Mark A. Atkinson

In vivo and in vitro characterization of insulin-producing cells obtained from murine bone marrow.

Heterophile antibodies segregate in families and are associated with protection from type 1 diabetes.

Adeno-associated virus vector-mediated IL-10 gene delivery prevents type 1 diabetes in NOD mice.

Adeno-associated virus transduction of islets with interleukin-4 results in impaired metabolic function in syngeneic marginal islet mass transplantation.

Fatal attraction: chemokines and type 1 diabetes.

Adeno-associated virus-mediated IL-10 gene therapy inhibits diabetes recurrence in syngeneic islet cell transplantation of NOD mice.

Gene delivery in renal tubular epithelial cells using recombinant adeno-associated viral vectors.

Systemic overexpression of IL-10 induces CD4+CD25+ cell populations in vivo and ameliorates type 1 diabetes in nonobese diabetic mice in a dose-dependent fashion.

Why can't we prevent type 1 diabetes?: maybe it's time to try a different combination.

Timing of initial cereal exposure in infancy and risk of islet autoimmunity.

Heme oxygenase-1 modulates early inflammatory responses: evidence from the heme oxygenase-1-deficient mouse.

Diabetes acceleration or prevention by a coxsackievirus B4 infection: critical requirements for both interleukin-4 and gamma interferon.

Efficient transduction of vascular endothelial cells with recombinant adeno-associated virus serotype 1 and 5 vectors.

Changes in hippocampal IL-15, related cytokines, and neurogenesis in IL-2 deficient mice.

An integral role for heme oxygenase-1 and carbon monoxide in maintaining peripheral tolerance by CD4+CD25+ regulatory T cells.

ADA Outstanding Scientific Achievement Lecture 2004. Thirty years of investigating the autoimmune basis for type 1 diabetes: why can't we prevent or reverse this disease?

Functional defects and the influence of age on the frequency of CD4+ CD25+ T-cells in type 1 diabetes.

Interleukin 10 attenuates neointimal proliferation and inflammation in aortic allografts by a heme oxygenase-dependent pathway.

Localized gene expression following administration of adeno-associated viral vectors via pancreatic ducts.

A comprehensive review of interventions in the NOD mouse and implications for translation.

Systemic overexpression of interleukin-10 fails to protect allogeneic islet transplants in nonobese diabetic mice.

Glucose transporter-2 (GLUT2) promoter mediated transgenic insulin production reduces hyperglycemia in diabetic mice.

IL-10 suppresses chemokines, inflammation, and fibrosis in a model of chronic renal disease.

Type 1 diabetes mellitus: etiology, presentation, and management.

Efficient delivery of siRNA into cytokine-stimulated insulinoma cells silences Fas expression and inhibits Fas-mediated apoptosis.

Enhanced IgE allergic response to Aspergillus fumigatus in CFTR-/- mice.

Uncoupling of vascular endothelial growth factor with nitric oxide as a mechanism for diabetic vasculopathy.

Role of Pax4 in Pdx1-VP16-mediated liver-to-endocrine pancreas transdifferentiation.

Cystic fibrosis transmembrane conductance regulator deficiency exacerbates islet cell dysfunction after beta-cell injury.

Noninvasive imaging of islet grafts using positron-emission tomography.

Autoantibody markers for the diagnosis and prediction of type 1 diabetes.

IL-10 regulation of lupus in the NZM2410 murine model.

Increased natural CD4+CD25+ regulatory T cells and their suppressor activity do not contribute to mortality in murine polymicrobial sepsis.

Diabetic endothelial nitric oxide synthase knockout mice develop advanced diabetic nephropathy.

MyD88-dependent expansion of an immature GR-1(+)CD11b(+) population induces T cell suppression and Th2 polarization in sepsis.

Treatment with GITR agonistic antibody corrects adaptive immune dysfunction in sepsis.

Novel synthesis of cerium oxide nanoparticles for free radical scavenging.

Murine antithymocyte globulin therapy alters disease progression in NOD mice by a time-dependent induction of immunoregulation.

Reversal of streptozotocin-induced diabetes in mice by cellular transduction with recombinant pancreatic transcription factor pancreatic duodenal homeobox-1: a novel protein transduction domain-based therapy.

