Larry A. Walker

Time-resolved spectroscopic studies of B(12) coenzymes: a comparison of the primary photolysis mechanism in methyl-, ethyl-, n-propyl-, and 5'-deoxyadenosylcobalamin.

Natural products inhibiting Candida albicans secreted aspartic proteases from Tovomita krukovii.

Biologically active secondary metabolites from Ginkgo biloba.

Antifungal activity of eupolauridine and its action on DNA topoisomerases.

New sesquiterpenoids from the root of Guatteria multivenia.

Natural products inhibiting Candida albicans secreted aspartic proteases from Lycopodium cernuum.

Characterization of Mycotypha metabolites found to be inhibitors of cell adhesion molecules.

Fatty acid synthase inhibitors from plants: isolation, structure elucidation, and SAR studies.

Flavanone glycosides from Miconia trailii.

Cytotoxic sesquiterpene lactones from Centaurothamnus maximus and Vicoa pentanema.

Genipatriol, a new cycloartane triterpene from Genipa spruceana.

Phenolic compounds from Nymphaea odorata.

Genome-wide expression profiling of the response to polyene, pyrimidine, azole, and echinocandin antifungal agents in Saccharomyces cerevisiae.

A new triterpene from Leandra chaetodon.

Antiparasitic alkaloids from Psychotria klugii.

Acetylenic acids inhibiting azole-resistant Candida albicans from Pentagonia gigantifolia.

Cytotoxic and antioxidant activities of alkylated benzoquinones from Maesa lanceolata.

Reversal of fluconazole resistance in multidrug efflux-resistant fungi by the Dysidea arenaria sponge sterol 9alpha,11alpha-epoxycholest-7-ene-3beta,5alpha,6alpha,19-tetrol 6-acetate.

Spectrophotometric determination of de novo hemozoin/beta-hematin formation in an in vitro assay.

Transport of parthenolide across human intestinal cells (Caco-2).

Circular dichroic properties of flavan-3,4-diols.

Antimalarial and antileishmanial activities of aroyl-pyrrolyl-hydroxyamides, a new class of histone deacetylase inhibitors.

Synthesis and anticancer activities of fatty acid analogs of podophyllotoxin.

A new antimalarial quassinoid from Simaba orinocensis.

Antifungal cyclopentenediones from Piper coruscans.

Piperazine-linked bisbenzamidines: a novel class of antileishmanial agents.

An alpha-proteobacterial type malate dehydrogenase may complement LDH function in Plasmodium falciparum. Cloning and biochemical characterization of the enzyme.

Antimicrobial and antileishmanial activities of hypocrellins A and B.

Synthesis, spectroscopic, and biological studies of novel estolides derived from anticancer active 4-O-podophyllotoxinyl 12-hydroxyl-octadec-Z-9-enoate.

Targeting the hemozoin synthesis pathway for new antimalarial drug discovery: technologies for in vitro beta-hematin formation assay.

Natural products and antifungal drug discovery.

Identification of bis-quindolines as new antiinfective agents.

Anticancer activity and possible mode of action of 4-O-podophyllotoxinyl 12-hydroxyl-octadec-Z-9-enoate.

Synthesis and in vitro cytotoxic activity of N-, F-, and S-ether derivatives of podophyllotoxin fatty acid adducts.

Phenolic glycosides from Potalia amara.

Antimycotic drug discovery in the age of genomics.

8-Aminoquinolines: future role as antiprotozoal drugs.

Growth, drug susceptibility, and gene expression profiling of Plasmodium falciparum cultured in medium supplemented with human serum or lipid-rich bovine serum albumin [corrected].

Role of heme in the antifungal activity of the azaoxoaporphine alkaloid sampangine.

Transport of Schisandra chinensis extract and its biologically-active constituents across Caco-2 cell monolayers - an in-vitro model of intestinal transport.

Antiparasitic activities and toxicities of individual enantiomers of the 8-aminoquinoline 8-[(4-amino-1-methylbutyl)amino]-6-methoxy-4-methyl-5-[3,4-dichlorophenoxy]quinoline succinate.

