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Increasing endogenous ceramide using inhibitors of sphingolipid metabolism maximizes ionizing radiation-induced mitochondrial injury and apoptotic cell killing.
International journal of cancer. Journal international du cancer Oct, 2002 | Pubmed ID: 12237902
Overcoming resistance to gamma-rays in squamous carcinoma cells by poly-drug elevation of ceramide levels.
Oncogene Apr, 2004 | Pubmed ID: 15048093
Subcellular compartmentalization of ceramide metabolism: MAM (mitochondria-associated membrane) and/or mitochondria?
The Biochemical journal Sep, 2004 | Pubmed ID: 15144238
Prevalence of drug-induced electrocardiographic pattern of the Brugada syndrome in a healthy population.
The American journal of cardiology Jul, 2004 | Pubmed ID: 15246910
Plasma BNP and NT-proBNP assays by automated immunoanalyzers: analytical and clinical study.
Annals of clinical and laboratory science , 2006 | Pubmed ID: 16951271
Torsades de pointes complicating atrioventricular block: evidence for a genetic predisposition.
Heart rhythm : the official journal of the Heart Rhythm Society Feb, 2007 | Pubmed ID: 17275752
Spatiotemporal electrocardiographic characterization of ventricular depolarization and repolarization abnormalities in long QT syndrome.
Journal of electrocardiology Oct, 2007 | Pubmed ID: 17316676
Radioresistance of human carcinoma cells is correlated to a defect in raft membrane clustering.
Free radical biology & medicine Sep, 2007 | Pubmed ID: 17664132
Protective role of Hsp27 protein against gamma radiation-induced apoptosis and radiosensitization effects of Hsp27 gene silencing in different human tumor cells.
International journal of radiation oncology, biology, physics Feb, 2008 | Pubmed ID: 17980509
Differential regulation of cell death in head and neck cell carcinoma through alteration of cholesterol levels in lipid rafts microdomains.
Biochemical pharmacology Feb, 2008 | Pubmed ID: 17996216
Radiobiologic parameters and local effect model predictions for head-and-neck squamous cell carcinomas exposed to high linear energy transfer ions.
International journal of radiation oncology, biology, physics Jun, 2008 | Pubmed ID: 18234427
A new C-terminal hERG mutation A915fs+47X associated with symptomatic LQT2 and auditory-trigger syncope.
Heart rhythm : the official journal of the Heart Rhythm Society Nov, 2008 | Pubmed ID: 18984536
Rapid, sensitive and inexpensive detection of SCN5A genetic variations by high resolution melting analysis.
Clinical biochemistry Apr, 2009 | Pubmed ID: 19026623
Diversity and complexity of ceramide generation after exposure of jurkat leukemia cells to irradiation.
International journal of radiation oncology, biology, physics Mar, 2009 | Pubmed ID: 19251092
Biophysical characterization of a new SCN5A mutation S1333Y in a SIDS infant linked to long QT syndrome.
FEBS letters Mar, 2009 | Pubmed ID: 19302788
Contribution of long-QT syndrome genetic variants in sudden infant death syndrome.
Pediatric cardiology May, 2009 | Pubmed ID: 19322600
Different mechanisms of cell death in radiosensitive and radioresistant p53 mutated head and neck squamous cell carcinoma cell lines exposed to carbon ions and x-rays.
International journal of radiation oncology, biology, physics May, 2009 | Pubmed ID: 19362238
Heat shock protein 27 as a new therapeutic target for radiation sensitization of head and neck squamous cell carcinoma.
Molecular therapy : the journal of the American Society of Gene Therapy Aug, 2009 | Pubmed ID: 19436268
Quantitative loss of heterozygosity analysis for urothelial carcinoma detection and prognosis.
Urology Aug, 2010 | Pubmed ID: 20206968
Prevalence and spectrum of mutations in a cohort of 192 unrelated patients with hypertrophic cardiomyopathy.
European journal of medical genetics Sep-Oct, 2010 | Pubmed ID: 20624503
[Microsatellite markers and methylation of promoters of tumour suppressor genes in bladder cancer].
Annales de pathologie Nov, 2010 | Pubmed ID: 21055568
Transient alteration of cellular redox buffering before irradiation triggers apoptosis in head and neck carcinoma stem and non-stem cells.
PloS one , 2011 | Pubmed ID: 21283807
Urinary PCA3 score predicts prostate cancer multifocality.
The Journal of urology Apr, 2011 | Pubmed ID: 21334023
[Value of PCA3 urinary test for prostate biopsy decision: the Lyon-Sud University Hospital experience].