Neonatal formula feeding leads to immunological alterations in an animal model of type 1 diabetes.

A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in the IL-2 receptor gamma chain gene.

Assessing the in vitro suppressive capacity of regulatory T cells.

Autologous umbilical cord blood infusion for type 1 diabetes.

Suppression by CD4+CD25+ regulatory T cells is dependent on expression of heme oxygenase-1 in antigen-presenting cells.

The pivotal role of VEGF on glomerular macrophage infiltration in advanced diabetic nephropathy.

CFTR mutations impart elevated immune reactivity in a murine model of cystic fibrosis related diabetes.

The "perfect storm" for type 1 diabetes: the complex interplay between intestinal microbiota, gut permeability, and mucosal immunity.

Murine model for cystic fibrosis bone disease demonstrates osteopenia and sex-related differences in bone formation.

Expansion of human regulatory T-cells from patients with type 1 diabetes.

Taking a daily vitamin to prevent type 1 diabetes?

Exendin-4 therapy in NOD mice with new-onset diabetes increases regulatory T cell frequency.

Exendin-4 treatment of nonobese diabetic mice increases beta-cell proliferation and fractional insulin reactive area.

Culture-independent identification of gut bacteria correlated with the onset of diabetes in a rat model.

Lowering blood pressure blocks mesangiolysis and mesangial nodules, but not tubulointerstitial injury, in diabetic eNOS knockout mice.

Rabbit polyclonal mouse antithymocyte globulin administration alters dendritic cell profile and function in NOD mice to suppress diabetogenic responses.

Influence of fecal sample storage on bacterial community diversity.

The pancreas in human type 1 diabetes: providing new answers to age-old questions.

Immune depletion with cellular mobilization imparts immunoregulation and reverses autoimmune diabetes in nonobese diabetic mice.

The road not taken: a path to curing type 1 diabetes?

Hepatocellular carcinoma immunopathogenesis: clinical evidence for global T cell defects and an immunomodulatory role for soluble CD25 (sCD25).

Autologous umbilical cord blood transfusion in very young children with type 1 diabetes.

Influence of membrane CD25 stability on T lymphocyte activity: implications for immunoregulation.

Lactobacillus johnsonii N6.2 mitigates the development of type 1 diabetes in BB-DP rats.

The pancreas in human type 1 diabetes.

The Juvenile Diabetes Research Foundation at forty: updates of research in type 1 diabetes.

Toward defining the autoimmune microbiome for type 1 diabetes.

Human antigen-specific regulatory T cells generated by T cell receptor gene transfer.

Butyrate and type 1 diabetes mellitus: can we fix the intestinal leak?

Type I diabetes. Preface.

Efforts to prevent and halt autoimmune beta cell destruction.

Influence of serum and soluble CD25 (sCD25) on regulatory and effector T-cell function in hepatocellular carcinoma.

It's time to consider changing the rules: the rationale for rethinking control groups in clinical trials aimed at reversing type 1 diabetes.

Inhibition of type 1 diabetes correlated to a Lactobacillus johnsonii N6.2-mediated Th17 bias.

Alpha-1 antitrypsin protein and gene therapies decrease autoimmunity and delay arthritis development in mouse model.

Persistence is the twin sister of excellence: an important lesson for attempts to prevent and reverse type 1 diabetes.

Multimodality imaging of β-cells in mouse models of type 1 and 2 diabetes.

How does type 1 diabetes develop?: the notion of homicide or β-cell suicide revisited.

Progressive erosion of β-cell function precedes the onset of hyperglycemia in the NOD mouse model of type 1 diabetes.

B cells enhance early innate immune responses during bacterial sepsis.

Evaluating preclinical efficacy.

Loss of intra-islet CD20 expression may complicate efficacy of B-cell-directed type 1 diabetes therapies.

Hyperglycemia-induced proliferation of adult human beta cells engrafted into spontaneously diabetic immunodeficient NOD-Rag1null IL2rγnull Ins2Akita mice.

Autologous umbilical cord blood transfusion in young children with type 1 diabetes fails to preserve C-peptide.

It's time to mow the GRAS in type 1 diabetes.

