Department of Molecular Biology
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A point mutation that confers constitutive activity to CXCR4 reveals that T140 is an inverse agonist and that AMD3100 and ALX40-4C are weak partial agonists.
The Journal of biological chemistry Jul, 2002 | Pubmed ID: 11923301
Directional bias during mating type switching in Saccharomyces is independent of chromosomal architecture.
The EMBO journal May, 2002 | Pubmed ID: 11980725
Rap1p and other transcriptional regulators can function in defining distinct domains of gene expression.
Nucleic acids research Feb, 2003 | Pubmed ID: 12582242
Making good neighbors: the right fence for the right job.
Nature structural biology Apr, 2003 | Pubmed ID: 12660719
Multiple roles of Tap42 in mediating rapamycin-induced transcriptional changes in yeast.
Molecular cell Jun, 2003 | Pubmed ID: 12820961
Constitutive activation of CCR5 and CCR2 induced by conformational changes in the conserved TXP motif in transmembrane helix 2.
The Journal of biological chemistry Sep, 2003 | Pubmed ID: 12837756
Molecular-size reduction of a potent CXCR4-chemokine antagonist using orthogonal combination of conformation- and sequence-based libraries.
Angewandte Chemie (International ed. in English) Jul, 2003 | Pubmed ID: 12876735
Theoretical and computational studies of the glucose signaling pathways in yeast using global gene expression data.
Biotechnology and bioengineering Dec, 2003 | Pubmed ID: 14708127
The Ras/protein kinase A pathway acts in parallel with the Mob2/Cbk1 pathway to effect cell cycle progression and proper bud site selection.
Eukaryotic cell Feb, 2004 | Pubmed ID: 14871942
Metastin and its variant forms suppress migration of pancreatic cancer cells.
Biochemical and biophysical research communications Feb, 2004 | Pubmed ID: 15013429
The Saccharomyces cerevisiae recombination enhancer biases recombination during interchromosomal mating-type switching but not in interchromosomal homologous recombination.
Genetics Mar, 2004 | Pubmed ID: 15082540
Ras and Gpa2 mediate one branch of a redundant glucose signaling pathway in yeast.
PLoS biology May, 2004 | Pubmed ID: 15138498
A dynamic transcriptional network communicates growth potential to ribosome synthesis and critical cell size.
Genes & development Oct, 2004 | Pubmed ID: 15466158
PP2A phosphatase activity is required for stress and Tor kinase regulation of yeast stress response factor Msn2p.
Eukaryotic cell Oct, 2004 | Pubmed ID: 15470255
Making the right choice--long-range chromosomal interactions in development.
Cell Nov, 2004 | Pubmed ID: 15550239
Sense and sensibility: nutritional response and signal integration in yeast.
Current opinion in microbiology Dec, 2004 | Pubmed ID: 15556035
Mutations in the nucleosome core enhance transcriptional silencing.
Molecular and cellular biology Mar, 2005 | Pubmed ID: 15713639
Design and synthesis of downsized metastin (45-54) analogs with maintenance of high GPR54 agonistic activity.
Bioorganic & medicinal chemistry letters Jan, 2006 | Pubmed ID: 16242330
Creation of GPCR-based chemical sensors by directed evolution in yeast.
Protein engineering, design & selection : PEDS Jan, 2006 | Pubmed ID: 16263727
The dynamics of homologous pairing during mating type interconversion in budding yeast.
PLoS genetics Jun, 2006 | Pubmed ID: 16789829
Single-cell observations reveal intermediate transcriptional silencing states.
Molecular cell Jul, 2006 | Pubmed ID: 16857588
Functional expression of CXCR4 in Saccharomyces cerevisiae in the development of powerful tools for the pharmacological characterization of CXCR4.
Methods in molecular biology (Clifton, N.J.) , 2006 | Pubmed ID: 16878688
Cross-talk and decision making in MAP kinase pathways.
Nature genetics Mar, 2007 | Pubmed ID: 17259986
Sch9 is a major target of TORC1 in Saccharomyces cerevisiae.
Molecular cell Jun, 2007 | Pubmed ID: 17560372
Protein kinase A and Sch9 cooperatively regulate induction of autophagy in Saccharomyces cerevisiae.