Annales de biologie clinique Jan-Feb, 2011 | Pubmed ID: 21463993
Chronic prostatitis does not influence urinary PCA3 score.
The Prostate Apr, 2012 | Pubmed ID: 21761426
DNA double-strand breaks induced by mammographic screening procedures in human mammary epithelial cells.
International journal of radiation biology Nov, 2011 | Pubmed ID: 21797809
Targeting a cornerstone of radiation resistance: cancer stem cell.
Cancer letters Sep, 2012 | Pubmed ID: 22459349
Internalization pathways into cancer cells of gadolinium-based radiosensitizing nanoparticles.
Biomaterials Jan, 2013 | Pubmed ID: 23046756
Telomere profiling: toward glioblastoma personalized medicine.
Molecular neurobiology Feb, 2013 | Pubmed ID: 23065374
Glutathione depletion and carbon ion radiation potentiate clustered DNA lesions, cell death and prevent chromosomal changes in cancer cells progeny.
PloS one , 2012 | Pubmed ID: 23185232
[Cancer stem cells, cornerstone of radioresistance and perspectives for radiosensitization: glioblastoma as an example].
Bulletin du cancer Dec, 2012 | Pubmed ID: 23228708
Impact of hyperthermic intraperitoneal chemotherapy on Hsp27 protein expression in serum of patients with peritoneal carcinomatosis.
Cell stress & chaperones Sep, 2013 | Pubmed ID: 23508575
Intraperitoneal cytokine level in patients with peritoneal surface malignancies. A study of the RENAPE (French Network for Rare Peritoneal Malignancies).
Annals of surgical oncology Aug, 2013 | Pubmed ID: 23519518
p53-independent early and late apoptosis is mediated by ceramide after exposure of tumor cells to photon or carbon ion irradiation.
BMC cancer , 2013 | Pubmed ID: 23530619
Targeting Head and Neck Cancer Stem Cells to Overcome Resistance to Photon and Carbon Ion Radiation.
Stem cell reviews Aug, 2013 | Pubmed ID: 23955575
PCA3 and PCA3-based nomograms improve diagnostic accuracy in patients undergoing first prostate biopsy.
International journal of molecular sciences , 2013 | Pubmed ID: 23994838
Microarray gene expression profiling and analysis of bladder cancer supports the sub classification of the T1 tumours in T1a and T1b stages.
BJU international Jul, 2013 | Pubmed ID: 24053469
Radiation-enhanced cell migration/invasion process: a review.
Critical reviews in oncology/hematology Nov, 2014 | Pubmed ID: 24908570
Combining ultrasmall gadolinium-based nanoparticles with photon irradiation overcomes radioresistance of head and neck squamous cell carcinoma.
Nanomedicine : nanotechnology, biology, and medicine Jan, 2015 | Pubmed ID: 24983891
[Radiation-induces increased tumor cell aggressiveness of tumors of the glioblastomas?].
Bulletin du cancer Sep, 2014 | Pubmed ID: 25296414
Cellular and molecular portrait of eleven human glioblastoma cell lines under photon and carbon ion irradiation.
Cancer letters Apr, 2015 | Pubmed ID: 25657111
Multiparameter Phase I trials: a tool for model-based development of targeted agent combinations--example of EVESOR trial.
Future oncology (London, England) , 2015 | Pubmed ID: 25963428
Telomerase inhibition improves tumor response to radiotherapy in a murine orthotopic model of human glioblastoma.
Molecular cancer , 2015 | Pubmed ID: 26183089
[Cancer stem cells: Radiotherapeutic features and therapeutic targets].
Bulletin du cancer Jan, 2016 | Pubmed ID: 26702506
[Radiosensitivity and/or radioresistance of head and neck cancers: Biological angle].
Bulletin du cancer Jan, 2016 | Pubmed ID: 26702507
Targeting head and neck tumoral stem cells: From biological aspects to therapeutic perspectives.
World journal of stem cells Jan, 2016 | Pubmed ID: 26839637
Gadolinium-Based Nanoparticles and Radiation Therapy for Multiple Brain Melanoma Metastases: Proof of Concept before Phase I Trial.
Theranostics , 2016 | Pubmed ID: 26909115
Preferential targeting of cancer stem cells in the radiosensitizing effect of ABT-737 on HNSCC.
Oncotarget Feb, 2016 | Pubmed ID: 26934442
Nanoparticles in radiation oncology: From bench-side to bedside.
Cancer letters Jun, 2016 | Pubmed ID: 26987625
Influence of Dose Rate on the Cellular Response to Low- and High-LET Radiations.
