James Broach

A point mutation that confers constitutive activity to CXCR4 reveals that T140 is an inverse agonist and that AMD3100 and ALX40-4C are weak partial agonists.

Directional bias during mating type switching in Saccharomyces is independent of chromosomal architecture.

Rap1p and other transcriptional regulators can function in defining distinct domains of gene expression.

Making good neighbors: the right fence for the right job.

Multiple roles of Tap42 in mediating rapamycin-induced transcriptional changes in yeast.

Constitutive activation of CCR5 and CCR2 induced by conformational changes in the conserved TXP motif in transmembrane helix 2.

Molecular-size reduction of a potent CXCR4-chemokine antagonist using orthogonal combination of conformation- and sequence-based libraries.

Theoretical and computational studies of the glucose signaling pathways in yeast using global gene expression data.

The Ras/protein kinase A pathway acts in parallel with the Mob2/Cbk1 pathway to effect cell cycle progression and proper bud site selection.

Metastin and its variant forms suppress migration of pancreatic cancer cells.

The Saccharomyces cerevisiae recombination enhancer biases recombination during interchromosomal mating-type switching but not in interchromosomal homologous recombination.

Ras and Gpa2 mediate one branch of a redundant glucose signaling pathway in yeast.

A dynamic transcriptional network communicates growth potential to ribosome synthesis and critical cell size.

PP2A phosphatase activity is required for stress and Tor kinase regulation of yeast stress response factor Msn2p.

Making the right choice--long-range chromosomal interactions in development.

Sense and sensibility: nutritional response and signal integration in yeast.

Mutations in the nucleosome core enhance transcriptional silencing.

Design and synthesis of downsized metastin (45-54) analogs with maintenance of high GPR54 agonistic activity.

Creation of GPCR-based chemical sensors by directed evolution in yeast.

The dynamics of homologous pairing during mating type interconversion in budding yeast.

Single-cell observations reveal intermediate transcriptional silencing states.

Functional expression of CXCR4 in Saccharomyces cerevisiae in the development of powerful tools for the pharmacological characterization of CXCR4.

Cross-talk and decision making in MAP kinase pathways.

Sch9 is a major target of TORC1 in Saccharomyces cerevisiae.

Protein kinase A and Sch9 cooperatively regulate induction of autophagy in Saccharomyces cerevisiae.

Evaluation of normalization and pre-clustering issues in a novel clustering approach: global optimum search with enhanced positioning.

How Saccharomyces responds to nutrients.

Microarray data mining: a novel optimization-based approach to uncover biologically coherent structures.

Ph.D. Training in cancer biology.

Predicting cellular growth from gene expression signatures.

Glucose regulates transcription in yeast through a network of signaling pathways.

Microarray profiling of phage-display selections for rapid mapping of transcription factor-DNA interactions.

Expression of CXCR4, a G-protein-coupled receptor for CXCL12 in yeast identification of new-generation inverse agonists.

Chromatin-dependent transcription factor accessibility rather than nucleosome remodeling predominates during global transcriptional restructuring in Saccharomyces cerevisiae.

Protein kinase A and TORC1 activate genes for ribosomal biogenesis by inactivating repressors encoded by Dot6 and its homolog Tod6.

The origin recognition complex interacts with a subset of metabolic genes tightly linked to origins of replication.

Initiation of the TORC1-regulated G0 program requires Igo1/2, which license specific mRNAs to evade degradation via the 5'-3' mRNA decay pathway.

Yeast cells can access distinct quiescent states.

Chromatin remodelers clear nucleosomes from intrinsically unfavorable sites to establish nucleosome-depleted regions at promoters.

Decoding complex chemical mixtures with a physical model of a sensor array.

Regulation of yeast pyruvate kinase by ultrasensitive allostery independent of phosphorylation.

High hydrostatic pressure activates gene expression that leads to ethanol production enhancement in a Saccharomyces cerevisiae distillery strain.

Nutritional control of growth and development in yeast.

High hydrostatic pressure activates transcription factors involved in Saccharomyces cerevisiae stress tolerance.

Noise and interlocking signaling pathways promote distinct transcription factor dynamics in response to different stresses.

Nucleotide degradation and ribose salvage in yeast.

The yeast environmental stress response regulates mutagenesis induced by proteotoxic stress.

Genetic heterogeneity of amyotrophic lateral sclerosis: implications for clinical practice and research.

A dynamic interplay of nucleosome and Msn2 binding regulates kinetics of gene activation and repression following stress.