Molecular biology of the cell Oct, 2007 | Pubmed ID: 17699586
Evaluation of normalization and pre-clustering issues in a novel clustering approach: global optimum search with enhanced positioning.
Journal of bioinformatics and computational biology Aug, 2007 | Pubmed ID: 17787062
How Saccharomyces responds to nutrients.
Annual review of genetics , 2008 | Pubmed ID: 18303986
Microarray data mining: a novel optimization-based approach to uncover biologically coherent structures.
BMC bioinformatics , 2008 | Pubmed ID: 18538024
Ph.D. Training in cancer biology.
Cancer research Nov, 2008 | Pubmed ID: 19010881
Predicting cellular growth from gene expression signatures.
PLoS computational biology Jan, 2009 | Pubmed ID: 19119411
Glucose regulates transcription in yeast through a network of signaling pathways.
Molecular systems biology , 2009 | Pubmed ID: 19225458
Microarray profiling of phage-display selections for rapid mapping of transcription factor-DNA interactions.
PLoS genetics Apr, 2009 | Pubmed ID: 19360118
Expression of CXCR4, a G-protein-coupled receptor for CXCL12 in yeast identification of new-generation inverse agonists.
Methods in enzymology , 2009 | Pubmed ID: 19446737
Chromatin-dependent transcription factor accessibility rather than nucleosome remodeling predominates during global transcriptional restructuring in Saccharomyces cerevisiae.
Molecular biology of the cell Aug, 2009 | Pubmed ID: 19494041
Protein kinase A and TORC1 activate genes for ribosomal biogenesis by inactivating repressors encoded by Dot6 and its homolog Tod6.
Proceedings of the National Academy of Sciences of the United States of America Nov, 2009 | Pubmed ID: 19901341
The origin recognition complex interacts with a subset of metabolic genes tightly linked to origins of replication.
PLoS genetics Dec, 2009 | Pubmed ID: 19997491
Initiation of the TORC1-regulated G0 program requires Igo1/2, which license specific mRNAs to evade degradation via the 5'-3' mRNA decay pathway.
Molecular cell May, 2010 | Pubmed ID: 20471941
Yeast cells can access distinct quiescent states.
Genes & development Feb, 2011 | Pubmed ID: 21289062
Chromatin remodelers clear nucleosomes from intrinsically unfavorable sites to establish nucleosome-depleted regions at promoters.
Molecular biology of the cell Jun, 2011 | Pubmed ID: 21508315
Decoding complex chemical mixtures with a physical model of a sensor array.
PLoS computational biology Oct, 2011 | Pubmed ID: 22046111
Regulation of yeast pyruvate kinase by ultrasensitive allostery independent of phosphorylation.
Molecular cell Oct, 2012 | Pubmed ID: 22902555
High hydrostatic pressure activates gene expression that leads to ethanol production enhancement in a Saccharomyces cerevisiae distillery strain.
Applied microbiology and biotechnology Mar, 2013 | Pubmed ID: 22915193
Nutritional control of growth and development in yeast.
Genetics Sep, 2012 | Pubmed ID: 22964838
High hydrostatic pressure activates transcription factors involved in Saccharomyces cerevisiae stress tolerance.
Current pharmaceutical biotechnology Dec, 2012 | Pubmed ID: 23072392
Noise and interlocking signaling pathways promote distinct transcription factor dynamics in response to different stresses.
Molecular biology of the cell Jun, 2013 | Pubmed ID: 23615444
Nucleotide degradation and ribose salvage in yeast.
Molecular systems biology , 2013 | Pubmed ID: 23670538
The yeast environmental stress response regulates mutagenesis induced by proteotoxic stress.
PLoS genetics , 2013 | Pubmed ID: 23935537
Genetic heterogeneity of amyotrophic lateral sclerosis: implications for clinical practice and research.
Muscle & nerve Jun, 2014 | Pubmed ID: 24488689
A dynamic interplay of nucleosome and Msn2 binding regulates kinetics of gene activation and repression following stress.
Nucleic acids research May, 2014 | Pubmed ID: 24598258
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