Children's Nutrition Research Center,
Department of Pediatrics,
Children's Nutrition Research Center, Department of Pediatrics
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A patient tumor-derived orthotopic xenograft mouse model replicating the group 3 supratentorial primitive neuroectodermal tumor in children.
Neuro-oncology Jun, 2014 | Pubmed ID: 24470556
USP21 negatively regulates antiviral response by acting as a RIG-I deubiquitinase.
The Journal of experimental medicine Feb, 2014 | Pubmed ID: 24493797
Inhibition of cancer-associated mutant isocitrate dehydrogenases: synthesis, structure-activity relationship, and selective antitumor activity.
Journal of medicinal chemistry Oct, 2014 | Pubmed ID: 25271760
Silencing BMI1 eliminates tumor formation of pediatric glioma CD133+ cells not by affecting known targets but by down-regulating a novel set of core genes.
Acta neuropathologica communications Dec, 2014 | Pubmed ID: 25526772
Cytogenetic landscape of paired neurospheres and traditional monolayer cultures in pediatric malignant brain tumors.
Neuro-oncology Jul, 2015 | Pubmed ID: 25537021
Functionally defined therapeutic targets in diffuse intrinsic pontine glioma.
Nature medicine Jun, 2015 | Pubmed ID: 25939062
Inhibition of Cancer-Associated Mutant Isocitrate Dehydrogenases by 2-Thiohydantoin Compounds.
Journal of medicinal chemistry Sep, 2015 | Pubmed ID: 26280302
Preservation of KIT genotype in a novel pair of patient-derived orthotopic xenograft mouse models of metastatic pediatric CNS germinoma.
Journal of neuro-oncology May, 2016 | Pubmed ID: 26956263
A chemical screen for medulloblastoma identifies quercetin as a putative radiosensitizer.
Oncotarget Jun, 2016 | Pubmed ID: 26967057
HDAC and PI3K Antagonists Cooperate to Inhibit Growth of MYC-Driven Medulloblastoma.
Cancer cell Mar, 2016 | Pubmed ID: 26977882
Xenotransplantation of pediatric low grade gliomas confirms the enrichment of V600E mutation and preservation of deletion in a novel orthotopic xenograft mouse model of progressive pleomorphic xanthoastrocytoma.
Oncotarget Oct, 2017 | Pubmed ID: 29152094
Concurrent Inhibition of Neurosphere and Monolayer Cells of Pediatric Glioblastoma by Aurora A Inhibitor MLN8237 Predicted Survival Extension in PDOX Models.
Clinical cancer research : an official journal of the American Association for Cancer Research May, 2018 | Pubmed ID: 29463553
Inhibition of Mutated Isocitrate Dehydrogenase 1 in Cancer.
Medicinal chemistry (Shariqah (United Arab Emirates)) , 2018 | Pubmed ID: 29792149
Systems biology-based drug repositioning identifies digoxin as a potential therapy for groups 3 and 4 medulloblastoma.
Science translational medicine Oct, 2018 | Pubmed ID: 30355798
Transcriptional repressor REST drives lineage stage-specific chromatin compaction at and increases AKT activation in a mouse model of medulloblastoma.
Science signaling Jan, 2019 | Pubmed ID: 30670636
Tumor necrosis factor overcomes immune evasion in p53-mutant medulloblastoma.
Nature neuroscience Jul, 2020 | Pubmed ID: 32424282
Patient-Derived Orthotopic Xenograft (PDOX) Mouse Models of Primary and Recurrent Meningioma.
Cancers Jun, 2020 | Pubmed ID: 32517016
Impact of SCID mouse gender on tumorigenicity, xenograft growth and drug-response in a large panel of orthotopic PDX models of pediatric brain tumors.
Cancer letters Nov, 2020 | Pubmed ID: 32891713
Functional Precision Medicine Identifies New Therapeutic Candidates for Medulloblastoma.
Cancer research Dec, 2020 | Pubmed ID: 33046443
Corrigendum to "Impact of SCID mouse gender on tumorigenicity, xenograft growth and drug-response in a large panel of orthotopic PDX models of pediatric brain tumors" [Cancer Lett. 493 (2020) 197-206].
Cancer letters Mar, 2021 | Pubmed ID: 33358190
Spatial Dissection of Invasive Front from Tumor Mass Enables Discovery of Novel microRNA Drivers of Glioblastoma Invasion.
Advanced science (Weinheim, Baden-Wurttemberg, Germany) Dec, 2021 | Pubmed ID: 34719887
Evaluation of an EZH2 inhibitor in patient-derived orthotopic xenograft models of pediatric brain tumors alone and in combination with chemo- and radiation therapies.
Laboratory investigation; a journal of technical methods and pathology Feb, 2022 | Pubmed ID: 34802040
Retraction Note: Tumor necrosis factor overcomes immune evasion in p53-mutant medulloblastoma.
Nature neuroscience Jan, 2022 | Pubmed ID: 34907396
Synergistic anti-tumor efficacy of mutant isocitrate dehydrogenase 1 inhibitor SYC-435 with standard therapy in patient-derived xenograft mouse models of glioma.
Translational oncology Apr, 2022 | Pubmed ID: 35182954
Regulation of TORC1 by MAPK Signaling Determines Sensitivity and Acquired Resistance to Trametinib in Pediatric BRAFV600E Brain Tumor Models.
Clinical cancer research : an official journal of the American Association for Cancer Research Sep, 2022 | Pubmed ID: 35797217
Epigenetic Alterations of Repeated Relapses in Patient-matched Childhood Ependymomas.
Nature communications Nov, 2022 | Pubmed ID: 36335125
Publisher Correction: Epigenetic alterations of repeated relapses in patient-matched childhood ependymomas.
Nature communications Dec, 2022 | Pubmed ID: 36550163
Targeting GBM with an Oncolytic Picornavirus SVV-001 alone and in combination with fractionated Radiation in a Novel Panel of Orthotopic PDX models.
Journal of translational medicine Jul, 2023 | Pubmed ID: 37415222
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