Structure-based selection of small molecules to alter allele-specific MHC class II antigen presentation.

Gut microbiome metagenomics analysis suggests a functional model for the development of autoimmunity for type 1 diabetes.

Central role for interleukin-2 in type 1 diabetes.

Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients.

Reversal of autoimmune diabetes by restoration of antigen-specific tolerance using genetically modified Lactococcus lactis in mice.

Formation of a human β-cell population within pancreatic islets is set early in life.

In vitro generation of functional insulin-producing cells from human bone marrow-derived stem cells, but long-term culture running risk of malignant transformation.

The pathogenesis and natural history of type 1 diabetes.

Serum levels of soluble CD25 as a marker for hepatocellular carcinoma.

Immune modulation of effector CD4+ and regulatory T cell function by sorafenib in patients with hepatocellular carcinoma.

Pancreas organ weight in individuals with disease-associated autoantibodies at risk for type 1 diabetes.

Anti-thymocyte globulin (ATG) differentially depletes naïve and memory T cells and permits memory-type regulatory T cells in nonobese diabetic mice.

Recent lessons learned from prevention and recent-onset type 1 diabetes immunotherapy trials.

Serum proteomics reveals systemic dysregulation of innate immunity in type 1 diabetes.

The granulocyte colony stimulating factor pathway regulates autoantibody production in a murine induced model of systemic lupus erythematosus.

Autologous umbilical cord blood infusion followed by oral docosahexaenoic acid and vitamin D supplementation for C-peptide preservation in children with Type 1 diabetes.

Inhibition of VEGFR-2 reverses type 1 diabetes in NOD mice by abrogating insulitis and restoring islet function.

Type 1 diabetes.

The autoimmune disease-associated SNP rs917997 of IL18RAP controls IFNγ production by PBMC.

Global reality of type 1 diabetes care in 2013.

GABA regulates both the survival and replication of human ss-cells.

The Juvenile Diabetes Research Foundation Network for Pancreatic Organ Donors with Diabetes (nPOD) Program: goals, operational model and emerging findings.

Pancreatic biopsies in type 1 diabetes: revisiting the myth of Pandora's box.

Improving diabetes care in resource-poor countries: challenges and opportunities.

Oral delivery of glutamic acid decarboxylase (GAD)-65 and IL10 by Lactococcus lactis reverses diabetes in recent-onset NOD mice.

Increased IFN-α-producing plasmacytoid dendritic cells (pDCs) in human Th1-mediated type 1 diabetes: pDCs augment Th1 responses through IFN-α production.

New insight on human type 1 diabetes biology: nPOD and nPOD-transplantation.

Losing a grip on the notion of β-cell specificity for immune responses in type 1 diabetes: can we handle the truth?

Anti-thymocyte globulin/G-CSF treatment preserves β cell function in patients with established type 1 diabetes.

Stem cells to insulin secreting cells: two steps forward and now a time to pause?

Early childhood gut microbiomes show strong geographic differences among subjects at high risk for type 1 diabetes.

Bacteroides dorei dominates gut microbiome prior to autoimmunity in Finnish children at high risk for type 1 diabetes.

Beta-cell destruction and preservation in childhood and adult onset type 1 diabetes.

The streetlight effect in type 1 diabetes.

A combination dual-sized microparticle system modulates dendritic cells and prevents type 1 diabetes in prediabetic NOD mice.

Divergent Phenotypes of Human Regulatory T Cells Expressing the Receptors TIGIT and CD226.

Current concepts on the pathogenesis of type 1 diabetes--considerations for attempts to prevent and reverse the disease.

A run on the biobank: what have we learned about type 1 diabetes from the nPOD tissue repository?

Combination Therapy Reverses Hyperglycemia in NOD Mice With Established Type 1 Diabetes.

Acute Versus Progressive Onset of Diabetes in NOD Mice: Potential Implications for Therapeutic Interventions in Type 1 Diabetes.

The role for gut permeability in the pathogenesis of type 1 diabetes--a solid or leaky concept?

A combination hydrogel microparticle-based vaccine prevents type 1 diabetes in non-obese diabetic mice.