Frontiers in oncology , 2016 | Pubmed ID: 27014633
MiR-422a promotes loco-regional recurrence by targeting NT5E/CD73 in head and neck squamous cell carcinoma.
Oncotarget Jul, 2016 | Pubmed ID: 27281619
Carbon ion irradiation withstands cancer stem cells' migration/invasion process in Head and Neck Squamous Cell Carcinoma (HNSCC).
Oncotarget Jul, 2016 | Pubmed ID: 27374096
Immunotherapy in head and neck cancer: Harnessing profit on a system disruption.
Oral oncology Nov, 2016 | Pubmed ID: 27623508
EVESOR, a model-based, multiparameter, Phase I trial to optimize the benefit/toxicity ratio of everolimus and sorafenib.
Future oncology (London, England) Apr, 2017 | Pubmed ID: 28076966
Corrigendum: Influence of Dose Rate on the Cellular Response to Low- and High-LET Radiations.
Frontiers in oncology , 2016 | Pubmed ID: 28105406
Preclinical models in HNSCC: A comprehensive review.
Oral oncology Feb, 2017 | Pubmed ID: 28109468
Differential pattern of HIF-1α expression in HNSCC cancer stem cells after carbon ion or photon irradiation: one molecular explanation of the oxygen effect.
British journal of cancer May, 2017 | Pubmed ID: 28407653
Non-invasive prediction of recurrence in bladder cancer by detecting somatic TERT promoter mutations in urine.
British journal of cancer Aug, 2017 | Pubmed ID: 28683471
Gadolinium-based nanoparticles as sensitizing agents to carbon ions in head and neck tumor cells.
Nanomedicine : nanotechnology, biology, and medicine Nov, 2017 | Pubmed ID: 28779947
Dual "mAb" HER family blockade in head and neck cancer human cell lines combined with photon therapy.
Scientific reports Sep, 2017 | Pubmed ID: 28939847
Evaluation of pre-analytical conditions and comparison of the performance of several digital PCR assays for the detection of major mutations in circulating DNA from non-small cell lung cancers: the CIRCAN_0 study.
Oncotarget Oct, 2017 | Pubmed ID: 29152135
Cross-platform comparison for the detection of RAS mutations in cfDNA (ddPCR Biorad detection assay, BEAMing assay, and NGS strategy).
Oncotarget Apr, 2018 | Pubmed ID: 29765524
ROS Production and Distribution: A New Paradigm to Explain the Differential Effects of X-ray and Carbon Ion Irradiation on Cancer Stem Cell Migration and Invasion.
Cancers Apr, 2019 | Pubmed ID: 30987217
Profiling of circulating tumor DNA in plasma of non-small cell lung cancer patients, monitoring of epidermal growth factor receptor p.T790M mutated allelic fraction using beads, emulsion, amplification, and magnetics companion assay and evaluation in future application in mimicking circulating tumor cells.
Cancer medicine Jul, 2019 | Pubmed ID: 31112372
Philippe Pérot1,2,
Valérie Cheynet1,2,
Myriam Decaussin-Petrucci1,3,4,
Guy Oriol1,2,
Nathalie Mugnier5,
Claire Rodriguez-Lafrasse1,4,6,
Alain Ruffion1,4,7,
François Mallet1,2
1, Joint Unit Hospices de Lyon-bioMérieux,
2Medical Diagnostic Discovery Department, BioMérieux,
3Department of Pathology and Cytology, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon,
4Medical Faculty, Lyon 1 University,
5Data and Knowledge Laboratory, BioMérieux,
6Department of Biochemistry and Molecular Biology, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon,
7Department of Urology, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon
Jessica Garcia1,2,3,
David Barthelemy1,2,3,
Florence Geiguer1,2,
Julie Ballandier1,2,3,
Kathryn W. Li4,
Jean-Phillippe Aurel4,
Frédérique Le Breton5,
Claire Rodriguez-Lafrasse1,
Brigitte Manship3,
Sébastien Couraud6,7,
Léa Payen1,2,3
1Laboratoire de Biochimie et Biologie Moléculaire, Groupe Hospitalier Sud, Hospices Civils de Lyon,
2Circulating Cancer (CIRCAN) Program, Hospices Civils de Lyon Cancer Institute,
3University of Lyon, Claude Bernard University, Cancer Research Center of Lyon,
4, Biolidics Limited,
5Institut de Pathologie Multisites des HCL-Site Sud, Hospices Civils de Lyon,
6Acute Respiratory Disease and Thoracic Oncology Department, Lyon Sud Hospital, Hospices Civils de Lyon Cancer Institute,
7EMR-3738 Therapeutic Targeting in Oncology, Lyon Sud Medical Faculty, Lyon 1 University
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