transformation.
American journal of stem cells Jun, 2012 | Pubmed ID: 22833839
The pathogenesis and natural history of type 1 diabetes.
Cold Spring Harbor perspectives in medicine Nov, 2012 | Pubmed ID: 23125199
Serum levels of soluble CD25 as a marker for hepatocellular carcinoma.
Oncology letters Oct, 2012 | Pubmed ID: 23205111
Immune modulation of effector CD4+ and regulatory T cell function by sorafenib in patients with hepatocellular carcinoma.
Cancer immunology, immunotherapy : CII Apr, 2013 | Pubmed ID: 23223899
Pancreas organ weight in individuals with disease-associated autoantibodies at risk for type 1 diabetes.
JAMA Dec, 2012 | Pubmed ID: 23232891
Anti-thymocyte globulin (ATG) differentially depletes naïve and memory T cells and permits memory-type regulatory T cells in nonobese diabetic mice.
BMC immunology Dec, 2012 | Pubmed ID: 23237483
Recent lessons learned from prevention and recent-onset type 1 diabetes immunotherapy trials.
Diabetes Jan, 2013 | Pubmed ID: 23258904
Serum proteomics reveals systemic dysregulation of innate immunity in type 1 diabetes.
The Journal of experimental medicine Jan, 2013 | Pubmed ID: 23277452
The granulocyte colony stimulating factor pathway regulates autoantibody production in a murine induced model of systemic lupus erythematosus.
Arthritis research & therapy Apr, 2013 | Pubmed ID: 23566364
Autologous umbilical cord blood infusion followed by oral docosahexaenoic acid and vitamin D supplementation for C-peptide preservation in children with Type 1 diabetes.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation Jul, 2013 | Pubmed ID: 23611977
Inhibition of VEGFR-2 reverses type 1 diabetes in NOD mice by abrogating insulitis and restoring islet function.
Diabetes Aug, 2013 | Pubmed ID: 23835340
Type 1 diabetes.
Lancet (London, England) Jan, 2014 | Pubmed ID: 23890997
The autoimmune disease-associated SNP rs917997 of IL18RAP controls IFNγ production by PBMC.
Journal of autoimmunity Aug, 2013 | Pubmed ID: 23891168
Global reality of type 1 diabetes care in 2013.
Diabetes care Sep, 2013 | Pubmed ID: 23970723
GABA regulates both the survival and replication of human ss-cells.
Diabetes Aug, 2013 | Pubmed ID: 23995958
The Juvenile Diabetes Research Foundation Network for Pancreatic Organ Donors with Diabetes (nPOD) Program: goals, operational model and emerging findings.
Pediatric diabetes Feb, 2014 | Pubmed ID: 24325575
Pancreatic biopsies in type 1 diabetes: revisiting the myth of Pandora's box.
Diabetologia Apr, 2014 | Pubmed ID: 24442510
Improving diabetes care in resource-poor countries: challenges and opportunities.
The lancet. Diabetes & endocrinology Dec, 2013 | Pubmed ID: 24622408
Oral delivery of glutamic acid decarboxylase (GAD)-65 and IL10 by Lactococcus lactis reverses diabetes in recent-onset NOD mice.
Diabetes Aug, 2014 | Pubmed ID: 24677716
Increased IFN-α-producing plasmacytoid dendritic cells (pDCs) in human Th1-mediated type 1 diabetes: pDCs augment Th1 responses through IFN-α production.
Journal of immunology (Baltimore, Md. : 1950) Aug, 2014 | Pubmed ID: 24973447
New insight on human type 1 diabetes biology: nPOD and nPOD-transplantation.
Current diabetes reports Oct, 2014 | Pubmed ID: 25142715
Losing a grip on the notion of β-cell specificity for immune responses in type 1 diabetes: can we handle the truth?
Diabetes Nov, 2014 | Pubmed ID: 25342726
Anti-thymocyte globulin/G-CSF treatment preserves β cell function in patients with established type 1 diabetes.
The Journal of clinical investigation Jan, 2015 | Pubmed ID: 25500887
Stem cells to insulin secreting cells: two steps forward and now a time to pause?
Cell stem cell Nov, 2014 | Pubmed ID: 25517460
Early childhood gut microbiomes show strong geographic differences among subjects at high risk for type 1 diabetes.
Diabetes care Feb, 2015 | Pubmed ID: 25519450
Bacteroides dorei dominates gut microbiome prior to autoimmunity in Finnish children at high risk for type 1 diabetes.