The influence of type 1 diabetes on pancreatic weight.

Staging presymptomatic type 1 diabetes: a scientific statement of JDRF, the Endocrine Society, and the American Diabetes Association.

Immune Depletion in Combination with Allogeneic Islets Permanently Restores Tolerance to Self-Antigens in Diabetic NOD Mice.

Insulitis and β-Cell Mass in the Natural History of Type 1 Diabetes.

A Preclinical Consortium Approach for Assessing the Efficacy of Combined Anti-CD3 Plus IL-1 Blockade in Reversing New-Onset Autoimmune Diabetes in NOD Mice.

Pancreatic duct hyperplasia/dysplasia in type 1 diabetes and pancreatic weight in individuals with and without diabetes. Reply to Kobayashi T, Aida K, Fukui T et al [letter] and Saisho Y [letter].

Type 1 diabetes cadaveric human pancreata exhibit a unique exocrine tissue proteomic profile.

Sulfatide Preserves Insulin Crystals Not by Being Integrated in the Lattice but by Stabilizing Their Surface.

Presumptive Type 1 Diabetes With Comorbidities and Rapid Progression Despite Numerous Insulin-Positive Islets.

Aberrant Menin expression is an early event in pancreatic neuroendocrine tumorigenesis.

Islet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetes.

Antithymocyte Globulin Plus G-CSF Combination Therapy Leads to Sustained Immunomodulatory and Metabolic Effects in a Subset of Responders With Established Type 1 Diabetes.

Rebranding asymptomatic type 1 diabetes: the case for autoimmune beta cell disorder as a pathological and diagnostic entity.

Autoimmune manifestations in aged mice arise from early-life immune dysregulation.

Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes.

Islet-derived CD4 T-cells targeting proinsulin in human autoimmune diabetes.

Tissue distribution and clonal diversity of the T and B cell repertoire in type 1 diabetes.

Type 1 Diabetes Prevention: A Goal Dependent on Accepting a Diagnosis of an Asymptomatic Disease.

Factors That Influence the Quality of RNA From the Pancreas of Organ Donors.

Re-addressing the 2013 consensus guidelines for the diagnosis of insulitis in human type 1 diabetes: is change necessary?

Serum Trypsinogen Levels in Type 1 Diabetes.

Plant-based vaccines for oral delivery of type 1 diabetes-related autoantigens: Evaluating oral tolerance mechanisms and disease prevention in NOD mice.

Expansion of Human Tregs from Cryopreserved Umbilical Cord Blood for GMP-Compliant Autologous Adoptive Cell Transfer Therapy.

Genetic and Small Molecule Disruption of the AID/RAD51 Axis Similarly Protects Nonobese Diabetic Mice from Type 1 Diabetes through Expansion of Regulatory B Lymphocytes.

Mary Tyler Moore (1936-2017): Diabetes Educator and Advocate.

Comparative Pathogenesis of Autoimmune Diabetes in Humans, NOD Mice, and Canines: Has a Valuable Animal Model of Type 1 Diabetes Been Overlooked?

N6.2 Modulates the Host Immune Responses: A Double-Blind, Randomized Trial in Healthy Adults.

High Illicit Drug Abuse and Suicide in Organ Donors With Type 1 Diabetes.

Impact of blood collection and processing on peripheral blood gene expression profiling in type 1 diabetes.

Untargeted metabolomic analysis in naturally occurring canine diabetes mellitus identifies similarities to human Type 1 Diabetes.

Dysglycemia and Index60 as Prediagnostic End Points for Type 1 Diabetes Prevention Trials.

Proteoliposome-based full-length ZnT8 self-antigen for type 1 diabetes diagnosis on a plasmonic platform.

Type 1 Interferons Potentiate Human CD8 T-Cell Cytotoxicity Through a STAT4- and Granzyme B-Dependent Pathway.

T cells display mitochondria hyperpolarization in human type 1 diabetes.

Pancreatic Histopathology of Human Monogenic Diabetes Due to Causal Variants in KCNJ11, HNF1A, GATA6, and LMNA.

Disease-specific biases in alternative splicing and tissue-specific dysregulation revealed by multitissue profiling of lymphocyte gene expression in type 1 diabetes.

