Philip R. Taylor

Characterisation of the expression and function of the GM-CSF receptor alpha-chain in mice.

Characterisation of murine MICL (CLEC12A) and evidence for an endogenous ligand.

Oncostatin M receptor-beta signaling limits monocytic cell recruitment in acute inflammation.

The induction of inflammation by dectin-1 in vivo is dependent on myeloid cell programming and the progression of phagocytosis.

12/15-Lipoxygenase regulates the inflammatory response to bacterial products in vivo.

The C-type lectin SIGNR1 binds Schistosoma mansoni antigens in vitro, but SIGNR1-deficient mice have normal responses during schistosome infection.

CLEC-2 is a phagocytic activation receptor expressed on murine peripheral blood neutrophils.

Cytosolic phospholipase a2 activation by Candida albicans in alveolar macrophages: role of dectin-1.

Phosphatidylethanolamine-esterified eicosanoids in the mouse: tissue localization and inflammation-dependent formation in Th-2 disease.

Complement C3 plays an essential role in the control of opportunistic fungal infections.

Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection.

The myeloid 7/4-antigen defines recently generated inflammatory macrophages and is synonymous with Ly-6B.

Pathways regulating cytosolic phospholipase A2 activation and eicosanoid production in macrophages by Candida albicans.

Endogenous oncogenic Nras mutation promotes aberrant GM-CSF signaling in granulocytic/monocytic precursors in a murine model of chronic myelomonocytic leukemia.

Esterified eicosanoids are acutely generated by 5-lipoxygenase in primary human neutrophils and in human and murine infection.

Fungal recognition enhances mannose receptor shedding through dectin-1 engagement.

Hoxb8 conditionally immortalised macrophage lines model inflammatory monocytic cells with important similarity to dendritic cells.

Paracetamol reduces influenza-induced immunopathology in a mouse model of infection without compromising virus clearance or the generation of protective immunity.

In vivo functional analysis and genetic modification of in vitro-derived mouse neutrophils.

Restoration of pattern recognition receptor costimulation to treat chromoblastomycosis, a chronic fungal infection of the skin.

A quantifiable proliferative burst of tissue macrophages restores homeostatic macrophage populations after acute inflammation.

Macrophage heterogeneity and acute inflammation.

Development of myeloproliferative disease in 12/15-lipoxygenase deficiency.

Anti-inflammatory activity of IgG1 mediated by Fc galactosylation and association of FcγRIIB and dectin-1.

Differential dependencies of monocytes and neutrophils on dectin-1, dectin-2 and complement for the recognition of fungal particles in inflammation.

Phagocytosis is the main CR3-mediated function affected by the lupus-associated variant of CD11b in human myeloid cells.

LAB/NTAL Facilitates Fungal/PAMP-induced IL-12 and IFN-γ Production by Repressing β-Catenin Activation in Dendritic Cells.

Distinct bone marrow-derived and tissue-resident macrophage lineages proliferate at key stages during inflammation.

Interleukin-6 limits influenza-induced inflammation and protects against fatal lung pathology.

Tissue-resident macrophages.

Interleukin-6 signaling drives fibrosis in unresolved inflammation.

Integrin CD11b positively regulates TLR4-induced signalling pathways in dendritic cells but not in macrophages.

miR-192 induces G2/M growth arrest in aristolochic acid nephropathy.

Neutrophils recruited by IL-22 in peripheral tissues function as TRAIL-dependent antiviral effectors against MCMV.

The transcription factor Gata6 links tissue macrophage phenotype and proliferative renewal.

Interleukin-10 regulates the inflammasome-driven augmentation of inflammatory arthritis and joint destruction.

Understanding local macrophage phenotypes in disease: shape-shifting macrophages.

CD200 receptor restriction of myeloid cell responses antagonizes antiviral immunity and facilitates cytomegalovirus persistence within mucosal tissue.

IL-27 Induced by Select Candida spp. via TLR7/NOD2 Signaling and IFN-β Production Inhibits Fungal Clearance.

IL-10 differentially controls the infiltration of inflammatory macrophages and antigen-presenting cells during inflammation.

Death Receptor 3 Promotes Chemokine-Directed Leukocyte Recruitment in Acute Resolving Inflammation and Is Essential for Pathological Development of Mesothelial Fibrosis in Chronic Disease.

Peritoneal macrophage heterogeneity is associated with different peritoneal dialysis outcomes.

Myeloid 12/15-LOX regulates B cell numbers and innate immune antibody levels .

miR-21 Promotes Fibrogenesis in Peritoneal Dialysis.

Death Receptor 3 regulates distinct pathological attributes of acute versus chronic murine allergic lung inflammation.

Networks of enzymatically oxidized membrane lipids support calcium-dependent coagulation factor binding to maintain hemostasis.

Peritoneal tissue-resident macrophages are metabolically poised to engage microbes using tissue-niche fuels.

Differential susceptibility of Dectin-1 isoforms to functional inactivation by neutrophil and fungal proteases.

Structural and Functional Analyses of the Shedding Protease ADAM17 in HoxB8-Immortalized Macrophages and Dendritic-like Cells.

Activation of naïve CD4 T cells re-tunes STAT1 signaling to deliver unique cytokine responses in memory CD4 T cells.

Development and characterization of novel anti-C5 monoclonal antibodies capable of inhibiting complement in multiple species.

The protective effect of inflammatory monocytes during systemic C. albicans infection is dependent on collaboration between C-type lectin-like receptors.

Dependence on Dectin-1 Varies With Multiple Species.

Effective Gene Modification in Mouse Tissue-Resident Peritoneal Macrophages by Intraperitoneal Delivery of Lentiviral Vectors.

Tissue-resident macrophages actively suppress IL-1beta release via a reactive prostanoid/IL-10 pathway.

Macrophage reprogramming for therapy.

Dependence on Mincle and Dectin-2 Varies With Multiple Species During Systemic Infection.

A Human Dectin-2 Deficiency Associated With Invasive Aspergillosis.

Single-Nucleus RNA Sequencing Identifies New Classes of Proximal Tubular Epithelial Cells in Kidney Fibrosis.

PIP2 depletion and altered endocytosis caused by expression of Alzheimer's disease-protective variant PLCγ2 R522.

Modest changes in Spi1 dosage reveal the potential for altered microglial function as seen in Alzheimer's disease.

A Novel Strategy to Identify Haematology Patients at High Risk of Developing Aspergillosis.

Oxylipin metabolism is controlled by mitochondrial β-oxidation during bacterial inflammation.

3R Blackboard: A platform for animal and organ sharing.

Terminal complement pathway activation drives synaptic loss in Alzheimer's disease models.

Th1 Cells Alter the Inflammatory Signature of IL-6 by Channeling STAT Transcription Factors to Alu-like Retroelements.