Frontiers in microbiology , 2014 | Pubmed ID: 25540641
Beta-cell destruction and preservation in childhood and adult onset type 1 diabetes.
Endocrine Aug, 2015 | Pubmed ID: 25605478
The streetlight effect in type 1 diabetes.
Diabetes Apr, 2015 | Pubmed ID: 25805758
A combination dual-sized microparticle system modulates dendritic cells and prevents type 1 diabetes in prediabetic NOD mice.
Clinical immunology (Orlando, Fla.) Sep, 2015 | Pubmed ID: 25842187
Divergent Phenotypes of Human Regulatory T Cells Expressing the Receptors TIGIT and CD226.
Journal of immunology (Baltimore, Md. : 1950) Jul, 2015 | Pubmed ID: 25994968
Current concepts on the pathogenesis of type 1 diabetes--considerations for attempts to prevent and reverse the disease.
Diabetes care Jun, 2015 | Pubmed ID: 25998290
A run on the biobank: what have we learned about type 1 diabetes from the nPOD tissue repository?
Current opinion in endocrinology, diabetes, and obesity Aug, 2015 | Pubmed ID: 26087339
Combination Therapy Reverses Hyperglycemia in NOD Mice With Established Type 1 Diabetes.
Diabetes Nov, 2015 | Pubmed ID: 26185279
Acute Versus Progressive Onset of Diabetes in NOD Mice: Potential Implications for Therapeutic Interventions in Type 1 Diabetes.
Diabetes Nov, 2015 | Pubmed ID: 26216853
The role for gut permeability in the pathogenesis of type 1 diabetes--a solid or leaky concept?
Pediatric diabetes Nov, 2015 | Pubmed ID: 26269193
A combination hydrogel microparticle-based vaccine prevents type 1 diabetes in non-obese diabetic mice.
Scientific reports Aug, 2015 | Pubmed ID: 26279095
The influence of type 1 diabetes on pancreatic weight.
Diabetologia Jan, 2016 | Pubmed ID: 26358584
Staging presymptomatic type 1 diabetes: a scientific statement of JDRF, the Endocrine Society, and the American Diabetes Association.
Diabetes care Oct, 2015 | Pubmed ID: 26404926
Immune Depletion in Combination with Allogeneic Islets Permanently Restores Tolerance to Self-Antigens in Diabetic NOD Mice.
PloS one , 2015 | Pubmed ID: 26580221
Insulitis and β-Cell Mass in the Natural History of Type 1 Diabetes.
Diabetes Mar, 2016 | Pubmed ID: 26581594
A Preclinical Consortium Approach for Assessing the Efficacy of Combined Anti-CD3 Plus IL-1 Blockade in Reversing New-Onset Autoimmune Diabetes in NOD Mice.
Diabetes 05, 2016 | Pubmed ID: 26718498
Pancreatic duct hyperplasia/dysplasia in type 1 diabetes and pancreatic weight in individuals with and without diabetes. Reply to Kobayashi T, Aida K, Fukui T et al [letter] and Saisho Y [letter].
Diabetologia Apr, 2016 | Pubmed ID: 26861059
Type 1 diabetes cadaveric human pancreata exhibit a unique exocrine tissue proteomic profile.
Proteomics 05, 2016 | Pubmed ID: 26935967
Sulfatide Preserves Insulin Crystals Not by Being Integrated in the Lattice but by Stabilizing Their Surface.
Journal of diabetes research , 2016 | Pubmed ID: 26981544
Presumptive Type 1 Diabetes With Comorbidities and Rapid Progression Despite Numerous Insulin-Positive Islets.
Diabetes care 07, 2016 | Pubmed ID: 27330131
Aberrant Menin expression is an early event in pancreatic neuroendocrine tumorigenesis.
Human pathology 10, 2016 | Pubmed ID: 27342911
Islet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetes.
Diabetologia 11, 2016 | Pubmed ID: 27506584
Antithymocyte Globulin Plus G-CSF Combination Therapy Leads to Sustained Immunomodulatory and Metabolic Effects in a Subset of Responders With Established Type 1 Diabetes.
Diabetes Dec, 2016 | Pubmed ID: 27669730
Rebranding asymptomatic type 1 diabetes: the case for autoimmune beta cell disorder as a pathological and diagnostic entity.
Diabetologia 01, 2017 | Pubmed ID: 27785529
Autoimmune manifestations in aged mice arise from early-life immune dysregulation.
Science translational medicine 10, 2016 | Pubmed ID: 27798262
Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes.