Association Between Early-Life Antibiotic Use and the Risk of Islet or Celiac Disease Autoimmunity.

Transient BAFF Blockade Inhibits Type 1 Diabetes Development in Nonobese Diabetic Mice by Enriching Immunoregulatory B Lymphocytes Sensitive to Deletion by Anti-CD20 Cotherapy.

Hospital time prior to death and pancreas histopathology: implications for future studies.

Loss of B-Cell Anergy in Type 1 Diabetes Is Associated With High-Risk HLA and Non-HLA Disease Susceptibility Alleles.

Methyldopa blocks MHC class II binding to disease-specific antigens in autoimmune diabetes.

Type 1 Diabetes TrialNet: A Multifaceted Approach to Bringing Disease-Modifying Therapy to Clinical Use in Type 1 Diabetes.

Strength in Numbers: Opportunities for Enhancing the Development of Effective Treatments for Type 1 Diabetes-The TrialNet Experience.

Islet Microvasculature Alterations With Loss of Beta-cells in Patients With Type 1 Diabetes.

Protective Role of Myeloid Cells Expressing a G-CSF Receptor Polymorphism in an Induced Model of Lupus.

Low-Dose Anti-Thymocyte Globulin (ATG) Preserves β-Cell Function and Improves HbA in New-Onset Type 1 Diabetes.

Islet-Derived eATP Fuels Autoreactive CD8 T Cells and Facilitates the Onset of Type 1 Diabetes.

Nanowell-mediated two-dimensional liquid chromatography enables deep proteome profiling of <1000 mammalian cells.

Transcription Factor 7-Like 2 () Gene Polymorphism and Progression From Single to Multiple Autoantibody Positivity in Individuals at Risk for Type 1 Diabetes.

The challenge of modulating β-cell autoimmunity in type 1 diabetes.

Relative Pancreas Volume Is Reduced in First-Degree Relatives of Patients With Type 1 Diabetes.

Type 1 Diabetes Risk in African-Ancestry Participants and Utility of an Ancestry-Specific Genetic Risk Score.

Rationale for enteroviral vaccination and antiviral therapies in human type 1 diabetes.

Characterization of Non-hormone Expressing Endocrine Cells in Fetal and Infant Human Pancreas.

A Map of Human Type 1 Diabetes Progression by Imaging Mass Cytometry.

Multiplexed In Situ Imaging Mass Cytometry Analysis of the Human Endocrine Pancreas and Immune System in Type 1 Diabetes.

Trying to make a difference for those with Type 1 diabetes: a lesson in patience as well as a willingness to fail mightily.

Boosting to Amplify Signal with Isobaric Labeling (BASIL) Strategy for Comprehensive Quantitative Phosphoproteomic Characterization of Small Populations of Cells.

Increased risk for T cell autoreactivity to ß-cell antigens in the mice expressing the A obesity-associated gene.

Low-Dose Anti-Thymocyte Globulin Preserves C-Peptide, Reduces HbA, and Increases Regulatory to Conventional T-Cell Ratios in New-Onset Type 1 Diabetes: Two-Year Clinical Trial Data.

Large enteroviral vaccination studies to prevent type 1 diabetes should be well founded and rely on scientific evidence. Reply to Skog O, Klingel K, Roivainen M et al [letter].

Islet amyloidosis in a child with type 1 diabetes.

Dual-Sized Microparticle System for Generating Suppressive Dendritic Cells Prevents and Reverses Type 1 Diabetes in the Nonobese Diabetic Mouse Model.

NIH Initiative to Improve Understanding of the Pancreas, Islet, and Autoimmunity in Type 1 Diabetes: The Human Pancreas Analysis Program (HPAP).

Pleiotropic roles of the insulin-like growth factor axis in type 1 diabetes.

The Influence of Type 2 Diabetes-Associated Factors on Type 1 Diabetes.

Genetic risk for autoimmunity is associated with distinct changes in the human gut microbiome.

Regulated hAAT Expression from a Novel rAAV Vector and Its Application in the Prevention of Type 1 Diabetes.

Who Is Enrolling? The Path to Monitoring in Type 1 Diabetes TrialNet's Pathway to Prevention.