Antioxidant constituents of Nymphaea caerulea flowers.

In vitro metabolic stability and intestinal transport of P57AS3 (P57) from Hoodia gordonii and its interaction with drug metabolizing enzymes.

New labdane diterpenes from Leonurus cardiaca.

Indolizidine, antiinfective and antiparasitic compounds from Prosopis glandulosa var. glandulosa.

Alkaloids and saponins as cytochrome P450 inhibitors from blue cohosh (Caulophyllum thalictroides) in an in vitro assay.

Analysis of quaternary structure of a [LDH-like] malate dehydrogenase of Plasmodium falciparum with oligomeric mutants.

Bioactive (+)-manzamine A and (+)-8-hydroxymanzamine A tertiary bases and salts from Acanthostrongylophora ingens and their preparations.

Cytochrome P(450)-dependent toxic effects of primaquine on human erythrocytes.

Antimicrobial, antiparasitic and cytotoxic spermine alkaloids from Albizia schimperiana.

Characterization of in vitro pharmacokinetic properties of hoodigogenin A from Hoodia gordonii.

Structure and function of Plasmodium falciparum malate dehydrogenase: role of critical amino acids in co-substrate binding pocket.

Cytochrome P450-dependent toxicity of dapsone in human erythrocytes.

Selective inhibition of human leukemia cell growth and induction of cell cycle arrest and apoptosis by pseudolaric acid B.

Bioavailability, pharmacokinetics, and tissue distribution of the oxypregnane steroidal glycoside P57AS3 (P57) from Hoodia gordonii in mouse model.

How physicians should evaluate dietary supplements.

Antimicrobial and antiparasitic abietane diterpenoids from the roots of Clerodendrum eriophyllum.

Analysis of primaquine and its metabolite carboxyprimaquine in biological samples: enantiomeric separation, method validation and quantification.

Identification of 3-phenylaminoquinolinium and 3-phenylaminopyridinium salts as new agents against opportunistic fungal pathogens.

Benzothieno[3,2-b]quinolinium and 3-(phenylthio)quinolinium compounds: Synthesis and evaluation against opportunistic fungal pathogens.

Methemoglobinemia caused by 8-aminoquinoline drugs: DFT calculations suggest an analogy to H4B's role in nitric oxide synthase.

Oxidized low-density lipoprotein and tissue factor are involved in monocrotaline/lipopolysaccharide-induced hepatotoxicity.

The marine sponge-derived polyketide endoperoxide plakortide F acid mediates its antifungal activity by interfering with calcium homeostasis.

Silencing of tissue factor by antisense deoxyoligonucleotide prevents monocrotaline/LPS renal injury in mice.

Optimization of 3-(phenylthio)quinolinium compounds against opportunistic fungal pathogens.

Dietary supplements: safety issues and quality control.

δ-Carbolines and their ring-opened analogs: synthesis and evaluation against fungal and bacterial opportunistic pathogens.

Tissue factor dependent liver injury causes release of retinoid receptors (RXR-α and RAR-α) as lipid droplets.

Potential utility of natural products as regulators of breast cancer-associated aromatase promoters.

DFT study on the radical anions formed by primaquine and its derivatives.

Epigenetic events associated with breast cancer and their prevention by dietary components targeting the epigenome.

Antiparasitic and antimicrobial isoflavanquinones from Abrus schimperi.

Inhibition of human monoamine oxidase A and B by 5-phenoxy 8-aminoquinoline analogs.

Understanding the mechanisms for metabolism-linked hemolytic toxicity of primaquine against glucose 6-phosphate dehydrogenase deficient human erythrocytes: evaluation of eryptotic pathway.

Tissue factor antisense deoxyoligonucleotide prevents monocrotaline/LPS hepatotoxicity in mice.

CYP450 phenotyping and accurate mass identification of metabolites of the 8-aminoquinoline, anti-malarial drug primaquine.

Pentacyclic ingamine alkaloids, a new antiplasmodial pharmacophore from the marine sponge Petrosid Ng5 Sp5.

Antiparasitic and anticancer carvotacetone derivatives of Sphaeranthus bullatus.