Nature medicine Dec, 2016 | Pubmed ID: 27798614
Islet-derived CD4 T-cells targeting proinsulin in human autoimmune diabetes.
Diabetes Dec, 2016 | Pubmed ID: 27920090
Tissue distribution and clonal diversity of the T and B cell repertoire in type 1 diabetes.
JCI insight Dec, 2016 | Pubmed ID: 27942583
Type 1 Diabetes Prevention: A Goal Dependent on Accepting a Diagnosis of an Asymptomatic Disease.
Diabetes 11, 2016 | Pubmed ID: 27959859
Factors That Influence the Quality of RNA From the Pancreas of Organ Donors.
Pancreas Feb, 2017 | Pubmed ID: 27984510
Re-addressing the 2013 consensus guidelines for the diagnosis of insulitis in human type 1 diabetes: is change necessary?
Diabetologia Apr, 2017 | Pubmed ID: 28070616
Serum Trypsinogen Levels in Type 1 Diabetes.
Diabetes care 04, 2017 | Pubmed ID: 28115475
Plant-based vaccines for oral delivery of type 1 diabetes-related autoantigens: Evaluating oral tolerance mechanisms and disease prevention in NOD mice.
Scientific reports 02, 2017 | Pubmed ID: 28205558
Expansion of Human Tregs from Cryopreserved Umbilical Cord Blood for GMP-Compliant Autologous Adoptive Cell Transfer Therapy.
Molecular therapy. Methods & clinical development Mar, 2017 | Pubmed ID: 28345003
Genetic and Small Molecule Disruption of the AID/RAD51 Axis Similarly Protects Nonobese Diabetic Mice from Type 1 Diabetes through Expansion of Regulatory B Lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 06, 2017 | Pubmed ID: 28461573
Mary Tyler Moore (1936-2017): Diabetes Educator and Advocate.
Diabetes care 06, 2017 | Pubmed ID: 28533256
Comparative Pathogenesis of Autoimmune Diabetes in Humans, NOD Mice, and Canines: Has a Valuable Animal Model of Type 1 Diabetes Been Overlooked?
Diabetes 06, 2017 | Pubmed ID: 28533295
N6.2 Modulates the Host Immune Responses: A Double-Blind, Randomized Trial in Healthy Adults.
Frontiers in immunology , 2017 | Pubmed ID: 28659913
High Illicit Drug Abuse and Suicide in Organ Donors With Type 1 Diabetes.
Diabetes care Sep, 2017 | Pubmed ID: 28679687
Impact of blood collection and processing on peripheral blood gene expression profiling in type 1 diabetes.
BMC genomics Aug, 2017 | Pubmed ID: 28821222
Untargeted metabolomic analysis in naturally occurring canine diabetes mellitus identifies similarities to human Type 1 Diabetes.
Scientific reports 08, 2017 | Pubmed ID: 28842637
Dysglycemia and Index60 as Prediagnostic End Points for Type 1 Diabetes Prevention Trials.
Diabetes care 11, 2017 | Pubmed ID: 28860125
Proteoliposome-based full-length ZnT8 self-antigen for type 1 diabetes diagnosis on a plasmonic platform.
Proceedings of the National Academy of Sciences of the United States of America 09, 2017 | Pubmed ID: 28874568
Type 1 Interferons Potentiate Human CD8 T-Cell Cytotoxicity Through a STAT4- and Granzyme B-Dependent Pathway.
Diabetes 12, 2017 | Pubmed ID: 28877912
T cells display mitochondria hyperpolarization in human type 1 diabetes.
Scientific reports 09, 2017 | Pubmed ID: 28883439
Pancreatic Histopathology of Human Monogenic Diabetes Due to Causal Variants in KCNJ11, HNF1A, GATA6, and LMNA.
The Journal of clinical endocrinology and metabolism Jan, 2018 | Pubmed ID: 28938416
Disease-specific biases in alternative splicing and tissue-specific dysregulation revealed by multitissue profiling of lymphocyte gene expression in type 1 diabetes.
Genome research 11, 2017 | Pubmed ID: 29025893
Association Between Early-Life Antibiotic Use and the Risk of Islet or Celiac Disease Autoimmunity.
JAMA pediatrics 12, 2017 | Pubmed ID: 29052687
Transient BAFF Blockade Inhibits Type 1 Diabetes Development in Nonobese Diabetic Mice by Enriching Immunoregulatory B Lymphocytes Sensitive to Deletion by Anti-CD20 Cotherapy.