Temporal Analysis of Amylase Expression in Control, Autoantibody-Positive, and Type 1 Diabetes Pancreatic Tissues.

Introducing the Endotype Concept to Address the Challenge of Disease Heterogeneity in Type 1 Diabetes.

The risk of progression to type 1 diabetes is highly variable in individuals with multiple autoantibodies following screening.

Interleukin-27 Is Essential for Type 1 Diabetes Development and Sjögren Syndrome-like Inflammation.

Insulin-Like Growth Factor Dysregulation Both Preceding and Following Type 1 Diabetes Diagnosis.

Single Islet Autoantibody at Diagnosis of Clinical Type 1 Diabetes is Associated With Older Age and Insulin Resistance.

Early and late C-peptide responses during oral glucose tolerance testing are oppositely predictive of type 1 diabetes in autoantibody-positive individuals.

Innate inflammation drives NK cell activation to impair Treg activity.

Obesity Treatment Among Adolescents: A Review of Current Evidence and Future Directions.

Commercially Available Insulin Products Demonstrate Stability Throughout the Cold Supply Chain Across the U.S.

Pancreas tissue slices from organ donors enable in situ analysis of type 1 diabetes pathogenesis.

Large-scale electron microscopy database for human type 1 diabetes.

Multiplexing DNA methylation markers to detect circulating cell-free DNA derived from human pancreatic β cells.

Intestinal Delivery of Proinsulin and IL-10 via Combined With Low-Dose Anti-CD3 Restores Tolerance Outside the Window of Acute Type 1 Diabetes Diagnosis.

Removing Formaldehyde-Induced Peptidyl Crosslinks Enables Mass Spectrometry Imaging of Peptide Hormone Distributions from Formalin-Fixed Paraffin-Embedded Tissues.

Comparing Beta Cell Preservation Across Clinical Trials in Recent-Onset Type 1 Diabetes.

Organisation of the human pancreas in health and in diabetes.

CD226 Deletion Reduces Type 1 Diabetes in the NOD Mouse by Impairing Thymocyte Development and Peripheral T Cell Activation.

Immunomodulatory Dual-Sized Microparticle System Conditions Human Antigen Presenting Cells Into a Tolerogenic Phenotype and Inhibits Type 1 Diabetes-Specific Autoreactive T Cell Responses.

Expression of SARS-CoV-2 Entry Factors in the Pancreas of Normal Organ Donors and Individuals with COVID-19.

Pancreatlas: Applying an Adaptable Framework to Map the Human Pancreas in Health and Disease.

Image-Based Machine Learning Algorithms for Disease Characterization in the Human Type 1 Diabetes Pancreas.

Evaluation for type 1 diabetes associated autoantibodies in diabetic and non-diabetic Australian terriers and Samoyeds.

Genetic Composition and Autoantibody Titers Model the Probability of Detecting C-Peptide Following Type 1 Diabetes Diagnosis.

Exocrine Pancreatic Enzymes Are a Serological Biomarker for Type 1 Diabetes Staging and Pancreas Size.

Exocrine Pancreas Dysfunction in Type 1 Diabetes.

Modulation of Leukocytes of the Innate Arm of the Immune System as a Potential Approach to Prevent the Onset and Progression of Type 1 Diabetes.

Integrative analyses of TEDDY Omics data reveal lipid metabolism abnormalities, increased intracellular ROS and heightened inflammation prior to autoimmunity for type 1 diabetes.

Index60 as an additional diagnostic criterion for type 1 diabetes.

Interleukin-27 is essential for type 1 diabetes development and Sjögren syndrome-like inflammation.

TCR/BCR dual-expressing cells and their associated public BCR clonotype are not enriched in type 1 diabetes.

Low-dose ATG/GCSF in Established Type 1 Diabetes: A Five-Year Follow-up Report.

Insulin Receptor-Expressing T Cells Appear in Individuals at Risk for Type 1 Diabetes and Can Move into the Pancreas in C57BL/6 Transgenic Mice.

Islet sympathetic innervation and islet neuropathology in patients with type 1 diabetes.

Distinguishing the real from the hyperglycaemia: does COVID-19 induce diabetes?