Journal of immunology (Baltimore, Md. : 1950) 12, 2017 | Pubmed ID: 29055002
Hospital time prior to death and pancreas histopathology: implications for future studies.
Diabetologia 04, 2018 | Pubmed ID: 29128936
Loss of B-Cell Anergy in Type 1 Diabetes Is Associated With High-Risk HLA and Non-HLA Disease Susceptibility Alleles.
Diabetes 04, 2018 | Pubmed ID: 29343548
Methyldopa blocks MHC class II binding to disease-specific antigens in autoimmune diabetes.
The Journal of clinical investigation 05, 2018 | Pubmed ID: 29438107
Type 1 Diabetes TrialNet: A Multifaceted Approach to Bringing Disease-Modifying Therapy to Clinical Use in Type 1 Diabetes.
Diabetes care 04, 2018 | Pubmed ID: 29559451
Strength in Numbers: Opportunities for Enhancing the Development of Effective Treatments for Type 1 Diabetes-The TrialNet Experience.
Diabetes 07, 2018 | Pubmed ID: 29769238
Islet Microvasculature Alterations With Loss of Beta-cells in Patients With Type 1 Diabetes.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 01, 2019 | Pubmed ID: 29771178
Protective Role of Myeloid Cells Expressing a G-CSF Receptor Polymorphism in an Induced Model of Lupus.
Frontiers in immunology , 2018 | Pubmed ID: 29868014
Low-Dose Anti-Thymocyte Globulin (ATG) Preserves β-Cell Function and Improves HbA in New-Onset Type 1 Diabetes.
Diabetes care Sep, 2018 | Pubmed ID: 30012675
Islet-Derived eATP Fuels Autoreactive CD8 T Cells and Facilitates the Onset of Type 1 Diabetes.
Diabetes 10, 2018 | Pubmed ID: 30065030
Nanowell-mediated two-dimensional liquid chromatography enables deep proteome profiling of <1000 mammalian cells.
Chemical science Sep, 2018 | Pubmed ID: 30210768
Transcription Factor 7-Like 2 () Gene Polymorphism and Progression From Single to Multiple Autoantibody Positivity in Individuals at Risk for Type 1 Diabetes.
Diabetes care 12, 2018 | Pubmed ID: 30275285
The challenge of modulating β-cell autoimmunity in type 1 diabetes.
The lancet. Diabetes & endocrinology 01, 2019 | Pubmed ID: 30528099
Relative Pancreas Volume Is Reduced in First-Degree Relatives of Patients With Type 1 Diabetes.
Diabetes care 02, 2019 | Pubmed ID: 30552130
Type 1 Diabetes Risk in African-Ancestry Participants and Utility of an Ancestry-Specific Genetic Risk Score.
Diabetes care 03, 2019 | Pubmed ID: 30659077
Rationale for enteroviral vaccination and antiviral therapies in human type 1 diabetes.
Diabetologia 05, 2019 | Pubmed ID: 30675626
Characterization of Non-hormone Expressing Endocrine Cells in Fetal and Infant Human Pancreas.
Frontiers in endocrinology , 2018 | Pubmed ID: 30687234
A Map of Human Type 1 Diabetes Progression by Imaging Mass Cytometry.
Cell metabolism 03, 2019 | Pubmed ID: 30713109
Multiplexed In Situ Imaging Mass Cytometry Analysis of the Human Endocrine Pancreas and Immune System in Type 1 Diabetes.
Cell metabolism 03, 2019 | Pubmed ID: 30713110
Trying to make a difference for those with Type 1 diabetes: a lesson in patience as well as a willingness to fail mightily.
Expert review of endocrinology & metabolism Jul, 2013 | Pubmed ID: 30736146
Boosting to Amplify Signal with Isobaric Labeling (BASIL) Strategy for Comprehensive Quantitative Phosphoproteomic Characterization of Small Populations of Cells.
Analytical chemistry May, 2019 | Pubmed ID: 30843680
Increased risk for T cell autoreactivity to ß-cell antigens in the mice expressing the A obesity-associated gene.
Scientific reports 03, 2019 | Pubmed ID: 30862859
Low-Dose Anti-Thymocyte Globulin Preserves C-Peptide, Reduces HbA, and Increases Regulatory to Conventional T-Cell Ratios in New-Onset Type 1 Diabetes: Two-Year Clinical Trial Data.
Diabetes 06, 2019 | Pubmed ID: 30967424
Large enteroviral vaccination studies to prevent type 1 diabetes should be well founded and rely on scientific evidence. Reply to Skog O, Klingel K, Roivainen M et al [letter].
Diabetologia 06, 2019 | Pubmed ID: 31016358
Islet amyloidosis in a child with type 1 diabetes.
Islets , 2019 | Pubmed ID: 31084520
Dual-Sized Microparticle System for Generating Suppressive Dendritic Cells Prevents and Reverses Type 1 Diabetes in the Nonobese Diabetic Mouse Model.
ACS biomaterials science & engineering May, 2019 | Pubmed ID: 31119191
NIH Initiative to Improve Understanding of the Pancreas, Islet, and Autoimmunity in Type 1 Diabetes: The Human Pancreas Analysis Program (HPAP).
Diabetes 07, 2019 | Pubmed ID: 31127054
Pleiotropic roles of the insulin-like growth factor axis in type 1 diabetes.
Current opinion in endocrinology, diabetes, and obesity 08, 2019 | Pubmed ID: 31145130
The Influence of Type 2 Diabetes-Associated Factors on Type 1 Diabetes.
Diabetes care 08, 2019 | Pubmed ID: 31167894
Genetic risk for autoimmunity is associated with distinct changes in the human gut microbiome.
Nature communications 08, 2019 | Pubmed ID: 31399563
Regulated hAAT Expression from a Novel rAAV Vector and Its Application in the Prevention of Type 1 Diabetes.
Journal of clinical medicine Aug, 2019 | Pubmed ID: 31466263
Who Is Enrolling? The Path to Monitoring in Type 1 Diabetes TrialNet's Pathway to Prevention.
Diabetes care 12, 2019 | Pubmed ID: 31558546
Temporal Analysis of Amylase Expression in Control, Autoantibody-Positive, and Type 1 Diabetes Pancreatic Tissues.
Diabetes 01, 2020 | Pubmed ID: 31597639
Introducing the Endotype Concept to Address the Challenge of Disease Heterogeneity in Type 1 Diabetes.
Diabetes care 01, 2020 | Pubmed ID: 31753960
The risk of progression to type 1 diabetes is highly variable in individuals with multiple autoantibodies following screening.
Diabetologia 03, 2020 | Pubmed ID: 31768570
Interleukin-27 Is Essential for Type 1 Diabetes Development and Sjögren Syndrome-like Inflammation.
Cell reports 12, 2019 | Pubmed ID: 31801074
Insulin-Like Growth Factor Dysregulation Both Preceding and Following Type 1 Diabetes Diagnosis.
Diabetes 03, 2020 | Pubmed ID: 31826866
Single Islet Autoantibody at Diagnosis of Clinical Type 1 Diabetes is Associated With Older Age and Insulin Resistance.
The Journal of clinical endocrinology and metabolism 05, 2020 | Pubmed ID: 31867614
Early and late C-peptide responses during oral glucose tolerance testing are oppositely predictive of type 1 diabetes in autoantibody-positive individuals.
Diabetes, obesity & metabolism 06, 2020 | Pubmed ID: 32003110
Innate inflammation drives NK cell activation to impair Treg activity.
Journal of autoimmunity 03, 2020 | Pubmed ID: 32035746
Obesity Treatment Among Adolescents: A Review of Current Evidence and Future Directions.
JAMA pediatrics 06, 2020 | Pubmed ID: 32202626
Commercially Available Insulin Products Demonstrate Stability Throughout the Cold Supply Chain Across the U.S.
Diabetes care 06, 2020 | Pubmed ID: 32273273
Pancreas tissue slices from organ donors enable in situ analysis of type 1 diabetes pathogenesis.
JCI insight 04, 2020 | Pubmed ID: 32324170
Large-scale electron microscopy database for human type 1 diabetes.
Nature communications 05, 2020 | Pubmed ID: 32424134
Multiplexing DNA methylation markers to detect circulating cell-free DNA derived from human pancreatic β cells.
JCI insight 07, 2020 | Pubmed ID: 32573495
Intestinal Delivery of Proinsulin and IL-10 via Combined With Low-Dose Anti-CD3 Restores Tolerance Outside the Window of Acute Type 1 Diabetes Diagnosis.
Frontiers in immunology , 2020 | Pubmed ID: 32582188
Removing Formaldehyde-Induced Peptidyl Crosslinks Enables Mass Spectrometry Imaging of Peptide Hormone Distributions from Formalin-Fixed Paraffin-Embedded Tissues.
Angewandte Chemie (International ed. in English) 12, 2020 | Pubmed ID: 32762062
Comparing Beta Cell Preservation Across Clinical Trials in Recent-Onset Type 1 Diabetes.
Diabetes technology & therapeutics 12, 2020 | Pubmed ID: 32833543
Organisation of the human pancreas in health and in diabetes.
Diabetologia 10, 2020 | Pubmed ID: 32894306
CD226 Deletion Reduces Type 1 Diabetes in the NOD Mouse by Impairing Thymocyte Development and Peripheral T Cell Activation.
Frontiers in immunology , 2020 | Pubmed ID: 33013915
Immunomodulatory Dual-Sized Microparticle System Conditions Human Antigen Presenting Cells Into a Tolerogenic Phenotype and Inhibits Type 1 Diabetes-Specific Autoreactive T Cell Responses.
Frontiers in immunology , 2020 | Pubmed ID: 33193362
Expression of SARS-CoV-2 Entry Factors in the Pancreas of Normal Organ Donors and Individuals with COVID-19.
Cell metabolism 12, 2020 | Pubmed ID: 33207244
Pancreatlas: Applying an Adaptable Framework to Map the Human Pancreas in Health and Disease.
Patterns (New York, N.Y.) Nov, 2020 | Pubmed ID: 33294866
Image-Based Machine Learning Algorithms for Disease Characterization in the Human Type 1 Diabetes Pancreas.
The American journal of pathology 03, 2021 | Pubmed ID: 33307036
Evaluation for type 1 diabetes associated autoantibodies in diabetic and non-diabetic Australian terriers and Samoyeds.
Canine medicine and genetics Aug, 2020 | Pubmed ID: 33323126
Genetic Composition and Autoantibody Titers Model the Probability of Detecting C-Peptide Following Type 1 Diabetes Diagnosis.
Diabetes Apr, 2021 | Pubmed ID: 33419759
Exocrine Pancreatic Enzymes Are a Serological Biomarker for Type 1 Diabetes Staging and Pancreas Size.
Diabetes Apr, 2021 | Pubmed ID: 33441381
Exocrine Pancreas Dysfunction in Type 1 Diabetes.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists Dec, 2020 | Pubmed ID: 33471743
Modulation of Leukocytes of the Innate Arm of the Immune System as a Potential Approach to Prevent the Onset and Progression of Type 1 Diabetes.
Diabetes Feb, 2021 | Pubmed ID: 33472941
Integrative analyses of TEDDY Omics data reveal lipid metabolism abnormalities, increased intracellular ROS and heightened inflammation prior to autoimmunity for type 1 diabetes.
Genome biology Jan, 2021 | Pubmed ID: 33478573
Index60 as an additional diagnostic criterion for type 1 diabetes.
Diabetologia Apr, 2021 | Pubmed ID: 33496819
Interleukin-27 is essential for type 1 diabetes development and Sjögren syndrome-like inflammation.
Cell reports Feb, 2021 | Pubmed ID: 33535031
TCR/BCR dual-expressing cells and their associated public BCR clonotype are not enriched in type 1 diabetes.
Cell Feb, 2021 | Pubmed ID: 33545036
Low-dose ATG/GCSF in Established Type 1 Diabetes: A Five-Year Follow-up Report.
Diabetes Feb, 2021 | Pubmed ID: 33632742
Insulin Receptor-Expressing T Cells Appear in Individuals at Risk for Type 1 Diabetes and Can Move into the Pancreas in C57BL/6 Transgenic Mice.
Journal of immunology (Baltimore, Md. : 1950) Apr, 2021 | Pubmed ID: 33658296
Islet sympathetic innervation and islet neuropathology in patients with type 1 diabetes.
Scientific reports Mar, 2021 | Pubmed ID: 33753784
Distinguishing the real from the hyperglycaemia: does COVID-19 induce diabetes?
The lancet. Diabetes & endocrinology Apr, 2021 | Pubmed ID: 33838106
Mollie K. Huber1,
Denise M. Drotar2,3,4,
Helmut Hiller1,
Maria L. Beery1,
Paul Joseph1,
Irina Kusmartseva1,
Stephan Speier2,3,4,
Mark A. Atkinson1,
Clayton E. Mathews1,
Edward A. Phelps5
1Department of Pathology, Immunology, and Laboratory Medicine, University of Florida,
2, Paul Langerhans Institute Dresden (PLID) of the Helmholtz Zentrum München at the University Clinic Carl Gustav Carus of Technische Universität Dresden,
3Institute of Physiology, Faculty of Medicine, Technische Universität Dresden,
4, German Center for Diabetes Research (DZD),
5J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida
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